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  1. 6201
    “…BRCA testing was performed for 260 young women, with a BRCA1/2 mutation in 44 (17% of those tested) In young HR+/HER2– patients, chemotherapy (CT) was given as the frontline treatment more frequently compared with older ones (89.6% versus 68.8%, respectively, p < 0.0001). …”
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    Real-world evidence of the management and prognosis of young women (⩽40 years) with de novo metastatic breast cancer
  2. 6202
    “…METHODS: A multidisciplinary team of frontline clinicians and data scientists worked to create the Northwell COVIDARDS dataset (NorthCARDS) leveraging over 11,542 COVID-19 hospital admissions. …”
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    Trajectories of hypoxemia and pulmonary mechanics of COVID-19 ARDS in the NorthCARDS dataset
  3. 6203
    “…Participants representing three organisational levels (senders: politicians, n = 3; messengers: senior management, n = 7; and receivers: middle- and frontline managers, n = 13) were interviewed and documents collected. …”
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    A comparison of three organisational levels in one health care region in Sweden implementing person-centred care: coupled, decoupled or recoupled in a complex organisation
  4. 6204
    “…IMPORTANCE Toxoplasma gondiiis a widespread intracellular parasite infecting a variety of warm-blooded animals, including humans. Current frontline treatment of toxoplasmosis suffers many drawbacks, including toxicity, drug resistance, and failure to eradicate tissue cysts, underscoring the need to identify novel drug targets for suppression or treatment of toxoplasmosis. …”
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    Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite
  5. 6205
    “…Immunisation Programme at UMMC started on 1(st) March 2021, prioritising medical and non-medical frontline staff. All HCWs were included in the study if they have received either one or completed both doses of BNT162b2 (Pfizer-BioNTech) vaccine and was subsequently inflicted with COVID-19 between 1(st) March until 31(st) May 2021. …”
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    Post-vaccination COVID-19 among Healthcare workers in a Tertiary Care Hospital, Malaysia
  6. 6206
    “…Our results provide clinicians and policymakers with an evidence-based tool for prioritizing COVID-19 healthcare resources in other population groups aside from those with higher exposure to SARS-CoV-2 and frontline workers.…”
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    Development and validation of a population-based risk stratification model for severe COVID-19 in the general population
  7. 6207
    “…We used purposive sampling to select 24 frontline EMS professionals from one ambulance service in the United Kingdom and conducted semi-structured interviews. …”
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    The role of feedback in emergency ambulance services: a qualitative interview study
  8. 6208
    “…As high as 17.9% (n = 356) of the respondents admitted that they were trying to avoid specialty with frontline exposure to COVID-19, while 353 students (17.8%) were considering local training programs only. …”
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    Impact of COVID-19 pandemic on Saudi medical students’ career choices and perceptions of health specialties: findings from a national cross-sectional study
  9. 6209
    “…These included: urgency in adapting, with an obvious imperative for change; overcoming inconsistent involvement and support through the formation of self-organized frontline coalitions; attempts to develop strategy and vision via initially reactive but eventually consistent communication; empowering a volunteer army through co-creation and a flattened hierarchy; and efforts to sustain improvement and positive momentum with celebration of trial, error, and growth. …”
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    Educational adaptation to clinical training during the COVID-19 pandemic: a process analysis
  10. 6210
    “…OBJECTIVES: The Impact of COVID-19 on Nurses (ICON) interview study examined the impacts of the pandemic on frontline nursing staff's psychosocial and emotional wellbeing. …”
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    ‘You can't walk through water without getting wet’ UK nurses’ distress and psychological health needs during the Covid-19 pandemic: A longitudinal interview study
  11. 6211
    “…It compares undergraduate and postgraduate students in non-health related subjects with health care students, many of whom were preparing for, or working in, frontline roles. The survey was conducted as part of a wider study by the COVID-HL research consortium. …”
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    Differences in digital health literacy and future anxiety between health care and other university students in England during the COVID-19 pandemic
  12. 6212
    “…DISCUSSION: Training, supervision, and a focus on effectiveness in cervical cancer screening are interventions that contribute to improving frontline provider competencies and maintaining a high quality of health care service delivery.…”
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    Training, Supervision, and Competence Assessment of Cameroonian Health Care Providers Using HPV Self-Sampling, Triage by Visual Inspection, and Treatment by Thermal Ablation in a Single Visit
  13. 6213
    “…A multi-method situation appraisal of the different functional domains revealed serious health system deficiencies and operational defects, notably fragmentation of healthcare programmes and frontline services, as well as challenges related to governance, accountability and human resources for health. …”
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    Improving public health sector service delivery in the Free State, South Africa: development of a provincial intervention model
  14. 6214
    “…Coverage of family planning program indicators were significantly lower in Manipur than Punjab – frontline workers’ (FLWs) outreach for family planning was only 18% in Manipur compared to 52% in Punjab. …”
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    Comparative analysis of contraceptive use in Punjab and Manipur: exploring beyond women’s education and empowerment
  15. 6215
    “…METHOD: Design: Participants will be first randomized into two frontline interventions for 12 weeks. They will then be placed or randomized to three adaptive strategies for another 12 weeks. …”
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    An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial
  16. 6216
    “…BACKGROUND: Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. …”
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    P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro
  17. 6217
    “…INTRODUCTION: From an oncologic perspective, genetic detection is becoming a frontline clinical test, used to identify actionable alterations for targeted therapy, monitor molecular clonal tumor evolution, indicate disease progression and prognosis, and predict medication efficacy and resistance. …”
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    Genomic Alteration Spectrum of Non-Small Cell Lung Cancer Patients in East-China Characterized by Tumor Tissue DNA and Cell-Free DNA
  18. 6218
    “…The findings indicate the issues which should be addressed to improve the quality of life of frontline workers who fight against the pandemic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12913-022-07961-z.…”
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    Quality of life (QoL) among COVID-19 recovered healthcare workers in Bangladesh
  19. 6219
    “…BACKGROUND: Children with recurrent atypical teratoid rhabdoid tumor (recATRT) who fail frontline therapies have dismal outcomes. The association of ATRT molecular groups (SHH, TYR and MYC) and presence of underlying cancer predisposition with survival post-recurrence (postRD) is unknown. …”
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    ATRT-22. Outcomes for children with recurrent atypical teratoid rhabdoid tumor: A single institution study with updated molecular and germline analysis
  20. 6220
    “…Qualitative semi-structured interviews with patients, frontline clinician, and administrators were analyzed in an inductive-deductive approach to identify key themes. …”
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    A 360 degree mixed-methods evaluation of a specialized COVID-19 outpatient clinic and remote patient monitoring program
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