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  1. 82421
    “…In the clinical benefit cohort, 61% of patients had genomic high-risk tumors; those who received the recommended adjuvant radiation therapy (ART) had 2-year PSA recurrence of 3 vs. 25% for those who did not (HR 0.1 [95% CI 0.0–0.6], p = 0.013). For the genomic low/intermediate-risk patients, 93% followed recommendations for observation, with similar 2-year PSA recurrence rates compared with those who received ART (p = 0.93). …”
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    Prospective study to define the clinical utility and benefit of Decipher testing in men following prostatectomy
  2. 82422
    “…In multivariate Cox regression analysis, risk score was still an independent prognostic factor (HR = 1.922, 95% CI = 1.573–2.349, P < 0.001). Cumulative curve showed that the survival time of patients with low-risk score was significantly longer than that of patients with high-risk score (P < 0.001). …”
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    Identification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients
  3. 82423
    “…At median follow-up of 9.5 months, median OS (mOS) was comparable between groups: nivolumab, 9.8 months (95% CI, 8.2-11.8); bevacizumab, 10.0 months (95% CI, 9.0-11.8); HR, 1.04 (95% CI, 0.83-1.30); P = .76. The 12-month OS was 42% in both groups. …”
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    Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial
  4. 82424
    “…In one trial, the benefit of time to clinical improvement was not statistically significant (21 vs 23 days, HR 1.23, 95% CI 0.87–1.75), although the study was underpowered. …”
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    Remdesivir in Treatment of COVID-19: A Systematic Benefit–Risk Assessment
  5. 82425
    “…After multivariable adjustment for relevant covariates, the association of DM to MACCE disappeared [HR 1.11 (0.89‐1.38)]. Because chronic kidney disease (CKD) was clearly associated with increased 1 year MACCE after multivariate adjustment [odds ratio (OR) 2.11 (1.68–2.64)], a subgroup analysis was performed showing a strong trend towards more perioperative complications in DM patients with CKD [OR 2.16 (0.9–5.21)], while no effect of DM was observed in patients without CKD [OR 0.73 (0.42–1.28)]. …”
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    Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry
  6. 82426
    “…The maximal decrease in MAP was significantly higher in the group C than in group U after spinal injection (P < 0.001), without any modifications HR in either group. Eight patients in group C and two patients in group U required ephedrine (P = 0.038). …”
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    Dural sac cross-sectional area is a highly effective parameter for spinal anesthesia in geriatric patients undergoing transurethral resection of the prostate: a prospective, double blinded, randomized study
  7. 82427
    “…RESULTS: Dex decreased the requirement of propofol in a dose-dependent manner(P = 0.000). Heart rate (HR) and mean arterial pressure (MAP) displayed no significant difference among groups (P = 0.397 and 0.863). …”
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    Nebulized dexmedetomidine improves pulmonary shunt and lung mechanics during one-lung ventilation: a randomized clinical controlled trial
  8. 82428
    “…After adjusting for disease severity and relevant clinical factors, even small amounts of myocardial injury (e.g., troponin I >0.03 to 0.09 ng/ml; n = 455; 16.6%) were significantly associated with death (adjusted hazard ratio: 1.75; 95% CI: 1.37 to 2.24; p < 0.001) while greater amounts (e.g., troponin I >0.09 ng/dl; n = 530; 19.4%) were significantly associated with higher risk (adjusted HR: 3.03; 95% CI: 2.42 to 3.80; p < 0.001). CONCLUSIONS: Myocardial injury is prevalent among patients hospitalized with COVID-19; however, troponin concentrations were generally present at low levels. …”
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    Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection
  9. 82429
    por Fang, Qiongxuan, Chen, Hongsong
    Publicado 2020
    “…Moreover, multivariate Cox regression analysis indicated that the two-gene signature was an independent factor for predicting prognosis (HR = 1.087, 95% CI: 1.007–1.172). Correlation analysis between the gene signature and clinical features revealed that the risk stratification was significantly correlated with grade and survival state. …”
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    The significance of m6A RNA methylation regulators in predicting the prognosis and clinical course of HBV-related hepatocellular carcinoma
  10. 82430
    “…Moreover, T2DM patients with ESBL-E. coli UTIs had higher all-cause mortality (hazard ratio [HR], 4.09; 95%, 1.14–14.59) than those with K. pneumoniae UTIs. …”
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    Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients
  11. 82431
    “…AKI was not associated with increased risk of mortality (HR 1.1; 95% CI: 0.8 to 1.6; p=0.67). ICPi nephrotoxicity was attributed via biopsy or nephrologist assessment in 12 patients (six interstitial nephritis, two membranous nephropathy, two minimal change disease, and two thrombotic microangiopathy). …”
