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  1. 1801
    “…Cross-reactivity of 1H6 to immobilized single stranded T-rich DNA next to its previously reported specificity for bona fide G4 structures needs to be taken into account in the interpretation of 1H6 binding to (sub-) cellular structures.…”
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    Guanine quadruplex monoclonal antibody 1H6 cross-reacts with restrained thymidine-rich single stranded DNA
  2. 1802
    “…These findings suggest that a high level of CD73 expression is a bona fide biomarker of ccRCC stem-like cells. Future research will aim at the elucidation of the underlying mechanisms of CD73 in RCC development and the distinct aspects of ccRCC stem-like cells from other tumor types.…”
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    Ecto-5′-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells
  3. 1803
    “…After corroborating SUMOylation of Prp3 in cultured cells, we defined Lys 289 and Lys 559 as bona fide SUMO attachment sites within this spliceosomal protein. …”
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    SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
  4. 1804
    “…Here, we provide evidence that the HpaB and HpaD proteins do act as bona fide R. solanacearum class IB chaperones that associate with several T3Es. …”
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    HpaB-Dependent Secretion of Type III Effectors in the Plant Pathogens Ralstonia solanacearum and Xanthomonas campestris pv. vesicatoria
  5. 1805
    “…We also find that these temperature- and polyglutamine-dependent conformational changes are sensitive to bona-fide phosphorylation on S13 and S16 within the N17 domain of HTT. …”
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    Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
  6. 1806
    “…Within macrophages and amoeba, the Legionella-containing vacuole (LCV) membrane is derived from the ER. The bona fide F-box AnkB effector protein of L. pneumophila strain AA100/130b is anchored to the cytosolic side of the LCV membrane through host-mediated farnesylation of its C-terminal eukaryotic “CaaX” motif. …”
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    Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane
  7. 1807
    “…The unicellular alga Chlamydomonas reinhardtii contains many types of small RNAs (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remains unclear. To address their possible function(s) in responses to nutrient availability, we examined miRNA expression in cells cultured under different trophic conditions (mixotrophic in the presence of acetate or photoautotrophic in the presence or absence of nitrogen). …”
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    miRNAs in the alga Chlamydomonas reinhardtii are not phylogenetically conserved and play a limited role in responses to nutrient deprivation
  8. 1808
    “…De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase. …”
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    In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology
  9. 1809
    “…The NS1/2-FFAT mimic region interacted with the VAPA-MSP domain in a manner similar to that seen with bona fide host FFAT motifs. Amino acids in the FFAT mimic region of the NS1 domain that are important for viral replication are highly conserved across murine norovirus strains. …”
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    Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2
  10. 1810
    “…CONCLUSION: We provided the first evidence that CDK16 is an bona fide oncogene in HCC, and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC. …”
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    Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression
  11. 1811
    “…In summary, Gata1(low) mice are a bona fide model of MF, which recapitulates the hyperactivation of the TPO/MPL/JAK2 axis observed in megakaryocytes from myelofibrotic patients.…”
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    The thrombopoietin/MPL axis is activated in the Gata1(low) mouse model of myelofibrosis and is associated with a defective RPS14 signature
  12. 1812
    “…We bioinformatically characterized all putative sRNAs and applied machine learning approaches to calculate the probability of a nucleotide sequence to be a bona fide sRNA. The resulting quantitative model was able to correctly classify 95.2% of sequences in a validation set. …”
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    Genome-wide identification and characterization of small RNAs in Rhodobacter capsulatus and identification of small RNAs affected by loss of the response regulator CtrA
  13. 1813
    “…These data provide the impetus to address the bona fide therapeutic potential of FXR activation in disease with BA-associated development of HCC.…”
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    Long-term Administration of Nuclear Bile Acid Receptor FXR Agonist Prevents Spontaneous Hepatocarcinogenesis in Abcb4(−/−) Mice
  14. 1814
    por Gupta, Payal, Dash, Prasanta K.
    Publicado 2017
    “…PLA(2) activity of the cloned sPLA(2)s were biochemically assayed authenticating them as bona fide phospholipase A(2). Physiochemical properties of both the sPLA(2)s revealed they are thermostable proteins requiring di-valent cations for optimum activity.While, structural analysis of both the proteins revealed deviations in the amino acid sequence at C- & N-terminal regions; hydropathic study revealed LusPLA(2)I as a hydrophobic protein and LusPLA(2)II as a hydrophilic protein. …”
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    Molecular details of secretory phospholipase A(2) from flax (Linum usitatissimum L.) provide insight into its structure and function
  15. 1815
    “…For 255 of the novel genes, annotated homologs in other bacteria were found, and a machine-learning algorithm, trained on small protein-coding E. coli genes, predicted that 89% of these translated open reading frames represent bona fide genes. The remaining 210 putative novel genes without annotated homologs were compared to the 255 novel genes with homologs and to 250 short annotated genes of this E. coli strain. …”
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    Discovery of numerous novel small genes in the intergenic regions of the Escherichia coli O157:H7 Sakai genome
  16. 1816
    “…Previous studies of primed adaptation have been complicated by intrinsically high interference efficiency of most systems against bona fide targets. As such, most primed adaptation to date has been studied within the context of imperfect sequence complementarity between spacers and targets. …”
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    Priming in a permissive type I-C CRISPR–Cas system reveals distinct dynamics of spacer acquisition and loss
  17. 1817
    “…Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) has recently been found to be a bona fide marker of colorectal CSCs. Our previous study showed that LGR5 functions as a tumor promoter in cervical cancer by activating the Wnt/β-catenin pathway. …”
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    LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer
  18. 1818
    “…Thus, DUSP12 is a bona fide MAPK phosphatase, playing an important role in MAPK-regulated responses to bacterial infection. …”
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    Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection
  19. 1819
    “…Synteny analyses revealed bona fide paralogs and Arabidopsis orthologs. Co-expression analysis between MATE and regulatory genes revealed 78 positive and 8 negative strong associations (ρ≥|0.8|). …”
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    Global analysis of the MATE gene family of metabolite transporters in tomato
  20. 1820
    “…We identified 25,869 CAGE peaks, representing bona fide promoters. For each peak we provide detailed annotation, expanding the landscape of ‘known’ macaque genes, and we show concrete examples on how to use the resulting data. …”
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    Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system
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