Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

por Cheeseman, Matthew D., Chessum, Nicola E. A., Rye, Carl S., Pasqua, A. Elisa, Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M., Eccles, Suzanne A., Workman, Paul, Jones, Keith
Publicado 2016

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N(2)-(2...

por Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen
Publicado 2018

Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study

por Bwakura-Dangarembizi, Mutsa, Amadi, Beatrice, Bourke, Claire D, Robertson, Ruairi C, Mwapenya, Benjamin, Chandwe, Kanta, Kapoma, Chanda, Chifunda, Kapula, Majo, Florence, Ngosa, Deophine, Chakara, Pamela, Chulu, Nivea, Masimba, Faithfull, Mapurisa, Idah, Besa, Ellen, Mutasa, Kuda, Mwakamui, Simutanyi, Runodamoto, Thompson, Humphrey, Jean H, Ntozini, Robert, Wells, Jonathan C K, Manges, Amee R, Swann, Jonathan R, Walker, A Sarah, Nathoo, Kusum J, Kelly, Paul, Prendergast, Andrew J
Publicado 2019

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

por Maura, Francesco, Bolli, Niccoló, Angelopoulos, Nicos, Dawson, Kevin J., Leongamornlert, Daniel, Martincorena, Inigo, Mitchell, Thomas J., Fullam, Anthony, Gonzalez, Santiago, Szalat, Raphael, Abascal, Federico, Rodriguez-Martin, Bernardo, Samur, Mehmet Kemal, Glodzik, Dominik, Roncador, Marco, Fulciniti, Mariateresa, Tai, Yu Tzu, Minvielle, Stephane, Magrangeas, Florence, Moreau, Philippe, Corradini, Paolo, Anderson, Kenneth C., Tubio, Jose M. C., Wedge, David C., Gerstung, Moritz, Avet-Loiseau, Hervé, Munshi, Nikhil, Campbell, Peter J.
Publicado 2019

Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

por Gehrmann, Ulf, Burbage, Marianne, Zueva, Elina, Goudot, Christel, Esnault, Cyril, Ye, Mengliang, Carpier, Jean-Marie, Burgdorf, Nina, Hoyler, Thomas, Suarez, Guadalupe, Joannas, Leonel, Heurtebise-Chrétien, Sandrine, Durand, Sylvère, Panes, Rébecca, Bellemare-Pelletier, Angélique, Sáez, Pablo J., Aprahamian, Fanny, Lefevre, Deborah, Adoue, Veronique, Zine El Aabidine, Amal, Muhammad Ahmad, Maqbool, Hivroz, Claire, Joffre, Olivier, Cammas, Florence, Kroemer, Guido, Gagnon, Etienne, Andrau, Jean-Christophe, Amigorena, Sebastian
Publicado 2019

Urinary TERT promoter mutations are detectable up to 10 years prior to clinical diagnosis of bladder cancer: Evidence from the Golestan Cohort Study

por Hosen, Md Ismail, Sheikh, Mahdi, Zvereva, Maria, Scelo, Ghislaine, Forey, Nathalie, Durand, Geoffroy, Voegele, Catherine, Poustchi, Hossein, Khoshnia, Masoud, Roshandel, Gholamreza, Sotoudeh, Masoud, Nikmanesh, Arash, Etemadi, Arash, Avogbe, Patrice Hodonou, Chopard, Priscilia, Delhomme, Tiffany Myriam, Foll, Matthieu, Manel, Arnaud, Vian, Emmanuel, Weiderpass, Elisabete, Kamangar, Farin, Boffetta, Paolo, Pharaoh, Paul D., Dawsey, Sanford M., Abnet, Christian C., Brennan, Paul, McKay, James, Malekzadeh, Reza, Calvez-Kelm, Florence Le
Publicado 2020

