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82801por Picariello, Stefania, Walters, Brownen, Bowman, Richard, Slater, Olga, Jorgensen, Mette, Dahl, Christine, O'Hare, Patricia, Spoudeas, Helen A, Gan, Hong-Wei, Aquilina, Kristian, Chang, Yen Ch'in, D'Arco, Felice, Hargrave, Darren, Opocher, Enrico“…Infants < 1 year had significantly inferior 10-yrPFS (5.6%), post-chiasmatic involvement was associated with visual deterioration (HR 2.91, 95%CI=1.1- 7.7), and baseline bilateral abnormal for age vision predicted WHO blindness at follow-up (OR 17.9, 95%CI=3.2 – 101.1). …”
Publicado 2022
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82802por Zhang, Mengjun, Liu, Yuan, Yin, Yue, Sun, Zhenxing, Wang, Yan, Zhang, Zexue, Li, Fei, Chen, Xiuwei“…Kaplan–Meier survival analysis and Immunohistochemistry indicated that overexpression of UBE2S was related to poor prognosis of OV (HR > 1, P < 0.05). Results of in vitro experiments indicated that UBE2S gene knockdown might inhibit the proliferation, invasion, and prognosis of OV cells by inhibiting the PI3K/AKT/mTOR signaling pathway, thereby blocking the cell cycle and promoting apoptosis (P < 0.05). …”
Publicado 2022
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82803por Pu, Hongjiang, Pang, Xiaolin, Fu, Jiangping, Zheng, Rui, Chen, Yaxue, Zhang, Dafu, Fang, Xiangdong“…Multivariate analysis confirmed that patients with 4 or more tumor deposits + the number of lymph node metastases (hazard ratio [HR], 1.88; 95% CI, 1.24–2.87) were independently associated with a shorter RFS. …”
Publicado 2022
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82804por Sundar, Raghav, Huang, Kie-Kyon, Kumar, Vikrant, Ramnarayanan, Kalpana, Demircioglu, Deniz, Her, Zhisheng, Ong, Xuewen, Bin Adam Isa, Zul Fazreen, Xing, Manjie, Tan, Angie Lay-Keng, Tai, David Wai Meng, Choo, Su Pin, Zhai, Weiwei, Lim, Jia Qi, Das Thakur, Meghna, Molinero, Luciana, Cha, Edward, Fasso, Marcella, Niger, Monica, Pietrantonio, Filippo, Lee, Jeeyun, Jeyasekharan, Anand D, Qamra, Aditi, Patnala, Radhika, Fabritius, Arne, De Simone, Mark, Yeong, Joe, Ng, Cedric Chuan Young, Rha, Sun Young, Narita, Yukiya, Muro, Kei, Guo, Yu Amanda, Skanderup, Anders Jacobsen, So, Jimmy Bok Yan, Yong, Wei Peng, Chen, Qingfeng, Göke, Jonathan, Tan, Patrick“…APB(high) gastric cancer exhibited significantly poorer progression-free survival compared with APB(low) (median 55 days vs 121 days, HR 0.40, 95% CI 0.18 to 0.93, p=0.032). CONCLUSION: These findings demonstrate an association between alternate promoter use and the tumour microenvironment, leading to immune evasion and immunotherapy resistance.…”
Publicado 2022
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82805por Rochefort, Gabrielle, Brassard, Didier, Robitaille, Julie, Provencher, Véronique, Lemieux, Simone, Lamarche, Benoît“…Dietary intakes were evaluated using a validated web-based 24hr dietary recall (R24W) repeated on three unannounced occasions. …”
Publicado 2022
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82806por Patel, Lekha, Wei, Lulu, Gidon, Ariel, Martinez-Machado, Sasha, Bae, Edward, Lee, Judy, Markell, Mariana“…METHODS: A random sample of 34 dialysis pts was interviewed regarding knowledge about dietary guidelines and 24-hr food recall was recorded and analyzed using ASA-24. …”
Publicado 2022
