“…Incidence of dementia among patients taking trazodone was higher than in matched users of other antidepressants (1.8 versus 1.1 per 100 person-years), with a hazard ratio (HR) of 1.80 (95% confidence interval [CI] 1.56–2.09; p < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Similarly, V20 > 42.22 cc was found to result in a statistically significant higher risk of TLI (subdistribution hazard ratio [sHR] =3.123, P < 0.05). CONCLUSIONS: TL D1cc and V20 were predictive of TLI after IMRT for T4 NPC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In multivariable Cox proportional hazards regression analyses, lower age and higher BMI was independently associated with long-term survival, adjusted HR (95% CI) 1.08 (1.05–1.11) per year and 0.91 (0.85–0.97) per kg/m(2). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Kaplan-Meier analysis revealed that the two groups differed significantly with respect to 90-day survival (log-rank P = 0.007), and Cox regression analysis showed that an IS level ≥ 2.74 μg/ml was significantly associated with a 2.0-fold increased risk of death (adjusted hazard ratio [HR], 2.92; 95% confidence interval [CI], 1.76 to 4.86; P < 0.001) compared with an IS level < 2.74 μg/ml. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, PD-L1 expression predicted pCR (P = 0.002) and correlated with sTIL infiltration (P < 0.001). sTIL infiltration of more than 10% of the stroma was a significant predictor of improved OS (HR 0.47, 95% CI 0.27–0.81, P = 0.006) in a multivariate model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In multivariable analysis, IHS was associated with higher mortality over five years post-stroke in each cohort (1995–2001: HR 1.27, 95%CI 1.03–1.57, 2002–2008: 1.24, 0.99–1.55, 2009–2016: 1.39, 0.95–2.04). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The estimated 5-year overall survival (OS), disease-free survival (DFS), and local control (LC) rates of patients were 75.1%, 70.9%, and 95.5%, respectively. pCR was an independent prognostic factor for DFS (HR 0.13, 95% CI: 0.02–0.93, P = 0.043), but it did not improve OS or LC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: When combining both cohorts, worse survival was found for patients with CCND1-amplified tumours in luminal A (HR = 1.68; 95% CI, 1.15–2.46), luminal B (1.37; 1.01–1.86) and ER+/LN−/HER2− (1.66; 1.14–2.41) subgroups. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multivariate Cox proportional hazards modeling indicated that HOXD-AS1 was an independent risk predictor of EOC patients (HR = 1.92, p = 0.004). SiRNA inhibition of HOXD-AS1 reduced cell migration, invasion, and epithelial-mesenchymal transition (EMT) in EOC cells in vitro by preventing HOXD-AS1 directly binding to miR-186-5p, and resulting in down-regulating of PIK3R3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Compared to people who waited ≤30 days for a HCP, individuals who waited more than 6 months had an almost 20% excess risk of death (adjusted hazard ratio (aHR), 95%CI = (1.18, 1.16-1.21)) 2 years after entry into a HCP. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multivariate survival analysis, controlling for T-stage, histology stage, invasion depth, demonstrated NGAHIC-positive was a reproducible prognostic factor for poorer disease-specific survival (HR = 17.24, 95% CI 3.93–75.60, P < 0.001). In contrast, human grading was only prognostic for one reader on D2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, clinical cohort results showed that the number of HLA-DR(−/low)CD33(+)CD16(−) cells in the donor graft was the only independent risk factor inversely correlated with the incidence of grade II–IV acute GVHD in the recipients (HR 0.388, 95% CI 0.158–0.954, p = 0.039). CONCLUSION: HLA-DR(−/low)CD33(+)CD16(−) cells represent functional MDSCs that may control acute GVHD in allo-HSCT. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Assuming linear whole-body clearance, linear regression projected complete elimination (x-intercept) at 256.5hr (R(2)=0.96; 95%CI 186.1 to 489.2h). CONCLUSION: (111)In-CHX-A”-DTPA trastuzumab can be safely imaged in humans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTERVENTIONS: Healthy volunteers were challenged IV with endotoxin twice, at a 1-week interval, with each challenge consisting of a bolus of 1 ng/kg followed by continuous administration of 1 ng/kg/hr during 3 hours. Volunteers were randomized to acetylsalicylic acid prophylaxis (80 mg acetylsalicylic acid daily for a 14-d period, starting 7 d before the first endotoxin challenge), acetylsalicylic acid treatment (80 mg acetylsalicylic acid daily for the 7-d period in-between both endotoxin challenges), or the control group (receiving placebo). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multivariate regression analysis showed the same result (HR = 1.23, 95% CI: 0.76–1.52, P = 0.47). Calcification on group had higher recurrent angina than non-calcification group (13.51% vs. 17.65%, P < 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on host cells, ultimately leading to malignant transformation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After adjusting for confounding factors, early epinephrine administration was a risk factor of mortality in the HS group (HR 4.52, 95% CI 2.73–15.91). CONCLUSION: Early epinephrine was significantly associated with achieving sustained ROSC in pediatric cases of HS and non-HS traumatic OHCA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After propensity-score adjustment for age, sex, and baseline HBeAg, ALT, and total bilirubin, virological breakthrough was higher in the de novo combination of Lam and Adv (HR 2.83, 95% CI 1.37–5.86; P<0.01). The cumulative rate of liver-related events, including decompensation and hepatocellular carcinoma, at 1, 2, and 3 years was 2.9%, 4.2%, and 6.1% in the Etv group and 2.2%, 2.2%, and 6.7% in combination group, respectively (P=0.83). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…No significant difference was found in percentage of patients with ventilator-associated pneumonia between enteral (8%) and parenteral (10%) nutrition groups (HR 0.78 (0.26, 2.28)). CONCLUSIONS: Our results suggest that enteral and parenteral nutrition are associated with high rates of microaspiration, although oropharyngeal microaspiration was more common with enteral nutrition and gastric microaspiration was more common with parenteral nutrition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CPRs presented with an internal validation tend to get an independent external validation sooner (HR = 1.73, 95% CI, 0.77–3.93). CPRs reporting all the information necessary for calculating individual risk were 2.65 (95% CI, 1.01–6.96) times more likely to have an independent external validation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso