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1001por Jiang, Hongzhan, Li, Yi, Shen, Jiali, Lin, Huihui, Fan, Siyue, Qiu, Rongliang, He, Jiaxi, Lin, Ende, Chen, Lijuan“…Thyroid cancer outcomes were selected from the FinnGen GWAS (989 thyroid cancer cases and 217,803 control cases). …”
Publicado 2023
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1002“…RESEARCH DESIGN AND METHODS—The FinnDiane Study has characterized 20% (4,800 patients) of adults with type 1 diabetes in Finland. …”
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1003por Groop, Per-Henrik, Thomas, Merlin C., Moran, John L., Wadèn, Johan, Thorn, Lena M., Mäkinen, Ville-Petteri, Rosengård-Bärlund, Milla, Saraheimo, Markku, Hietala, Kustaa, Heikkilä, Outi, Forsblom, Carol“…RESEARCH DESIGN AND METHODS: The Finnish Diabetic Nephropathy (FinnDiane) study is a national multicenter prospective follow-up study of 4,201 adults with type 1 diabetes from 21 university and central hospitals, 33 district hospitals, and 26 primary health care centers across Finland. …”
Publicado 2009
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1004por Linna, Milla S, Kaprio, Jaakko, Raevuori, Anu, Sihvola, Elina, Keski-Rahkonen, Anna, Rissanen, Aila“…Therefore, we investigated whether a nonlinear (U-shaped) trend would better describe this relationship, and whether eating disorders might account for the association in young adults. METHODS: FinnTwin16 study evaluated multiple measures of subjective well-being, including life satisfaction, General Health Questionnaire (GHQ-20), satisfaction with leisure time, work, and family relationships, and satisfaction with sex life in young adulthood in the 1975–79 birth cohorts of Finnish twins (n=5240). …”
Publicado 2013
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1005por Larrick, James W., Alfenito, Mark R., Scott, Jamie K., Parren, Paul W. H. I., Burton, Dennis R., Bradbury, Andrew R. M., Lemere, Cynthia A., Messer, Anne, Huston, James S., Carter, Paul J., Veldman, Trudi, Chester, Kerry A., Schuurman, Janine, Adams, Gregory P., Reichert, Janice M.“…Burton (The Scripps Research Institute), who will review progress toward a neutralizing antibody-based HIV vaccine; Olivera J. Finn, (University of Pittsburgh School of Medicine), who will discuss prophylactic cancer vaccines as a source of therapeutic antibodies; and Paul Richardson (Dana-Farber Cancer Institute), who will provide a clinical update on daratumumab for multiple myeloma. …”
Publicado 2016
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1006por Barr, Peter B., Ksinan, Albert, Su, Jinni, Johnson, Emma C., Meyers, Jacquelyn L., Wetherill, Leah, Latvala, Antti, Aliev, Fazil, Chan, Grace, Kuperman, Samuel, Nurnberger, John, Kamarajan, Chella, Anokhin, Andrey, Agrawal, Arpana, Rose, Richard J., Edenberg, Howard J., Schuckit, Marc, Kaprio, Jaakko, Dick, Danielle M.“…Using data from both a population-based sample [the FinnTwin12 (FT12) study] and a high-risk sample [the Collaborative Study on the Genetics of Alcoholism (COGA)], we examined the association between PRSs derived from genome-wide association studies (GWASs) of (1) alcohol dependence/alcohol problems, (2) alcohol consumption, and (3) risky behaviors with AUD and other substance use disorder (SUD) criteria. …”
Publicado 2020
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1007por Friedersdorff, Jessica C. A., Kingston-Smith, Alison H., Pachebat, Justin A., Cookson, Alan R., Rooke, David, Creevey, Christopher J.“…Based on sequence similarity and genome distances, the five phages represent four species from three separate genera, consisting of: (1) Butyrivibrio phages Arian and Bo-Finn; (2) Butyrivibrio phages Idris and Arawn; and (3) Butyrivibrio phage Ceridwen. …”
Publicado 2020
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1008por Yuan, Shuai, Zheng, Ju-Sheng, Mason, Amy M., Burgess, Stephen, Larsson, Susanna C.“…Summary-level data for 15 CVDs were obtained from corresponding genetic consortia, the UK Biobank study, and the FinnGen consortium. The inverse-variance-weighted method was the primary analysis method, supplemented by the weighted median and MR-Egger methods. …”
Publicado 2022
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1009por Thyvalappil, Anoop, Sridharan, Rajiv, Amrutha, M. P., Nair, Gayathri, Sreenivasan, Ajayakumar“…MATERIALS AND METHODS: A total of 276 cases with footwear dermatitis who underwent patch test with FWS using Finn chamber method were studied. Statistical analysis was done using statistical package for social sciences (SPSS) version 24. …”
Publicado 2020
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1010por Mars, Nina, Widén, Elisabeth, Kerminen, Sini, Meretoja, Tuomo, Pirinen, Matti, della Briotta Parolo, Pietro, Palta, Priit, Palotie, Aarno, Kaprio, Jaakko, Joensuu, Heikki, Daly, Mark, Ripatti, Samuli“…Here we show that among 122,978 women in the FinnGen study with 8401 breast cancer cases, the PRS modifies the breast cancer risk of two high-impact frameshift risk variants. …”
