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  1. 81741
    “…According to the results of the hierarchical clustering, we identified two groups of patients presenting statistically different median LR-PFSs (22.8 months vs. 9.9 months; HR = 2.64; 95% CI 0.97–7.15; p = 0.0573). We also identified two radiomic features (“F_rlm_rl_entr_per” and “F_rlm_2_5D_rl_entr”) significantly associated with LR-PFS. …”
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    Could 18-FDG PET-CT Radiomic Features Predict the Locoregional Progression-Free Survival in Inoperable or Unresectable Oesophageal Cancer?
  2. 81742
    por Aftimos, Philippe, Oliveira, Mafalda, Irrthum, Alexandre, Fumagalli, Debora, Sotiriou, Christos, Gal-Yam, Einav Nili, Robson, Mark E., Ndozeng, Justin, Di Leo, Angelo, Ciruelos, Eva M., de Azambuja, Evandro, Viale, Giuseppe, Scheepers, Elsemieke D., Curigliano, Giuseppe, Bliss, Judith M., Reis-Filho, Jorge S., Colleoni, Marco, Balic, Marija, Cardoso, Fatima, Albanell, Joan, Duhem, Caroline, Marreaud, Sandrine, Romagnoli, Dario, Rojas, Beatriz, Gombos, Andrea, Wildiers, Hans, Guerrero-Zotano, Angel, Hall, Peter, Bonetti, Andrea, Larsson, Karolina Fs, Degiorgis, Martina, Khodaverdi, Silvia, Greil, Richard, Sverrisdóttir, Ásgerdur, Paoli, Marta, Seyll, Ethel, Loibl, Sibylle, Linderholm, Barbro, Zoppoli, Gabriele, Davidson, Nancy E., Johannsson, Oskar Th, Bedard, Philippe L., Loi, Sherene, Knox, Susan, Cameron, David A., Harbeck, Nadia, Montoya, Maite Lasa, Brandão, Mariana, Vingiani, Andrea, Caballero, Carmela, Hilbers, Florentine S., Yates, Lucy R., Benelli, Matteo, Venet, David, Piccart, Martine J.
    Publicado 2021
    “…High tumor mutational burden correlated to shorter time to relapse in HR(+)/HER2(−) cancers. ESCAT tier I/II alterations were detected in 51% of patients and matched therapy was used in 7%. …”
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    Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative
  3. 81743
    “…METHODS: A fictitious refractive index (FRI) was determined (Pentacam HR®) based on the PPPA ratio in 50 eyes undergoing triple DMEK. …”
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    Optimizing intraocular lens power calculation using adjusted conventional keratometry for cataract surgery combined with Descemet membrane endothelial keratoplasty
  4. 81744
    “…The multivariable-adjusted HR for incident moderate/severe VMSs was 1.37 (95% CI: 1.08–1.73) in participants with LDL ≥ 130 mg/dL, compared to those with LDL < 100 mg/dL. …”
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    High low-density lipoprotein cholesterol level is associated with an increased risk of incident early-onset vasomotor symptoms
  5. 81745
    “…RESULTS: The mean systemic vascular resistance index (SVRI, 1447.23 ± 324.71 dyn*s*cm(−5)*m(2)), mean central venous pressure (CVP, 10.69 ± 3.16) and mean global end-diastolic volume index (GEDVI, 801.79 ± 158.95 ml/m(2)) deviated from the reference range, while the mean cardiac index (CI), mean stroke volume index (SVI), mean arterial pressure (MAP), and mean heart rate (HR) were within the reference range, as indicated in the literature. …”
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    Pilot study: advanced haemodynamic monitoring after acute spinal cord injury-Keep the pressure up?
  6. 81746
    “…High-risk stage III CC was associated with worse OS compared with low-risk disease (HR 0.35, 0.34-0.36, P < .001). Multi-agent chemotherapy was associated with a better 5-year OS compared with SAC (P < .001). …”
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    Survival Outcomes of Adjuvant Chemotherapy in Elderly Patients with Stage III Colon Cancer
  7. 81747
    “…Abbreviations: ARCON:accelerated radiotherapy with carbogen and nicotinamide; ATG: autophagy related; BrdUrd: bromodeoxyuridine; CA9/CAIX: carbonic anhydrase 9; HIF1A/HIF1α: hypoxia inducible factor 1 subunit alpha; HNSCC: head and neck squamous cell carcinoma; HPV: human papilloma virus; HR: hazard ratio; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MEF: mouse embryonic fibroblast; mRNA: messenger ribonucleic acid; PCR: polymerase chain reaction; SLC2A1/GLUT1: solute carrier family 2 member 1; TCGA: the Cancer Genome Atlas; TME: tumor microenvironment; UTR: untranslated region; VEGF: vascular endothelial growth factor…”
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    ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer
  8. 81748
    “…In subanalyses using time-varying occupational noise exposure, we observed an indication of higher stroke risk among the most exposed (≥85 dB(A)), particularly when restricting analyses to people exposed to occupational noise within the last year (HR: 1.27; 95% CI: 0.99 to 1.63). CONCLUSIONS: We found no association between occupational noise and risk of overall stroke after adjustment for confounders. …”
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    Occupational noise exposure and risk of incident stroke: a pooled study of five Scandinavian cohorts
  9. 81749
    “…And higher level of CD8(+) TILs was demonstrated to associate with better PFS in CPS PD-L1-negative patients treated with chemoimmunotherapy (HR =23.70, 95% CI: 1.15–488.30, P=0.04). CONCLUSIONS: Intratumoral CD8(+) TILs may be a potential positive predictive factor of clinical response for chemoimmunotherapy in PD-L1-negative advanced GC. …”
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    Intratumoral CD8(+) T cells as a potential positive predictor of chemoimmunotherapy response in PD-L1-negative advanced gastric cancer patients: a retrospective cohort study
  10. 81750
