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82141por Rajamani, Kushwin, Colman, Peter G, Li, Li Ping, Best, James D, Voysey, Merryn, D'Emden, Michael C, Laakso, Markku, Baker, John R, Keech, Anthony C“…The risks of first amputation (45 vs 70 events; hazard ratio [HR] 0·64, 95% CI 0·44–0·94; p=0·02) and minor amputation events without known large-vessel disease (18 vs 34 events; 0·53, 0·30–0·94; p=0·027) were lower for patients assigned to fenofibrate than for patients assigned to placebo, with no difference between groups in risk of major amputations (24 vs 26 events; 0·93, 0·53–1·62; p=0·79). …”
Publicado 2009
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82142por Parkash, Om, Almas, Aysha, Jafri, SM Wasim, Hamid, Saeed, Akhtar, Jaweed, Alishah, Hasnain“…Cox regression analysis also showed significantly higher mortality in severe hepatitis group (H.R (4.91; 95% CI 1.74-13.87 and P value 0.003) and in DHF/DSS (5.43; CI 1.86-15.84 and P value 0.002). …”
Publicado 2010
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82143“…RESULTS: The βA group experienced a significant rightward shift in HR@OBLA beats.min(-1 )(p < 0.01) pre/post (161.6 ± 19.2 to 173.6 ± 9.9) but remained unchanged in the PL group (166.8 ± 15.8 to 169.6 ± 16.1). …”
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82144“…The AaKLC2.1 promoter activity reached ~1600 fold over the negative control at 5 hr after egg deposition. CONCLUSIONS: Transcriptome profiling by use of high throughput sequencing technologies has proven to be a valuable method for the identification and discovery of early and transient zygotic genes. …”
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82145“…Methods: We performed experimental MI/R with 30 min of ischemia and 4 hr of reperfusion in 8–12 wk old C57BL/6 (WT) mice. …”
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82146por Abraham, Jean E, Maranian, Mel J, Driver, Kristy E, Platte, Radka, Kalmyrzaev, Bolot, Baynes, Caroline, Luccarini, Craig, Shah, Mitul, Ingle, Susan, Greenberg, David, Earl, Helena M, Dunning, Alison M, Pharoah, Paul DP, Caldas, Carlos“…RESULTS: In tamoxifen treated patients, there was weak evidence that the poor-metaboliser variant, CYP2D6*6 (MAF = 0.01), was associated with decreased BCSS (P = 0.02; HR = 1.95; 95% CI = 1.12-3.40). No other variants, including CYP2D6*4 (MAF = 0.20), previously reported to be associated with poorer clinical outcomes, were associated with differences in BCSS, in either the tamoxifen or non-tamoxifen groups. …”
Publicado 2010
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82147“…The rural group had an increased adjusted mortality probability, adjusted hazards ratio 2.41 (CI: 1.25-4.67) and the rural/urban group had an increased adjusted LTFU probability, aHR 2.85 (CI: 1.41-5.79). The rural/urban group had a decreased adjusted probability of virological suppression compared with the urban group at any timepoint on treatment, adjusted odds ratio 0.67 (CI: 0.48-0.93). …”
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82148por Boulware, David R., Meya, David B., Bergemann, Tracy L., Wiesner, Darin L., Rhein, Joshua, Musubire, Abdu, Lee, Sarah J., Kambugu, Andrew, Janoff, Edward N., Bohjanen, Paul R.“…CM-IRIS was independently associated with death (HR = 2.3, 95% CI 1.1–5.1, p = 0.04). Patients experiencing subsequent CM-IRIS had 4-fold higher median serum cryptococcal antigen (CRAG) levels pre-ART (p = 0.006). …”
Publicado 2010
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82149por Bauer, Alison K., Rondini, Elizabeth A., Hummel, Kristin A., Degraff, Laura M., Walker, Christopher, Jedlicka, Anne E., Kleeberger, Steven R.“…Methods: C3H/HeJ (HeJ; Tlr4 mutant) and C3H/HeOuJ (OuJ; Tlr4 normal) mice were exposed continuously to 0.3 ppm O(3) or filtered air for 6, 24, 48, or 72 hr. We assessed inflammation using bronchoalveolar lavage and molecular analysis by mRNA microarray, quantitative RT-PCR (real-time polymerase chain reaction), immunoblots, immunostaining, and ELISAs (enzyme-linked immunosorbent assays). …”
Publicado 2011
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82150“…The Plan focuses on national health priorities, which include the human resources (HR) crisis. In this paper we describe the way the HRH establishment is distributed in the different provinces of Zambia, with a view to assess the dimension of shortages and of imbalances in the distribution of health workers by province and by level of care. …”
