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  1. 41
    “…RATIONALE: Regular consumption of gamma-hydroxybutyrate (GHB) may result in a dependence syndrome that can lead to withdrawal symptoms. …”
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    Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review
  2. 42
    “…HYPOTHESIS: An enzymatic assay for quantification of γ-hydroxybutyric acid (GHB) in biofluids can be employed for targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) in selected populations. …”
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    Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids
  3. 43
    “…Due to the endogenous nature of GHB and its fast metabolism in vivo, the detection window of exogenous GHB is however narrow, making it challenging to prove use of GHB in DFSA cases. …”
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    A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans: New Potential Markers and Changes in Metabolism Related to GHB Consumption
  4. 44
    “…Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients. …”
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    Baclofen to Prevent Relapse in Gamma-Hydroxybutyrate (GHB)-Dependent Patients: A Multicentre, Open-Label, Non-Randomized, Controlled Trial
  5. 45
    “…The endogenous neurotransmitter and approved drug, gamma‐hydroxybutyric acid (GHB), is often illegally used for drug‐facilitated crimes by spiking GHB into alcoholic beverages. …”
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    Easy and convenient millimole‐scale synthesis of new, potential biomarkers for gamma‐hydroxybutyric acid (GHB) intake: Feasible for analytical laboratories
  6. 46
    “…CONCLUSION: GHB and ketamine should be added to the panel of drugs we screen at the point of care in the Amsterdam acute setting.…”
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    Toxicological screening in the Amsterdam acute setting becomes more relevant if the standard panel of the drugs-of-abuse point-of-care test is expanded with GHB and ketamine
  7. 47
    “…The GMO Panel concludes that there is no evidence in renewal application EFSA–GMO–RX–018 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on cotton GHB614.…”
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    Assessment of genetically modified cotton GHB614 for renewal authorisation under Regulation (EC) No 1829/2003 (application EFSA–GMO–RX–018)
  8. 48
    “…Cotton GHB811 was developed to confer tolerance to glyphosate and HPPD inhibitor herbicides. …”
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    Assessment of genetically modified cotton GHB811 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐ES‐2018‐154)
  9. 49
    “…The limit of detection was 10 copies for GHB119 and Cry2Ae and 25 copies for T304-40. The limit of quantification was 25 copies for GHB119 and Cry2Ae and 50 copies for T304-40. …”
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    A novel quadruplex real-time PCR method for simultaneous detection of Cry2Ae and two genetically modified cotton events (GHB119 and T304-40)
  10. 50
    “…The three‐event stack cotton GHB614 × LLCotton25 × MON 15985 was produced by conventional crossing to combine three single cotton events, GHB614, LLCotton25 and MON 15985. …”
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    Assessment of genetically modified cotton GHB614 × LLCotton25 × MON 15985 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2011‐94)
  11. 51
    por Cánovas, Guillermo
    Publicado 2002
    Libro
    Adolescencia y drogas de diseño : éxtasis, píldora del amor, eva, crack, speed, LSD, casper, PCP, ketamina, GHB, ecstacy, nexus... ¿inocuas o peligrosas? ¿qué son y cómo afectan? ¿cómo detectar el consumo en casa? la prevención desde la familia /
  12. 52
    “…γ-Hydroxybutyric acid (GHB) is an endogenous short chain fatty acid that acts as a neurotransmitter and neuromodulator in the mammalian brain. …”
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    Metabolic Alterations Associated with γ-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure
  13. 53
    “…The sodium salt of GHB, sodium oxybate, has been used for the treatment of narcolepsy and cataplexy, whereas GHB was termed as a date rape drug or a club drug in the 1990s. …”
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    Interaction between γ-Hydroxybutyric Acid and Ethanol: A Review from Toxicokinetic and Toxicodynamic Perspectives
  14. 54
    por Kwatra, Nisha V., Morris, Marilyn E.
    Publicado 2021
    “…γ-hydroxybutyric acid (GHB) is widely abused alone and in combination with other club drugs such as ketamine. …”
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    Toxicokinetic/Toxicodynamic Interaction Studies in Rats between the Drugs of Abuse γ-Hydroxybutyric Acid and Ketamine and Treatment Strategies for Overdose
  15. 55
    por Ishiwari, Keita, Sircar, Ratna
    Publicado 2016
    “…In the brain, GHB binds to specific GHB-binding sites as well as to γ-aminobutyric acid type B (GABA(B)) receptors. …”
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    Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382
  16. 56
    “…As the structural analogue of GABA, GHB is suggested as the primary mediator of GHB/GBL effects. …”
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    Repurposing of substances with lactone moiety for the treatment of γ-Hydroxybutyric acid and γ-Butyrolactone intoxication through modulating paraoxonase and PPARγ
  17. 57
    “…We observed that the number of ATP-responsive cells decreased with increasing concentration of either SUC or GHB. Moreover, the concentration dependence of the number of ATP-responsive cells were highly identical as a function of both [SUC] and [GHB], suggesting a mutual receptor for SUC and GHB, therefore implying the existence of a distinct GHB-recognizing astroglial SUC receptor in the brain. …”
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    Activation of Astroglial Calcium Signaling by Endogenous Metabolites Succinate and Gamma-Hydroxybutyrate in the Nucleus Accumbens
  18. 58
    “…We reported that gamma-hydroxybutyrate (GHB) is released upon Herpes Simplex Virus Type-1 (HSV-1) acute infection. …”
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    Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection
  19. 59
    “…Among paracrine factors, glucose-stimulated release of the GABA metabolite γ-hydroxybutyric acid (GHB) from pancreatic β-cells might mediate glucose suppression of glucagon release via GHB receptors on α-cells. …”
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    γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
  20. 60
    “…The main aim of this review is to summarise updated knowledge about GHB pharmacokinetics and pharmacodynamics, acute poisoning, and clinical features of GHB withdrawal syndrome, its diagnosis and medical treatment. …”
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    Gamma-hydroxybutyrate Abuse: Pharmacology and Poisoning and Withdrawal Management
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