    “…Finally, a prognostic model constructed based on NPRL2-related genes could predict the prognosis of STAD patients (AUC =0.641), and the risk score was an independent prognostic factor for STAD patients (HR =4.855, 95% CI: 2.683–8.785, P<0.001). CONCLUSIONS: The present study provided a comprehensive analysis of the role and potential mechanisms of NPRL2 in STAD, suggesting that NPRL2 is a potential biomarker for the survival and prediction of immunotherapy response in STAD.…”
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    Bioinformatics analysis of the prognostic and immunotherapeutic significance of NPRL2 in stomach adenocarcinoma
  11. 81751
    “…After adjusting for age, gender, and clinical stage, the risk score was also considered as and independent risk factor affecting the overall survival of LUAD patients (HR =2.949, 95% CI: 1.762–4.937). Moreover, low-risk score group exhibited a higher Immune score and lower Tumor purity compared with high-risk score group. ssGSEA results proved that the enrichment scores of most immune cells and immune related signal pathway in low-risk score group was significant higher than that in high-risk score group. …”
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    A novel pyroptosis related genes signature for predicting prognosis and estimating tumor immune microenvironment in lung adenocarcinoma
  12. 81752
    “…Vaccine effectiveness (VE) for prevention of infection, hospitalisation and mortality was evaluated using the formula VE=(1-adjustedHR)x100. FINDINGS: 45.7% (467/1021) had evidence of prior infection. …”
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    Comparison of immunogenicity and clinical effectiveness between BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines in people with end-stage kidney disease receiving haemodialysis: A prospective, observational cohort study
  13. 81753
    “…Genotyping was performed on all high-risk HPV (HR-HPV)-positive samples. Test characteristics were calculated based on histological review. …”
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    Performance of human papillomavirus E6/E7 mRNA assay for primary cervical cancer screening and triage: Population-based screening in China
  14. 81754
    “…RESULTS: As compared to healthy controls, patients with fibromyalgia exhibited significantly lower CPT survival (HR = 2.17, 95% CI: [1.42, 3.31], p = 0.00035). As indicated by Cox regression models, the significant group difference in CPT survival did not relate to our selected psychological and clinical measures (p > 0.05). …”
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    Evaluation by Survival Analysis of Cold Pain Tolerance in Patients with Fibromyalgia and Opioid Use
  15. 81755
    “…The deposition dose rate (DDR) of BC was up to 3 times higher during commute inside a public transport compared to walking (11.6 versus 4.4 μg hr(−1), respectively). This is twice higher than reported in similar studies. …”
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    A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity
  16. 81756
    “…The risk score was associated with the stage of disease (p < 0.05) and was an independent prognostic factor for NSCLC when adjusted for age and UICC stage (p < 0.001, hazard ratio (HR): 1.888). The constructed nomogram showed a good predictive value. …”
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    Signature based on RNA-binding protein-related genes for predicting prognosis and guiding therapy in non-small cell lung cancer
  17. 81757
    “…All the patients were subjected to the following investigations: uMCP-1, erythrocyte sedimentation rate (ESR), complement C3 (C3), complement C4 (C4), creatinine, albumin/creatinine ratio (uACR), creatinine clearance, quantitative assessment of proteinuria by 24-hour urine proteinuria (24hr UP) and percutaneous renal biopsy. RESULTS: Sixty patients from group I (71.4%) showed glomerular lesions on renal biopsy (SLN), and class II was the predominant class. uMCP-1 had a sensitivity of 95.2% and a specificity of 98% in the detection of SLN, and uMCP-1 values were markedly higher in patients with OLN in comparison to SLN. …”
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    Silent Lupus Nephritis: Renal Histopathological Profile and Early Detection with Urinary Monocyte Chemotactic Protein 1
  18. 81758
    “…RESULTS: There was no significant difference in recurrence-free survival (RFS) between the HAIC-Surgery group and the Surgery group (HR: 1.140, 95% CI: 0.8027–1.618, p=0.444). The HAIC-Surgery group had a higher incidence of surgery-related complications than the Surgery group [biliary leakage (10.3% vs 4.2%, p=0.035), abdominal bleeding (10.3% vs 3.8%, p=0.020), pleural effusion (56.1% vs 23.0%, p<0.0001) and ascites effusion (17.8% vs 5.2%, p<0.0001)]. …”
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    Hepatic Arterial Infusion Chemotherapy as a Timing Strategy for Conversion Surgery to Treat Hepatocellular Carcinoma: A Single-Center Real-World Study
  19. 81759
    “…On multivariate analysis, hydronephrosis remained as an independently associated factor with worse overall survival (HR=2.06; 95% CI 1.12 to 3.79, p=0.02). CONCLUSION: Patients with locally advanced cervical cancer with hydronephrosis had lower overall survival even after controlling for potential confounding factors, but no difference in progression-free survival. …”
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    Prognostic role of hydronephrosis in the treatment of patients with locally advanced cervical cancer: a retrospective cohort
  20. 81760
    “…Sexual dysfunction and poor HR-QoL was identified on validated questionnaires in both groups. …”
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    Differences in polysomnographic, nocturnal penile tumescence and penile doppler ultrasound findings in men with stuttering priapism and sleep-related painful erections
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