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82151“…Mean power output (W), speed (km.hr(-1)) and distance covered (km) were assessed throughout both trials. …”
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82152por Kala, Petr, Kanovsky, Jan, Rokyta, Richard, Smid, Michal, Pospisil, Jan, Knot, Jiri, Rohac, Filip, Poloczek, Martin, Ondrus, Tomas, Holicka, Maria, Spinar, Jindrich, Jarkovsky, Jiri, Dusek, Ladislav“…Severe heart failure on admission (Killip III-IV) was associated with the worst prognosis in the whole group of patients, though its significance was higher in the youngers (HR 6.04 vs. 3.14, p = 0.051 for Killip III and 12.24 vs. 5.65, p = 0.030 for Killip IV). …”
Publicado 2012
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82153por Rozenberg, J., Wieling, W., Schon, I. K., Westerhof, B., Frampton, C., Jardine, D.“…In both groups, MAP remained below baseline during early and late recovery: PPFH 84 ± 5 versus 51 ± 5 and 64 ± 5 mmHg (p = 0.001, p = 0.001); NR 104 ± 5 versus 83 ± 5 and 93 ± 5 mmHg (p = 0.001, p = 0.03). However, MAP and HR were lower in the PPFH group (p = 0.004, p = 0.023). …”
Publicado 2012
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82154por Carlsson, Marcus, Andersson, Ruslana, Bloch, Karin Markenroth, Steding-Ehrenborg, Katarina, Mosén, Henrik, Stahlberg, Freddy, Ekmehag, Bjorn, Arheden, Hakan“…There was no difference in CI between athletes and age-controlled healthy subjects but HR was lower and indexed SV higher in athletes. …”
Publicado 2012
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82155por Ryan, Marion T, Hamill, Ruth M, O’Halloran, Aisling M, Davey, Grace C, McBryan, Jean, Mullen, Anne M, McGee, Chris, Gispert, Marina, Southwood, Olwen I, Sweeney, Torres“…HAP2 was associated with IMFL% GP-influenced traits pH at 24 hr in LTL (pHULT), pH at 45 min in LTL (pH(45)LT) and pH at 45 min in the M. semimembranosus muscle (pH(45)SM). …”
Publicado 2012
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82156por Gemmati, Donato, Zeri, Giulia, Orioli, Elisa, De Gaetano, Francesca E, Salvi, Fabrizio, Bartolomei, Ilaria, D’Alfonso, Sandra, Dall’Osso, Claudia, Leone, Maurizio A, Singh, Ajay V, Asselta, Rosanna, Zamboni, Paolo“…Finally, HEPC -582G-carriers had a significantly higher chance to switch into the progressive form (HR=3.55; 1.83-6.84; log-rank P=0.00006). CONCLUSIONS: Polymorphisms in the genes coding for iron binding and transporting proteins, in the presence of local iron overload, might be responsible for suboptimal iron handling. …”
Publicado 2012
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82157“…RESULTS: Of the 85 kinases identified in the screen, 28 of them were further silenced by siRNAs on MDA-MB-231 (TNBC), BT474-M1 (ER(+)/HER2(+), a metastatic variant), and HR5 (ER(+)/HER2(+), a trastuzumab-resistant model) cells and showed a broad spectrum of growth inhibition. …”
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82158“…Abn CBPV {systolic [+5.4(0.8); p = 0.002, diastolic [+1.7(0.1); p = 0.07 and pulse pressure [PP] [+3.5(0.4); p = 0.003 mm Hg} or elevated heart rate [HR] [+4.9(0.5) bpm; p = 0.003] ensued. Resting RHI declined by 0.47(0.004) from initial 2.24(0.09) to 1.77(0.1); p = 0.001, indicating endothelial dysfunction [ED]. …”
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82159por Musapa, Mulenga, Kumwenda, Taida, Mkulama, Mtawa, Chishimba, Sandra, Norris, Douglas E., Thuma, Philip E., Mharakurwa, Sungano“…The Chelex approach required three simple reagents and 37 min to complete, while the salting out protocol entailed 10 different reagents and 2 hr and 47 min' processing time, including an overnight step. …”
Publicado 2013
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82160por O´Leary, Patrick C, Penny, Sarah A, Dolan, Roisin T, Kelly, Catherine M, Madden, Stephen F, Rexhepaj, Elton, Brennan, Donal J, McCann, Amanda H, Pontén, Fredrik, Uhlén, Mathias, Zagozdzon, Radoslaw, Duffy, Michael J, Kell, Malcolm R, Jirström, Karin, Gallagher, William M“…However, multivariate Cox regression demonstrated that the signature was not a significant predictor of BCSS (HR = 6.38; 95% CI = 0.79-51.26, p = 0.082). CONCLUSIONS: We have developed a comprehensive biomarker pathway that extends from discovery through to validation on a TMA platform. …”
Publicado 2013
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