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  1. 82601
    “…Cox multivariate analysis demonstrated that plasma mutation abundance was an independent predictive factor for PFS [hazard ratio (HR) 2.41, 95% confidence interval (CI): 1.12–5.20; P=0.025]. …”
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    Online Artículo Texto
    Plasma EGFR mutation abundance affects clinical response to first-line EGFR-TKIs in patients with advanced non-small cell lung cancer
  2. 82602
    “…VTE was not associated with death (HR, 0.79; 95% CI, 0.55–1.12). CONCLUSIONS: Incidence of symptomatic VTE in our COVID-19 cohort is consistent with that of other real-life studies recently published. …”
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    Online Artículo Texto
    Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region
  3. 82603
    “…In the multivariate cox regression ddCT showed a 18% lower risk of progression (HR 0.82, 95% CI 0.68–0.99, p = 0.04). Overall survival data is immature, but suggested better outcomes for ddCT (not reached versus 78.8 months; p = 0.07). …”
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    Comparison of dose-dense vs. 3-weekly paclitaxel and carboplatin in the first-line treatment of ovarian cancer in a propensity score-matched cohort
  4. 82604
    por Libura, Marta, Bialopiotrowicz, Emilia, Giebel, Sebastian, Wierzbowska, Agnieszka, Roboz, Gail J., Piatkowska-Jakubas, Beata, Pawelczyk, Marta, Gorniak, Patryk, Borg, Katarzyna, Wojtas, Magdalena, Florek, Izabella, Matiakowska, Karolina, Jazwiec, Bozena, Solarska, Iwona, Noyszewska-Kania, Monika, Piechna, Karolina, Zawada, Magdalena, Czekalska, Sylwia, Salamanczuk, Zoriana, Karabin, Karolina, Wasilewska, Katarzyna, Paluszewska, Monika, Urbanowska, Elzbieta, Gajkowska-Kulik, Justyna, Semenczuk, Grazyna, Rybka, Justyna, Wrobel, Tomasz, Ejduk, Anna, Kata, Dariusz, Grosicki, Sebastian, Robak, Tadeusz, Pluta, Agnieszka, Kominek, Agata, Piwocka, Katarzyna, Pyziak, Karolina, Sroka-Porada, Agnieszka, Wrobel, Anna, Przybylowicz, Agnieszka, Wojtaszewska, Marzena, Lewandowski, Krzysztof, Gil, Lidia, Piekarska, Agnieszka, Knopinska, Wanda, Bolkun, Lukasz, Warzocha, Krzysztof, Kuliczkowski, Kazimierz, Sacha, Tomasz, Basak, Grzegorz, Jedrzejczak, Wieslaw Wiktor, Holowiecki, Jerzy, Juszczynski, Przemysław, Haus, Olga
    Publicado 2021
    “…In multivariate analysis, DAC independently improved the survival of IDH2(+) patients (HR = 0.6 [0.37–0.93]; p = 0.024; censored at transplant), indicating that this group specifically benefits from cladribine-containing therapy. …”
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    Online Artículo Texto
    IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen
  5. 82605
    “…ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. …”
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    Online Artículo Texto
    n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
  6. 82606
    “…METHODS: Participants aged 70 to 90 years with the ability to walk safely without any walking aid for at least 300 meters, who had no walking disabilities or episodes of falling while walking in the last 12 months, were asked to walk 150 meters at their preferred pace wearing a vívoactive HR device (Garmin Ltd) and actual steps were monitored and tallied by a researcher using a hand-tally counter to assess the performance of the device at a natural speed. …”
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    Online Artículo Texto
    Usability and Accuracy of a Smartwatch for the Assessment of Physical Activity in the Elderly Population: Observational Study
  7. 82607
    “…With a median follow-up of 19 months (range, 0–54), no significant differences in the median PFS were observed between the two arms (C-Rd 23 months, Rd 29 months; HR 0.783, p = 0.14), despite a higher rate of complete response (CR) or better in the C-Rd group (22.6% vs 14.4%, p = 0.048). …”
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    Online Artículo Texto
    Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial
  8. 82608
    “…Late initiation of early breastfeeding (EBF) after 1 hr. [AHR: 2.9; 95% CI: 1.32, 6.37], 5th min APGAR score <5 [AHR: 3; 95% CI: 1.32; 6.88], low birth weight [AHR: 2.59; 95% CI: 1.1,6.26], hypothermia [AHR: 2.6; 95% CI: 1.1, 6.22] and mothers’ time of rupture of membrane >12 hours before delivery [AHR: 2.49; 95% CI: 1.25, 4.97] were increased the risk of neonatal mortality, while cesarean section delivery 91.6% [AHR= 0.084; 95% CI: 0.10, 0.65] and antenatal care (ANC) utilization 61% [AHR: 0.39; 95% CI: 0.15–0.91] decreased the risk of neonatal mortality. …”
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    Online Artículo Texto
    Survival and Predictors of Mortality Among Neonates Admitted to Neonatal Intensive Care Unit at Bombe Primary Hospital, Southern Ethiopia: Institution-Based Retrospective Cohort Study
  9. 82609
    “…PDRT plus eRT was associated with a significantly improved 3-year bRFS compared to PDRT alone (53 vs. 37%; p = 0.001) and remained an independent factor in multivariate analysis (p = 0.006, HR 0.29, 95% CI 0.12–0.68). This effect was more pronounced in the subgroup of patients who were treated with PDRT and elective prostate bed radiotherapy (ePBRT) with a 3-year bRFS of 61% versus 22% (p <0.001). …”
