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621por Xiang, Yaoxian, Zhang, Chan, Wang, Jing, Cheng, Yurong, Wang, Li, Tong, Yingying, Yan, Dong“…The results of a meta-analysis of the MR estimates from the AGWAS and the FinnGen datasets showed that family Porphyromonadaceae and genera Slackia, Anaerotruncus, and Intestinibacter replicated the same causal association. …”
Publicado 2023
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622“…GWAS data for infections were derived from UK Biobank and the FinnGen consortium. The primary analysis was conducted using the inverse variance weighted method on the UK Biobank data, along with a series of sensitivity analyses. …”
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623por Wang, Yong-Bo, Yang, Lan, Deng, Yu-Qing, Yan, Si-Yu, Luo, Li-Sha, Chen, Ping, Zeng, Xian-Tao“…Results from UK Biobank and FinnGen consortium were combined using fixed-effect meta-analysis. …”
Publicado 2022
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624por Rayes, Bilal, Ardissino, Maddalena, Slob, Eric A. W., Patel, Kiran Haresh Kumar, Girling, Joanna, Ng, Fu Siong“…Female-specific summary-level data from FinnGen (sixth release). EXPOSURES: Uncorrelated (r(2)<0.001) single-nucleotide variants (SNVs) were selected as instrumental variants from the FinnGen consortium summary statistics for exposures of any HDP, gestational hypertension, and preeclampsia or eclampsia. …”
Publicado 2023
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628por Fowler-Finn, KaseyEnlace del recurso
Publicado 2023
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629“…METHODS: To investigate the association between CMV infection and ASD, we conducted this 2-sample Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from FinnGen and the IEU Open GWAS project. RESULTS: Our results showed no significant relationship between all 3 CMV infections (unspecified cytomegaloviral diseases, anti-CMV IgG levels, and maternal CMV) and ASD. …”
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630por Lee, Jiwoo, Jukarainen, Sakari, Karvanen, Antti, Dixon, Padraig, Davies, Neil M., Smith, George Davey, Natarajan, Pradeep, Ganna, Andrea“…We calculated healthcare costs for 373,160 participants from the FinnGen Study and replicated our results in 323,774 individuals from the United Kingdom and Netherlands. …”
Publicado 2023
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631“…Summary data on gut microbiota and cholelithiasis were obtained from the MiBioGen (n=13,266) and FinnGen R8 consortia (n=334,367), respectively. RESULTS: Clostridium senegalense, Coprococcus3, and Lentisphaerae increased the risk of cholelithiasis and expressed more bile salt hydrolases. …”
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632por Ottensmann, Linda, Tabassum, Rubina, Ruotsalainen, Sanni E., Gerl, Mathias J., Klose, Christian, Widén, Elisabeth, Simons, Kai, Ripatti, Samuli, Pirinen, Matti“…We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. …”
Publicado 2023
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633por Bennett, Cavan, Jackson, Victoria E., Pettikiriarachchi, Anne, Hayman, Thomas, Schaeper, Ute, Moir-Meyer, Gemma, Fielding, Katherine, Ataide, Ricardo, Clucas, Danielle, Baldi, Andrew, Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Loughran, Stephen J., Baxter, E. Joanna, Green, Anthony R., Alexander, Warren S., Bahlo, Melanie, Burbury, Kate, Ng, Ashley P., Pasricha, Sant-Rayn“…Our genome-wide association study of 440 PV cases and 403 351 controls using UK Biobank data showed that single nucleotide polymorphisms in HFE known to cause hemochromatosis are highly associated with PV diagnosis, linking iron regulation to PV. Analysis of the FinnGen dataset independently confirmed overrepresentation of homozygous HFE variants in patients with PV. …”
Publicado 2023
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634por Raevuori, Anu, Keski-Rahkonen, Anna, Bulik, Cynthia M, Rose, Richard J, Rissanen, Aila, Kaprio, Jaakko“…METHODS: As a part of a questionnaire assessment of health-related behaviors in the population-based FinnTwin16 study, we assessed factors associated with muscle dissatisfaction in 1245 men aged 22–27 using logistic regression models. …”
Publicado 2006
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635por Raevuori, Anu, Hoek, Hans W., Susser, Ezra, Kaprio, Jaakko, Rissanen, Aila, Keski-Rahkonen, Anna“…METHODS AND FINDINGS: Men (N = 2122) from FinnTwin16 birth cohorts were screened for lifetime eating disorders by a questionnaire. …”
Publicado 2009
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636por Kotimäki, Sanni, Härkönen, Juho, Karlsson, Linnea, Karlsson, Hasse, Scheinin, Noora M.“…Using the prospective FinnBrain Cohort Study data on 2763 pregnant women over the three pregnancy trimesters and Finnish register data, we estimated multilevel regressions to describe educational differences in prenatal anxiety and depressive symptoms and to analyze whether they can be explained by socioeconomic background, parental mental disorders and adverse experiences during childhood. …”
Publicado 2020
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637por Levey, Daniel F., Stein, Murray B., Wendt, Frank R., Pathak, Gita A., Zhou, Hang, Aslan, Mihaela, Quaden, Rachel, Harrington, Kelly M., Nuñez, Yaira Z., Overstreet, Cassie, Radhakrishnan, Krishnan, Sanacora, Gerard, McIntosh, Andrew M., Shi, Jingchunzi, Shringarpure, Suyash S., Concato, John, Polimanti, Renato, Gelernter, Joel“…We report results of a large meta-analysis of depression using data from the Million Veteran Program (MVP), 23andMe Inc., UK Biobank, and FinnGen; including individuals of European ancestry (n=1,154,267; 340,591 cases) and African ancestry (n=59,600; 25,843 cases). …”
Publicado 2021
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638por Sliz, Eeva, Tyrmi, Jaakko S., Rahmioglu, Nilufer, Zondervan, Krina T., Becker, Christian M., Uimari, Outi, Kettunen, Johannes“…To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. …”
Publicado 2023
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