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  1. 82541
    “…Patients with secondary resistance were less likely to receive further systemic therapy (28% vs 57%, p<0.001) yet had significantly better PPS (HR 0.503, 95% CI 0.288 to 0.879, p=0.02). CONCLUSIONS: Radiological dynamics were variable, yet significantly correlated with survival outcomes. …”
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    Radiological dynamics and SITC-defined resistance types of advanced melanoma during anti-PD-1 monotherapy: an independent single-blind observational study on an international cohort
  2. 82542
    “…Nos pacientes CC-Dis, encontramos uma associação significativa de níveis mais elevados de Gal-3 (≥15,3 ng/mL) e morte ou transplante cardíaco em acompanhamento de cinco anos (Hazard ratio – HR 3,11; IC95% 1,21– 8,04; p=0,019). CONCLUSÕES: Em pacientes com CC, níveis mais elevados de Gal-3 estiveram significativamente associados a formas graves da doença e maior taxa de mortalidade em longo prazo, o que significa que pode ser um meio efetivo para identificar pacientes de alto risco. …”
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    Galectina-3 Associada a Formas Graves e Mortalidade em Longo Prazo em Pacientes com Doença de Chagas
  3. 82543
    “…Despite COD and ST exercise being matched for classically defined intensity measures (speed × distance and number of accelerations/decelerations), COD exercise elicited greater movement (GPS-Playerload), physiological (HR), metabolic (lactate) as well as central and peripheral (differential RPE) exertion measures compared with ST exercise, suggesting COD exercise evoked a higher exercise intensity. …”
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    The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle
  4. 82544
    “…Accounting for the competing risk of death, children were less likely to recover kidney function compared with adults (sub-hazard ratio [sub-HR] 0.81; 95% CI 0.74–0.89, p-value <0.001; point estimates <1 indicating increased risk for a negative outcome). …”
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    Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data
  5. 82545
    “…After PSM, CSS for the surgery group was significantly longer [median: 19 vs. 9 months; hazard ratio (HR) 0.52, P<0.001] compared with the no-surgery group. …”
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    A population-based predictive model predicting candidate for primary tumor surgery in patients with metastatic esophageal cancer
  6. 82546
    por Solaymani-Dodaran, Masoud, Ghanei, Mostafa, Bagheri, Mehdi, Qazvini, Ali, Vahedi, Ensieh, Hassan Saadat, Seyed, Amin Setarehdan, Seyed, Ansarifar, Akram, Biganeh, Hossein, Mohazzab, Arash, Khalili, Davood, Hosein Ghazale, Amir, Reza Heidari, Mohammad, Taheri, Ali, Khoramdad, Maliheh, Mahdi Asadi, Mohammad, Nazemieh, Masoud, Varshochi, Mojtaba, Abbasian, Samaneh, Bakhtiari, Ali, Mosaed, Reza, Hosseini-shokouh, Seyyed-Javad, Shahrokhi, Masoume, Yassin, Zeynab, Ali Zohal, Mohammad, Qaraati, Maryam, Rastgoo, Nafiseh, Sami, Ramin, Javad Eslami, Mohammad, Asghari, Akram, Namazi, Mansoor, Ziaie, Shadi, Jafari-Moghaddam, Raana, Kalantari, Saeid, Memarian, Mohammad, Khodadadi, Javad, Hossein Afshari, Mohammad, Momen-Heravi, Mansooreh, Behzadseresht, Niusha, Reza Mobayen, Ahmad, Mozafari, Abolfazl, Movasaghi, Fatemeh, Haddadzadeh Shoushtari, Maryam, Moazen, Javad
    Publicado 2021
    “…Time to clinical recovery in the Favipiravir group was similar to Lopinavir/Ritonavir group (HR = 0.94, 95% CI 0.75 – 1.17) and likewise the changes in the daily SpO(2) after discontinuation of supplemental oxygen (p = 0.46) CONCLUSION: Adding Favipiravir to the treatment protocol did not reduce the number of ICU admissions or intubations or In-hospital mortality compared to Lopinavir/Ritonavir regimen. …”
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    Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia
  7. 82547
    “…After multivariable adjustment, individuals with both elevated NT-proBNP and frequent SVEs had a significantly increased incidence of AF, compared to subjects without elevated NT-proBNP or frequent SVEs (hazard ratio (HR) 4.61, 95% confidence interval (CI) 2.45–8.69), and compared to individuals with either elevated NT-proBNP or frequent SVEs (both P < 0.05). …”
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    Supraventricular arrhythmia, N-terminal pro-brain natriuretic peptide and troponin T concentration in relation to incidence of atrial fibrillation: a prospective cohort study
  8. 82548
    “…ABBREVIATIONS: ASA: American Society of Anesthesiologists; CCI: Charlson Comorbidity Index; CIS: carcinoma in situ; CRP: C-reactive protein; CSM: cancer-specific mortality; CSS: cancer-specific survival; ECOG PS: Eastern Cooperative Oncology Group Performance Status; HDL: high-density lipoprotein; (S)HR: (subdistribution) hazard ratio; LND: lymphadenectomy; LVI: lymphovascular invasion; mGPS: modified Glasgow Prognostic Score; NLR: neutrophil-to-lymphocyte ratio; NOC: non-organ-confined; OM: overall mortality; OR: odds ratio; OS: overall survival; RC: radical cystectomy; RNU: radical nephroureterectomy; UBC: urothelial bladder cancer; UTUC: upper urinary tract urothelial carcinoma…”
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    Oncological impact of inflammatory biomarkers in elderly patients treated with radical cystectomy for urothelial bladder cancer
  9. 82549
    “…After adjustment for confounders, SLD was independently associated with mortality [HR3.347; 95% CI 1.401–7.999; p < 0.01]. CONCLUSION: One-third of critically ill patients with COVID-19 suffer from SLD, which is associated with high mortality. …”
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    Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
