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1741por Jackson, Belinda M., Abete-Luzi, Patricia, Krause, Michael W., Eisenmann, David M.“…A subset of the up-regulated genes was shown to have altered expression in mutants with decreased or increased Wnt signaling; we consider these genes to be bona fide C. elegans Wnt pathway targets. Among these was a group of six genes, including the cuticular collagen genes, bli-1col-38, col-49, and col-71. …”
Publicado 2014
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1742por Salat-Canela, Clàudia, Sesé, Marta, Peula, Cristina, Ramón y Cajal, Santiago, Aasen, Trond“…Through direct RNA transfection experiments, we provide evidence that internal translation is not due to a bona fide cap-independent IRES-mediated mechanism, as upstream ribosomal scanning or translation is required. …”
Publicado 2014
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1743por Cruz, Rui, Huesgen, Pitter, Riley, Sean P., Wlodawer, Alexander, Faro, Carlos, Overall, Christopher M., Martinez, Juan J., Simões, Isaura“…Finally, we demonstrated that APRc is sufficient to catalyze the in vitro processing of two conserved high molecular weight autotransporter adhesin/invasion proteins, Sca5/OmpB and Sca0/OmpA, thereby suggesting the participation of this enzyme in a relevant proteolytic pathway in rickettsial life-cycle. As a novel bona fide member of the retropepsin family of aspartic proteases, APRc emerges as an intriguing target for therapeutic intervention against fatal rickettsioses.…”
Publicado 2014
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1744por Samad, Aysha, James, Andrew, Wong, James, Mankad, Parini, Whitehouse, John, Patel, Waseema, Alves-Simoes, Marta, Siriwardena, Ajith K., Bruce, Jason I. E.“…These data provide the first evidence that insulin directly protects pancreatic acinar cell injury induced by bona fide pancreatitis-inducing agents, such as POA. This may have important therapeutic implications for the treatment of pancreatitis.…”
Publicado 2014
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1745por Rolandsson, Sara, Andersson Sjöland, Annika, Brune, Jan C, Li, Hongzhe, Kassem, Moustapha, Mertens, Fredrik, Westergren, Albert, Eriksson, Leif, Hansson, Lennart, Skog, Ingrid, Bjermer, Leif, Scheding, Stefan, Westergren-Thorsson, Gunilla“…This study therefore aimed to identify and characterise the ‘bona fide’ MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients. …”
Publicado 2014
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1746por Lin, Changsheng, Ear, Jason, Midde, Krishna, Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Garcia-Marcos, Mikel, Kufareva, Irina, Abagyan, Ruben, Ghosh, Pradipta“…We discovered a unifying mechanism that allows GIV/Girdin, a bona fide metastasis-related protein and a guanine-nucleotide exchange factor (GEF) for Gαi, to serve as a direct platform for multiple RTKs to activate Gαi proteins. …”
Publicado 2014
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1747“…Finally, DNMT3B establishes secondary methylation marks at imprinted loci, which distinguishes bona fide germline from somatic methylation imprints. …”
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1748por Mollo, Maria Rosaria, Antonini, Dario, Mitchell, Karen, Fortugno, Paola, Costanzo, Antonio, Dixon, Jill, Brancati, Francesco, Missero, Caterina“…Taken together, our results indicate that Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 control.…”
Publicado 2015
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1749por Dunn, Tamara N., Akiyama, Tasuku, Lee, Hyun Woo, Kim, Jae Bum, Knotts, Trina A., Smith, Steven R., Sears, Dorothy D., Carstens, Earl, Adams, Sean H.“…Specific regulation of the synuclein-γ gene (Sncg) by PPARγ requires further evaluation, especially in peripheral neurons, prompting us to test if Sncg is a bona fide PPARγ target in murine adipocytes and peripheral somatosensory neurons derived from the dorsal root ganglia (DRG). …”
Publicado 2015
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1750“…PURPOSE: Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in vitro. …”
