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82961por Khoshnoudi-Rad, Bayyeneh, Hosseinpour-Niazi, Somayeh, Javadi, Maryam, Mirmiran, Parvin, Azizi, Fereidoun“…In the crude model, DIL and DII were associated with a higher risk of weight gain [HR: 1.74: 95% CI 1.50–2.03, and 1.70 (1.46–1.98), respectively]. …”
Publicado 2022
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82962por Smeijer, J. David, Koomen, Jeroen V., Kohan, Donald E., McMurray, John J. V., Bakris, George L., Correa‐Rotter, Ricardo, Hou, Fan‐Fan, Kitzman, Dalane W., Makino, Hirofumi, Mayer, Gert, Nowicki, Michal, Perkovic, Vlado, Rossing, Peter, Tobe, Sheldon, Parving, Hans‐Henrik, de Zeeuw, Dick, Heerspink, Hiddo J. L.“…Among patients with a normal OATP1B1 phenotype, the hazard ratio (HR) with atrasentan for the primary kidney and HHF outcomes were 0.61 (95% confidence interval (CI): 0.45–0.81) and 1.35 (95% CI: 0.84–2.13), respectively. …”
Publicado 2022
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82963por Cunillera-Puértolas, Oriol, Vizcaya, David, Cerain-Herrero, M. Jesús, Gil-Terrón, Neus, Cobo-Guerrero, Silvia, Salvador-González, Betlem“…In the multivariate analysis, with the CKD without HTN/T2D group as reference, the ACM Hazard Ratio (HR) was 0.74 (95%CI 0.72–0.75) for the CKD with HTN group, 0.81 (95%CI 0.79–0.83) for CKD with HTN/T2D and 1.14 (95%CI 1.10–1.19) for the CKD with T2D group. …”
Publicado 2022
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82964por Kemeny, M. Margaret, Zhao, Fengmin, Forastiere, Arlene A., Catalano, Paul, Hamilton, Stanley R., Miedema, Brent W., Dawson, Nancy A., Weiner, Louis M., Smith, Brian D., Mason, Bernard A., Graziano, Stephen L., Gilman, Paul B., Venook, Alan P., Pinto, Harlan A., Whitehead, Robert P., O’Dwyer, Peter J., Benson, Al B.“…Among patients with Dukes’ B3 and C disease, there was no statistically significant difference in OS [median 10.3 years (95% CI 8.4, 13.2) for perioperative chemotherapy and 9.3 years (95% CI 5.7, 12.3) for no perioperative therapy, one-sided log-rank p = 0.178, HR = 0.88 (95% CI 0.66, 1.16)] or disease-free survival (DFS). …”
Publicado 2022
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82965por Hayashi, Hiroya, Kataoka, Yu, Murai, Kota, Sawada, Kenichiro, Iwai, Takamasa, Matama, Hideo, Honda, Satoshi, Fujino, Masashi, Yoneda, Shuichi, Takagi, Kensuke, Otsuka, Fumiyuki, Asaumi, Yasuhide, Izumiya, Yasuhiro, Fukuda, Daiju, Noguchi, Teruo“…Furthermore, after adjusting clinical characteristics, inactive cancer was an independent predictor for bleeding events (HR: 3.98, 95% CI: 1.90–8.34, P<0.001). Of particular interests, even after switching to single antithrombotic therapy, an elevated bleeding risk was still observed in inactive cancer subjects (P<0.001). …”
Publicado 2022
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82966por Erviti, Juan, Wright, James, Bassett, Ken, Ben-Eltriki, Mohamed, Jauca, Ciprian, Saiz, Luis Carlos, Leache, Leire, Gutiérrez-Valencia, Marta, Perry, Thomas L“…While cardiac and vascular deaths were not assessed as separate outcomes in the original trial analysis, after readjudication, we noted that cardiac deaths were numerically, but non-significantly, higher in the evolocumab group (113) than in the placebo group (88; relative risk (RR) 1.28, 95% CI 0.97 to 1.69, p=0.078), whereas non-cardiac vascular deaths were similar between groups (37 in each; RR 1.00, 95% CI 0.63 to 1.58, p=0.999). The reported HR for cardiovascular mortality in the original trial analysis was 1.05 (95% CI 0.88 to 1.25); after readjudication, we found a greater (although still non-significant) relative increase in cardiovascular mortality in the evolocumab treatment group (RR 1.20, 95% CI 0.95 to 1.51, p=0.13). …”
Publicado 2022
