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83181por Brantsæter, Anne Lise, Englund-Ögge, Linda, Haugen, Margareta, Birgisdottir, Bryndis Eva, Knutsen, Helle Katrine, Sengpiel, Verena, Myhre, Ronny, Alexander, Jan, Nilsen, Roy M., Jacobsson, Bo, Meltzer, Helle Margrete“…We used Cox regression to estimate hazard ratios (HR) with 95% confidence intervals (CI) for associations between total seafood, lean fish, fatty fish, and LCn-3PUFA intakes and preterm delivery. …”
Publicado 2017
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83182por Shao, Chihao, Dai, Wenzhu, Li, Haili, Tang, Wenru, Jia, Shuting, Wu, Xiaoming, Luo, Ying“…We found that RASSF1A gene promoter methylation and melanoma prognosis did not demonstrate any relationship (HR was 0.94 (95% CI = [0.69; 1.27], P = 0.694) with disease-free survival and 0.74 (95% CI = [0.53; 1.05], P = 0.106) for overall survival), and no significant difference was observed between RASSF1A gene promoter methylation and the clinical-pathological features of melanoma. …”
Publicado 2017
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83183por Parra, Federico, Miljkovitch, Raphaële, Persiaux, Gwenaelle, Morales, Michelle, Scherer, Stefan“…They were then exposed to three different BAT stimuli sets, whereas their faces, voices, heart rate (HR), and electrodermal activity (EDA) were recorded. …”
Publicado 2017
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83184“…Multivariate Cox proportional hazards analysis also showed that all of high PD-L1 expression, high HPV-L1 methylation, and multiple HPV infection status should increase the risk of HPV unclearance in premalignant cervical lesion patients; the hazard ratio (HR) was 2.043 (CI: 1.050–3.973), 2.797 (CI: 1.277–6.122), and 3.050 (CI: 1.406–6.615). …”
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83185por Stefansson, Olafur Andri, Hermanowicz, Stefan, van der Horst, Jasper, Hilmarsdottir, Holmfridur, Staszczak, Zuzanna, Jonasson, Jon Gunnlaugur, Tryggvadottir, Laufey, Gudjonsson, Thorkell, Sigurdsson, Stefan“…In this analysis, ALKBH3 promoter methylation at >20% CpG methylation was found to be statistically significantly associated with reduced survival (HR = 2.3; P = 0.012). By thresholding at the clinically relevant CpG methylation level (>20%), we find the incidence of ALKBH3 promoter methylation to be 5% (13 out of 265). …”
Publicado 2017
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83186por Backes, Yara, Elias, Sjoerd G., Bhoelan, Bibie S., Groen, John N., van Bergeijk, Jeroen, Seerden, Tom C. J., Pullens, Hendrikus J. M., Spanier, Bernhard W. M., Geesing, Joost M. J., Kessels, Koen, Kerkhof, Marjon, Siersema, Peter D., Cappel, Wouter H. de Vos tot Nederveen, van Lelyveld, Niels, Wolfhagen, Frank H. J., ter Borg, Frank, Offerhaus, G. Johan A., Lacle, Miangela M., Moons, Leon M. G.“…LN yield ≥ 10 was independently associated with a decreased risk for recurrence (IPW-adjusted HR 0.20; 95% CI 0.06–0.67; P = 0.009). LNM were detected in 84 patients (8.3%). …”
Publicado 2017
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83187por Lisgarten, David R., Palmer, Rex A., Lobley, Carina M. C., Naylor, Claire E., Chowdhry, Babur Z., Al-Kurdi, Zakieh I., Badwan, Adnan A., Howlin, Brendan J., Gibbons, Nicholas C. J., Saldanha, José W., Lisgarten, John N., Basak, Ajit K.“…The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16,000 keV (λ = 0.77 Å). …”
Publicado 2017
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83188“…[Figure 1] After adjusting for the covariates, the TI group had a higher risk for aseptic revision than the TT group (HR=1.4. 95% CI=1.1-1.7). CONCLUSION: In the largest known study of its type examining femoral tunnel drilling method for primary ACLR, after adjusting for age, sex, BMI, race and graft type, TI techniques were found to have a 1.4 times higher risk of revision than the TT method. …”
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83189por Xu, Benjamin, Kong, Xiangyi, Xu, Richard, Song, Yun, Liu, Lishun, Zhou, Ziyi, Gu, Rui, Shi, Xiuli, Zhao, Min, Huang, Xiao, He, Mingli, Fu, Jia, Cai, Yefeng, Li, Ping, Cheng, Xiaoshu, Wu, Changyan, Chen, Fang, Zhang, Yan, Tang, Genfu, Qin, Xianhui, Wang, Binyan, Xue, Hao, Chen, Yundai, Tian, Ye, Sun, Ningling, Cui, Yimin, Hou, Fan Fan, Li, Jianping, Huo, Yong“…A linear trend test, using natural log-transformed tHcy, resulted in an HR of 1.5 (95% confidence interval 1.2–1.9, P < .001) after adjustment for lifestyle and health-related variables. …”
Publicado 2017
