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361por Sormunen, Elina, Saarinen, Maiju M., Salokangas, Raimo K. R., Telama, Risto, Hutri-Kähönen, Nina, Tammelin, Tuija, Viikari, Jorma, Raitakari, Olli, Hietala, Jarmo“…A population-based cohort study “Cardiovascular Risk of Young Finns” started in 1980 with 3596 children and adolescents from six different age groups (3, 6, 9, 12, 15, and 18 years). …”
Publicado 2017
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362por Pekkala, Johanna, Blomgren, Jenni, Pietiläinen, Olli, Lahelma, Eero, Rahkonen, Ossi“…METHODS: A 70-per-cent random sample of Finns aged 25–64 linked to register data on medically certified sickness absence (of over 10 working days) in 2005–2014 was retrieved from the Social Insurance Institution of Finland. …”
Publicado 2017
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363por Koskinen, Juha, Magnussen, Costan G., Sinaiko, Alan, Woo, Jessica, Urbina, Elaine, Jacobs, David R., Steinberger, Julia, Prineas, Ronald, Sabin, Matthew A., Burns, Trudy, Berenson, Gerald, Bazzano, Lydia, Venn, Alison, Viikari, Jorma S.A., Hutri‐Kähönen, Nina, Raitakari, Olli, Dwyer, Terence, Juonala, Markus“…METHODS AND RESULTS: Five thousand eight‐hundred three participants were analyzed in 4 cohort studies (Cardiovascular Risk in Young Finns, Bogalusa Heart Study, Princeton Lipid Research Study, Insulin Study). …”
Publicado 2017
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364por Hakkarainen, Pirjo, Sund, Reijo, Arffman, Martti, Koski, Sari, Hänninen, Vilma, Moilanen, Leena, Räsänen, Kimmo“…Since so little is known about work life of individuals with type 1 diabetes, we examined incidence and prevalence trends of type 1 diabetes among working-aged Finns. We also investigated the employment rate and how workers with type 1 diabetes perceive their health and work ability, and their intended retirement age. …”
Publicado 2017
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365por Marques, Francine Z., Prestes, Priscilla R., Byars, Sean G., Ritchie, Scott C., Würtz, Peter, Patel, Sheila K., Booth, Scott A., Rana, Indrajeetsinh, Minoda, Yosuke, Berzins, Stuart P., Curl, Claire L., Bell, James R., Wai, Bryan, Srivastava, Piyush M., Kangas, Antti J., Soininen, Pasi, Ruohonen, Saku, Kähönen, Mika, Lehtimäki, Terho, Raitoharju, Emma, Havulinna, Aki, Perola, Markus, Raitakari, Olli, Salomaa, Veikko, Ala‐Korpela, Mika, Kettunen, Johannes, McGlynn, Maree, Kelly, Jason, Wlodek, Mary E., Lewandowski, Paul A., Delbridge, Lea M., Burrell, Louise M., Inouye, Michael, Harrap, Stephen B., Charchar, Fadi J.“…METHODS AND RESULTS: We used 3 experimental models: a polygenic model of cardiac hypertrophy and heart failure, a model of intrauterine growth restriction and Lcn2‐knockout mouse; cultured cardiomyocytes; and 2 human cohorts: 114 type 2 diabetes mellitus patients and 2064 healthy subjects of the YFS (Young Finns Study). In hypertrophic heart rats, cardiac and circulating Lcn2 was significantly overexpressed before, during, and after development of cardiac hypertrophy and heart failure. …”
Publicado 2017
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366“…Interestingly, population-specific carrier frequencies of loss-of-function variants in SLC genes associated with recessive Mendelian disease recapitulated the ethnogeographic variation of the corresponding disorders, including cystinuria in Jewish individuals, type II citrullinemia in East Asians, and lysinuric protein intolerance in Finns, thus providing a powerful resource for clinical geneticists to inform about population-specific prevalence and allelic composition of Mendelian SLC diseases. …”
