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  1. 1
    “…GHB overdose can result in death. Internationally, recent increases in GHB overdoses have been observed. …”
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    Understandings, attitudes, practices and responses to GHB overdose among GHB consumers
  2. 2
    “…BACKGROUND: Gamma-hydroxybutyric acid (GHB) is a recreational drug associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced comas. …”
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    Effect of GHB-use and GHB-induced comas on dorsolateral prefrontal cortex functioning in humans
  3. 3
    “…BACKGROUND AND AIMS: The regular use of gamma-hydroxybutyrate acid (GHB) can induce GHB-induced comas. Other substance use disorders are associated with alterations in brain structure and impulsivity. …”
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    Effects of Recreational GHB Use and Multiple GHB-Induced Comas on Brain Structure and Impulsivity
  4. 4
    por Everett, Worth
    Publicado 2001
    Materias: “…Part 2 of the GHB Review Article Serries…”
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    Gamma-Hydroxybutyrate (GHB) With-Drawal
  5. 5
    “…Detoxification by tapering with pharmaceutical GHB is a safe way to manage GHB withdrawal. However, a detailed description of the course of the GHB withdrawal syndrome is currently lacking. …”
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    Characterization of the GHB Withdrawal Syndrome
  6. 6
    “…Background: Gamma-hydroxybutyric acid (GHB) at low dosages has anxiolytic effects and promotes REM sleep and low-wave deep sleep. …”
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    Effect of Repeated Administration of ɣ-Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System
  7. 7
    “…BACKGROUND: GHB (gammahydroxybutyrate) and its precursors are popular recreational drugs due to their sedative, anxiolytic and sexually stimulating effects. …”
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    GHB: a life-threatening drug complications and outcome of GHB detoxification treatment—an observational clinical study
  8. 8
    “…Gamma-hydroxybutyric acid (GHB) is a naturally occurring analog of gamma-aminobutyric acid (GABA) that has been used in research and clinical medicine for many years. …”
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    GHB acid: A rage or reprive
  9. 9
    “…Gamma-hydroxybutyrate (GHB) remains a challenging clinical/forensic toxicology drug. …”
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    Urinary concentrations of GHB and its novel amino acid and carnitine conjugates following controlled GHB administration to humans
  10. 10
    “…In this context, to improve the outcome in GHB long-term treated alcoholics, we added disulfiram to GHB in the management of GHB treatment-resistant alcoholics. …”
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    Long-Term γ-Hydroxybutyric Acid (GHB) and Disulfiram Combination Therapy in GHB Treatment-Resistant Chronic Alcoholics
  11. 11
    “…Background: The short chain fatty acid gamma-hydroxybutyric acid (GHB) is a precursor, and the metabolite of gamma-aminobutyric acid is commonly used as an illegal recreational drug of abuse. …”
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    Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry Assay for Determination of Endogenous GHB and GHB-Glucuronide in Nails
  12. 12
    por Tini, Anastasio, Del Rio, Alessandro
    Publicado 2020
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    Has GBL Replaced GHB in Recreational Settings?
  13. 13
    “…In clinical practice, two pharmacological regimens are commonly used to counteract withdrawal symptoms during GHB detoxification: tapering with benzodiazepines (BZDs) or tapering with pharmaceutical GHB. …”
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    Tapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands
  14. 14
    “…OBJECTIVE: To examine the association of hyperglycemia, as measured by GHb, with subsequent mortality in a nationally representative sample of adults. …”
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    GHb Level and Subsequent Mortality Among Adults in the U.S.
  15. 15
    “…There is a complex interplay between GHB and GABA as GHB is both a prodrug and metabolite of GABA and GHB activates both GHB and GABA receptors. …”
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    Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) Abuse
  16. 16
    “…Gamma-hydroxybutyrate (GHB) is an endogenous molecule first used as anesthetic and then marketed as a nutritional supplement with a wide diffusion in the bodybuilding community. …”
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    Toxicological Characterization of GHB as a Performance-Enhancing Drug
  17. 17
    “…The main drugs usually described in chemsex related research are methamphetamine, mephedrone and GHB/GBL. OBJECTIVES: We present a narrative review of the evidence about the mechanisms of action of different drugs used in chemsex context. …”
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    Chemsex drugs: More than ghb, mephedrone and methamphetamine?
  18. 18
    “…Gamma‐aminobutyric acid (GABA) is an endogenous inhibitory neurotransmitter and precursor of gamma‐hydroxybutyric acid (GHB). NCS‐382 (6,7,8,9‐tetrahydro‐5‐hydroxy‐5H‐benzo‐cyclohept‐6‐ylideneacetic acid), a known GHB receptor antagonist, has shown significant efficacy in a murine model of succinic semialdehyde dehydrogenase deficiency (SSADHD), a heritable neurological disorder featuring chronic elevation of GHB that blocks the final step of GABA degradation. …”
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    A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication
  19. 19
    por Delic, M.
    Publicado 2023
    “…INTRODUCTION: Gamma-hydroxybutyrate (GHB) and its precursor gamma-butyrolactone (GBL) are popular drugs of abuse used for their euphoric, (potential) anabolic, sedative, and amnestic properties. …”
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    Inpatient treatment of GHB/GBL dependence: a case report
  20. 20
    por Liu, Yujun, Luo, Wenjie, Zhang, Yingxia
    Publicado 2022
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    Temporin-GHb of Hylarana guentheri induces apoptosis by the mitochondrial pathway in MDA-MB-231 cells : Temporin-GHb induces MDA-MB-231 cell apoptosis
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