“…We present a cosmic rack, the FinnCRack. This device is a silicon strip detector-based telescope that measures tracks of cosmic particles. …”
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“…Genetic liability to COVID-19 severity conferred a causal effect on epilepsy (FinnGen consortium: OR: 1.2454; 95% CI: 1.0850–1.4295, P(FDR) = 0.0162; ILAE: OR: 1.2724; 95% CI: 1.0347–1.5647, P(FDR) = 0.0403), focal epilepsy (FinnGen: OR: 1.6818; 95% CI: 1.1478–2.4642, P(FDR) = 0.0231; ILAE: OR: 1.6598; 95% CI: 1.2572–2.1914, P(FDR) = 0.0054), and generalized epilepsy (FinnGen: OR: 1.1486; 95% CI: 1.0274–1.2842, P(FDR) = 0.0335; ILAE: OR: 1.0439; 95% CI: 1.0159–1.0728, P(FDR) = 0.0086). …”
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“…FINN utilizes Brevitas, a quantization aware training library. …”
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“…Also, the behavior of liquefiable soil is simulated by the use of “Finn” constitutive model in the analysis models. …”
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“…Finally, a meta‐analysis was conducted based on the ILAE and FinnGen data. RESULTS: We found significant causal effects of MDD and ADHD on epilepsy in the meta‐analysis of the ILAE and FinnGen, with corresponding odds ratios (OR) of 1.20 (95% CI 1.08–1.34, p = .001) and 1.08 (95% CI 1.01–1.16, p = .020) by the inverse‐variance weighted (IVW) method respectively. …”
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“…Three SNPs in high linkage disequilibrium on chromosome 13 near relaxin family peptide receptor 2 (RXFP2) were associated with HbA(1c) in FinnDiane at genome-wide significance (P < 5 × 10(−8)). …”
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“…The association in the FinnGen consortium remained consistent in direction. …”
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“…The genetic association between SNP rs2228145 (A > C) and NAFLD was obtained from non-FinnGen GWAS (1,483 cases and 17,781controls) and FinnGen GWAS (894 cases and 217,898 controls). …”
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“…Variants rs6727834 and rs10188087, in linkage disequilibrium with rs62192851, replicated in the FinnGen-cohort (P < 0.05), but no variants replicated in the ANDIS-cohort. …”
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“…The odds ratio per 50% increase in genetically predicted coffee consumption ranged from 0.97 (95% confidence interval (CI), 0.63, 1.50) for intracerebral hemorrhage to 1.26 (95% CI, 1.00, 1.58) for deep vein thrombosis in the UK Biobank and from 0.86 (95% CI, 0.50, 1.49) for subarachnoid hemorrhage to 1.34 (95% CI, 0.81, 2.22) for intracerebral hemorrhage in FinnGen. The null findings remained in multivariable Mendelian randomization analyses adjusted for genetically predicted body mass index and smoking initiation, except for a suggestive positive association for intracerebral hemorrhage (odds ratio 1.91; 95% CI, 1.03, 3.54) in FinnGen. …”
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“…However, a further meta-analysis of both ILAEC and FinnGen showed a similar result (OR=1.085, 95% CI: 1.012-1.164, P = 0.022). …”
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“…However, this association was not observed in the Finn-b-M13_GOUT and Finn-b-GOUT_STRICT [OR (95% CI): 0.9992 (0.9909–1.0075), p = 0.8453 and OR (95% CI): 0.9996 (0.9932–1.0059), p = 0.8896, respectively]. …”
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“…Higher PRS for PA was also associated with lower risk of mortality in FinnGen. Our findings suggest small pleiotropic effects between PA and CMDs. …”
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“…RESULTS: Genetically determined diverticular disease was associated with a higher risk of colorectal cancer (beta = 0.441, 95%CI: 0.081–0.801, P = 0.016) in the FinnGen population, but the association was not found in the UK Biobank (beta = 0.208, 95%CI: -0.291,0.532, P = 0.207). …”
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“…The same direction of association for kidney cancer but not for multiple myeloma was observed in FinnGen. In the metaanalysis of UK Biobank and FinnGen, the OR of kidney cancer was 0.83 (95% CI: 0.69-1.00). …”
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“…Genetically predicted decreased eGFR was significantly associated with an increased risk of VTE in both FinnGen and UK Biobank. For one-unit decrease in log-transformed eGFR, the odds ratios of VTE were 2.93 (95% confidence interval (CI) 1.25, 6.84) and 4.46 (95% CI 1.59, 12.5) when using data from FinnGen and UK Biobank, respectively. …”
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“…Results from FinnGen and UKB were combined using the fixed‐effect model. …”
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“…A fixed-effect model meta-analysis was used to combine the results of the FinnGen and UKB data. RESULTS: In the FinnGen data, higher genetically predicted age at natural menopause, systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting insulin were associated with an increased risk of uterine leiomyoma, while higher age at menarche was associated with a reduced risk of uterine leiomyoma. …”
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