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367por Zwir, Igor, Arnedo, Javier, Del-Val, Coral, Pulkki-Råback, Laura, Konte, Bettina, Yang, Sarah S., Romero-Zaliz, Rocio, Hintsanen, Mirka, Cloninger, Kevin M., Garcia, Danilo, Svrakic, Dragan M., Rozsa, Sandor, Martinez, Maribel, Lyytikäinen, Leo-Pekka, Giegling, Ina, Kähönen, Mika, Hernandez-Cuervo, Helena, Seppälä, Ilkka, Raitoharju, Emma, de Erausquin, Gabriel A., Raitakari, Olli, Rujescu, Dan, Postolache, Teodor T., Sung, Joohon, Keltikangas-Järvinen, Liisa, Lehtimäki, Terho, Cloninger, C. Robert“…In a discovery sample of 2149 healthy Finns, we identified sets of single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (i.e., SNP sets) regardless of phenotype. …”
Publicado 2018
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368por Zwir, Igor, Arnedo, Javier, Del-Val, Coral, Pulkki-Råback, Laura, Konte, Bettina, Yang, Sarah S., Romero-Zaliz, Rocio, Hintsanen, Mirka, Cloninger, Kevin M., Garcia, Danilo, Svrakic, Dragan M., Rozsa, Sandor, Martinez, Maribel, Lyytikäinen, Leo-Pekka, Giegling, Ina, Kähönen, Mika, Hernandez-Cuervo, Helena, Seppälä, Ilkka, Raitoharju, Emma, de Erausquin, Gabriel A., Raitakari, Olli, Rujescu, Dan, Postolache, Teodor T., Sung, Joohon, Keltikangas-Järvinen, Liisa, Lehtimäki, Terho, Cloninger, C. Robert“…In a discovery sample of 2149 healthy Finns, we identified sets of single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (i.e., SNP sets) regardless of phenotype. …”
Publicado 2018
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369por Maleta, Kenneth, Fan, Yue-Mei, Luoma, Juho, Ashorn, Ulla, Bendabenda, Jaden, Dewey, Kathryn G, Hyöty, Heikki, Knip, Mikael, Kortekangas, Emma, Lehto, Kirsi-Maarit, Matchado, Andrew, Nkhoma, Minyanga, Nurminen, Noora, Parkkila, Seppo, Purmonen, Sami, Veijola, Riitta, Oikarinen, Sami, Ashorn, Per“…At age 18 mo, the mean ± SD concentration was almost double among the Finns compared with the Malawians [24.2 ± 11.3 compared with 12.5 ± 7.7 ng/mL, age- and sex-adjusted difference in mean (95% CI): 11.8 (9.9, 13.7) ng/mL; P < 0.01]. …”
Publicado 2020
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370por Hassan, Shabbeer, Surakka, Ida, Taskinen, Marja-Riitta, Salomaa, Veikko, Palotie, Aarno, Wessman, Maija, Tukiainen, Taru, Pirinen, Matti, Palta, Priit, Ripatti, Samuli“…We tested the downstream effects of the population-specific recombination rates in statistical phasing and genotype imputation in Finns as compared to the same analyses performed by using the NFE-based recombination rates. …”
Publicado 2020
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371por YANG, XIAOLIN, KULMALA, JANNE, HAKONEN, HARTO, HIRVENSALO, MIRJA, ROVIO, SUVI P., PAHKALA, KATJA, KUKKO, TUOMAS, HUTRI-KÄHÖNEN, NINA, RAITAKARI, OLLI T., TAMMELIN, TUIJA H.“…METHODS: A total of 2195 subjects (1236 women) 30–45 yr of age were randomly recruited from the ongoing Cardiovascular Risk in Young Finns Study in 2007 and were followed up in 2020. …”
Publicado 2021
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372por Cheng, Yurong, Li, Yong, Scherer, Nora, Grundner-Culemann, Franziska, Lehtimäki, Terho, Mishra, Binisha H., Raitakari, Olli T., Nauck, Matthias, Eckardt, Kai-Uwe, Sekula, Peggy, Schultheiss, Ulla T.“…GWAS revealed 3 loci (p<5.0E-08), two of which replicated in the population-based Young Finns Study (YFS) cohort (p<1.67E-03): rs10011284, upstream of SPP1 encoding the OPN protein and related to OPN production, and rs4253311, mapping into KLKB1 encoding prekallikrein (PK), which is processed to kallikrein (KAL) implicated through the kinin-kallikrein system (KKS) in blood pressure control, inflammation, blood coagulation, cancer, and cardiovascular disease. …”
Publicado 2022