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    Online Artículo Texto
    Combining (68)Ga-PSMA-PET/CT-Directed and Elective Radiation Therapy Improves Outcome in Oligorecurrent Prostate Cancer: A Retrospective Multicenter Study
  10. 82610
    “…Hemodynamic parameters, as cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were analyzed, as well as blood gas analysis. …”
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    Online Artículo Texto
    Gravity Threshold and Dose Response Relationships: Health Benefits Using a Short Arm Human Centrifuge
  11. 82611
    “…Considering variability in different studies, we selected the adverse events (AEs), overall survival (OS), progression-free survival (PFS), objective responses rate (ORR) and Hazard Ratio (HR) for PFS to evaluate the safety and efficacy profile of mogamulizumab. …”
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    Online Artículo Texto
    Safety and efficacy profile of mogamulizumab (Poteligeo) in the treatment of cancers: an update evidence from 14 studies
  12. 82612
    “…Finally, TPD52 immunopositivity is a predictive indicator of poor response to chemotherapy (HR 12.66 [95% CI 3.53–45.40], p < 0.0001), suggesting important implication for therapeutic choices. …”
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    Online Artículo Texto
    EMBR-21. CLINICALLY TRACTABLE OUTCOME PREDICTION OF GROUP 3/4 MEDULLOBLASTOMA BASED ON TPD52 IMMUNOHISTOCHEMISTRY: A MULTICOHORT STUDY
  13. 82613
    “…The cumulative incidence of common hATTR amyloidosis manifestations (carpal tunnel syndrome, polyneuropathy, cardiomyopathy, heart failure) was significantly enriched in V122I carriers compared with non-carriers (HR = 2.8, 95% CI 1.7–4.5, p = 2.6 × 10(−5)) in the UK Biobank, with 37.4% of V122I carriers having at least one of these manifestations by age 75. …”
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    Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry
  14. 82614
    “…Adjusted in multivariate Cox regression analysis of PFS, CT/TT genotypes were an independent factor for PFS [hazard ratio (HR) = 1.59, P = 0.011). Safety profile according to genotype status of V297 L failed to find significant difference. …”
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    The Influence of KDR Genetic Variation on the Efficacy and Safety of Patients With Advanced NSCLC Receiving First-Line Bevacizumab Plus Chemotherapy Regimen
  15. 82615
    “…MLKL was found to be an unfavorable prognostic factor (p-value = 0.023, HR = 2.070) and was inversely correlated with a clinically favorable immune cell signature (high CD8+/high FOXp3+/low CD163+). …”
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    Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma
  16. 82616
    “…This disparity persisted on multivariate survival analysis (low SES: HR = 1.46, p = 0.03). CONCLUSIONS: Despite improving therapies for CRPM, low-SES patients remain at a significant disadvantage. …”
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    Impact of Socioeconomic Status on Presentation and Outcomes in Colorectal Peritoneal Metastases Following Cytoreduction and Chemoperfusion: Persistent Inequalities in Outcomes at a High-Volume Center
  17. 82617
    “…However, patients with CDKN2A mutations showed significantly shorter OS (HR: 1.72, 95% CI: 1.34–2.21, p < 0.001) after adjusting for cancer type, age at diagnosis, and sex. …”
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    Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients
  18. 82618
    “…We also developed a prognostic index that considers this group of biomarkers, where high values in mRCC patients can predict higher risk of relapse (HR 5.28 [2.32–12.0], p < 0.0001). In conclusion, high plasma HGF, CXCL11, CXCL10 and IL-6 levels are associated with worse outcome in mRCC patients treated with sunitinib or pazopanib. …”
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    Circulating Levels of the Interferon-γ-Regulated Chemokines CXCL10/CXCL11, IL-6 and HGF Predict Outcome in Metastatic Renal Cell Carcinoma Patients Treated with Antiangiogenic Therapy
  19. 82619
    “…Restricting the outcome to CIN2+ cases that were HR-HPV positive and p16 staining positive, we found a significant association with PEG3 DMR methylation (OR: 1.56 95% CI: 1.03–2.36). …”
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    Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia
  20. 82620
    “…The results of meta-analysis showed that: the overall response rate [OR = 2.07, 95% CI (1.41, 3.06), P = 0.0002], the progression free survival [HR = 0.34, 95% CI (0.21, 0.55), P <0.0001], the partial response [OR = 1.71, 95% CI (1.19, 2.46), P = 0.003], P = 0.001], in alectinib group were higher than that of crizotinib group. …”
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    Comparison of Clinical Efficacy of Alectinib Versus Crizotinib in ALK-Positive Non-Small Cell Lung Cancer: A Meta-Analysis
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