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  1. 21
    “…Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. …”
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    Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
  2. 22
    por Sircar, R, Wu, L-C, Reddy, K, Sircar, D, Basak, A.K
    Publicado 2011
    “…We have earlier reported that γ-hydroxybutyric acid (GHB) disrupts the acquisition of spatial learning and memory in adolescent rats. …”
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    GHB–Induced Cognitive Deficits During Adolescence and the Role of NMDA Receptor
  3. 23
    “…γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. …”
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    γ-Hydroxybutyric Acid (GHB) Is Not an Agonist of Extrasynaptic GABA(A) Receptors
  4. 24
    “…GHB has serious toxicity, although many young users do not recognise GHB as a dangerous drug. …”
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    Symptoms and signs in interpreting Gamma-hydroxybutyrate (GHB) intoxication - an explorative study
  5. 25
    “…At the molecular level, GHB acts as a weak GABA‐B agonist, while the existence of a GHB receptor remains elusive. …”
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    A Critical Evaluation of the Gamma‐Hydroxybutyrate (GHB) Model of Absence Seizures
  6. 26
    “…BACKGROUND: Overdoses from so-called “club drugs” (GHB/GBL) have become a more frequent cause of overdoses attended by ambulance services. …”
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    Intoxication with GHB/GBL: characteristics and trends from ambulance-attended overdoses
  7. 27
    “…In addition, GhbHLH121 can directly activate the expression of GhbHLH38, GhFIT, and GhPYE independent of GhbHLH IVc. …”
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    The Molecular Mechanism of GhbHLH121 in Response to Iron Deficiency in Cotton Seedlings
  8. 28
    “…BACKGROUND: The illicit use and abuse of gamma-hydroxybutyric acid (GHB) occurs due to its sedative/hypnotic and euphoric effects. …”
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    GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats
  9. 29
    “…BACKGROUND: GHB dependence is a growing health problem in several western countries, especially the Netherlands. …”
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    Baclofen as relapse prevention in the treatment of Gamma- Hydroxybutyrate (GHB) dependence: an open label study
  10. 30
    “…The three‐event stack cotton GHB614 × T304‐40 × GHB119 was produced by conventional crossing to combine three single events, GHB614, T304‐40 and GHB119. …”
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    Assessment of genetically modified cotton GHB614 × T304‐40 × GHB119 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2014‐122)
  11. 31
    “…Two cases of fatal mixed intoxications including GHB intake are presented here. In both cases, GHB was used together with multiple other drugs. …”
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    Complications in post-mortem GHB cut-off values in urine samples: A case report
  12. 32
    “…Furthermore, we show that binding of GHB and related analogs to this site promotes concentration-dependent increases in hub thermal stability believed to alter holoenzyme functionality. …”
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    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
  13. 33
    “…In addition, GHB is recreationally used. Most clinical and recreational users regard GHB as an innocent drug devoid of adverse effects, despite its high dependence potential and possible neurotoxic effects. …”
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    Cognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review
  14. 34
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    Prise en charge de l’intoxication au γ-hydroxybutyrate (GHB) et son sevrage
  15. 35
    “…The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous system depressant and is often encountered during forensic investigations of living and deceased persons. …”
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    GHB Pharmacology and Toxicology: Acute Intoxication, Concentrations in Blood and Urine in Forensic Cases and Treatment of the Withdrawal Syndrome
  16. 36
    “…BACKGROUND: GHB (gamma-hydroxybutyrate) and its pro-drugs GBL (gamma-butyrolactone) and 1,4-butanediol (1,4-BD) are central nervous system depressants whose street names include ‘G’ and ‘liquid ecstasy’. …”
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    Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial
  17. 37
    “…Social distancing and lockdown measures may particularly affect the use of “party drugs” (e.g., stimulants, dissociatives, and GHB/GBL) through the absence of typical use settings. …”
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    No party, no drugs? Use of stimulants, dissociative drugs, and GHB/GBL during the early COVID-19 pandemic
  18. 38
    “…We recently presented γ-hydroxybutyrate (GHB) ligands as the first small molecules selectively targeting and stabilizing the CaMKIIα hub domain. …”
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    The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα
  19. 39
    “…Enhancing GHB levels via SSADH downregulation or GHB supplementation triggered cell conversion into a less aggressive phenotypic state. …”
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    A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma
  20. 40
    “…Gamma‐hydroxybutyrate acid (GHB) is a recreational drug with a high addictive potential. …”
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    Recreational use of GHB is associated with alterations of resting state functional connectivity of the central executive and default mode networks
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