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82601por Wang, Xiaohong, Liu, Yonggang, Meng, Zhiying, Wu, Yun, Wang, Shubin, Jin, Gaowa, Qin, Yingchun, Wang, Fengyun, Wang, Jing, Zhou, Haifei, Su, Xiaoxing, Fu, Xiuhua, Wang, Xiaolan, Shi, Xiaoyu, Wen, Zhenping, Jia, Xiaoqiong, Qin, Qiong, Gao, Yongqiang, Guo, Weidong, Lu, Shun“…Cox multivariate analysis demonstrated that plasma mutation abundance was an independent predictive factor for PFS [hazard ratio (HR) 2.41, 95% confidence interval (CI): 1.12–5.20; P=0.025]. …”
Publicado 2021
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82602por Arribalzaga, Karmele, Martínez-Alfonzo, Inés, Díaz-Aizpún, Carola, Gutiérrez-Jomarrón, Isabel, Rodríguez, Mario, Castro Quismondo, Nerea, Pérez-Fernández, Elia, Velasco-Rodríguez, Diego, Gómez, Elvira, Fernández, Begoña, Vilches, Alba, Martín-Herrero, Sara, Castilla, Lucía, Blanco, María Jesús, Gutiérrez, María del Mar, Rivas, Isabel, Pascual, Cristina, Rosado, Belén, Sola, Elena, Vidal-Laso, Rosa, Asenjo, Susana, Mora Casado, María Asunción, Benito-Parra, Laurentino, Carmona, Itziar, Marín, Karen, Acedo, Natalia, García-León, Natalia, Marcheco, Alexis, Guillén, Carolina, Fernández, Cristina, Rodríguez, Ramón, Pardo, Laura, Silva, Pablo, Montero, Laura, Meijón, Mar, Massó, Pilar, Llamas-Sillero, Pilar“…VTE was not associated with death (HR, 0.79; 95% CI, 0.55–1.12). CONCLUSIONS: Incidence of symptomatic VTE in our COVID-19 cohort is consistent with that of other real-life studies recently published. …”
Publicado 2021
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82603por Pirolli, Rafaela, de Alencar, Viviane Teixeira Loiola, Estati, Felipe Leonardo, Ribeiro, Adriana Regina Gonçalves, Honda, Daniella Yumi Tsuji, de Oliveira, Mariana, da Silveira Nogueira Lima, Joao Paulo, dos Santos, Elizabeth Santana, Guimarães, Andrea Paiva Gadelha, Baiocchi, Glauco, da Costa, Alexandre André Balieiro Anastácio“…In the multivariate cox regression ddCT showed a 18% lower risk of progression (HR 0.82, 95% CI 0.68–0.99, p = 0.04). Overall survival data is immature, but suggested better outcomes for ddCT (not reached versus 78.8 months; p = 0.07). …”
Publicado 2021
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82604por Libura, Marta, Bialopiotrowicz, Emilia, Giebel, Sebastian, Wierzbowska, Agnieszka, Roboz, Gail J., Piatkowska-Jakubas, Beata, Pawelczyk, Marta, Gorniak, Patryk, Borg, Katarzyna, Wojtas, Magdalena, Florek, Izabella, Matiakowska, Karolina, Jazwiec, Bozena, Solarska, Iwona, Noyszewska-Kania, Monika, Piechna, Karolina, Zawada, Magdalena, Czekalska, Sylwia, Salamanczuk, Zoriana, Karabin, Karolina, Wasilewska, Katarzyna, Paluszewska, Monika, Urbanowska, Elzbieta, Gajkowska-Kulik, Justyna, Semenczuk, Grazyna, Rybka, Justyna, Wrobel, Tomasz, Ejduk, Anna, Kata, Dariusz, Grosicki, Sebastian, Robak, Tadeusz, Pluta, Agnieszka, Kominek, Agata, Piwocka, Katarzyna, Pyziak, Karolina, Sroka-Porada, Agnieszka, Wrobel, Anna, Przybylowicz, Agnieszka, Wojtaszewska, Marzena, Lewandowski, Krzysztof, Gil, Lidia, Piekarska, Agnieszka, Knopinska, Wanda, Bolkun, Lukasz, Warzocha, Krzysztof, Kuliczkowski, Kazimierz, Sacha, Tomasz, Basak, Grzegorz, Jedrzejczak, Wieslaw Wiktor, Holowiecki, Jerzy, Juszczynski, Przemysław, Haus, Olga“…In multivariate analysis, DAC independently improved the survival of IDH2(+) patients (HR = 0.6 [0.37–0.93]; p = 0.024; censored at transplant), indicating that this group specifically benefits from cladribine-containing therapy. …”