Publicado 2020
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1011por Yuan, Shuai, Bruzelius, Maria, Xiong, Ying, Håkansson, Niclas, Åkesson, Agneta, Larsson, Susanna C.“…A Mendelian randomization study was conducted to investigate causal associations of BMI, WC, and WC adjusted for BMI with VTE using data from FinnGen and UK Biobank study. Population attributable fraction was calculated for overall and abdominal obesity for VTE. …”
Publicado 2020
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1012“…Here, we studied the stability of SARS-CoV-2 on blue fox, Finn raccoon, and American mink pelt, fake fur, cotton, plastic, faux leather, and polyester and tested its inactivation by UV light and heat treatment. …”
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1013por Østergaard, Jakob Appel, Jansson Sigfrids, Fanny, Forsblom, Carol, Dahlström, Emma H., Thorn, Lena M., Harjutsalo, Valma, Flyvbjerg, Allan, Thiel, Steffen, Hansen, Troels Krarup, Groop, Per-Henrik“…Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. …”
Publicado 2021
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1014por Copeland, Anni, Silver, Eero, Korja, Riikka, Lehtola, Satu J., Merisaari, Harri, Saukko, Ekaterina, Sinisalo, Susanne, Saunavaara, Jani, Lähdesmäki, Tuire, Parkkola, Riitta, Nolvi, Saara, Karlsson, Linnea, Karlsson, Hasse, Tuulari, Jetro J.“…Finally, we introduce the protocol used in scanning 2 to 5-week-old infants in the FinnBrain Birth Cohort Study, and tips for calming neonates during the scans.…”
Publicado 2021
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1015por Leskelä, Jaakko, Toppila, Iiro, Härma, Mari‐Anne, Palviainen, Teemu, Salminen, Aino, Sandholm, Niina, Pietiäinen, Milla, Kopra, Elisa, Pais de Barros, Jean‐Paul, Lassenius, Mariann I., Kumar, Anmol, Harjutsalo, Valma, Roslund, Kajsa, Forsblom, Carol, Loukola, Anu, Havulinna, Aki S., Lagrost, Laurent, Salomaa, Veikko, Groop, Per‐Henrik, Perola, Markus, Kaprio, Jaakko, Lehto, Markku, Pussinen, Pirkko J.“…The associations of the composed genetic risk score of endotoxemia and thrombosis‐related clinical end points for 195 170 participants were analyzed in FinnGen. Lipopolysaccharide activity had a genome‐wide significant association with 741 single‐nucleotide polymorphisms in 5 independent loci, which were mainly located at genes affecting the contact activation of the coagulation cascade and lipoprotein metabolism and explained 1.5% to 9.2% of the variability in lipopolysaccharide activity levels. …”
Publicado 2021
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1016por Song, Lijuan, Li, Hao, Wang, Jia, Xie, Junyang, Chen, Gui, Liang, Tianhao, Wang, Yiyan, Ye, Liyao, Wang, Xiaofen, Kuang, Xiaoxuan, Ren, Mei, Ye, Jinfeng, Tang, Yaqian, Ji, Ketong, Liao, Wenjing, Zhang, Xiaowen“…The outcome datasets related to OSA were from the FinnGen research project (www.finngen.fi/en/). Inverse variance-weighted, weighted-median, and Mendelian randomization–Egger analysis were used to estimate causal effects. …”
Publicado 2022
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1017“…Methods: We obtained summary-level data for eight CVDs [including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), stroke, ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke] from several large genome-wide association studies (GWASs) and the FinnGen consortium. Nine lead single-nucleotide polymorphisms associated with asthma (p < 5 × 10(−8)) were identified from the GWAS conducted by the Trans-National Asthma Genetic Consortium. …”
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1018“…METHODS: Instrumental variables of 211 GM taxa were obtained from genome wide association study (GWAS), and Mendelian randomization study was carried out to estimate their effects on DR risk from FinnGen GWAS (14,584 DR cases and 202,082 controls). …”
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1019por Copeland, Anni, Korja, Riikka, Nolvi, Saara, Rajasilta, Olli, Pulli, Elmo P., Kumpulainen, Venla, Silver, Eero, Saukko, Ekaterina, Hakanen, Hetti, Holmberg, Eeva, Kataja, Eeva-Leena, Häkkinen, Suvi, Parkkola, Riitta, Lähdesmäki, Tuire, Karlsson, Linnea, Karlsson, Hasse, Tuulari, Jetro J.“…We investigated whether maternal sensitivity at 8 or 30 months is associated with functional connectivity in a child’s brain at 5 years of age based on the FinnBrain Birth Cohort Study (17 and 39 mother–child dyads at 8 and 30 months, respectively, with an overlap of 13 dyads). …”
Publicado 2022
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1020“…Summary data for six liver function biomarkers and five liver diseases were obtained from the UK Biobank, the Estonian Biobank, the eMERGE network, and FinnGen consortium. Mendelian Randomization assessment of the effect of iron on liver function and liver diseases was conducted. …”
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