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61por Seifert, Theresa, Becker, Tim, Büttcher, Amelie Friederike, Herwig, Nadine, Raupach, Tobias“…Introduction: In summer term 2020, the clinical phase of the undergraduate medical curriculum at University Medical Center Göttingen was restructured since distance teaching had to be used predominantly due to contact restrictions during the COVID-19 pandemic. …”
Publicado 2021
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62por Lyhne, Mille K., Vegge, Andreas, Povlsen, Gro Klitgaard, Slaaby, Rita, Kildegaard, Jonas, Pedersen-Bjergaard, Ulrik, Olsen, Lisbeth H.Enlace del recurso
Publicado 2021
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63por Buyssens, Laura, De Clerck, Laura, Schelstraete, Wim, Dhaenens, Maarten, Deforce, Dieter, Ayuso, Miriam, Van Ginneken, Chris, Van Cruchten, Steven“…The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. …”
Publicado 2021
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64por Halecker, Sabrina, Krabben, Ludwig, Kristiansen, Yannick, Krüger, Luise, Möller, Lars, Becher, Dietmar, Laue, Michael, Kaufer, Benedikt, Reimer, Christian, Denner, Joachim“…We recently described the transmission of a human-tropic recombinant PERV-A/C, designated PERV-F, from peripheral blood mononuclear cells (PBMCs) of a Göttingen Minipig (GöMP) to human 293 cells (Krüger et al., in Viruses 12(1):38, 2019). …”
Publicado 2022
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65por Cirera, Susanna, Taşöz, Emirhan, Juul Jacobsen, Mette, Schumacher-Petersen, Camilla, Østergaard Christoffersen, Berit, Kaae Kirk, Rikke, Pagh Ludvigsen, Trine, Hvid, Henning, Duelund Pedersen, Henrik, Høier Olsen, Lisbeth, Fredholm, Merete“…CONCLUSION: The study shows that morbidly obese Göttingen Minipigs are protected against many of the metabolic and hepatic abnormalities associated with obesity due to a remarkable ability to expand the adipose compartments to accommodate excess calories.…”
Publicado 2020
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67por Kjærgaard, Kristoffer, Weber, Britta, Alstrup, Aage Kristian Olsen, Petersen, Jørgen Breede Baltzer, Hansen, Rune, Hamilton-Dutoit, Stephen Jacques, Mortensen, Frank Viborg, Sørensen, Michael“…Here, we examined the effects of radiation-induced liver injury on two specific liver functions and hepatocellular regeneration in a minipig model. Five Göttingen minipigs were exposed to whole-liver stereotactic body radiation therapy (SBRT) in one fraction (14 Gy) and examined 4–5 weeks after; five pigs were used as controls. …”
Publicado 2020
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68por Curtasu, Mihai V., Tafintseva, Valeria, Bendiks, Zachary A., Marco, Maria L., Kohler, Achim, Xu, Yetong, Nørskov, Natalja P., Nygaard Lærke, Helle, Bach Knudsen, Knud Erik, Hedemann, Mette Skou“…The metabolome and gut microbiota were investigated in a juvenile Göttingen minipig model. This study aimed to explore the metabolic effects of two carbohydrate sources with different degrees of risk in obesity development when associated with a high fat intake. …”
Publicado 2020
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69por Curtasu, Mihai Victor, Skou Hedemann, Mette, Nygaard Lærke, Helle, Bach Knudsen, Knud Erik“…The aim of this study was to examine the long-term effects of fructose compared to starch from high-amylose maize starch (HiMaize) at ad libitum feeding in a juvenile Göttingen Minipig model with 20% of the diet provided as fructose as a high-risk diet (HR, n = 15) and 20% as HiMaize as a lower-risk control diet (LR, n = 15). …”
Publicado 2021
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70por Valenzuela, Allan, Tardiveau, Claire, Ayuso, Miriam, Buyssens, Laura, Bars, Chloe, Van Ginneken, Chris, Fant, Pierluigi, Leconte, Isabelle, Braendli-Baiocco, Annamaria, Parrott, Neil, Schmitt, Georg, Tessier, Yann, Barrow, Paul, Van Cruchten, Steven“…The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications. …”
Publicado 2021
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72por Stroe, Marina-Stefania, Van Bockstal, Lieselotte, Valenzuela, Allan, Ayuso, Miriam, Leys, Karen, Annaert, Pieter, Carpentier, Sebastien, Smits, Anne, Allegaert, Karel, Zeltner, Adrian, Mulder, Antonius, Van Ginneken, Chris, Van Cruchten, Steven“…This is relevant information for laboratories using the neonatal Göttingen Minipig for other disease conditions or drug safety testing.…”
Publicado 2023
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73por Gieling, Elise, Wehkamp, Welmoed, Willigenburg, Remco, Nordquist, Rebecca E, Ganderup, Niels-Christian, van der Staay, Franz Josef“…RESULTS: Both the conventional pigs and the Göttingen minipigs learned the holeboard task, reaching nearly errorless asymptotic working and reference memory performance within approximately 100 acquisition trials. …”
Publicado 2013
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74“…This article describes the use of a bronchial blocking device and a sheathed bronchoscope which enabled sterile endobronchial substance administration in Göttingen minipigs, and allowed pulmonary aspiration studies to be conducted with each animal acting as its own control.…”
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75por Seidling, Roland, Lehmann, Lars J., Lingner, Manuel, Mauermann, Eckhard, Obertacke, Udo, Schwarz, Markus L. R.“…METHODS: In total, 72 dumbbell shape titan implants were inserted in the spongy bone of the femora of 18 Göttingen minipigs in a conservative gap model. Thirty-six titan implants were coated with a standard TPS surface and 36 with the hyperhydrophilic chromosulfuric acid (CSA) surface. …”
Publicado 2016
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76por Mentzel, Caroline M. Junker, Alkan, Ferhat, Keinicke, Helle, Jacobsen, Mette J., Gorodkin, Jan, Fredholm, Merete, Cirera, Susanna“…The aim of this study was to identify differentially expressed of protein-coding genes and miRNAs in a Göttingen minipig obesity model. Liver, skeletal muscle and abdominal adipose tissue were sampled from 7 lean and 7 obese minipigs. …”
Publicado 2016
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77por Leonhäuser, Dorothea, Stollenwerk, Katja, Seifarth, Volker, Zraik, Isabella M., Vogt, Michael, Srinivasan, Pramod K., Tolba, Rene H., Grosse, Joachim O.“…The aim of this study was to investigate potential bladder wall repair by two collagen scaffold prototypes, OptiMaix 2D and 3D, naïve and seeded with autologous vesical cells, as potential bladder wall substitute material in a large animal model. METHODS: Six Göttingen minipigs underwent cystoplastic surgery for tissue biopsy and cell isolation followed by implantation of unseeded scaffolds. …”
Publicado 2017
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79por Chopra, Sunita, Moroni, Maria, Sanjak, Jaleal, MacMillan, Laurel, Hritzo, Bernadette, Martello, Shannon, Bylicky, Michelle, May, Jared, Coleman, C. Norman, Aryankalayil, Molykutty J.“…Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents. …”
Publicado 2021
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