Publicado 2021
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82605por Qian, Frank, Ardisson Korat, Andres V., Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K., Zhou, Xia, Bassett, Julie K., Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Pertiwi, Kamalita, de Mello, Vanessa D., Guan, Weihua, Forouhi, Nita G., Wareham, Nick, Hu, InterAct Consortium, Frank B., Riserus, Ulf, Lind, Lars, Harris, William S., Shadyab, Aladdin H., Robinson, Jennifer G., Steffen, Lyn M., Hodge, Allison, Giles, Graham G., Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindström, Jaana, Laakso, Markku, Siscovick, David S., Helmer, Catherine, Geleijnse, Johanna M., Wu, Jason H.Y., Fretts, Amanda, Lemaitre, Rozenn N., Micha, Renata, Mozaffarian, Dariush, Sun, Qi“…ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. …”
Publicado 2021
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82606por Martinato, Matteo, Lorenzoni, Giulia, Zanchi, Tommaso, Bergamin, Alessia, Buratin, Alessia, Azzolina, Danila, Gregori, Dario“…METHODS: Participants aged 70 to 90 years with the ability to walk safely without any walking aid for at least 300 meters, who had no walking disabilities or episodes of falling while walking in the last 12 months, were asked to walk 150 meters at their preferred pace wearing a vívoactive HR device (Garmin Ltd) and actual steps were monitored and tallied by a researcher using a hand-tally counter to assess the performance of the device at a natural speed. …”
Publicado 2021
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82607por Puig, Noemi, Hernández, Miguel T., Rosiñol, Laura, González, Esther, de Arriba, Felipe, Oriol, Albert, González-Calle, Verónica, Escalante, Fernando, de la Rubia, Javier, Gironella, Mercedes, Ríos, Rafael, García-Sánchez, Ricarda, Arguiñano, José M., Alegre, Adrián, Martín, Jesús, Gutiérrez, Norma. C., Calasanz, María J., Martín, María L., Couto, María del Carmen, Casanova, María, Arnao, Mario, Pérez-Persona, Ernesto, Garzón, Sebastián, González, Marta S., Martín-Sánchez, Guillermo, Ocio, Enrique M., Coleman, Morton, Encinas, Cristina, Vale, Ana M., Teruel, Ana I., Cortés-Rodríguez, María, Paiva, Bruno, Cedena, M. Teresa, San-Miguel, Jesús F., Lahuerta, Juan J., Bladé, Joan, Niesvizky, Ruben, Mateos, María-Victoria“…With a median follow-up of 19 months (range, 0–54), no significant differences in the median PFS were observed between the two arms (C-Rd 23 months, Rd 29 months; HR 0.783, p = 0.14), despite a higher rate of complete response (CR) or better in the C-Rd group (22.6% vs 14.4%, p = 0.048). …”
Publicado 2021
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82608por Berhanu, Bizuayehu, Oljira, Lemessa, Demana, Melake, Negash, Belay, Mamo Ayana, Galana, Beshir Raru, Temam, Haile, Dereje“…Late initiation of early breastfeeding (EBF) after 1 hr. [AHR: 2.9; 95% CI: 1.32, 6.37], 5th min APGAR score <5 [AHR: 3; 95% CI: 1.32; 6.88], low birth weight [AHR: 2.59; 95% CI: 1.1,6.26], hypothermia [AHR: 2.6; 95% CI: 1.1, 6.22] and mothers’ time of rupture of membrane >12 hours before delivery [AHR: 2.49; 95% CI: 1.25, 4.97] were increased the risk of neonatal mortality, while cesarean section delivery 91.6% [AHR= 0.084; 95% CI: 0.10, 0.65] and antenatal care (ANC) utilization 61% [AHR: 0.39; 95% CI: 0.15–0.91] decreased the risk of neonatal mortality. …”