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82967por Marra, Giancarlo, Soria, Francesco, Peretti, Federica, Oderda, Marco, Dariane, Charles, Timsit, Marc-Olivier, Branchereau, Julien, Hedli, Oussama, Mesnard, Benoit, Tilki, Derya, Olsburgh, Jonathon, Kulkarni, Meghana, Kasivisvanathan, Veeru, Lebacle, Cedric, Rodriguez-Faba, Oscar, Breda, Alberto, Soeterik, Timo, Gandaglia, Giorgio, Todeschini, Paola, Biancone, Luigi, Gontero, Paolo“…On univariable analysis, no major influence of immunosuppression type was noted, with the exception of a protective effect of antiproliferative agents (HR 0.39, 95% CI 0.16–0.97, p = 0.04) associated with a decreased risk of biochemical recurrence (BCR) or progression after AS. …”
Publicado 2022
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82968por Feunaing, Romeo Toko, Tamfu, Alfred Ngenge, Gbaweng, Abel Joel Yaya, Mekontso Magnibou, Larissa, Ntchapda, Fidele, Henoumont, Celine, Laurent, Sophie, Talla, Emmanuel, Dinica, Rodica Mihaela“…Herein, extract from roots of the medicinal plant Pterocarpus erinaceus was purified by column chromatography and afforded ten compounds which were characterized by EIMS, HR-FAB-MS, 1D and 2D NMR techniques. Amongst them were, a new trimeric derivative of epicatechin, named 2,3-Epoxyprocyanidin C1 (1); two pentacyclic triterpenoids, friedelin (2) and betulin (3); angolensin (4); flavonoids such as 7-methoxygenistein (5), 7-methoxydaidzein (6), apigenin 7-O-glucoronide (8) and naringenin 7-O-β-D-glucopyranoside (9); and an ellagic acid derivative (10). …”
Publicado 2022
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82969por Vranken, Lisanne, de Bruin, Irma J.A., Driessen, Annemariek H.M., Geusens, Piet P.M., Eisman, John A., Center, Jacqueline R., van der Velde, Robert Y., Janzing, Heinrich M.J., Kaarsemaker, Sjoerd, van den Bergh, Joop P., Wyers, Caroline E.“…In patients with a major/hip index fracture, mortality risk was lower post‐FLS (hazard ratio [HR] 0.84; 95% confidence interval [CI], 0.73–0.96) and subsequent major/hip fracture risk was lower in the first 360 days after index fracture post‐FLS compared to pre‐FLS (SHR 0.67; 95% CI, 0.52–0.87). …”
Publicado 2022
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82970por Deng, Heran, Wang, Liying, Wang, Na, Zhang, Kejin, Zhao, Yanxia, Qiu, Pengfei, Qi, Xiaowei, Zhang, Danhua, Xu, Fei, Liu, Jieqiong“…The DFS of patients with pCR2 and non-pCR2 after neoadjuvant therapy was significantly different (HR = 0.28, 95% CI 0.10–0.79; P = 0.038). The most common AEs were nausea (63.4%), fatigue (42.7%), leucopenia (30.0%) and elevated transaminase (11.7%). …”
Publicado 2023
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82971“…The median PFS in combination group was significantly longer than chemotherapy group [10.03 vs. 6.24 months, hazard ratio (HR) 0.603, 95% confidence interval (CI): 0.368–0.989, P=0.045]. …”
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82972por Kairaitis, Kristina, Amis, Terence C., Perri, Rita, Lee, Sharon, Drury, Anne, Lambeth, Christopher, Mitchell, Paul, Lindley, Richard I., Wheatley, John R.“…Mean evening CRAE and CRVE values did not change across the intervention (n = 66), but evening CRVE decreased ~6.0 μm for individuals with AHI >30 events/hr. CONCLUSION: No major SDB associations with CRAE or CRVE were identified, although the RFM/CPAP intervention reduced evening CRVE for severe OSA patients. …”
Publicado 2023
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82973por Wang, Ruiling, Li, Jiale, Chen, Huimin, Xiao, Zezhou, Xu, Rongning, Hu, Yu, Chen, Sikai, Wang, Xiaowu, Zheng, Shaoyi“…While in the multivariate regression model, we found ACAG was act as an independent risk factor for both the in-hospital mortality [odds ratio (OR): 1.248 (1.060, 1.470), P=0.008] and the 4-year mortality [hazard ratio (HR): 1.134 (1.063, 1.210), P<0.001]. An ACAG ≥16.0 mmol/L was significantly associated with a 2.7-fold risk of in-hospital mortality [OR: 2.732 (1.129, 6.610), P=0.026]. …”
Publicado 2022
