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83121por Taher Mohie el-dien, Radwa, Mahmoud, Basma Khalaf, Abdelwahab, Miada F., Khedr, Amgad I. M., Kamel, Mohamed Salah, Yahia, Ramadan, Mohamed, Nada M., Zawily, Amr El, Kamel, Eman S., Salem, Aliasger K, Abdelmohsen, Usama Ramadan, Fouad, Mostafa A.“…Metabolomics profiling of the different extracts using LC-HR-ESI-MS, besides molecular docking studies for the dereplicated compounds were performed to unveil the chemical profile and the cytotoxic mechanism of the soft coral associated fungi. …”
Publicado 2023
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83122por den Brok, Melina G. H. E., van Dalen, Jan Willem, Marcum, Zachary A., Busschers, Wim B., van Middelaar, Tessa, Hilkens, Nina, Klijn, Catharina J. M., Moll van Charante, Eric P., van Gool, Willem A., Crane, Paul K., Larson, Eric B., Richard, Edo“…At age 90 years, BPV was associated with 35% higher dementia risk (hazard ratio [HR], 1.35; 95% CI, 1.02-1.79). Meta-regression of HRs calculated separately for each age (60-90 years) indicated that associations of high BPV with higher dementia risk were present only at older ages, whereas the association of SBP with dementia gradually shifted direction linearly from being incrementally to inversely associated with older ages. …”
Publicado 2023
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83123por He, Xinyue, Shao, Wei, Yu, Senhai, Yu, Jiazhou, Huang, Changzhen, Ren, Haiqing, Liu, Chengguo, Xu, Yuying, Zhu, Yimin“…Compared with participants with a poor HLS, those with 4–5 low-risk lifestyle factors showed a 60% reduction in the risk of developing T2DM (adjusted HR, 0.40; 95% CI: 0.28–0.57). Further, the population-attributable risk percent (95% CI) of T2DM for poor adherence to the overall healthy lifestyle (< 4 low-risk factors) was 43.24% (30.02%, 56.46%). …”
Publicado 2023
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83124por Roussel-Simonin, Cyril, Blanc-Durand, Felix, Tang, Roseline, Vasseur, Damien, Le Formal, Audrey, Chardin, Laure, Yaniz, Elisa, Gouy, Sébastien, Maulard, Amandine, Scherier, Stéphanie, Sanson, Claire, Lacroix, Ludovic, Cotteret, Sophie, Mauny, Lea, Zaccarini, François, Rouleau, Etienne, Leary, Alexandra“…METHODS: We collected ascites/peritoneal washings from 53 EOC patients (19 from retrospective cohort and 34 from prospective cohort) and performed a Cancer Gene Panel (CGP) using NGS for TP53/HR genes and shallow Whole Genome Sequencing (sWGS) for genomic instability on cfDNA. …”
Publicado 2023
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83125“…A fully adjusted Cox model showed that TyG index was closely associated with the incidence of CMM: the hazard ratio (HR) [95% confidence interval (CI)] for each 1.0-unit increment in TyG index for CMM was 1.54 (1.29–1.84); and the HRs (95% CIs) for Q3 and Q4 (Q1 as reference) of the TyG index for CMM were 1.41 (1.05–1.90) and 1.61 (1.18–2.20), respectively. …”
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83126por Wadström, Benjamin N., Pedersen, Kasper M., Wulff, Anders B., Nordestgaard, Børge G.“…Multivariable adjusted HR (95% CI) per doubling of remnant cholesterol was 1.6 (1.1, 2.3; p=0.01) for peripheral artery disease, 1.8 (1.2, 2.5; p=0.002) for myocardial infarction, 1.5 (1.0, 2.1; p=0.04) for ischaemic stroke, and 1.6 (1.2, 2.0; p=0.0003) for any ASCVD. …”
Publicado 2023
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83127“…SCIENTIFIC CONTRIBUTION: Developed, implemented and tested new metrics for assessing plausibility of candidate molecular formulae obtained from HR-MS data. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13321-023-00776-y.…”