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    Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes
  12. 82432
    “…Furthermore, the 3-year survival was longer in group 1 (72% vs 59% in group 2) (HR 1.50; 95% CI 1.22–1.84).The variables independently associated with worse survival were: group 2, age > 70 years and stage at the moment of diagnosis. …”
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    Impact of the faecal immunochemical test on colorectal cancer survival
  13. 82433
    “…Interestingly, the age at Kasai procedure was strongly associated with the development of liver cirrhosis (p = 0.02), but not with the patients’ survival (p = 0.33), while the degree of fibrosis and cholestasis were significantly correlated with the patients’ survival, with HR of 3.9 (95% CI = 1.7–9.0; p = 0.017) and 3.1 (95% CI = 1.4–7.0; p = 0.016), respectively. …”
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    Histopathological findings for prediction of liver cirrhosis and survival in biliary atresia patients after Kasai procedure
  14. 82434
    por Sarin, Shiv Kumar, Choudhury, Ashok, Lau, George K., Zheng, Ming-Hua, Ji, Dong, Abd-Elsalam, Sherief, Hwang, Jaeseok, Qi, Xiaolong, Cua, Ian Homer, Suh, Jeong Ill, Park, Jun Gi, Putcharoen, Opass, Kaewdech, Apichat, Piratvisuth, Teerha, Treeprasertsuk, Sombat, Park, Sooyoung, Wejnaruemarn, Salisa, Payawal, Diana A., Baatarkhuu, Oidov, Ahn, Sang Hoon, Yeo, Chang Dong, Alonzo, Uzziel Romar, Chinbayar, Tserendorj, Loho, Imelda M., Yokosuka, Osamu, Jafri, Wasim, Tan, Soeksiam, Soo, Lau Ing, Tanwandee, Tawesak, Gani, Rino, Anand, Lovkesh, Esmail, Eslam Saber, Khalaf, Mai, Alam, Shahinul, Lin, Chun-Yu, Chuang, Wan-Long, Soin, A. S., Garg, Hitendra K., Kalista, Kemal, Batsukh, Badamnachin, Purnomo, Hery Djagat, Dara, Vijay Pal, Rathi, Pravin, Al Mahtab, Mamun, Shukla, Akash, Sharma, Manoj K., Omata, Masao
    Publicado 2020
    “…Liver related complications increased (p < 0.05) with stage of liver disease; a Child-Turcotte Pugh score of 9 or more at presentation predicted high mortality [AUROC 0.94, HR = 19.2 (95 CI 2.3–163.3), p < 0.001, sensitivity 85.7% and specificity 94.4%). …”
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    Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)
  15. 82435
    “…D/NAO subjects showed a worsening disability risk of 1.69 times (95% CI: 1.11–2.57), ND/AO subjects showed a 2-fold increased risk (95% CI: 1.34–2.98), while being D/AO more than trebled the risk, even after adjustment for confounding factors (HR: 3.39, 95%; CI: 1.91–6.02). By dividing the study population according to the relative ASMM/FM% tertiles, no groups showed an increased risk of worsening disability. …”
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    Worsening Disability and Hospitalization Risk in Sarcopenic Obese and Dynapenic Abdominal Obese: A 5.5 Years Follow-Up Study in Elderly Men and Women
  16. 82436
    “…Multivariate Cox proportional hazards analysis showed that 1-unit increase of TyG index was independently associated with higher risk of primary endpoint, independent of other risk factors [hazard ratio (HR) 3.208 per 1-unit increase, 95% confidence interval (CI) 2.400–4.289, P < 0.001]. …”
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    Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China
  17. 82437
    Publicado 2016
    “…The multiple-factor analysis showed that the efficacy of DICE was an independent prognostic factor of OS [HR=4.24 (95%CI 2.12–8.50), P<0.001]. ⑤The major adverse events included neutropenia (84.54%), thrombocytopenia (41.24%), anemia (68.04%), and nausea/vomiting (65.98%), 14 patients (14.43%) had liver function abnormality, 1 patient had acute renal function injury during the treatment period. …”
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    DICE方案治疗97例复发／难治非霍奇金淋巴瘤患者的疗效及生存分析
  18. 82438
    Publicado 2015
    “…Meanwhile COX-2 expression was a unique independent prognostic factor analyzed by COX proportional hazards regression model (HR=0.091, 95% CI 0.017–0.505, P=0.006). CONCLUSION: The expression rate of COX-2, p16(INK4A) and p53 in the cHL were relatively high; and they were not statistically correlated with tumor EBV infection status; the COX-2 positive group had poor prognosis, but only event free survival time becomes statistically significant shorter. …”
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    COX-2、p16(INK4A)、p53蛋白在经典型霍奇金淋巴瘤患者中的表达及其预后相关分析
  19. 82439
    “…Axial length (AL), anterior segment parameters, and corneal biomechanical properties were obtained with the Lenstar LS900, Pentacam HR and Corvis ST, respectively. RESULTS: Mean (±SD) SE was − 7.29 ± 4.31D (range: − 0.63 to − 25.75D). …”
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    Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging
  20. 82440
    “…Presence of CND was an independent predictor of death (HR 2.129, 95% CI: 1.382–3.280) but not a severer Covid-19 disease (OR: 1.75, 95% CI: 0.970–3.158). …”
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    Neurological Comorbidity Is a Predictor of Death in Covid-19 Disease: A Cohort Study on 576 Patients
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