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82807por Jang, Hajin, Kim, Rockli, Lee, Dong Hoon, Lee, Jong-Tae, Giovannucci, Edward, Oh, Hannah“…Compared with normal-weight adults (BMI 18.5–22.9), the lowest risk of all-cause and cardiovascular mortality was observed among overweight adults (BMI 23.0–24.9: HR [95% CI] = 0.89 [0.83–0.96]; 0.94 [0.79–1.13]; respectively), while for cancer mortality among grade I obesity (BMI 25.0–29.9: 0.91 [0.83–1.01]). …”
Publicado 2022
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82808por Fornacon-Wood, Isabella, Chan, Clara, Bayman, Neil, Banfill, Kathryn, Coote, Joanna, Garbett, Alex, Harris, Margaret, Hudson, Andrew, Kennedy, Jason, Pemberton, Laura, Salem, Ahmed, Sheikh, Hamid, Whitehurst, Philip, Woolf, David, Price, Gareth, Faivre-Finn, Corinne“…Patients treated with curative-intent during period C had a survival improvement compared to time period A when adjusting for clinical variables (HR=0.725 (0.632-0.831), p<0.001). CONCLUSION: IMRT was associated with to more patients receiving curative-intent radiotherapy. …”
Publicado 2022
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82809por Gauthier, Marie-Pier, Law, Jennifer H., Le, Lisa W., Li, Janice J.N., Zahir, Sajda, Nirmalakumar, Sharon, Sung, Mike, Pettengell, Christopher, Aviv, Steven, Chu, Ryan, Sacher, Adrian, Liu, Geoffrey, Bradbury, Penelope, Shepherd, Frances A., Leighl, Natasha B.“…RESULTS: Automated extraction required considerably less time (<1 day) than manual extraction (∼225 person-hr). The collection of demographic data (age, sex, diagnosis) was highly accurate and concordant with both methods (96%–100%). …”
Publicado 2022
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82810por Moll, Matthew, Hobbs, Brian D., Menon, Aravind, Ghosh, Auyon J., Putman, Rachel K., Hino, Takuya, Hata, Akinori, Silverman, Edwin K., Quackenbush, John, Castaldi, Peter J., Hersh, Craig P., McGeachie, Michael J., Sin, Don D., Tal-Singer, Ruth, Nishino, Mizuki, Hatabu, Hiroto, Hunninghake, Gary M., Cho, Michael H.“…However, an ILA score derived from IPF score genes was associated with ILA (meta-analysis of test datasets OR 1.4 [95% CI: 1.2–1.6]) and mortality (HR 1.25 [95% CI: 1.12–1.41]). Six of the 11 genes in the ILA score had discordant directions of effects compared to the IPF score. …”
Publicado 2022
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82811por Honda, Yuki, Wakabayashi, Kohei, Sato, Chisato, Ikeda, Naoko, Sato, Ken, Suzuki, Toshiaki, Shibata, Keita, Shinke, Toshiro“…Urinary albumin (mg/gCr) was associated with MACCE in the SMI subgroup [HR 3.37, 95%CI (1.170–9.521), P = 0.025] after adjusting for age, sex, and conventional risk factors. …”
Publicado 2022
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82812por Chen, Yuanyuan, Xu, Mingyue, Ye, Qianwen, Xiang, Jia, Xue, Tianhui, Yang, Tao, Liu, Long, Yan, Bing“…DpC was an independent risk factor for prognosis (HR = 2.54, 95% CI: 1.32–4.88, P = 0.01). CONCLUSIONS: IDacT had a profound effect on the outcome for stage II-III CRC. …”
Publicado 2022
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82813por Riess, Christin, del Moral, Katharina, Fiebig, Adina, Kaps, Philipp, Linke, Charlotte, Hinz, Burkhard, Rupprecht, Anne, Frank, Marcus, Fiedler, Tomas, Koczan, Dirk, Troschke-Meurer, Sascha, Lode, Holger N., Engel, Nadja, Freitag, Thomas, Classen, Carl Friedrich, Maletzki, Claudia“…SEQ-abemaciclib/SpyADI treatment suppressed the DSB repair system via NHEJ and HR, whereas SEQ-dinaciclib/SpyADI treatment increased γ-H2AX accumulation and induced Rad51/Ku80. …”