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma

por Choi, Jiyeon, Zhang, Tongwu, Vu, Andrew, Ablain, Julien, Makowski, Matthew M., Colli, Leandro M., Xu, Mai, Hennessey, Rebecca C., Yin, Jinhu, Rothschild, Harriet, Gräwe, Cathrin, Kovacs, Michael A., Funderburk, Karen M., Brossard, Myriam, Taylor, John, Pasaniuc, Bogdan, Chari, Raj, Chanock, Stephen J., Hoggart, Clive J., Demenais, Florence, Barrett, Jennifer H., Law, Matthew H., Iles, Mark M., Yu, Kai, Vermeulen, Michiel, Zon, Leonard I., Brown, Kevin M.
Publicado 2020

Immunogenicity and safety of the AS04-HPV-16/18 and HPV-6/11/16/18 human papillomavirus vaccines in asymptomatic young women living with HIV aged 15–25 years: A phase IV randomized...

por Folschweiller, Nicolas, Teixeira, Julio, Joshi, Smita, Goldani, Luciano Z, Supparatpinyo, Khuanchai, Basu, Partha, Chotpitayasunondh, Tawee, Chetchotisakd, Ploenchan, Ruxrungtham, Kiat, Roteli-Martins, Cecilia, Grinsztejn, Beatriz, Quintana, Silvana Maria, Kumarasamy, Nagalingeswaran, Poongulali, Selvamuthu, Kulkarni, Vinay, Lin, Lan, Datta, Sanjoy K, Descamps, Dominique, Dodet, Monique, Dubin, Gary, Friel, Damien, Hezareh, Marjan, Karkada, Naveen, Meric Camilleri, Dorothee, Poncelet, Sylviane, Salaun, Bruno, Tavares-da-Silva, Fernanda, Thomas-Jooris, Florence, Struyf, Frank
Publicado 2020

Serum Detection of Nonadherence to Adjuvant Tamoxifen and Breast Cancer Recurrence Risk

por Pistilli, Barbara, Paci, Angelo, Ferreira, Arlindo R., Di Meglio, Antonio, Poinsignon, Vianney, Bardet, Aurelie, Menvielle, Gwenn, Dumas, Agnes, Pinto, Sandrine, Dauchy, Sarah, Fasse, Leonor, Cottu, Paul H., Lerebours, Florence, Coutant, Charles, Lesur, Anne, Tredan, Olivier, Soulie, Patrick, Vanlemmens, Laurence, Jouannaud, Christelle, Levy, Christelle, Everhard, Sibille, Arveux, Patrick, Martin, Anne Laure, Dima, Alexandra, Lin, Nancy U., Partridge, Ann H., Delaloge, Suzette, Michiels, Stefan, André, Fabrice, Vaz-Luis, Ines
Publicado 2020

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

por Huynh, Kevin, Lim, Wei Ling Florence, Giles, Corey, Jayawardana, Kaushala S., Salim, Agus, Mellett, Natalie A., Smith, Adam Alexander T., Olshansky, Gavriel, Drew, Brian G., Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Arnold, Matthias, Nho, Kwangsik, Saykin, Andrew J., Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N., Meikle, Peter J.
Publicado 2020

Development of Sensitive Droplet Digital PCR Assays for Detecting Urinary TERT Promoter Mutations as Non-Invasive Biomarkers for Detection of Urothelial Cancer

por Hosen, Md Ismail, Forey, Nathalie, Durand, Geoffroy, Voegele, Catherine, Bilici, Selin, Avogbe, Patrice Hodonou, Delhomme, Tiffany Myriam, Foll, Matthieu, Manel, Arnaud, Vian, Emmanuel, Meziani, Sonia, De Tilly, Berengere, Polo, Gilles, Lole, Olesia, Francois, Pauline, Boureille, Antoine, Pisarev, Eduard, Salas, Andrei R. O. S. E., Monteiro-Reis, Sara, Henrique, Rui, Byrnes, Graham, Jeronimo, Carmen, Scelo, Ghislaine, McKay, James D., Calvez-Kelm, Florence Le, Zvereva, Maria
Publicado 2020

