Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

por Hoobler, Eric K., Rai, Ganesha, Warrilow, Andrew G. S., Perry, Steven C., Smyrniotis, Christopher J., Jadhav, Ajit, Simeonov, Anton, Parker, Josie E., Kelly, Diane E., Maloney, David J., Kelly, S. L., Holman, Theodore R.
Publicado 2013

Spatial distribution and identification of potential risk regions to rice blast disease in different rice ecosystems of Karnataka

por Amoghavarsha, Chittaragi, Pramesh, Devanna, Sridhara, Shankarappa, Patil, Balanagouda, Shil, Sandip, Naik, Ganesha R., Naik, Manjunath K., Shokralla, Shadi, El-Sabrout, Ahmed M., Mahmoud, Eman A., Elansary, Hosam O., Nayak, Anusha, Prasannakumar, Muthukapalli K.
Publicado 2022

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression

por Lavudi, Kousalya, Banerjee, Ananya, Li, Na, Yang, Yajing, Cai, Shurui, Bai, Xuetao, Zhang, Xiaoli, Li, Aidan, Wani, Elsa, Yang, Shyh-Ming, Zhang, Junran, Rai, Ganesha, Backes, Floor, Patnaik, Srinivas, Guo, Peixuan, Wang, Qi-En
Publicado 2023

Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants

por Jain, Sankalp, Talley, Daniel C., Baljinnyam, Bolormaa, Choe, Jun, Hanson, Quinlin, Zhu, Wei, Xu, Miao, Chen, Catherine Z., Zheng, Wei, Hu, Xin, Shen, Min, Rai, Ganesha, Hall, Matthew D., Simeonov, Anton, Zakharov, Alexey V.
Publicado 2021

Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases

por Wiedmann, Mareike, Dranchak, Patricia K., Aitha, Mahesh, Queme, Bryan, Collmus, Christopher D., Kashipathy, Maithri M., Kanter, Liza, Lamy, Laurence, Rogers, Joseph M., Tao, Dingyin, Battaile, Kevin P., Rai, Ganesha, Lovell, Scott, Suga, Hiroaki, Inglese, James
Publicado 2021

Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents

por Hochuli, Joshua E., Jain, Sankalp, Melo-Filho, Cleber, Sessions, Zoe L., Bobrowski, Tesia, Choe, Jun, Zheng, Johnny, Eastman, Richard, Talley, Daniel C., Rai, Ganesha, Simeonov, Anton, Tropsha, Alexander, Muratov, Eugene N., Baljinnyam, Bolormaa, Zakharov, Alexey V.
Publicado 2022

Allosteric Binders of ACE2 Are Promising Anti-SARS-CoV-2 Agents

por Hochuli, Joshua E., Jain, Sankalp, Melo-Filho, Cleber, Sessions, Zoe L., Bobrowski, Tesia, Choe, Jun, Zheng, Johnny, Eastman, Richard, Talley, Daniel C., Rai, Ganesha, Simeonov, Anton, Tropsha, Alexander, Muratov, Eugene N., Baljinnyam, Bolormaa, Zakharov, Alexey V.
Publicado 2022

Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies

por Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H., van Leyen, Klaus, Maloney, David J., Holman, Theodore R.
Publicado 2014

A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

por Schiller, Rachel, Scozzafava, Giuseppe, Tumber, Anthony, Wickens, James R, Bush, Jacob T, Rai, Ganesha, Lejeune, Clarisse, Choi, Hwanho, Yeh, Tzu-Lan, Chan, Mun Chiang, Mott, Bryan T, McCullagh, James S O, Maloney, David J, Schofield, Christopher J, Kawamura, Akane
Publicado 2014

Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry

por Tea, Fiona, Pilli, Deepti, Ramanathan, Sudarshini, Lopez, Joseph A., Merheb, Vera, Lee, Fiona X. Z., Zou, Alicia, Liyanage, Ganesha, Bassett, Chelsea B., Thomsen, Selina, Reddel, Stephen W., Barnett, Michael H., Brown, David A., Dale, Russell C., Brilot, Fabienne
Publicado 2020

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma

por Laraba, Liyam, Hillson, Lily, de Guibert, Julio Grimm, Hewitt, Amy, Jaques, Maisie R, Tang, Tracy T, Post, Leonard, Ercolano, Emanuela, Rai, Ganesha, Yang, Shyh-Ming, Jagger, Daniel J, Woznica, Waldemar, Edwards, Philip, Shivane, Aditya G, Hanemann, C Oliver, Parkinson, David B
Publicado 2022

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

por Yan, Wenjing, Zhong, Yongwang, Hu, Xin, Xu, Tuan, Zhang, Yinghua, Kales, Stephen, Qu, Yanyan, Talley, Daniel C., Baljinnyam, Bolormaa, LeClair, Christopher A., Simeonov, Anton, Polster, Brian M., Huang, Ruili, Ye, Yihong, Rai, Ganesha, Henderson, Mark J., Tao, Dingyin, Fang, Shengyun
Publicado 2023

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

por Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.
Publicado 2018

Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders

por Pilli, Deepti, Zou, Alicia, Dawes, Ruebena, Lopez, Joseph A, Tea, Fiona, Liyanage, Ganesha, Lee, Fiona XZ, Merheb, Vera, Houston, Samuel D, Pillay, Aleha, Jones, Hannah F, Ramanathan, Sudarshini, Mohammad, Shekeeb, Kelleher, Anthony D, Alexander, Stephen I, Dale, Russell C, Brilot, Fabienne
Publicado 2020

The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

por Gandelman, Mandi, Dansithong, Warunee, Kales, Stephen C., Paul, Sharan, Maag, Gentrie, Aoyama, Erika, Zakharov, Alexey, Rai, Ganesha, Dexheimer, Thomas, Whitehill, Brooke M., Sun, Hongmao, Jadhav, Ajit, Simeonov, Anton, Henderson, Mark J., Huynh, Duong P., Pulst, Stefan M., Scoles, Daniel R.
Publicado 2021

Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement

por Sanchez, Tino W., Ronzetti, Michael H., Owens, Ashley E., Antony, Maria, Voss, Ty, Wallgren, Eric, Talley, Daniel, Balakrishnan, Krishna, Leyes Porello, Sebastian E., Rai, Ganesha, Marugan, Juan J., Michael, Samuel G., Baljinnyam, Bolormaa, Southall, Noel, Simeonov, Anton, Henderson, Mark J.
Publicado 2022

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

por King, Oliver N. F., Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R., Ng, Stanley S., Quinn, Amy M., Rai, Ganesha, Mott, Bryan T., Beswick, Paul, Klose, Robert J., Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D., Maloney, David J., Schofield, Christopher J., Simeonov, Anton
Publicado 2010

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

por Ruan, Jingjing, Liang, Dongdong, Yan, Wenjing, Zhong, Yongwang, Talley, Daniel C., Rai, Ganesha, Tao, Dingyin, LeClair, Christopher A., Simeonov, Anton, Zhang, Yinghua, Chen, Feihu, Quinney, Nancy L., Boyles, Susan E., Cholon, Deborah M., Gentzsch, Martina, Henderson, Mark J., Xue, Fengtian, Fang, Shengyun
Publicado 2022

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Mode...

por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado 2016

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

por Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Sagor, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Publicado 2016