Publicado 2021
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82609por Kirste, Simon, Kroeze, Stephanie G. C., Henkenberens, Christoph, Schmidt-Hegemann, Nina-Sophie, Vogel, Marco M. E., Becker, Jessica, Zamboglou, Constantinos, Burger, Irene, Derlin, Thorsten, Bartenstein, Peter, Ruf, Juri, la Fougère, Christian, Eiber, Matthias, Christiansen, Hans, Combs, Stephanie E., Müller, Arndt-Christian, Belka, Claus, Guckenberger, Matthias, Grosu, Anca-Ligia“…PDRT plus eRT was associated with a significantly improved 3-year bRFS compared to PDRT alone (53 vs. 37%; p = 0.001) and remained an independent factor in multivariate analysis (p = 0.006, HR 0.29, 95% CI 0.12–0.68). This effect was more pronounced in the subgroup of patients who were treated with PDRT and elective prostate bed radiotherapy (ePBRT) with a 3-year bRFS of 61% versus 22% (p <0.001). …”
Publicado 2021
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82610por Kourtidou-Papadeli, Chrysoula, Frantzidis, Christos A., Gilou, Sotiria, Plomariti, Christina E., Nday, Christiane M., Karnaras, Dimitrios, Bakas, Lefteris, Bamidis, Panagiotis D., Vernikos, Joan“…Hemodynamic parameters, as cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were analyzed, as well as blood gas analysis. …”
Publicado 2021
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82611por Zhang, Ting, Sun, Jing, Li, Jinying, Zhao, Yunuo, Zhang, Tao, Yang, Ruoning, Ma, Xuelei“…Considering variability in different studies, we selected the adverse events (AEs), overall survival (OS), progression-free survival (PFS), objective responses rate (ORR) and Hazard Ratio (HR) for PFS to evaluate the safety and efficacy profile of mogamulizumab. …”
Publicado 2021
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82612por Delaidelli, Alberto, Dunham, Christopher, Santi, Maria Rita, Negri, Gian Luca, Triscott, Joanna, Zheludkova, Olga, Golanov, Andrey, Ryzhova, Marina, Okonechnikov, Konstantin, Schrimpf, Daniel, Stichel, Damian, von Deimling, Andreas, Kool, Marcel, Pfister, Stefan, Ramaswamy, Vijay, Korshunov, Andrey, Taylor, Michael, Sorensen, Poul“…Finally, TPD52 immunopositivity is a predictive indicator of poor response to chemotherapy (HR 12.66 [95% CI 3.53–45.40], p < 0.0001), suggesting important implication for therapeutic choices. …”
Publicado 2021
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82613por Parker, Margaret M., Damrauer, Scott M., Tcheandjieu, Catherine, Erbe, David, Aldinc, Emre, Hawkins, Philip N., Gillmore, Julian D., Hull, Leland E., Lynch, Julie A., Joseph, Jacob, Ticau, Simina, Flynn-Carroll, Alexander O., Deaton, Aimee M., Ward, Lucas D., Assimes, Themistocles L., Tsao, Philip S., Chang, Kyong-Mi, Rader, Daniel J., Fitzgerald, Kevin, Vaishnaw, Akshay K., Hinkle, Gregory, Nioi, Paul“…The cumulative incidence of common hATTR amyloidosis manifestations (carpal tunnel syndrome, polyneuropathy, cardiomyopathy, heart failure) was significantly enriched in V122I carriers compared with non-carriers (HR = 2.8, 95% CI 1.7–4.5, p = 2.6 × 10(−5)) in the UK Biobank, with 37.4% of V122I carriers having at least one of these manifestations by age 75. …”
Publicado 2021
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82614“…Adjusted in multivariate Cox regression analysis of PFS, CT/TT genotypes were an independent factor for PFS [hazard ratio (HR) = 1.59, P = 0.011). Safety profile according to genotype status of V297 L failed to find significant difference. …”