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83128“…The objective of this study was to analyze the cost-utility of Palbociclib and Ribociclib in comparison with Letrozole monotherapy as the first-line treatment for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2–) MBC patients in Iran. …”
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83129por Dou, Jiahao, Guo, Chen, Wang, Yawen, Peng, Zihe, Wu, Ruiyun, Li, Qiangqiang, Zhao, Hong, Song, Shoufang, Sun, Xuelu, Wei, Jin“…In comparison to the lowest TyG-BMI group, the fully adjusted Cox model yielded a hazard ratio (HR) of 0.24 (95% CI: 0.10, 0.59; p = 0.002) for 360-day mortality. …”
Publicado 2023
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83130por Nagel, Gabriele, Kurz, Deborah, Peter, Raphael S., Rosenbohm, Angela, Koenig, Wolfgang, Dupuis, Luc, Bäzner, Hansjörg, Börtlein, Axel, Dempewolf, Silke, Schabet, Martin, Hecht, Martin, Kohler, Andreas, Opherk, Christian, Naegele, Andrea, Sommer, Norbert, Lindner, Alfred, Tumani, Hayrettin, Ludolph, Albert C., Rothenbacher, Dietrich“…In this cohort of ALS cases, eGFR and CKD stage ≥ 3 (HR 0.94; 95% CI 0.64, 1.38) were not associated with prognosis. …”
Publicado 2023
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83131por Feng, Zeying, Zhao, Qiuping, Wu, Jingjing, Yang, Yiping, Jia, Xinru, Ma, Junlong, Tang, Haibo, Yuan, Hong, Yang, Guoping, Lu, Yao“…Among the 105,763 participants included in the cohort analysis using data from the UK Biobank, individuals who used NBBs had a significantly increased risk of PD compared to nonusers (HR, 1.47; 95% CI 1.04–2.06). The MR analysis revealed a significant association between higher expression of the β2 adrenergic receptor (ADRB2) gene, a drug target blocked by NBBs, and a reduced risk of PD (OR, 0.85; 95% CI 0.73–0.99). …”
Publicado 2023
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83132“…Recombinant human GALNS (elosulfase alfa), 2.0 mg/kg/week, was planned to administer IV in 4 hr. [Figure: see text] CONCLUSION: Because of the progressive nature of MPS- IVA, early diagnosis and early initiation of enzyme replacement therapy are critical to prevent cumulative systemic manifestations of the patient, especially the skeletal system.…”
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83133por Nors, Jesper, Iversen, Lene Hjerrild, Erichsen, Rune, Gotschalck, Kåre Andersson, Andersen, Claus Lindbjerg“…Cancers detected through screening were associated with lower stage-adjusted risks of recurrence (sHR, 0.81; 95% CI, 0.73-0.91) compared with cancers not detected through screening. …”
Publicado 2023
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83134por Xu, Man, Wang, Wenqiang, Chen, Ruoling, Zhou, Li, Hu, Hui, Qiao, Guiyuan, Wang, Ling, Liu, Xuezhen, Wang, Qiuhong, Ai, Yating, Ren, Hairong, Hu, Ping“…There appeared to be a combined effect of ePWV and SIRI on stroke; Participants with high levels of both ePWV and SIRI had a higher risk of total stroke and hemorrhagic stroke, with multiple adjusted HR of 2.43 (95% CI, 1.09–5.42). Additionally, the incorporation of ePWV in addition to traditional cardiovascular risk factors significantly improved the predictive accuracy for total stroke with C statistic increased from 0.684 (95% CI, 0.661–0.707) to 0.687 (95% CI, 0.664–0.710; x(2 )= 6.65; p for difference = 0.010), and (suggestively) for ischemic stroke with C statistic increased from 0.684 (95% CI, 0.659–0.71) to 0.691(95% CI, 0.666–0.717; x(2 )= 3.13, p for difference = 0.077), respectively. …”
Publicado 2023
