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41por Rittase, W. Bradley, McCart, Elizabeth A., Muir, Jeannie M., Bouten, Roxane M., Slaven, John E., Mungunsukh, Ognoon, Bylicky, Michelle A., Wilkins, W. Louis, Lee, Sang-Ho, Gudmundsson, Kristbjorn O., Di Pucchio, Tiziana, Olsen, Cara H., Du, Yang, Day, Regina M.“…Here we investigated the effects of captopril treatment against radiation injuries in the Göttingen mini pig model of Hematopoietic-Acute Radiation Syndrome (H-ARS). …”
Publicado 2021
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42por Ramot, Yuval, Steiner, Michal, Lavie, Yossi, Ezov, Nati, Laub, Orgad, Cohen, Eran, Schwartz, Yotam, Nyska, Abraham“…Herein, the safety and efficacy of sFilm-FS were compared using a liver and spleen puncture model of Göttingen minipigs with those of the standard hemostatic techniques (control animals) and EVARREST(®), a reference fibrin sealant. …”
Publicado 2021
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43por Pernold, Clara P.S., Lagumdzic, Emil, Stadler, Maria, Mair, Kerstin H., Jäckel, Sven, Schmitt, Michael W., Ladinig, Andrea, Knecht, Christian, Dürlinger, Sophie, Kreutzmann, Heinrich, Martin, Vera, Sawyer, Spencer, Saalmüller, Armin“…Interest in Ellegaard Göttingen Minipigs (EGMs) as a model in experimental medicine is continuously growing. …”
Publicado 2022
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45por Schirrmacher, Arne“…Quantum mechanics – the grandiose theory that describes nature down to the submicroscopic level – was first formulated in Göttingen in 1925. How did this come about and why is it that Göttingen became the pre-eminent location for a revolution in physics? …”
Publicado 2019
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47por Ettrup, Kaare S., Glud, Andreas N., Orlowski, Dariusz, Fitting, Lise M., Meier, Kaare, Soerensen, Jens Christian, Bjarkam, Carsten R., Alstrup, Aage K. Olsen“…The emergence of the Göttingen minipig in research of topics such as neuroscience, toxicology, diabetes, obesity, and experimental surgery reflects the close resemblance of these animals to human anatomy and physiology (1-6).The size of the Göttingen minipig permits the use of surgical equipment and advanced imaging modalities similar to those used in humans (6-8). …”
Publicado 2011
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48por Morozov, Vladimir A., Morozov, Alexey V., Rotem, Avi, Barkai, Uriel, Bornstein, Stefan, Denner, Joachim“…Anti-HEV immunoglobulins G were detected in one sow and maternal antibodies in her six day old piglet. Since Göttingen minipigs were negative for many xenotransplantation-relevant microorganisms, they can now be classified as safe. …”
Publicado 2015
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49por Schumacher-Petersen, Camilla, Christoffersen, Berit Østergaard, Kirk, Rikke Kaae, Ludvigsen, Trine Pagh, Zois, Nora Elisabeth, Pedersen, Henrik Duelund, Vyberg, Mogens, Olsen, Lisbeth Høier“…BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in humans, and ranges from steatosis to non-alcoholic steatohepatitis (NASH), the latter with risk of progression to cirrhosis. The Göttingen Minipig has been used in studies of obesity and diabetes, but liver changes have not been described. …”
Publicado 2019
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50por Krüger, Luise, Kristiansen, Yannick, Reuber, Emelie, Möller, Lars, Laue, Michael, Reimer, Christian, Denner, Joachim“…Using a new comprehensive strategy, we then analyzed an isolated subpopulation of Göttingen Minipigs which remained at the University of Göttingen. …”
Publicado 2019
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51por Markert, Michael“…The Human Embryology Collection at the Centre of Anatomy Göttingen, created between 1942 and 1970, represents a unique interrelation of histological sectional series of human embryos and large-format physical models open to the public based on them. …”
Publicado 2020