  10. 82550
    “…Average applicator-reported wind speeds were about 0.9 m •sec(− 1) (2 mi •hr(− 1)) lower than corresponding speeds from the nearest weather station values. …”
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    Examining the role of wind in human illness due to pesticide drift in Washington state, 2000–2015
  11. 82551
    “…The positive test result occurred a median of 19 hours (interquartile range, 0.8–34.0 hr) before acute kidney injury manifested by serum creatinine or urine output. …”
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    Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection
  12. 82552
    “…Our result suggested patients treated with RWD-cetuximab after RWD-CPI had worse OS compared to no prior RWD-CPI (HR 1.81, 95% CI 1.02–3.16). Our data suggest the combination of cetuximab and nivolumab is well tolerated. …”
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    Concurrent Cetuximab and Nivolumab as a Second-Line or beyond Treatment of Patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results of Phase I/II Study
  13. 82553
    “…The multivariable hazard ratio (HR) and 95% confidence interval (CI) on GDM/macrosomia group was [1.32 (1.02–1.72)]; the risk was more prominent among non-hypertensive women [1.41 (1.07–1.85); P for interaction: 0.046]. …”
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    Macrosomia is a risk factor for incident maternal chronic kidney disease
  14. 82554
    “…Although not statistically significant, this study found that patients with true progression had worse OS compared to those with PsP (Hazard Ratio [HR] 1.44, 95% CI 0.86–2.43, P = 0.178). This study also found that patients with high ALC (dichotomized by median) post-radiation had longer OS. …”
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    The predictive value of absolute lymphocyte counts on tumor progression and pseudoprogression in patients with glioblastoma
  15. 82555
    “…Furthermore, we examined the factors of time to first abortion after sexual debut using multivariable Cox regression and reported the estimates using adjusted Hazard Ratio (aHR) and 95% confidence intervals (CI). Statistical significance was determined at p < 0.05. …”
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    Prognostic factors of time to first abortion after sexual debut among fragile state Congolese women: a survival analysis
  16. 82556
    “…Those who lived 75 km or further from the district hospital, amongst children who were admitted and survived discharge from hospital, had a three times greater chance of dying within one year compared to those living within 25 km (adjusted HR 3.23, 95% CI 1.54,6.75). The probability of surviving the first 30 days post hospitalization was 94.4% [95% CI 94.4, 94.9], compared to 98.8% [95% CI 97.199.5] in non-hospitalized children of the same age in the commuity. …”
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    A cohort study of survival following discharge from hospital in rural Tanzanian children using linked data of admissions with community-based demographic surveillance
  17. 82557
    “…With POC testing, 72% of infants received results on the same day as sample collection; HIV‐positive infants with a same‐day diagnosis had six times the rate of ART initiation compared to those diagnosed one or more days after sample collection (HR: 6.39; 95% CI: 3.44 to 11.85). CONCLUSIONS: Same‐day diagnosis and treatment initiation for infants is possible with POC EID within routine government‐led and ‐supported public sector healthcare facilities in resource‐limited settings. …”
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    Point‐of‐care testing can achieve same‐day diagnosis for infants and rapid ART initiation: results from government programmes across six African countries
  18. 82558
    “…The NLR was determined to be a significant independent prognostic indicator by univariable and multivariable analyses (HR = 5.56, P < 0.05). Furthermore, TNM stage and the NLR were integrated, and the area under the curve (AUC) of for the NLR-TNM system was larger than that of for the TNM system when predicting overall survival (0.84 vs 0.73, P = 0.04). …”
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    Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in papillary renal cell carcinoma patients after receiving curative surgery based on a retrospective cohort
  19. 82559
    “…While pretransplant DST predicted the development of posttransplant BPAR (OR 5.18, 95% CI=1.64–16.34, p=0.005) and particularly T cell mediated rejection (OR 5.33, 95% CI=1.45–19.66, p=0.012), patients developing dnDST were at significantly higher risk of subsequent dnDSA formation (HR 2.64, 95% CI=1.08–6.45, p=0.03). In vitro experiments showed that unlike preformed DST that is predominantly primed by CD8+ direct pathway T cells, posttransplant DST may also be activated by the indirect pathway of alloantigen presentation, and predominantly driven by CD4+ alloreactive T cells in an important proportion of patients. …”
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    Donor/Recipient HLA Molecular Mismatch Scores Predict Primary Humoral and Cellular Alloimmunity in Kidney Transplantation
  20. 82560
    “…PURPOSE: Abemaciclib in combination with endocrine therapy (ET) has demonstrated significant efficacy benefits in HR+ , HER2− advanced breast cancer patients in the Phase 3 studies MONARCH 2 (fulvestrant as ET) and MONARCH 3 (letrozole or anastrozole as ET). …”
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    Safety and efficacy of abemaciclib plus endocrine therapy in older patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: an age-specific subgroup analysis of MONARCH 2 and 3 trials
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