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

por Philippe, Aurélien, Chocron, Richard, Gendron, Nicolas, Bory, Olivier, Beauvais, Agathe, Peron, Nicolas, Khider, Lina, Guerin, Coralie L., Goudot, Guillaume, Levasseur, Françoise, Peronino, Christophe, Duchemin, Jerome, Brichet, Julie, Sourdeau, Elise, Desvard, Florence, Bertil, Sébastien, Pene, Frédéric, Cheurfa, Cherifa, Szwebel, Tali-Anne, Planquette, Benjamin, Rivet, Nadia, Jourdi, Georges, Hauw-Berlemont, Caroline, Hermann, Bertrand, Gaussem, Pascale, Mirault, Tristan, Terrier, Benjamin, Sanchez, Olivier, Diehl, Jean-Luc, Fontenay, Michaela, Smadja, David M.
Publicado 2021

Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020

por Bal, Antonin, Destras, Gregory, Gaymard, Alexandre, Stefic, Karl, Marlet, Julien, Eymieux, Sébastien, Regue, Hadrien, Semanas, Quentin, d’Aubarede, Constance, Billaud, Geneviève, Laurent, Frédéric, Gonzalez, Claudia, Mekki, Yahia, Valette, Martine, Bouscambert, Maude, Gaudy-Graffin, Catherine, Lina, Bruno, Morfin, Florence, Josset, Laurence, Casalegno, Jean-Sébastien, Frobert, Emilie, Escuret, Vanessa, Icard, Vinca, Jeannoel, Marion, Milon, Marie-Paule, Ramière, Christophe, Scholtès, Caroline, Tardy, Jean-Claude, Trabaud, Mary-Anne, Schuffenecker, Isabelle
Publicado 2021

Whither Magnetic Hyperthermia? A Tentative Roadmap

por Rubia-Rodríguez, Irene, Santana-Otero, Antonio, Spassov, Simo, Tombácz, Etelka, Johansson, Christer, De La Presa, Patricia, Teran, Francisco J., Morales, María del Puerto, Veintemillas-Verdaguer, Sabino, Thanh, Nguyen T. K., Besenhard, Maximilian O., Wilhelm, Claire, Gazeau, Florence, Harmer, Quentin, Mayes, Eric, Manshian, Bella B., Soenen, Stefaan J., Gu, Yuanyu, Millán, Ángel, Efthimiadou, Eleni K., Gaudet, Jeff, Goodwill, Patrick, Mansfield, James, Steinhoff, Uwe, Wells, James, Wiekhorst, Frank, Ortega, Daniel
Publicado 2021

Plaque morphology in acute symptomatic intracranial atherosclerotic disease

por Leung, Thomas W, Wang, Li, Zou, Xinying, Soo, Yannie, Pu, Yuehua, Ip, Hing Lung, Chan, Anne, Au, Lisa Wing Chi, Fan, Florence, Ma, Sze Ho, Ip, Bonaventure, Ma, Karen, Lau, Alexander Yuk-lun, Leung, Howan, Hui, Kwok Fai, Li, Richard, Li, Siu Hung, Fu, Michael, Fong, Wing Chi, Liu, Jia, Mok, Vincent, Wong, Ka Sing Lawrence, Miao, Zhongrong, Ma, Ning, Yu, Simon C H, Leng, Xinyi
Publicado 2021

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

por Fumagalli, Laura, Young, Florence L., Boeynaems, Steven, De Decker, Mathias, Mehta, Arpan R., Swijsen, Ann, Fazal, Raheem, Guo, Wenting, Moisse, Matthieu, Beckers, Jimmy, Dedeene, Lieselot, Selvaraj, Bhuvaneish T., Vandoorne, Tijs, Madan, Vanesa, van Blitterswijk, Marka, Raitcheva, Denitza, McCampbell, Alexander, Poesen, Koen, Gitler, Aaron D., Koch, Philipp, Berghe, Pieter Vanden, Thal, Dietmar Rudolf, Verfaillie, Catherine, Chandran, Siddharthan, Van Den Bosch, Ludo, Bullock, Simon L., Van Damme, Philip
Publicado 2021

Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data

por Connon, Roisin, George, Elizabeth C., Olupot-Olupot, Peter, Kiguli, Sarah, Chagaluka, George, Alaroker, Florence, Opoka, Robert O., Mpoya, Ayub, Walsh, Kevin, Engoru, Charles, Nteziyaremye, Julius, Mallewa, Macpherson, Kennedy, Neil, Nakuya, Margaret, Namayanja, Cate, Nabawanuka, Eva, Sennyondo, Tonny, Amorut, Denis, Williams Musika, C., Bates, Imelda, Boele van Hensbroek, M., Evans, Jennifer A., Uyoga, Sophie, Williams, Thomas N., Frost, Gary, Gibb, Diana M., Maitland, Kathryn, Walker, A. Sarah
Publicado 2021

Concurrent sampling of transitional and coastal waters by Diffusive Gradient in Thin-films (DGT) and spot sampling for trace metals analysis

por Bersuder, Philippe, Amouroux, Isabelle, Belzunce-Segarra, María Jesús, Bolam, Thi, Caetano, Miguel, Carvalho, Inês, Correia dos Santos, Margarida, Fones, Gary R., Gonzalez, Jean-Louis, Guesdon, Stephane, Larreta, Joana, Marras, Barbara, McHugh, Brendan, Menet-Nédélec, Florence, Menchaca, Iratxe, Gabet, Vanessa Millán, Montero, Natalia, Nolan, Martin, Regan, Fiona, Robinson, Craig D., Rosa, Nuno, Sanz, Marta Rodrigo, Rodríguez, José Germán, Schintu, Marco, White, Blánaid, Zhang, Hao
Publicado 2021

Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units

por Martin-Mons, Séverine, Gouyon, Béatrice, Lorrain, Séverine, Abasse, Soumeth, Alexandre, Cénéric, Binson, Guillaume, Brat, Roselyne, Caeymaex, Laurence, Couringa, Yvan, Desbruyeres, Cécile, Meglio, Marine Dorsi-Di, Escourrou, Guillaume, Flamein, Florence, Flechelles, Olivier, Girard, Olivier, Kermorvant-Duchemin, Elsa, Lapillonne, Alexandre, Lafon, Catherine, Di Maio, Massimo, Mazeiras, Gaël, Mourdie, Julien, Moussy-Durandy, Amélie, Pages, Anne-Sophie, Ramful, Duksha, Razafimahefa, Hasinirina, Rosenthal, Jean-Marc, Iacobelli, Silvia, Gouyon, Jean-Bernard
Publicado 2021

Genomic Instability Is Defined by Specific Tumor Microenvironment in Ovarian Cancer: A Subgroup Analysis of AGO OVAR 12 Trial

por Fumet, Jean-David, Lardenois, Emilie, Ray-Coquard, Isabelle, Harter, Philipp, Joly, Florence, Canzler, Ulrich, Truntzer, Caroline, Tredan, Olivier, Liebrich, Clemens, Lortholary, Alain, Pissaloux, Daniel, Leary, Alexandra, Pfisterer, Jacobus, Eeckhoutte, Alexandre, Hilpert, Felix, Fabbro, Michel, Caux, Christophe, Alexandre, Jérôme, Houlier, Aurélie, Sehouli, Jalid, Sohier, Emilie, Kimmig, Rainer, Dubois, Bertrand, Spaeth, Dominique, Treilleux, Isabelle, Frenel, Jean-Sébastien, Herwig, Uwe, Le Saux, Olivia, Bendriss-Vermare, Nathalie, du Bois, Andreas
Publicado 2022