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82615por Lomphithak, Thanpisit, Akara-amornthum, Perawatt, Murakami, Keigo, Hashimoto, Masatoshi, Usubuchi, Hajime, Iwabuchi, Erina, Unno, Michiaki, Cai, Zhenyu, Sasano, Hironobu, Jitkaew, Siriporn“…MLKL was found to be an unfavorable prognostic factor (p-value = 0.023, HR = 2.070) and was inversely correlated with a clinically favorable immune cell signature (high CD8+/high FOXp3+/low CD163+). …”
Publicado 2021
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82616por Rieser, Caroline J., Hoehn, Richard S., Zenati, Mazen, Hall, Lauren B., Kang, Eliza, Zureikat, Amer H., Lee, Andrew, Ongchin, Melanie, Holtzman, Matthew P., Pingpank, James F., Bartlett, David L., Choudry, M. Haroon A.“…This disparity persisted on multivariate survival analysis (low SES: HR = 1.46, p = 0.03). CONCLUSIONS: Despite improving therapies for CRPM, low-SES patients remain at a significant disadvantage. …”
Publicado 2021
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82617por Roosan, Moom R., Mambetsariev, Isa, Pharaon, Rebecca, Fricke, Jeremy, Baroz, Angel R., Chao, Joseph, Chen, Chen, Nasser, Mohd W., Chirravuri-Venkata, Ramakanth, Jain, Maneesh, Smith, Lynette, Yost, Susan E., Reckamp, Karen L., Pillai, Raju, Arvanitis, Leonidas, Afkhami, Michelle, Wang, Edward W., Chung, Vincent, Cristea, Mihaela, Fakih, Marwan, Koczywas, Marianna, Massarelli, Erminia, Mortimer, Joanne, Yuan, Yuan, Batra, Surinder K., Pal, Sumanta, Salgia, Ravi“…However, patients with CDKN2A mutations showed significantly shorter OS (HR: 1.72, 95% CI: 1.34–2.21, p < 0.001) after adjusting for cancer type, age at diagnosis, and sex. …”
Publicado 2021
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82618por Esteban, Emilio, Exposito, Francisco, Crespo, Guillermo, Lambea, Julio, Pinto, Alvaro, Puente, Javier, Arranz, Jose A., Redrado, Miriam, Rodriguez-Antona, Cristina, de Andrea, Carlos, Lopez-Brea, Marta, Redin, Esther, Rodriguez, Angel, Serrano, Diego, Garcia, Jorge, Grande, Enrique, Castellano, Daniel, Calvo, Alfonso“…We also developed a prognostic index that considers this group of biomarkers, where high values in mRCC patients can predict higher risk of relapse (HR 5.28 [2.32–12.0], p < 0.0001). In conclusion, high plasma HGF, CXCL11, CXCL10 and IL-6 levels are associated with worse outcome in mRCC patients treated with sunitinib or pazopanib. …”
Publicado 2021
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82619por Bosire, Claire, Vidal, Adriana C., Smith, Jennifer S., Jima, Dereje, Huang, Zhiqing, Skaar, David, Valea, Fidel, Bentley, Rex, Gradison, Margaret, Yarnall, Kimberly S. H., Ford, Anne, Overcash, Francine, Murphy, Susan K., Hoyo, Cathrine“…Restricting the outcome to CIN2+ cases that were HR-HPV positive and p16 staining positive, we found a significant association with PEG3 DMR methylation (OR: 1.56 95% CI: 1.03–2.36). …”
Publicado 2021
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82620“…The results of meta-analysis showed that: the overall response rate [OR = 2.07, 95% CI (1.41, 3.06), P = 0.0002], the progression free survival [HR = 0.34, 95% CI (0.21, 0.55), P <0.0001], the partial response [OR = 1.71, 95% CI (1.19, 2.46), P = 0.003], P = 0.001], in alectinib group were higher than that of crizotinib group. …”
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