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  1. 5821
    “…CONCLUSIONS: ARID1A-mutant GC displayed immunogenic TME and might be a candidate for both monotherapy and the combination of frontline chemotherapy and PD-1 blockade. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00262-022-03326-x.…”
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    Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapy
  2. 5822
    “…The emergency use authorization for COVID-19 vaccines brought both hopes to healthcare workers at the frontline against the COVID-19 pandemic. Vaccine effectiveness against COVID-19 has been measured in the sanitized environment of clinical trials; however, determining these vaccines' real-world impact is still under research. …”
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    P107 - Vaccine effectiveness against SARS-CoV-2 infection in Romanian healthcare workers: A prospective cohort study
  3. 5823
    “…Multivariate logistic regression results indicated that individuals who were aged 50 years or older, self-identified as Black/African American, were obese, and were employed as frontline health care workers or nursing home staff were more likely to self-report COVID-19 test positivity. …”
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    COVID-19 Testing Practices, Preventive Behaviors, and Factors Associated With Test Positivity: Population-Based Statewide Survey Study
  4. 5824
    “…Multivariate logistic regressions were used, and an Adjusted Odds Ratio (AOR) with 95% Confidence Intervals (CIs) was reported. (3) Results: Among 803 participants, 70% (n = 556) were females, and the median age was 27 years; 35% (n = 278) were frontline or essential service workers; and 24% (n = 195) reported comorbid conditions including mental health illness. …”
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    COVID-19: Factors Associated with the Psychological Distress, Fear and Resilient Coping Strategies among Community Members in Saudi Arabia
  5. 5825
    “…Documented enablers for successful implementation of reactive surveillance and response strategy included frontline health workers having good knowledge of reactive surveillance and response activities and availability of Basic Health Staff for timely implementation of foci response activities. …”
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    Reactive surveillance and response strategies for malaria elimination in Myanmar: a literature review
  6. 5826
    “…All patients received gemcitabine plus cisplatin as the frontline therapy, and 53.2% received fluoropyrimidine plus oxaliplatin (FOLFOX) before ICI. …”
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    The efficacy of immune checkpoint inhibitors in biliary tract cancer with KRAS mutation
  7. 5827
    “…ED staff interviews provided insight into the ED frontline challenges and offered practical recommendations for ED health service improvement.…”
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    Access block and overcrowding at the emergency department at Tupua Tamasese Meaole Hospital in Samoa
  8. 5828
    “…The general challenges of frontline care clinical workflow have been well documented in the literature. …”
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    Determinants for scalable adoption of autonomous AI in the detection of diabetic eye disease in diverse practice types: key best practices learned through collection of real-world data
  9. 5829
    “…While quantitative research has been conducted on the psychological impact of the pandemic on other frontline healthcare workers, none has explored the impact on contact tracing staff. …”
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    Exploring the psychological impact of contact tracing work on staff during the COVID-19 pandemic
  10. 5830
    “…CONCLUSION: The AEEQ is a valid and reliable instrument to evaluate the AED service which helps to build the engagement platform for promoting patient-centered care between patients and frontline healthcare professionals and improving healthcare quality in the future.…”
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    Validation of the accident and emergency experience questionnaire: a cross-sectional survey
  11. 5831
    “…We report that while P. falciparum dominated both symptomatic and asymptomatic malaria cases, P. ovale in mono or co-infections caused 7.16% of symptomatic malaria. Frontline antimalarials artesunate and lumefantrine inhibited P. ovale as potently as P. falciparum. …”
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    Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
  12. 5832
    “…Anaesthesia has been at the frontline of enhancing patient safety – testing and implementing knowledge from other high-reliability industries, such as aviation, in the complex, adaptive system of an operating room. …”
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    Exploring everyday work as a dynamic non-event and adaptations to manage safety in intraoperative anaesthesia care: an interview study
  13. 5833
    “…CONCLUSIONS: The study recommends regular counselling and support for all nurses working at the frontline to help them better cope with the devastating effects of the pandemic so that they could build resilience towards future pandemics.…”
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    Work-related psychosocial challenges and coping strategies among nursing workforce during the COVID-19 pandemic: a scoping review
  14. 5834
    “…Multivariate analysis identified two variables associated with worse overall survival: perineural invasion (HR 2.36, 95% CI 1.162–4.818, p = 0.018) and performing frontline colectomy (HR 3.286, 95% CI 1.256–8.597, p = 0.015). …”
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    Impact of perineural invasion on the outcome of patients with synchronous colorectal liver metastases treated with neoadjuvant chemotherapy and surgery
  15. 5835
    “…This provides an ideal opportunity for dentists to be the frontline healthcare professionals who can collect the salivary samples; however the awareness of this amongst dentists is uncertain. …”
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    Deciphering the role of Saliva in COVID 19: A global cross-sectional study on the knowledge, awareness and perception among dentists
  16. 5836
    “…BACKGROUND: Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibiting the Solute Carrier family 7 member 11 (SLC7A11), with inadequate ferroptosis notably contributing to SOR resistance in tumor cells. …”
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    Fe(3+)-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma
  17. 5837
    “…INTERPRETATION: Camrelizumab plus famitinib exhibited encouraging efficacy and tolerable safety profiles in patients with RM-NPC who failed frontline immunotherapy. Further studies are needed to confirm and expand these findings. …”
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    Camrelizumab plus famitinib in patients with recurrent or metastatic nasopharyngeal carcinoma treated with PD-1 blockade: data from a multicohort phase 2 study
  18. 5838
    “…Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous recombination (HR) repair deficiency. …”
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    ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression
  19. 5839
    “…The bad news: many of them are expensive, kill embryos during evaluation, are too complicated, and/or are laborious and thus useless in the frontline, i.e., thousands of embryo production/transfer facilities. …”
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    Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond
  20. 5840
    “…METHODS: Qualitative analysis of semi-structured interviews of clinical leaders, implementation teams, and frontline champions. RESULTS: We completed 30 interviews across palliative care, oncology, primary care, and hospital medicine. …”
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    Improving serious illness communication: a qualitative study of clinical culture
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