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81“…Gamma-hydroxybutyrate (GHB) is a central nervous system depressant that has gained popularity as an illicit recreational drug. …”
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82“…γ-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central nervous system depressant effect. …”
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83por Youn, Su-Chung, Chen, Li-You, Chiou, Ruei-Jen, Lai, Te-Jen, Liao, Wen-Chieh, Mai, Fu-Der, Chang, Hung-Ming“…Excessive exposure to club drug (GHB) would cause cognitive dysfunction in which impaired hippocampal Ca(2+)-mediated neuroplasticity may correlate with this deficiency. …”
Publicado 2015
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84“…PURPOSE: Gamma-hydroxybutyrate (GHB) withdrawal is a life-threatening condition that does not always respond to standard treatment with benzodiazepines. …”
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85“…Gamma-hydroxybutyrate (GHB) is a neurotransmitter found naturally in the human brain. …”
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86“…γ-Hydroxybutyric acid (GHB) reduces (a) alcohol intake and alcohol motivational properties in alcohol-preferring rats and (b) alcohol drinking and craving for alcohol in human alcoholics. …”
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87por Yung, Justin Hou Ming, Yeung, Lucy Shu Nga, Ivovic, Aleksandar, Tan, Yao Fang, Jentz, Emelien Mariella, Batchuluun, Battsetseg, Gohil, Himaben, Wheeler, Michael B., Joseph, Jamie W., Giacca, Adria, Mamelak, Mortimer“…GHB may owe its antioxidant and insulin secretory effects to the formation of NADPH.…”
Publicado 2022
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88por Rousseau, Anne-Françoise, Bargues, Laurent, Bever, Hervé Le, Vest, Philippe, Cavalier, Etienne, Ledoux, Didier, Piérard, Gérald E., Damas, Pierre“…Gamma-hydroxybutyrate (GHB) stimulates endogenous GH secretion. AIM: To assess effects of GHB sedation on keratinocytes proliferation (based on immunohistochemical techniques). …”
Publicado 2014
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89“…SSA can be reduced to γ-hydroxybutyrate (GHB) under oxygen deficiency and high light conditions. …”
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90por Loche, Antonella, Simonetti, Francesco, Lobina, Carla, Carai, Mauro A. M., Colombo, Giancarlo, Castelli, M. Paola, Barone, Domenico, Cacciaglia, Roberto“…N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide (GET73) is a newly synthesized compound structurally related to the clinically used, alcohol-substituting agent, gamma-hydroxybutyric acid (GHB). The present study was designed to assess whether GET73 may share with GHB the capacity to reduce alcohol intake in rats. …”
Publicado 2012
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91por Tuchmann‐Durand, Caroline, Thevenet, Eloise, Moulin, Florence, Lesage, Fabrice, Bouchereau, Juliette, Oualha, Mehdi, Khraiche, Diala, Brassier, Anaïs, Wicker, Camille, Gobin‐Limballe, Stéphanie, Arnoux, Jean‐Baptiste, Lacaille, Florence, Wicart, Clotilde, Coat, Bruno, Schlattler, Joel, Cisternino, Salvatore, Renolleau, Sylvain, Secretan, Philippe‐Henri, De Lonlay, Pascale“…The coma was soon attributed to a medication prescribing error: administration of GHB instead of BHB on day 8 post‐LT. The patient recovered fully within a few hours of GHB withdrawal. …”
Publicado 2020
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92por Elsaeed, Shimaa. M., Zaki, Elsayed Gamal, Omar, Walaa A. E., Ashraf Soliman, Ahmed, Attia, Attia Mahmoud“…Furthermore, GH (5 g/L) and GHB (2 g/L) slightly enhanced the rock water wettability as confirmed by contact angle measurements for GH and the relative permeability saturation curves for GH and GHB.…”
Publicado 2021
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93por Su, Shi-Xing, Wang, Xue-Tao, Li, Xi-Feng, Duan, Chuan-Zhi, Bi, Yi-Ming, Zhang, Xin“…A nonlinear association between GHB and IA rupture was observed, whose inflection points were 5.5 and 8.9. …”
Publicado 2022
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94por Alattas, Ibtihal M, Alwajeeh, Sultan A, Alamoudi, Osama O, Alzahrani, Abdulmajeed H, Alhatali, Badria A“…Gamma-hydroxybutyrate (GHB) is a central nervous system (CNS) depressant with limited clinical use but has been misused in the last few decades. …”
Publicado 2022
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95Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates“…[Image: see text] Herein we report a study combining metabolomics and mass isotopomer analysis used for investigation of the biochemical fate of γ-hydroxybutyric acid (GHB). Using various (13)C incorporation labeling patterns into GHB, we have discovered that GHB is catabolized by previously unknown processes that include (i) direct β-oxidation to acetyl-CoA and glycolate, (ii) α-oxidation to 3-hydroxypropionyl-CoA and formate, and (iii) cleavage of C-4 to yield 3-hydroxypropionate and CO(2). …”
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96por Khounnorath, Sengmanivong, Chamberlain, Karen, Taylor, Ann M., Soukaloun, Douangdao, Mayxay, Mayfong, Lee, Sue J., Phengdy, Bounthom, Luangxay, Khonsavanh, Sisouk, Kongkham, Soumphonphakdy, Bandit, Latsavong, Khaysy, Akkhavong, Kongsin, White, Nicholas J., Newton, Paul N.“…Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity <0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0–12) months, 79.2% were breastfed, 5.1% had α>31% and 13.4 % basal ETK<0.59 micromoles/min/gHb. …”
Publicado 2011
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97“…Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. …”
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98“…In addition, pop2 ssadh seedlings are more sensitive to exogenous SSA or GHB relative to wild type, because GHB and/or SSA accumulate in these plants. …”
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99por Nantakomol, Duangdao, Paul, Rick, Palasuwan, Attakorn, Day, Nicholas PJ, White, Nicholas J, Imwong, Mallika“…G6PD activity was 11 ± 2.5 IU/gHb in non-deficient females (mean ± SD), and 10.9 ± 0.6 IU/gHb in non-deficient males. …”
Publicado 2013
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100por Pednekar, Lina, Pathan, Ansar A., Paudyal, Basudev, Tsolaki, Anthony G., Kaur, Anuvinder, Abozaid, Suhair M., Kouser, Lubna, Khan, Haseeb A., Peerschke, Ellinor I., Shamji, Mohamed H., Stenbeck, Gudrun, Ghebrehiwet, Berhane, Kishore, Uday“…The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. …”
Publicado 2016
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