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1751por Chu, Chen, Zheng, Guangyong, Hu, Shuanggang, Zhang, Jinsong, Xie, Shengsong, Ma, Wubin, Ni, Minjie, Tang, Chunhua, Zhou, Lu, Zhou, Yuchuan, Liu, Mofang, Li, Yixue, Zhang, Yonglian“…By GSEA analysis, the differential expression of miR-200 family between caput and cauda was shown to be negatively correlated with their predicted target genes, among which 4 bona fide targets were verified by luciferase reporter assay. …”
Publicado 2015
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1752por Zhang, Lei, Tang, Fengyuan, Terracciano, Luigi, Hynx, Debby, Kohler, Reto, Bichet, Sandrine, Hess, Daniel, Cron, Peter, Hemmings, Brian A., Hergovich, Alexander, Schmitz-Rohmer, Debora“…CONCLUSIONS: We establish mammalian NDR1/2 as bona fide kinases that target YAP1 on S127 in vitro and in vivo. …”
Publicado 2015
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1753por ZHANG, YINGYING, CHEN, XIONG, LIAN, HAIWEI, LIU, JIANMIAO, ZHOU, BEIYAN, HAN, SONG, PENG, BIWEN, YIN, JUN, LIU, WANHONG, HE, XIAOHUA“…In addition, we identified insulin-like growth factor-1 (IGF-1R) receptor mRNA is a bona fide target of miR-503 by computational analysis followed by luciferase reporter assays. …”
Publicado 2014
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1754por Herbert, Andrew S., Davidson, Cristin, Kuehne, Ana I., Bakken, Russell, Braigen, Stephen Z., Gunn, Kathryn E., Whelan, Sean P., Brummelkamp, Thijn R., Twenhafel, Nancy A., Chandran, Kartik, Walkley, Steven U., Dye, John M.“…Taken together, our results show that NPC1 is critical for replication and pathogenesis in animals and is a bona fide target for development of antifilovirus therapeutics. …”
Publicado 2015
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1755por Gershburg, Svetlana, Geltz, Joshua, Peterson, Karin E., Halford, William P., Gershburg, Edward“…Herpes simplex virus type 1 (HSV-1) encodes two bona fide serine/threonine protein kinases, the US3 and UL13 gene products. …”
Publicado 2015
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1756por Alves, Mónica N., Neto, Sónia E., Alves, Alexandra S., Fonseca, Bruno M., Carrêlo, Afonso, Pacheco, Isabel, Paquete, Catarina M., Soares, Cláudio M., Louro, Ricardo O.“…Most are multiheme cytochromes that carry electrons to terminal reductases of insoluble electron acceptors located at the cell surface, or bona fide terminal reductases of soluble electron acceptors. …”
Publicado 2015
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1757por Shamseldin, Hanan E., Tulbah, Maha, Kurdi, Wesam, Nemer, Maha, Alsahan, Nada, Al Mardawi, Elham, Khalifa, Ola, Hashem, Amal, Kurdi, Ahmed, Babay, Zainab, Bubshait, Dalal K., Ibrahim, Niema, Abdulwahab, Firdous, Rahbeeni, Zuhair, Hashem, Mais, Alkuraya, Fowzan S.“…An approach that considers embryonic lethality as a bona fide Mendelian phenotype has the potential to reveal novel genetic causes, which will further our understanding of early human development at a molecular level. …”
Publicado 2015
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1758por Parrish, Nicholas F., Fujino, Kan, Shiromoto, Yusuke, Iwasaki, Yuka W., Ha, Hongseok, Xing, Jinchuan, Makino, Akiko, Kuramochi-Miyagawa, Satomi, Nakano, Toru, Siomi, Haruhiko, Honda, Tomoyuki, Tomonaga, Keizo“…Three of the seven human EBLNs fall within annotated piRNA clusters and two marmoset EBLNs give rise to bona fide piRNAs. In both rats and mice, at least two of the five EBLNs give rise to abundant piRNAs in the male gonad. …”
Publicado 2015
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1759por Law, Jennifer, Salla, Mohamed, Zare, Alaa, Wong, Yoke, Luong, Le, Volodko, Natalia, Svystun, Orysya, Flood, Kayla, Lim, Jonathan, Sung, Miranda, Dyck, Jason R. B., Tan, Chong Teik, Su, Yu-Chin, Yu, Victor C., Mackey, John, Baksh, Shairaz“…Although RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a tumor suppressor protein has yet to be determined. …”
Publicado 2015
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1760“…In summary, we established a novel method for the quantitative production of murine bona fide osteoclasts from ER-Hoxb8 stem cells generated from wild type or genetically manipulated mouse lines. …”
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