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21por Haagensen, Annika Maria Juul, Sørensen, Dorte Bratbo, Sandøe, Peter, Matthews, Lindsay R., Birck, Malene Muusfeldt, Fels, Johannes Josef, Astrup, Arne“…Twenty four young, male Göttingen minipigs were fed either a high fat/cholesterol, low carbohydrate diet or a low fat, high carbohydrate/sucrose diet in contrast to a standard low fat, high carbohydrate minipig diet. …”
Publicado 2014
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22por Renner, Simone, Blutke, Andreas, Dobenecker, Britta, Dhom, Georg, Müller, Timo D., Finan, Brian, Clemmensen, Christoffer, Bernau, Maren, Novak, Istvan, Rathkolb, Birgit, Senf, Steffanie, Zöls, Susanne, Roth, Mirjam, Götz, Anna, Hofmann, Susanna M., Hrabĕ de Angelis, Martin, Wanke, Rüdiger, Kienzle, Ellen, Scholz, Armin M., DiMarchi, Richard, Ritzmann, Mathias, Tschöp, Matthias H., Wolf, Eckhard“…To deepen the relevance towards translation to human patients, we established a corresponding DIO model in Göttingen minipigs (GM). METHODS: Young adult female ovariectomized GM were fed a high-fat/high-energy diet for a period of 70 weeks. …”
Publicado 2018
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24por Alyanak, OğuzEnlace del recurso
Publicado 2020
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25por Lumley, Lucille, Du, Fu, Marrero-Rosado, Brenda, Stone, Michael, Keith, Zora-Maya, Schultz, Caroline, Whitten, Kimberly, Walker, Katie, Acon-Chen, Cindy, Wright, Linnzi, Shih, Tsung-Ming“…We determined the intramuscular (IM) median lethal dose (LD(50)) of GD in adult male Göttingen minipigs using an up-and-down dosing method. …”
Publicado 2021
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26“…In the present study, we test the hypothesis that learning rate in a GNG task correlates with the behavioral response of Göttingen minipigs to novelty. In a group of 12 minipigs of mixed genders, response to novelty was measured by numbers of contacts with a novel object, and the total duration of exploration of the novel object. …”
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27“…Comparison was made on the 100-days-old Göttingen minipig (G-mini) neocortex between estimates of total neuron number derived from Giemsa staining using morphological criteria and immunohistochemistry-based cell counting with NeuN. …”
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28por Christensen, Bjørn Borsøe, Foldager, Casper Bindzus, Olesen, Morten Lykke, Vingtoft, Louise, Rölfing, Jan Hendrik Duedal, Ringgaard, Steffen, Lind, Martin“…Based on this study the use of two defects per knee, one in the medial and one in the lateral trochlear facet, in male Göttingen minipigs is recommended.…”
Publicado 2015
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29por Bergadano, Alessandra, Amen, Eva Maria, Jacobsen, Björn, Belli, Sara, Vandjour, Anthony, Rapp, Christelle, Senn, ClaudiaEnlace del recurso
Publicado 2019
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30por Feng, Y., Cirera, S., Taşöz, E., Liu, Y., Olsen, L. H., Christoffersen, B. Ø., Pedersen, H. D., Ludvigsen, T. P., Kirk, R. K., Schumacher-Petersen, C., Deng, Y., Fredholm, M., Gao, F.“…The aim of this study was to investigate obesity-related epigenetic changes and the potential for reversal of these changes in the liver of Göttingen minipigs subjected to diet interventions. …”
Publicado 2021
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31por Mahan, Brandon, Tacail, Theo, Lewis, Jamie, Elliott, Tim, Habekost, Mette, Turner, Simon, Chung, Roger, Moynier, Frédéric“…Here, K isotope compositions of Göttingen minipig brain regions for two AD models at midlife are reported. …”
Publicado 2022
