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  1. 1901
    “…Importantly, only the full-length protein from the first group is a bona fide effector protein injected into host cells during infection and has anti-apoptotic activity. …”
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    The anti-apoptotic Coxiella burnetii effector protein AnkG is a strain specific virulence factor
  2. 1902
    “…Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum. huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. …”
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    Attenuated P. falciparum Parasite Shows Cytokine Variations in Humanized Mice
  3. 1903
    “…Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. …”
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    Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801
  4. 1904
    “…Using small interfering RNA suppression, lipid reactive oxygen species (ROS), iron tracers and bona fide inducers of ferroptosis, we find that dynasore treatment in lung adenocarcinoma and neuronal cell lines strongly protects these from ferroptosis. …”
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    Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration
  5. 1905
    “…This shows SRRM4, in which its expression is correlated with poor prognosis in gliomas, acts as a bona fide circRNA biogenesis factor. Given the known roles of MEs and circRNAs in oncogenesis, the identification of these previously unrecognized ME-circRNAs further increases the complexity and functional purview of this non-coding RNA family.…”
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    SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion
  6. 1906
    “…These results identify SOX10 as a bona fide master regulator of the RTK I subtype, with both tumour cell-intrinsic and microenvironmental effects.…”
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    Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
  7. 1907
    “…Drug tolerant/resistant leukemic stem cell (LSC) subpopulations may explain frequent relapses in acute myeloid leukemia (AML), suggesting that these relapse-initiating cells (RICs) persistent after chemotherapy represent bona fide targets to prevent drug resistance and relapse. …”
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    Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells
  8. 1908
    “…In particular, the results reported here point to a prominent role of PDCD10 as a bona fide oncogene.…”
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    Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer
  9. 1909
    “…We furthermore establish H1 as a bona fide tumor suppressor, whose mutation drives malignant transformation primarily through three-dimensional genome reorganization, followed by epigenetic reprogramming and derepression of developmentally silenced genes.…”
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    Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
  10. 1910
    por Fujibayashi, Kana, Mima, Joji
    Publicado 2021
    “…Here, using a chemically-defined reconstitution approach with purified proteins of two representative Arf isoforms in humans (Arf1, Arf6) and synthetic liposomes for model membranes, we discovered that Arf6 can function as a bona fide membrane tether, directly and physically linking two distinct lipid bilayers even in the absence of any other tethering factors, whereas Arf1 retained little potency to trigger membrane tethering under the current experimental conditions. …”
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    The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
  11. 1911
    “…Moreover, we identify LZTS2 as a bona fide substrate of the E3 ligase β-Trcp and protein kinase CK1δ, which are responsible for the ubiquitination and degradation of LZTS2. …”
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    β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma
  12. 1912
    “…One such inhibitor, AcrIC3, is found in an ‘anti-Cas3’ cluster within conjugative elements, encoded alongside bona fide Cas3 inhibitors AcrIF3 and AcrIE1. Our findings demonstrate an active battle between an MGE-encoded CRISPR–Cas system and its diverse MGE targets.…”
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    Mobile element warfare via CRISPR and anti-CRISPR in Pseudomonas aeruginosa
  13. 1913
    por Pan, Mengwu, Blattner, Christine
    Publicado 2021
    “…In the nucleus, p53 functions as a bona-fide transcription factor which activates and represses transcription of a number of target genes. …”
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    Regulation of p53 by E3s
  14. 1914
    “…Statistical modeling confirmed bona fide synergistic activity in both the adjuvant (p = 0.007) and metastatic settings (p < 0.001). …”
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    Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
  15. 1915
    “…JCOG1412 is a high-quality lymphadenectomy trial in terms of the quality of surgical procedures, which would draw the bona-fide conclusions regarding the therapeutic role of lymphadenectomy for endometrial cancer.…”
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    Lymphadenectomy issues in endometrial cancer
  16. 1916
    “…The synthesis of bona fide organometallic Ce(IV) complexes is a formidable challenge given the typically oxidizing properties of the Ce(IV) cation and reducing tendencies of carbanions. …”
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    Isolation and characterization of a covalent Ce(IV)-Aryl complex with an anomalous (13)C chemical shift
  17. 1917
    “…Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. …”
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    SARS-CoV-2 Infection is Effectively Treated and Prevented by EIDD-2801
  18. 1918
    “…Our results demonstrate that the [6 + 4]-adduct instead of [4 + 2]-adduct is the bona fide biosynthetic intermediate.…”
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    A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
  19. 1919
    “…However, data from biological replicates and comparisons between mock and infected samples reduced the number of bona fide targets—i.e., those identified with high confidence in two infected biological replicates but not in the mock controls—to only eight mRNAs that encode proteins involved in development, transcription or defense. …”
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    Degradome Analysis of Tomato and Nicotiana benthamiana Plants Infected with Potato Spindle Tuber Viroid
  20. 1920
    “…While CLEC-4 function appears to be associated with the regulation of feeding behavior, we show that CLEC-41 and CLEC-42 proteins likely function as bona fide immune effector proteins that have bacterial binding and antimicrobial capacities. …”
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    Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins
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