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52por Vaure, Céline, Grégoire-Barou, Véronique, Courtois, Virginie, Chautard, Emilie, Dégletagne, Cyril, Liu, Yuanqing“…Our data suggest that the Göttingen minipig is an attractive preclinical model to predict the long-term immunogenicity of human vaccines against Bordetella pertussis and potentially also vaccines against other pathogens.…”
Publicado 2021
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53por Lützhøft, Ditte Olsen, Sinioja, Tim, Christoffersen, Berit Ø., Jakobsen, Rasmus Riemer, Geng, Dawei, Ahmad, Hajar Fauzan Bin, Straarup, Ellen Marie, Pedersen, Karen-Margrethe, Kot, Witold, Pedersen, Henrik Duelund, Cirera, Susanna, Hyötyläinen, Tuulia, Nielsen, Dennis Sandris, Hansen, Axel Kornerup“…The aim of this study was to describe the impact of a choline-deficient amino acid defined high fat diet (CDAHFD) on the gut microbiota in a male Göttingen Minipig model and on selected pathways implicated in the development of NASH. …”
Publicado 2022
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54por Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, Clara Sandkamm, Flethøj, Mette, Lyhne, Mille Kronborg, Møller, Jacob Eifer, Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier, Kilpeläinen, Tuomas O.“…Serum cfDNA and gDNA were obtained from 10 lean and 7 obese Göttingen Minipigs both with experimentally induced myocardial infarction and sequenced using Oxford Nanopore MinION. …”
Publicado 2023
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55por Moroni, Maria, Lombardini, Eric, Salber, Rudolph, Kazemzedeh, Mehdi, Nagy, Vitaly, Olsen, Cara, Whitnall, Mark H.“…We have previously shown that the Gottingen minipig manifests hematopoietic ARS phases and symptoms similar to those observed in canines, NHPs, and humans. …”
Publicado 2011
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56por Scholz-Ahrens, Katharina E., Glüer, Claus-Christian, Bronner, Felix, Delling, Günter, Açil, Yahya, Hahne, Hans-Jürgen, Hassenpflug, Joachim, Timm, Wolfram, Schrezenmeir, JürgenEnlace del recurso
Publicado 2013
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57por Egli, Jerome, Schmucki, Roland, Loos, Benjamin, Reichl, Stephan, Grabole, Nils, Roller, Andreas, Ebeling, Martin, Odermatt, Alex, Iglesias, Antonio“…Safety and efficacy of therapeutic antibodies are often dependent on their interaction with Fc receptors for IgG (FcγRs). The Göttingen minipig represents a valuable species for biomedical research but its use in preclinical studies with therapeutic antibodies is hampered by the lack of knowledge about the porcine FcγRs. …”
Publicado 2018
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58por Orlowski, Dariusz, Glud, Andreas N., Palomero-Gallagher, Nicola, Sørensen, Jens Christian H., Bjarkam, Carsten R.Enlace del recurso
Publicado 2019
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59por Ørstrup, Laura Hvidsten, Tvilling, Laura, Orlowski, Dariusz, Zaer, Hamed, Bjarkam, Carsten Reidies, von Voss, Pia, Andersen, Pia Skårup, Christoffersen, Berit Ø., Hedemann Sørensen, Jens Christian, Laursen, Torben, Thygesen, Peter, Lykkesfeldt, Jens, Glud, Andreas Nørgaard“…NEW METHOD: In this study, we evaluate methods for a new large non-primate animal model of GH deficiency in post pubertal Göttingen Minipigs (minipig). Lesions in the pituitary gland were made by stereotaxic monopolar thermo-coagulation guided by magnetic resonance imaging (MRI), and pituitary function was evaluated using insulin tolerance test (ITT) with measurements of growth hormone secretion induced by hypoglycemia. …”
Publicado 2019
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60por Christoffersen, Berit Ø., Skyggebjerg, Rikke Bjerring, Bugge, Anne, Kirk, Rikke Kaae, Vestergaard, Bill, Uldam, Henriette Kold, Fels, Johannes Josef, Pyke, Charles, Sensfuss, Ulrich, Sanfridson, Annika, Clausen, Trine Ryberg“…Subsequently, obese Göttingen Minipigs were treated subcutaneously (s.c.) once daily for 13 weeks with vehicle, NN9056 low dose (regulated from 5 to 2 nmol/kg) or NN9056 high dose (10 nmol/kg) (n = 7–8). …”
Publicado 2019
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