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32por Christoffersen, Berit Østergaard, Kristensen, Camilla Aarup, Lindgaard, Rikke, Kirk, Rikke Kaae, Viuff, Birgitte Martine, Kvist, Peter Helding, Pedersen, Henrik Duelund, Ludvigsen, Trine Pagh, Skovgaard, Tine, Fels, Johannes Josef, Martinussen, Torben, Christiansen, Liselotte Bruun, Cirera, Susanna, Olsen, Lisbeth Høier“…The purpose was to study effects of a fat, fructose and cholesterol-rich (FFC) diet with and without salt in order to induce hypertension on kidney function and morphology in Göttingen Minipigs with and without diabetes. Male Göttingen Minipigs were divided into 4 groups: SD (standard diet, n = 8), FFC (FFC diet, n = 16), FFC-DIA (FFC diet + diabetes, n = 14), FFC-DIA + S (FFC diet with extra salt + diabetes, n = 14). …”
Publicado 2023
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34por van der Staay, F. Josef, Pouzet, Bruno, Mahieu, Michel, Nordquist, Rebecca E., Schuurman, Teun“…For this reason, we speculated that Göttingen miniature pigs, which show strong physiological and genetic homology with humans, might be a better model for investigating the effects of antipsychotics. …”
Publicado 2009
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35por Haagensen, Annika Maria Juul, Klein, Anders Bue, Ettrup, Anders, Matthews, Lindsay R., Sørensen, Dorte Bratbo“…We sought to contrast the effect of a high fat/cholesterol, low carbohydrate diet and a low fat, high carbohydrate/sucrose diet, relative to a standard low fat, high carbohydrate minipig diet on spatial cognition with regards to working memory and reference memory in 24 male Göttingen minipigs performing in a spatial hole-board discrimination test. …”
Publicado 2013
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36por Lorenzen, Emma, Kudirkiene, Egle, Gutman, Nicole, Grossi, Anette Blak, Agerholm, Jørgen Steen, Erneholm, Karin, Skytte, Christina, Dalgaard, Marlene Danner, Bojesen, Anders Miki“…We found a higher abundance of Lactobacillaceae in the prepubertal Göttingen Minipigs compared to sexually mature non-pregnant Göttingen Minipigs. …”
Publicado 2015
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37por Roldán, J. Camilo, Schulz, Peter, Klünter, Tim, Deisinger, Ulrike, Diez, Claudius, Waiss, Waltraud, Kirschneck, Christian, Reichert, Torsten E., Detsch, Rainer“…METHODS: Four craniotomies with a diameter of 15 mm (critical-size defect) were grafted with different highly porous (92–94 vol%) calcium phosphate ceramics [hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP; a mixture of HA and TCP)] in 10 Göttingen minipigs: (a) group I (n = 5): HA versus BCP; (b) group II (n = 5): TCP versus BCP. …”
Publicado 2017
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38por Valerius, Oliver, Asif, Abdul R., Beißbarth, Tim, Bohrer, Rainer, Dihazi, Hassan, Feussner, Kirstin, Jahn, Olaf, Majcherczyk, Andrzej, Schmidt, Bernhard, Schmitt, Kerstin, Urlaub, Henning, Lenz, Christof“…The symposium was held in Göttingen, Germany on 23 May, 2019, as part of a series of regular symposia organized by the Göttingen Proteomics Forum.…”
Publicado 2019
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39por Christiansen, Liselotte Bruun, Dohlmann, Tine Lovsø, Ludvigsen, Trine Pagh, Parfieniuk, Ewa, Ciborowski, Michal, Szczerbinski, Lukasz, Kretowski, Adam, Desler, Claus, Tiano, Luca, Orlando, Patrick, Martinussen, Torben, Olsen, Lisbeth Høier, Larsen, Steen“…Atorvastatin concentrations were analyzed in each of the three tissues and in plasma from the Göttingen Minipigs. In treated minipigs, atorvastatin was detected in the liver and in plasma. …”
Publicado 2021
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40por Sharp, Thomas E., Scarborough, Amy L., Li, Zhen, Polhemus, David J., Hidalgo, Hunter A., Schumacher, Jeffery D., Matsuura, Timothy R., Jenkins, J. Stephen, Kelly, Daniel P., Goodchild, Traci T., Lefer, David J.“…The combination of a Western diet and 11-deoxycorticosterone acetate salt−induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.…”
Publicado 2021
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