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  1. 1841
    por Bitzan, Martin, Zieg, Jakub
    Publicado 2017
    “…Two patients had bona fide TTP with ADAMTS13 activity <10%. Median age was 15 years (range 0.5–68 years), two thirds were male. …”
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    Influenza-associated thrombotic microangiopathies
  2. 1842
    “…Therefore, our findings provide strong evidence, for the first time, that deficiency of miR-144/451 expression may play a bona fide role in derepression of silenced c-Myc, which contributes to tumor development including B-lymphomagenesis.…”
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    Activating and sustaining c-Myc by depletion of miR-144/451 gene locus contributes to B-lymphomagenesis
  3. 1843
    “…Employing restricted and integration-free expression of SOX2 and c-MYC, we generated a fully functional, bona fide NSC population from adult blood cells that remains highly responsive to regional patterning cues. …”
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    A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
  4. 1844
    “…We also developed a bioinformatics approach to filter snoRNA-target interactions for bona fide methylation guide interactions. Results: We recovered 241,420 hybrids, out of which 190,597 were classed as reproducible, high energy hybrids. …”
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    Mapping targets for small nucleolar RNAs in yeast
  5. 1845
    por Schwartz, Schraga
    Publicado 2018
    “…Only 53 of the sites detected in the latter study likely reflect bona-fide internal modifications of cytoplasmically encoded mRNA molecules, nearly all of which are likely TRMT6/TRMT61A substrates and typically modified at low to undetectable levels. …”
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    m(1)A within cytoplasmic mRNAs at single nucleotide resolution: a reconciled transcriptome-wide map
  6. 1846
    “…We investigated whether the bona fide MTH1 inhibitor TH588 affects responses of cultured colorectal tumor cells to ionizing radiation (IR) in normoxia and in moderate or severe hypoxia. …”
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    The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia
  7. 1847
    “…We use these approaches to validate Myc, Met, Pten and Rb1 as bona fide drivers in BRCA1-associated mammary tumorigenesis. …”
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    Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
  8. 1848
    “…CONCLUSIONS: In our mouse model, firefly luciferase activity serves as a bona fide reporter for dynamic regulation of Ucp1. In addition, by means of iRFP713 we are able to monitor Ucp1 expression in a non-invasive fashion.…”
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    A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment
  9. 1849
    “…Mutated proto-oncogene BRAF is a bona fide therapeutic target for melanomas. Regrettably, melanoma acquires resistance to BRAF inhibitors, e.g., vemurafenib (PLX4032) casting doubt on this promising melanoma targeted therapy. …”
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    Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death
  10. 1850
    “…Copper and riboflavin uptake abilities of these strains were compared with those expressing R. capsulatus CcoA and Rhizobium leguminosarum RibN as bona fide copper and riboflavin importers, respectively. …”
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    Cu Transport by the Extended Family of CcoA-like Transporters (CalT) in Proteobacteria
  11. 1851
    “…Most importantly the influence of salicylic acid (SA) on these interactions has become clearer with NPR1, NPR3, and NPR4 being considered bone fide SA receptors. Additionally, post-translational modification of NPR1 has garnered attention during the past years, adding to the growing regulatory complexity of this protein. …”
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    The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and Related Family: Mechanistic Insights in Plant Disease Resistance
  12. 1852
    “…Members of the PEA3 transcription factors are emerging as bone fide targets for fibroblast growth factor (FGF) signaling. …”
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    Characterization of Tg(Etv4-GFP) and Etv5(RFP) Reporter Lines in the Context of Fibroblast Growth Factor 10 Signaling During Mouse Embryonic Lung Development
  13. 1853
    “…Our mutational analysis showed that 200IVDI203 and 257IKVV260 are two bona fide SIMs that mediate IN-SUMO noncovalent interactions. …”
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    Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
  14. 1854
    “…The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of cell entry. …”
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    Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors
  15. 1855
    “…To date, several screening studies have been carried out to discover bona fide ICD inducers and reveal the inherent capacity of a wide variety of drugs to induce cell death-associated exposure of danger signals and to bring about in vivo anti-cancer immune responses. …”
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    Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
  16. 1856
    “…Despite the general effectiveness of bona fide psychotherapies, the number of patients who deteriorate or fail to improve is still problematic. …”
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    Successful and Less Successful Psychotherapies Compared: Three Therapists and Their Six Contrasting Cases
  17. 1857
    “…Intriguingly, PilE1 more closely resembles pseudopilins forming shorter Tff than bona fide Tfp-forming major pilins, underlining the evolutionary relatedness among different Tff. …”
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    Global biochemical and structural analysis of the type IV pilus from the Gram-positive bacterium Streptococcus sanguinis
  18. 1858
    “…Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2 (RIPK2), myeloid differentiation primary response 88 (MYD88), and C-X-C motif chemokine ligand 12 (CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. …”
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    MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors
  19. 1859
    “…We benchmarked NeoMutate by simulating more than 10,000 bona fide cancer-related mutations into three well-characterized Genome in a Bottle (GIAB) reference samples. …”
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    NeoMutate: an ensemble machine learning framework for the prediction of somatic mutations in cancer
  20. 1860
    “…Methods: We isolated bona fide Tregs from expansion cultures based on their selective surface expression of latency-associated peptide (LAP). …”
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    Human LAP(+)GARP(+)FOXP3(+) regulatory T cells attenuate xenogeneic graft versus host disease
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