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373por Meng, Yaxing, Buscot, Marie‐Jeanne, Juonala, Markus, Wu, Feitong, Armstrong, Matthew K., Fraser, Brooklyn J., Pahkala, Katja, Hutri‐Kähönen, Nina, Kähönen, Mika, Laitinen, Tomi, Viikari, Jorma S. A., Raitakari, Olli T., Magnussen, Costan G., Sharman, James E.“…METHODS AND RESULTS: The sample comprised 1869 participants from the Cardiovascular Risk in Young Finns Study who had blood pressure measured in childhood (6–18 years), young‐adulthood (21–30 years), and mid‐adulthood (33–45 years). …”
Publicado 2022
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374por Song, Jie, Li, Aole, Qian, Yu, Liu, Bin, Lv, Linshuoshuo, Ye, Ding, Sun, Xiaohui, Mao, Yingying“…METHOD: We used genetic variants associated with circulating levels of cytokines from a meta-analysis of genome-wide association studies (GWASs) of 8,293 Finns as instrumental variables. Summary level data of 20 site-specific cancer were obtained from the UK BioBank including up to 456,348 participants of European ancestry. …”
Publicado 2022
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375por Saarinen, Aino, Lyytikäinen, Leo-Pekka, Hietala, Jarmo, Dobewall, Henrik, Lavonius, Veikka, Raitakari, Olli, Kähönen, Mika, Sormunen, Elina, Lehtimäki, Terho, Keltikangas-Järvinen, Liisa“…Participants came from the population-based Young Finns Study (n = 1292). The polygenic risk score for schizophrenia (PRS) was calculated on the basis of the most recent genome-wide association study (GWAS). …”
Publicado 2022
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376“…METHODS: We examined social anxiety symptoms, their temporal changes, and their associations with COVID-19 related factors in a sample of 450 000 13-to-20-year-old Finns in 2013–2021. Data from nationwide School Health Promotion study was used. …”
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377por Meng, Yaxing, Sharman, James E., Koskinen, Juhani S., Juonala, Markus, Viikari, Jorma S. A., Buscot, Marie-Jeanne, Wu, Feitong, Fraser, Brooklyn J., Rovio, Suvi P., Kähönen, Mika, Rönnemaa, Tapani, Jula, Antti, Niinikoski, Harri, Raitakari, Olli T., Pahkala, Katja, Magnussen, Costan G.“…The findings for carotid IMT were replicated in the Cardiovascular Risk in Young Finns Study that assessed systolic BP from childhood and carotid IMT in adulthood (33 to 45 years). …”
Publicado 2023
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378por Kasteenpohja, Teija, Marttunen, Mauri, Aalto-Setälä, Terhi, Perälä, Jonna, Saarni, Samuli I., Suvisaari, Jaana“…METHODS: A questionnaire containing several mental health screens was sent to a nationally representative two-stage cluster sample of 1894 Finns aged 19 to 34 years. All screen positives and a random sample of screen negatives were invited to a mental health assessment including a SCID interview. …”
Publicado 2016
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379por Hakkarainen, Pirjo, Moilanen, Leena, Hänninen, Vilma, Heikkinen, Jarmo, Räsänen, Kimmo“…METHODS: A questionnaire was mailed to 2500 randomly sampled 18- to 65-year-old Finns with type 1 diabetes; 49.3 % responded. Work-related diabetes distress was measured by combining worry and exhaustion in reconciling work with diabetes. …”
Publicado 2016
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380por Kaila-Kangas, Leena, Koskinen, Aki, Leino-Arjas, Päivi, Virtanen, Marianna, Härkänen, Tommi, Lallukka, Tea“…METHODS: The data of the population-based Health 2000 Survey (BRIF8901) of 3666 Finns aged 30–55 were linked with national registers on medically certified sickness absences lasting for > 10 working days (long-term) for all causes (2000 − 2010) and for mental or musculoskeletal disorders (2004-2010), as well as with registers on pensions and death (2000-2010). …”
Publicado 2018
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