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  1. 1621
    “…RBD-targeting IgAs were found to associate with the secretory component, indicating their bona fide transcytotic origin and their polymeric multivalent nature. …”
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    Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA
  2. 1622
    “…Mechanistic analyses revealed that the gene encoding for protein kinase C alpha (PKCα) is a bona fide target of miR-186. Activation of this kinase significantly reversed the miR-186m-repressed angiogenic activity of HDMECs. …”
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    Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha
  3. 1623
    “…Here, we have applied immunoprecipitation followed by tandem mass spectrometry using the autophagosome marker protein ATG8 as bait and have identified the E3 ligase of the ufmylation system Ufl1 as a bona fide ATG8 interactor under salt stress. Notably, core components in the ufmylation cascade, Ufl1 and Ufm1, interact with the autophagy kinase complexes proteins ATG1 and ATG6. …”
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    Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis
  4. 1624
    “…Knockdown of either SREBF1 or ChREBP attenuated the lipogenic effect of FTO, suggesting that they are bona fide effectors for FTO in regulating lipogenesis. …”
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    Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m(6)A methylation and increasing the stability of SREBF1 and ChREBP mRNAs
  5. 1625
    por Yang, Zetian, Freiwald, Winrich A.
    Publicado 2023
    “…We further found that MD cells encode motion of head, mouth, and eyes in a separable manner, requiring the use of multiple reference frames. Thus, MD is a bona fide face–motion area that uses highly heterogeneous cell populations to create codes capturing even complex facial motion trajectories.…”
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    Encoding of dynamic facial information in the middle dorsal face area
  6. 1626
    Publicado 1998
    Tabla de Contenidos: “…Aetas carmen melodiae (1:16) -- Parce Christus spes reorum (5:47) -- Tempus adest floridum (2:19) -- Resonet in laudibus (3:21) -- Cedit hyems eminus (4:00) -- Personent hodie (2:11) -- Psallat fidelis concio (8:04) -- Jesu dulcis memoria (2:43) -- In dulci jubilo (2:23) -- Florens juventus virginis (9:48) -- Jeremiae prophetae (6:06) -- Ave maris stella (6:09) -- Puer natus in Bethlehem (4:36).…”
    CD Audiom
    Let voices resound songs from Piae cantiones (1582).
  7. 1627
    “…Malignant T cells promote the expansion and proliferation of LAM, which are a bone fide dependency in these lymphomas, and are effectively depleted with a dual CSF1R/JAK inhibitor. …”
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    Targeting Lymphoma-associated Macrophage Expansion via CSF1R/JAK Inhibition is a Therapeutic Vulnerability in Peripheral T-cell Lymphomas
  8. 1628
    “…NC1-induced killing was not inhibited by caspase blockers, anti-apoptotic BCL2 overexpression or TNFα neutralization, suggesting that NC1 elicits a bona fide necrotic pathway. However, pharmacological or genetic inhibition of necroptosis, pyroptosis and ferroptosis failed to block NC1-mediated cell death. …”
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    Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells
  9. 1629
    “…By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identify a receptor tyrosine kinase inhibitor ponatinib that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT-associated telomere synthesis, and targets, in vivo, ALT-positive cells. …”
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    Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)
  10. 1630
    “…Target validation assays identified phospholipase C beta 1 as a bona fide novel target exhibiting antagonistic expression pattern in disease and post‐therapy cohorts. miR‐26a‐5p transfected cells secreted higher levels of cytokine/chemokines upon stimulation with periopathogens and demonstrated impaired cell migration and cytoskeletal rearrangement. …”
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    Downregulation of miRNA‐26 in chronic periodontitis interferes with innate immune responses and cell migration by targeting phospholipase C beta 1
  11. 1631
    “…Lastly, we map YTHDC1 interacting protein partners in myoblasts and unveil a myriad of factors governing mRNA splicing, nuclear export, and transcription, among which hnRNPG appears to be a bona fide interacting partner of YTHDC1. Altogether, our findings uncover YTHDC1 as an essential factor controlling SC regenerative ability through multifaceted gene regulatory mechanisms in mouse myoblast cells.…”
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    Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export
  12. 1632
    “…The macrofossils herein with bona fide organic walls reinforce the biogenicity of Horodyskia. …”
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    Tonian carbonaceous compressions indicate that Horodyskia is one of the oldest multicellular and coenocytic macro-organisms
  13. 1633
    “…The results unequivocally demonstrate that some lesions that do not approach current histologic thresholds are bona fide neoplastic precursors with clinically-relevant driver events that can be detected by the 3-marker panel. …”
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    β-catenin, Pax2, and Pten Panel Identifies Precancers Among Histologically Subdiagnostic Endometrial Lesions
  14. 1634
    “…Single-cell RNA-Seq analysis verifies that MECOM-positive cells are exclusively enriched in the cell cluster of bona fide endothelial cells derived from induced pluripotent stem cells. …”
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    Epigenetic landscape reveals MECOM as an endothelial lineage regulator
  15. 1635
    “…Open reading frames (ORFs) with fewer than 100 codons are generally not annotated in genomes, although bona fide genes of that size are known. Newer biochemical studies have suggested that thousands of small protein-coding ORFs (smORFs) may exist in the human genome, but the true number and the biological significance of the micropeptides they encode remain uncertain. …”
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    Small open reading frames: a comparative genetics approach to validation
  16. 1636
    “…Then, using our optimized techniques, we tested the ability to detect human papillomavirus (HPV) DNA– a bona fide cancer biomarker in a subset of head and neck cancers– from patient saliva samples. …”
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    Isolation of salivary cell-free DNA for cancer detection
  17. 1637
    “…Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deubiquitinase for PD-1. Mechanistically, USP5 interacts with PD-1, leading to deubiquitination and stabilization of PD-1. …”
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    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
  18. 1638
    “…Evidence has suggested that FOXOs behave as ‘bona fide’ tumour suppressors, through transcriptional programmes regulating several cellular behaviours including cell cycle arrest and apoptosis. …”
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    The discrete roles of individual FOXO transcription factor family members in B-cell malignancies
  19. 1639
    “…Of these misorientations, 81% correspond to bona fide large inversion polymorphisms in the human species, most of which are flanked by large segmental duplications. …”
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    Gaps and complex structurally variant loci in phased genome assemblies
  20. 1640
    “…Thus, this work is the first to show that VirB is a bona fide CTP-binding protein and links Shigella virulence phenotypes to the nucleoside triphosphate, CTP.…”
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    VirB, a key transcriptional regulator of Shigella virulence, requires a CTP ligand for its regulatory activities
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