Publicado 2022
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82814por Husni, M Elaine, Chang, Eunice, Broder, Michael S, Paydar, Caleb, Bognar, Katalin, Desai, Pooja, Klyachkin, Yuri, Khilfeh, Ibrahim“…Additionally, APR users had a lower risk of biologic initiation than MTX users (HR, 0.46 [95% CI, 0.37–0.57]; P < 0.001) during the 1-year follow-up. …”
Publicado 2022
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82815por Freudenberger, Devon C., Deng, Xiaoyan, Vudatha, Vignesh, Riner, Andrea N., Herremans, Kelly M., Bandyopadhyay, Dipankar, Fernandez, Leopoldo J., Trevino, Jose G.“…The occurrence of a major complication was the only factor associated with overall survival (HR 2.188 [1.502, 3.188], p< 0.0001). CONCLUSIONS: Despite differences in patient socioeconomic factors and comorbid conditions, outcomes were similar between Black and White patients receiving CRS and HIPEC at our institution. …”
Publicado 2022
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82816por Yu, Danxia, Yang, Jae Jeong, Keohane, Laura, Shu, Xiao-Ou, Lipworth, Loren, Braun, Kyle, Dai, Qi, Steinwandel, Mark, Shrubsole, Martha, Zheng, Wei, Blot, William“…Healthy lifestyles were individually associated with 11%–25% reduced risk of ADRD: multivariable-adjusted HR (95% CI) was 0.87 (0.76–0.99) for never vs. current smoking, 0.81 (0.72–0.92) for low-to-moderate vs. no alcohol consumption, 0.89 (0.77–1.03) for ≥150 minutes of moderate or ≥75 minutes of vigorous LTPA per week vs. none, 0.75 (0.64–0.87) for 7–9 hours vs. >9 hours of sleep, and 0.85 (0.75–0.96) for the highest vs. lowest tertiles of Healthy Eating Index. …”
Publicado 2022
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82817“…RESULTS: Combined AI and video messaging (treatment group II) led to a lower dropout rate from the program compared to the control group, and the Cox proportional-hazards model estimate showed a hazard ratio (HR) of 0.078, which was statistically significant at the 5% level. …”
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82818
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82819por Ooki, Akira, Morita, Satoshi, Tsuji, Akihito, Iwamoto, Shigeyoshi, Hara, Hiroki, Tanioka, Hiroaki, Satake, Hironaga, Kataoka, Masato, Kotaka, Masahito, Kagawa, Yoshinori, Nakamura, Masato, Shingai, Tatsushi, Ishikawa, Masashi, Miyake, Yasuhiro, Suto, Takeshi, Hashiguchi, Yojiro, Yabuno, Taichi, Ando, Masahiko, Sakamoto, Junichi, Yamaguchi, Kensei“…RESULTS: ETS was achieved in 82 (64.1%) of 128 mCRC patients treated with first-line cetuximab plus chemotherapy, and these patients had a significantly longer OS than those without ETS (HR, 0.38; 95% CI, 0.20–0.72; P = .002). Asymptomatic patients with ETS had a favorable OS, while symptomatic patients without ETS had a worse OS (2-year OS rates, 77.8% vs. 42.5%). …”
Publicado 2022
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82820por Salem, Mohamed, Rizk, Awad, Mosbah, Esam, Zaghloul, Adel, Karrouf, Gamal, Abass, Marwa“…Prior to and during surgery, the following parameters were recorded in a regular pre-set time interval: onset time of analgesia (OT), duration of flaccid paralysis (DFP), duration of analgesia (DA), onset and duration of sensory blockade, onset and duration of motor blockade, heart rate (HR), respiratory rate (RR), and rectal temperature (RT). …”
Publicado 2022
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