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1241por Kajtez, Janko, Wesseler, Milan Finn, Birtele, Marcella, Khorasgani, Farinaz Riyahi, Rylander Ottosson, Daniella, Heiskanen, Arto, Kamperman, Tom, Leijten, Jeroen, Martínez‐Serrano, Alberto, Larsen, Niels B., Angelini, Thomas E., Parmar, Malin, Lind, Johan U., Emnéus, JennyEnlace del recurso
Publicado 2022
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1242por Finn, Arkadiy, Selvaraj, Vijairam, Peterson, Elijah, Banerjee, Debasree, Lal, Amos, Grewal, Himmat, Martin, Edward, Dapaah-Afriyie, KwameEnlace del recurso
Publicado 2022
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1243por Finn, Arkadiy, Selvaraj, Vijairam, Peterson, Elijah, Banerjee, Debasree, Lal, Amos, Grewal, Himmat, Martin, Edward, Dapaah-Afriyie, KwameEnlace del recurso
Publicado 2022
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1244por croxford, W., Banfill, K., Fornacon-Wood, I., Britten, A., Carson, C., Hatton, M., Thippu Jayaprakash, K., Jegannathen, A., Keng Koh, P., Panakis, N., Peedell, C., Pope, A., Powell, C., Stilwell, C., Thomas, B., Wood, V., Yun Zhou, S., Price, G., Faivre-Finn, C.Enlace del recurso
Publicado 2021
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1245por von Eyben, Finn E., Kristiansen, Karsten, Kapp, Daniel S., Hu, Rong, Preda, Ovidiu, Nogales, Francisco F.Enlace del recurso
Publicado 2023
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1246“…METHODS: Data were taken from the summary statistics of a genome-wide association study, FinnGen consortium and United Kingdom Biobank. Dementia, epilepsy, and multiple sclerosis were used as outcomes, and genetic variants associated with plasma cortisol were used as instrumental variables. …”
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1247por Du, Yongwei, Xie, Baohui, Wang, Maoyuan, Zhong, Yanbiao, Lv, Zhimai, Luo, Yun, He, Qiwei, Liu, Zhen“…Taking osteoporosis as the outcome (FinnGen biobank, 332,020 samples), we conducted a Mendelian randomization (MR) analysis to establish the association between 25(OH)D and these sex hormones. …”
Publicado 2023
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1248“…Two separate databases (a large GWAS meta-analysis and the FinnGen cohort) for both IBS and IBD were consulted to retrieve statistics on instrument-outcome associations. …”
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1249“…METHODS: We obtained the single nucleotide polymorphisms (SNPs) associated with breast cancer from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium (BCAC). The FinnGen consortium’s latest and largest accessible GWAS thyroid cancer data at the summary level. …”
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1250“…The PHN dataset obtained from FinnGen biobank had 195,191 individuals with 16,380,406 SNPs. …”
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1251por Yuan, Shuai, Titova, Olga E, Zhang, Ke, Chen, Jie, Li, Xue, Klarin, Derek, Åkesson, Agneta, Damrauer, Scott M, Larsson, Susanna C“…Mendelian randomization analyses were undertaken using cis-genetic variants strongly associated with the proteins as instrumental variables and genetic association summary statistic data for PAD from the FinnGen study (11 924 cases and 288 638 controls) and the Million Veteran Program (31 307 cases and 211 753 controls). …”
Publicado 2023
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1252“…No significant horizontal pleiotropy was detected by MR-Egger Intercept p except summary data from FinnGen consortium. CONCLUSION: Genetically predicted AD is a risk factor for both T1D and T2D. …”
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1253“…Single-nucleotide polymorphisms (SNPs) for VD were extracted from 417,580 Europeans in the UK Biobank, and the summary-level data of male factor infertility (825 cases and 85,722 controls) were extracted from the FinnGen. RESULTS: Totally 99 SNPs robustly associated with the 25OHD were included, and a 1-unit increase in genetically predicted natural-log transformed 25OHD levels was associated with decreased risk of male factor infertility (odds ratio [OR], 0.62; 95% confidence interval [CI], 0.44–0.89; p=0.010), which was consistent in all three sensitivity analyses (MR-Egger, weighted median, and weighted mode methods). …”
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1254por Chang, Zhenglin, An, Lingyue, Lei, Min, Song, Zhenfeng, Deng, Jian, Tang, Ruizheng, Cheng, Zhangkai J., Wu, Wenqi, Sun, Baoqing“…METHODS: Genome-wide association study (GWAS) statistics for COVID-19 and 28 genitourinary symptoms with consistent definitions were collected from the COVID‐19 Host Genetic Initiative, FinnGen, and UK Biobanks. Mendelian randomization (MR) analyses were applied to explore the causal effects of COVID-19 on genitourinary symptoms by selecting single-nucleotide polymorphisms as instrumental variables. …”
Publicado 2023
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1255“…METHODS AND RESULTS: We identified all individuals with hypertension who were prescribed at least one anti-hypertensive medication from the FinnGen Study, a cohort of randomly selected individuals across Finland. …”
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1256por Zhang, Shuwan, Zhang, Wenchuan, Ren, Haiyue, Xue, Rui, Wang, Zitong, Wang, Zhe, Lv, Qingjie“…GWAS summary statistics for overall breast cancer risk and hormone receptor subtype-specific analyses were obtained from the UK Biobank and FinnGen databases, totaling 400,000 individuals. …”
Publicado 2023
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1257“…Summary statistics of common digestive diseases were primarily obtained from the UK Biobank study and the FinnGen study. Two-sample Mendelian randomization analyses were then conducted using the inverse variance-weighted (IVW), Mendelian randomization-Egger regression (MR Egger), weighted median estimation, weighted mode, and simple mode methods. …”
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1258“…METHODS: The study utilized genome-wide association study (GWAS) datasets for T1D, T2D, and CKD from the FinnGen research project. GWAS summary statistics datasets for 118 exposure traits were obtained from the IEU OpenGWAS database. …”
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1259por Wang, Qiubo, Liu, Yingbo, Xu, Zhenxing, Wang, Zhimiao, Xue, Mei, Li, Xinran, Wang, Ye“…Summary data of mediators was obtained from the FinnGen database, the UK Biobank, the EBI database, MRC-IEU database, the International Consortium of Blood Pressure, the Consortium of Within family GWAS. …”
Publicado 2023
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1260“…Genetic variants associated with these rheumatic diseases and glaucoma were extracted from the genome-wide association studies and FinnGen8 database, respectively. First, a two-sample MR was used to investigate the potential causal association. …”
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