“…RESULTS: Our probe showed a radiochemical purity of 96.5±0.15% at 1 hr and specific activity of 8.7±0.53 MBq/μg. The uptake rate in the (177)Lu-asPNA group was much higher than that in the (177)Lu-DOTA-nonsense-PNA ((177)Lu-nonsense-PNA) and (177)Lu-DOTA groups (P<0.05). …”
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“…METHODS: We enrolled 60 active smokers (≥3 cigarettes per day) and recorded continuous step counts with the Fitbit Charge HR. MVPA was defined as a cadence of greater than or equal to 100 steps per minute. …”
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“…The drug release process is divided into two stages: a rapid stage over the first 10 hr, then the release becomes gradual and stable. …”
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“…Herein we describe iron(iv)–tosylimido complexes [Fe(IV)(NTs)(MePy(2)tacn)](OTf)(2) (1((IV))[double bond, length as m-dash]NTs) and [Fe(IV)(NTs)(Me(2)(CHPy(2))tacn)](OTf)(2) (2((IV))[double bond, length as m-dash]NTs), (MePy(2)tacn = N-methyl-N,N-bis(2-picolyl)-1,4,7-triazacyclononane, and Me(2)(CHPy(2))tacn = 1-(di(2-pyridyl)methyl)-4,7-dimethyl-1,4,7-triazacyclononane, Ts = Tosyl). 1((IV))[double bond, length as m-dash]NTs and 2((IV))[double bond, length as m-dash]NTs are rare examples of octahedral iron(iv)–imido complexes and are isoelectronic analogues of the recently described iron(iv)–oxo complexes [Fe(IV)(O)(L)](2+) (L = MePy(2)tacn and Me(2)(CHPy(2))tacn, respectively). 1((IV))[double bond, length as m-dash]NTs and 2((IV))[double bond, length as m-dash]NTs are metastable and have been spectroscopically characterized by HR-MS, UV-vis, (1)H-NMR, resonance Raman, Mössbauer, and X-ray absorption (XAS) spectroscopy as well as by DFT computational methods. …”
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“…Risk ratio (RR) with 95% confidence interval (CI) was calculated for binary outcomes, mean difference (MD) or the standardized mean difference (SMD) with 95% CI for continuous outcomes, and the hazard ratio (HR) for time-to-event outcomes. Review Manager 5.3 and STATA software were used for the meta-analysis. …”
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“…One retrospective study reported no difference in long-term survival (approximately 6 to 12 years) between those who had a prior esophagogastroduodenoscopy and those who had not (adjusted HR 0.93, 95% confidence interval (CI) 0.58–1.50). …”
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“…RESULTS: At the 2 year follow-up (n = 2062; control: n = 1031; intervention: n = 1031), in the intention-to-treat population the HR for development of type 2 diabetes calculated using a discrete-time proportional hazards model was 0.89 (95% CI 0.74, 1.07; p = 0.22). …”
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“…These samples were kept at 100°C for 1 hr (boiled kefiran) and the supernatant was precipitated by ethanol (pure kefiran). …”
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“…RESULTS: Primary analyses showed statistically significant reductions in the rate of arrhythmia recurrence with RF ablation with Ablation Index compared to CB in unmatched, unadjusted (HR 0.50, 95% CI 0.27–0.95) and matched (0.42, 0.21–0.86) analyses. …”
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“…The only valuable association in PanC patients was found between miR-1273g-3p and tumor stage, and increased miR-122-5p levels emerged as independent negative prognostic factor for PanC patients (HR = 1.58, 95% CI = 1.03–2.43, p = 0.037). Our data highlighted a role for circulating miR-1273g-3p and miR-122-5p as new diagnostic and prognostic biomarkers for PanC.…”
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“…Also, HCC patients with a higher level of miR-193a-3p expression tended to have a favorable overall survival (OS: HR = 0.7, 95% CI [0.43–1.13], P = 0.14). For the KEGG pathway analysis, the most related pathway was “proteoglycans in cancer”, while the most enriched GO term was “protein binding”. …”
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“…There were no differences between the CRT OFF and CRT ON groups in overall mortality (Log rank p = 0.32, adjusted HR = 1.14 [0.54–2.22], p = 0.71), heart transplantation, cardiac and noncardiac mortality, all cause hospitalizations, hospitalizations for ICD shocks, and number and frequency of ICD shocks or anti-tachycardia pacing therapy. …”
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“…Furthermore, the Cox regression model was performed to assay the hazard ratio (HR). The association between miR-146a and COX2 expression level in ESCC patients was evaluated by nonparametric Spearman’s rho analysis. …”
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“…METHODS AND RESULTS: Using DNA DSB repair assays, we evaluated the efficiency of specific repair pathways, and found that PR, GR and GA decrease the efficiency of non-homologous end joining (NHEJ), single strand annealing (SSA), and microhomology-mediated end joining (MMEJ), but not homologous recombination (HR). We found that PR inhibits DNA DSB repair, in part, by binding to the nucleolar protein nucleophosmin (NPM1). …”
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“…After adjusting for baseline characteristics, the higher risk of the functional decline group relative to the no functional decline group remained significant (adjusted HR 1.46; 95% CI 1.24 to 1.71; p<0.001). CONCLUSIONS: Independent risk factors of functional decline in very old patients with ADHF were related to both frailty and severity of HF. …”
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“…Circulating MMP-7 was capable of predicting events over and above the traditional risk factors (HR = 1.15 P = .006). When the model was associated with the variables of interest, the risk predicted by (18)F-FDG-PET was not significant. …”
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“…Allocation to the combined fibrate-statin treatment arm during the trial period had a beneficial legacy effect on all-cause mortality (adjusted HR = 0.65, 95% CI 0.45–0.94; P = 0.02). CONCLUSIONS: Fibrate treatment during the initial trial period was associated with a legacy benefit of improved survival over a post-trial follow-up. …”
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“…Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), stroke index (SI), cardiac index (CI) and heart rate variability (HRV) were continuously monitored. …”
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“…PSS-nonL patients were stratified into low risk (LR), moderate risk (MR) and high risk (HR) groups according to the lymphoma risk score proposed by Fragkioudaki et al. …”
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“…The possibility of a tissue recovering was investigated using (1)H High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance ((1)H HR-MAS NMR) spectroscopy, thus allowing the detection of metabolites/osmolytes related with hydrocephalus severity and outcome in the neocortex. …”
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