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  1. 1941
    “…Here, we use expression of the P/Q rich secretory calcium-binding phosphoprotein 5 (scpp5) to characterize the cells lining the so-called bone of attachment in the zebrafish dentition. scpp5 is expressed in late cytodifferentiation stage odontoblasts but not in the cells depositing the “bone of attachment”. nor in bona fide osteoblasts lining the supporting pharyngeal jaw bone. …”
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    Cells at the Edge: The Dentin–Bone Interface in Zebrafish Teeth
  2. 1942
    “…Mechanistically, we found TRIM26, via its C-terminal PRYSPRY domain, but independent of its RING domain, stabilizes SOX2 protein by directly inhibiting the interaction of SOX2 with WWP2, which we identify as a bona fide SOX2 E3 ligase in GSCs. Our work identifies E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for GSC identity and maintenance.…”
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    Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
  3. 1943
    “…Six of these sequences were found to be bona fide substrates for FTase, with several meeting or surpassing the in vitro efficiency of the benchmark sequence CMIIM. …”
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    MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase
  4. 1944
    “…Where pertinent, we show how these bona fide mechanisms may mutually accentuate α-synuclein-mediated neurodegeneration in the DLB brain.…”
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    α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
  5. 1945
    por Vulpe, Alina, Menuz, Karen
    Publicado 2021
    “…Together, our data establish the role of Ir76b as a bona fide co-receptor, which acts in partnership with Ir25a. …”
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    Ir76b is a Co-receptor for Amine Responses in Drosophila Olfactory Neurons
  6. 1946
    “…By establishing a new analysis pipeline, we unraveled 85 prime miRNA–mRNA interactions supporting the downregulation of candidate tumor suppressors and the upregulation of bona fide oncogenes such as survivin (BIRC5) in ATC. This miRNA-dependent reprogramming of the ATC transcriptome provided an mRNA signature comprising 65 genes sharply distinguishing ATC from other thyroid carcinomas. …”
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    MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression
  7. 1947
    “…To better understand the functional role of AjNLRC4, we confirmed that AjNLRC4 was a bona fide membrane PRR with two transmembrane structures. …”
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    A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin
  8. 1948
    “…The in vitro-generated ILC3s phenotypically, functionally, and transcriptionally resemble bona fide tissue ILC3 with high expression of the transcription factors (TF) RorγT, AHR, and ID2, as well as the surface receptors CD117, CD56, and NKp44. …”
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    Efficient In Vitro Generation of IL-22-Secreting ILC3 From CD34(+) Hematopoietic Progenitors in a Human Mesenchymal Stem Cell Niche
  9. 1949
    “…We confirmed experimentally the enrichment of our substratome in bona fide L-CK1.2 substrates and showed they were also phosphorylated by human CK1δ. …”
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    Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay
  10. 1950
    por Ershov, N.I., Maslov, D.E., Bondar, N.P.
    Publicado 2020
    “…SLTS is involved in the RNA processing of more than half of O. felineus genes, making it hard to determine the structure of outrons and bona fide transcription start sites of the corresponding genes and operons, being based solely on mRNA-seq data. …”
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    Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus
  11. 1951
    por Bar Yaacov, Dan
    Publicado 2022
    “…Furthermore, independent knockdown of adar1 and adar2 reduced the number of infected cells with a dsRNA virus, suggesting they suppress a bona fide anti-viral dsRNA-response activity. Knockdown of adar1 also resulted in lesion formation and animal lethality, thus attesting to its essentiality. …”
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    Functional analysis of ADARs in planarians supports a bilaterian ancestral role in suppressing double-stranded RNA-response
  12. 1952
    “…Here, we investigated the effect of CF on the expression of two bona fide regulators of circulating low-density lipoprotein cholesterol (LDLc) levels; the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the low-density lipoprotein receptor (LDLR). …”
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    Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
  13. 1953
    “…RBM22 is also involved in gene regulation, and is able to bind DNA, acting as a bona fide transcription factor on a large number of target genes. …”
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    RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer
  14. 1954
    “…Our study has revealed a bona fide tumor‐promoting role for ERK3 using genetically engineered mouse models. …”
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    Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice
  15. 1955
    “…We demonstrate that γδ T-cells exhibit bona fide tissue-residency in human liver and HCC, with γδT(RM) showing no egress from hepatic vasculature, persistence for >10 years and superior anti-tumour cytokine production. …”
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    Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma
  16. 1956
    “…R. asembonensis has only recently been shown to be a bona-fide human pathogen. As such, and compounded by a lack of available genomic information, it remains understudied. …”
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    Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis of Rickettsia asembonensis in Peru
  17. 1957
    “…Overall, our study shows that the pancreatic microenvironment-derived factors can mimic in vivo conditions in an in vitro system to generate bona fide β-cells for translational applications.…”
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    Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling
  18. 1958
    “…Here we show, using conditional deletion strategies of the canonical Notch signaling mediator Rbpj, that loss of endothelial Notch signaling in adult mice induces the spontaneous formation of bona fide TLS in the kidney, liver and lung, based on molecular, cellular and structural criteria. …”
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    Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures
  19. 1959
    “…We demonstrate that the bromodomain and extraterminal (BET) protein, BRD4, is a bona fide ‘reader’ of H2A.Z acetylation, and further provide evidence that BET family protein inhibition ameliorates transcriptional abnormalities in patient-derived neurons. …”
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    Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
  20. 1960
    “…Taken together, these findings demonstrate that OTUD3 is a bona fide deubiquitylase for IRP2 and plays a critical role in the nigral iron deposits in PD.…”
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    Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2
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