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  1. 1821
    “…Moreover, several other examples of TA module toxins that are bona fide substrates of conjugative T4SS indicate that their recruitment as interbacterial effectors is prevalent and serves yet unknown biological functions in the context of bacterial conjugation. …”
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    A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella
  2. 1822
    “…Mimicry leads to fluorescently labeled pyoS2(NTD) being imported into FpvAI-expressing P. aeruginosa cells by a process analogous to that used by bona fide TBDT ligands. PyoS2(NTD) induces unfolding by TonB1 of a force-labile portion of the plug domain that normally occludes the central channel of FpvAI. …”
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    Exploitation of an iron transporter for bacterial protein antibiotic import
  3. 1823
    “…Here, we reveal the existence of a bona fide PRMT4 homolog in the chicken, Gallus gallus. …”
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    Identification and in silico structural analysis of Gallus gallus protein arginine methyltransferase 4 (PRMT4)
  4. 1824
    “…We then provided molecular and genetic evidence that this motif could contribute to Pol δ-PCNA interaction indirectly, although it is not a bona fide PIP. Overall, our results suggest that the primary role of PCNA ubiquitination is to allow TLS polymerases to outcompete Pol δ for PCNA access upon DNA damage.…”
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    The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ
  5. 1825
    “…RNA-Seq analysis showed that RNF43-mutated CACs had elevated expression of c-Myc and its target genes, suggesting that RNF43 is a bona fide driver of CAC development. This study provides evidence that somatic mutation of RNF43 is the driver genetic alteration that links chronic inflammation and cancer development in about 10% of CACs.…”
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    Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling
  6. 1826
    “…Recent studies that have emerged on the diversity of RNA modification in tumors suggest their eligibility as bona fide targets in diagnosis and drug discovery. N6-methyladenosine (m(6)A) was first reported and is most common in epitranscriptome modification of various RNAs. …”
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    Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer
  7. 1827
    “…We have identified TIMP-1 as a bona fide target of miR-125a-5p, and their interaction resulted in an increase in p53 expression. …”
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    TIMP-1 downregulation modulates miR-125a-5p expression and triggers the apoptotic pathway
  8. 1828
    “…Density gradients and triglyceride analysis revealed that iHLCs secreted very-low density lipoprotein (VLDL)-like lipoproteins, providing a putative platform for bona fide lipoviroparticles. iHLCs supported the full HCV life cycle, but in contrast to Huh7 and Huh7.5 cells, replication and viral RNA levels decreased continuously. …”
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    Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell–derived hepatocytes
  9. 1829
    “…LC/X shares the core fold common to all other BoNTs, demonstrating that LC/X is a bona fide member of BoNT-LCs. We found that access to the catalytic pocket of LC/X is more restricted, and the regions lining the catalytic pocket are not conserved compared to other BoNTs. …”
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    Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity
  10. 1830
    “…Moreover, HOX gene level decreased after transfection of miR‐99a mimics in BMSCs, which indicated that KDM6B is a bona fide target of miR‐99a. Furthermore, in a model of in vivo bone regeneration, osteoblast‐specific gain‐ and loss‐of‐function experiments performed using cranial bone defects revealed that miR‐99a mimics‐transfected BMSCs reduced bone formation, and conversely, miR‐99a inhibitors‐transfected BMSCs increased in vivo bone formation. …”
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    MicroRNA‐99a is a novel regulator of KDM6B‐mediated osteogenic differentiation of BMSCs
  11. 1831
    “…In addition, AvrRps4(N) triggers a hypersensitive response in lettuce that is attenuated by coexpression of AvrRps4(C), further supporting the role of AvrRps4(N) as a bona fide effector domain. Based on these results we propose that evolutionarily, fusion of AvrRps4(C) to AvrRps4(N) may have counteracted recognition of AvrRps4(N), and that the plant RPS4/RRS1 resistance gene pair was selected as a countermeasure. …”
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    The bacterial type III-secreted protein AvrRps4 is a bipartite effector
  12. 1832
    “…IKKα directly activates stemness-related genes through an interaction with AhR as a bone fide chromatin modifier. Thus, AhR is functionally linked with cancer stem-like properties, and it drives tumorigenesis in the occurrence of radioresistance.…”
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    Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance
  13. 1833
    “…Analysis of the 16S rRNA genes at the bacterial community level showed a very diverse microbiome that was dominated by Alphaproteobacteria in all sites. Bona fide methane-oxidizing taxa were not very abundant (relative abundance less than 0.1%). …”
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    The influence of oxygen and methane on nitrogen fixation in subarctic Sphagnum mosses
  14. 1834
    “…In summary, our findings demonstrate that ZNF382 functions as a bona fide tumour suppressor inhibiting ESCC pathogenesis through inhibiting the Wnt/β-catenin signalling pathway.…”
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    The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/β-catenin signalling
  15. 1835
    “…Astronomical observations show that typical interstellar dust consists of amorphous (a-) silicate and organic carbon. Bona fide physical samples for laboratory studies would yield unprecedented insight about solar system formation, but they were largely destroyed. …”
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    Multiple generations of grain aggregation in different environments preceded solar system body formation
  16. 1836
    “…Based on periodicity, favoring enrichment over the coding regions, it determines the read lengths corresponding to bona fide ribosome protected fragments. The specific codon under translation (P-site) is determined by automatic offset calculations resulting in sub-codon resolution. …”
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    Shoelaces: an interactive tool for ribosome profiling processing and visualization
  17. 1837
    “…We therefore suggest that α‐catenin represents a bona fide tumor suppressor for the development of lobular‐type breast cancer and as such provides an alternative event to E‐cadherin inactivation, adherens junction (AJ) dysfunction, and subsequent constitutive actomyosin contraction. © 2018 The Authors. …”
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    αE‐catenin is a candidate tumor suppressor for the development of E‐cadherin‐expressing lobular‐type breast cancer
  18. 1838
    “…We characterized the function of miR‐106a through in vitro and in vivo experiments and employed transcriptomic analysis, western blotting, and 3′UTR luciferase assays to establish LITAF as a bona fide target of miR‐106a. Using our well‐characterized radiation‐resistant cell lines, we identified that miR‐106a was overexpressed in radiation‐resistant cells compared to parental cells. …”
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    miRNA‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation
  19. 1839
    “…The invigorated GARD scrutiny presented in this review enhances the validity of autocatalytic sets as a bona fide early evolution scenario and provides essential infrastructure for a paradigm shift towards a systems protobiology view of life's origin.…”
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    Systems protobiology: origin of life in lipid catalytic networks
  20. 1840
    “…Here we report that Brg1 is a bona fide ubiquitin substrate of SCF(FBW7). We reveal that CK1δ phosphorylates Brg1 at Ser31/Ser35 residues to facilitate the binding of Brg1 to FBW7, leading to ubiquitination-mediated degradation. …”
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    SCF(FBW7)-mediated degradation of Brg1 suppresses gastric cancer metastasis
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