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83135“…GRAPHICAL ABSTRACT: CI confidence interval, EF ejection fraction, eGFR estimated glomerular filtration rate, HF heart failure, HHF hospitalization for HF, HR hazard ratio, LVEF left ventricular ejection fraction, SGLT2i sodium-glucose cotransporter-2 inhibitor, UACR urine albumin-creatinine ratio. a Mean value, unless otherwise stated, b SGLT2i vs. placebo, c Data reanalyzed using more conventional endpoints (≥ 50% sustained decrease in eGFR, and including renal death) (UACR at baseline not stated in trial reports) [Image: see text]…”
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83136por Kagimu, Enock, Bangdiwala, Ananta, Kasibante, John, Kabahubya, Mable, Gakuru, Jane, Timothy, Mugabi, Namombwe, Suzan, Kimuda, Sarah, Kasozi, Derrick, Rutakingirwa, Morris K, Ssebambulidde, Kenneth, Tugume, Lillian, Nuwagira, Edwin, Okurut, Samuel, Nsangi, Laura, Atukunda, Mucunguzi, Ellis, Jayne P, Williams, Darlisha A, Musubire, Abdu Kisekka, Boulware, David R, Meya, David, Bahr, Nathan C, Cresswell, Fiona V“…However, on adjustment for Glasgow Coma Scale (GCS), CSF OP, glucose, and CD4 count the association was less significant (aHR, 2.93, 0.82-10.4, P=0.13). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: 14-day mortality varied significantly by baseline CSF WBC group, being extremely high (73.6%) in those with a paucity of CSF inflammation (WBC < 5 cells/µl). …”
Publicado 2023
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83137por Isha, Shahin, Jonna, Sadhana, Raavi, Lekhya, Jenkins, Anna, Hanson, Abby J, Satashia, Parthkumar, Yarrarapu, Siva Naga S, Govero, Austin, Harrison, Michael F, Baig, Hassan Z, Caples, Sean M, Grek, Ami A, Vizzini, Michael R, Khan, Syed A, Heise, Katherine, Sekiguchi, Hiroshi, Cantrell, Warren, Smith, Jeffrey D, Gnanapandithan, Karthik, Thompson, Kristine M, Graham, Charles G, Cowdell, Jed C, Murawska Baptista, Aleksandra, Shapiro, Anna B, Bhattacharyya, Anirban, Chaudhary, Sanjay, Kiley, Sean, Guru, Pramod K, Libertin, Claudia, Moreno Franco, Pablo, Sanghavi, Devang K“…A multivariate model revealed NLR as an independent predictor of mortality (HR 1.003, 95% CI: 1.000-1.006, p=0.029) after adjusting for comorbidities, baseline clinical and laboratory variables. …”
Publicado 2023
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83138por Estrada-Mendizabal, Ricardo J, Tamez-Rivera, Oscar, Vela, Emelina Hinojosa, Murillo, Paulina Blanco, Alanis-Garza, Cordelia, Flores-Gouyonnet, Jaime, Garza, Jessica Suhail Sauceda, Medina, Gloria Yolanda Carranza, Vidales, Edgar Paolo Rodriguez, Rodriguez, Lilia Elida Garcia, Escamilla, Alma Rosa Marroquin“…Treatment with doxycycline (p=0.05) and a TTI of ≤ 24 hr (p=0.01) were associated with survival. [Figure: see text] [Figure: see text] Figure 3. …”
Publicado 2023
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83139por Hall, Frances C, Cheriyan, Joseph, Cope, Andrew P, Galloway, James, Wilkinson, Ian, Bond, Simon, Norton, Sam, Banham-Hall, Edward, Bayes, Hannah, Kostapanos, Michalis, Nodale, Marianna, Petchey, William G, Sheeran, Thomas, Underwood, Jonathan, Jayne, David R“…The estimated hazard ratio (HR) for reaching the composite primary endpoint was 1·11 (95% CI 0·62–1·99) for patients on baricitinib compared with standard of care alone, and 1·53 (0·88–2·67) for ravulizumab compared with standard of care alone. 45 serious adverse events (21 deaths) were reported in the standard-of-care group, 57 (24 deaths) in the baricitinib group, and 60 (18 deaths) in the ravulizumab group. …”
Publicado 2023
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83140“…Cox regression with survival‐time‐dependent covariate calculated the hazard ratio (HR) of bipolar HA was 0.41 in medium‐term (p = 0.039). …”
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