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82974por Makarious Laham, Majd, Easo, Jerry, Szczechowicz, Marcin, Roosta-Azad, Mehdy, Weymann, Alexander, Ruhparwar, Arjang, Kamler, Markus“…There was a significant interaction between early mortality risk of MV in patients with coronary artery disease (CAD) (OR 11.94, 95% CI 1.49–285.92, p = 0.04) and late mortality in patients with higher EuroSCORE II (HR 1.14, 95% CI 1.06–1.23, p < 0.001). The primary end-point showed 5-year survival rate was significantly higher in MVRe versus MVRp (90.06% vs. 79.54% respectively, p = 0.04). …”
Publicado 2023
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82975por Hasegawa, Shinichiro, Takahashi, Hidenori, Akita, Hirofumi, Mukai, Yosuke, Mikamori, Manabu, Asukai, Kei, Yamada, Daisaku, Wada, Hiroshi, Fujii, Yoshiaki, Sugase, Takahito, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Haraguchi, Naotsugu, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Ishikawa, Osamu, Sakon, Masato“…RESULTS: Univariate analysis identified normalisation of DUPAN-II levels after CRT as a significant prognostic factor (hazard ratio [HR] = 2.06, confidence interval [CI] = 1.03–4.24, p = 0.042). …”
Publicado 2023
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82976por Cassidy, Tali, Cornell, Morna, Makeleni, Bubele, Horsburgh, C. Robert, Duran, Laura Trivino, de Azevedo, Virginia, Boulle, Andrew, Fox, Matthew P.“…In the matched analysis (1451 person-years, 1568 patients) patients initiating ART at male clinics had lower attrition (HR 0.71; 95% CI 0.60–0.85). In separate analyses for each of the two male clinics, only the more established male clinic showed a protective effect. …”
Publicado 2022
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82977por Hoshino, Masahiro, van de Hoef, Tim P., Lee, Joo Myung, Hamaya, Rikuta, Kanaji, Yoshihisa, Boerhout, Coen K. M., de Waard, Guus A., Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A., Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H., Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Sasano, Tetsuo, Appelman, Yolande, Beijk, Marcel, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Piek, Jan J., Kakuta, Tsunekazu“…The risk of 2-year TVF was significantly higher in women with low versus high resting Pd/Pa (HR: 9.79; p < 0.001), whereas this trend was not seen in men. …”
Publicado 2023
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82978por Gadrey, Shrirang M., Mohanty, Piyus, Haughey, Sean P., Jacobsen, Beck A., Dubester, Kira J., Webb, Katherine M., Kowalski, Rebecca L., Dreicer, Jessica J., Andris, Robert T., Clark, Matthew T., Moore, Christopher C., Holder, Andre, Kamaleswaran, Rishi, Ratcliffe, Sarah J., Moorman, J. Randall“…MAIN OUTCOMES AND MEASURES: We measured primary outcomes (death or ICU transfer within 24 hr), ePFR, conventional hypoxemia measures, baseline predictors (age, sex, race, comorbidity), and acute predictors (National Early Warning Score [NEWS] and Sequential Organ Failure Assessment [SOFA]). …”
Publicado 2023
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82979por Ye, Jianfeng, Zhang, Luming, Lyu, Jun, Wang, Yidan, Yuan, Shiqi, Qin, Zhifeng, Liu, Yu, Huang, Tao, Tian, Jinwei, Yin, Haiyan“…After adjusting for potential confounding variables using multivariable Cox proportional hazards regression, the risk of all-cause in-hospital mortality was significantly higher in the cancer than the noncancer group, and the HR (95% CI) values for the cancer group were 1.56(1.22,1.98) and 1.35(1.01,1.79) in the MIMIC-IV database and the eICU-CRD, respectively. …”
Publicado 2023
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82980por Hessels, Niek R., Zhu, Yinjie, Bakker, Stephan J. L., de Borst, Martin H., Navis, Gerjan J., Riphagen, Ineke J.“…We found an increased risk for mortality in both the highest quartile (Q4, >4.7 g/day; hazard ratio (HR) 1.74 (95% confidence interval (CI) 1.03–2.95)) and the lowest two quartiles of sodium intake (Q1, 0.7–2.8 g/day; 2.05 (1.16–3.62); p = 0.01 and Q2, 2.8–3.6 g/day; 1.85 (1.08–3.20); p = 0.03), compared with the third quartile of sodium intake (Q3, 3.6–4.7 g/day). …”
Publicado 2023
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