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83190por De Carvalho, Flávia G., Galan, Bryan S. M., Santos, Priscila C., Pritchett, Kelly, Pfrimer, Karina, Ferriolli, Eduardo, Papoti, Marcelo, Marchini, Júlio S., de Freitas, Ellen C.“…A maximal incremental running test on a treadmill was performed in order to evaluate aerobic parameters: V(max), heart rate (HR) and rate of perceived exertion (RPE). Results: TAUchoc treatment during the 8 weeks resulted in increased taurine plasma levels (PRE 201.32 ± 29.03 μmol/L and POST 234.36 ± 35.51 μmol/L, p = 0.01), decreased malondialdehyde levels (19.4%, p = 0.03) and urinary nitrogen excretion (−33%, p = 0.03), and promoted positive nitrogen balance (p = 0.01). …”
Publicado 2017
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83191por Kostas, Athanasios, Siakavellas, Spyros I, Kosmidis, Charalambos, Takou, Anna, Nikou, Joanna, Maropoulos, Georgios, Vlachogiannakos, John, Papatheodoridis, George V, Papaconstantinou, Ioannis, Bamias, Giorgos“…The significant predictive value of baseline median with IQR FC for clinical relapse was confirmed by multivariate Cox analysis [HR for 100μg/g: 1.75 (95%CI: 1.28-2.39), P = 0.001]. …”
Publicado 2017
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83192por Black, Rachel J., Lester, Susan, Buchbinder, Rachelle, Barrett, Claire, Lassere, Marissa, March, Lyn, Whittle, Samuel, Hill, Catherine L.“…Use of biologic disease-modifying anti-rheumatic drugs (bDMARDs) was not associated with GC current use (0.98; 0.83–1.15) or GC cessation (HR 0.87; 95% CI 0.75–1.01), but it was associated with GC commencement (0.54; 0.47–0.62). …”
Publicado 2017
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83193por Mahanty, Siddhartha, Orrego, Miguel A., Cangalaya, Carla, Adrianzen, M. Paz, Arroyo, Gianfranco, Calcina, Juan, Gonzalez, Armando E., García, Héctor H., Guerra-Giraldez, Cristina, Nash, Theodore E.“…As measured by quantitative RT-PCR, ETN pretreatment depressed transcription of a wide range of proinflammatory, regulatory and matrix protease encoding genes at 120 hr post PZQ treatment in capsules of cysts that demonstrated extravasated Evans Blue (EB) (a measure of blood brain barrier dysfunction) compared to animals not receiving ETN. …”
Publicado 2017
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83194por Mytton, Oliver T., Forouhi, Nita G., Scarborough, Peter, Lentjes, Marleen, Luben, Robert, Rayner, Mike, Khaw, Kay Tee, Wareham, Nicholas J., Monsivais, Pablo“…After adjustment for covariates (sociodemographic, behavioural, and indices of cardiovascular risk), we found no association between consumption of less-healthy food and incident CVD (p = 0.84) or cardiovascular mortality (p = 0.90), but there was an association between consumption of less-healthy food and all-cause mortality (test for linear trend, p = 0.006; quintile group 5, highest consumption of less-healthy food, versus quintile group 1, HR = 1.11, 95% CI 1.02–1.20). Sensitivity analyses produced similar results. …”
Publicado 2018
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83195“…Renal cellular apoptosis was greater in the IH group as shown by an increased cortical Bax/Bcl-2 protein ratio (p< 0.01) and higher fluorometric TUNEL staining (p< 0.001). Finally, 24-hr urinary albumin levels were higher in mice exposed to IH (43.4 μg vs 9.7 μg, p< 0.01), while there were no differences in serum creatinine levels between the two groups. …”
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83196“…In a multivariate analysis, high TMB (>5.56) was an independent predictive factor for decreased DFS (adjusted hazard ratio [HR], 5.594; 95% CI: 1.694–18.473; P = 0.005). CONCLUSION: The preliminary results suggest that the level of TMB value in patients with breast cancer can be predicted based on the expression levels of ER, PR, HER-2, and Ki-67, which may indicate the prognostic and predictive value of immunotherapy in patients with breast cancer.…”
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83197por Lacey, Ben, Lewington, Sarah, Clarke, Robert, Kong, Xiang Ling, Chen, Yiping, Guo, Yu, Yang, Ling, Bennett, Derrick, Bragg, Fiona, Bian, Zheng, Wang, Shaojie, Zhang, Hua, Chen, Junshi, Walters, Robin G, Collins, Rory, Peto, Richard, Li, Liming, Chen, Zhengming“…At ages 40–79 years (mean age at event 64 years [SD 9]), usual systolic blood pressure was continuously and positively associated with incident major vascular disease throughout the range 120–180 mm Hg: each 10 mm Hg higher usual systolic blood pressure was associated with an approximately 30% higher risk of ischaemic heart disease (HR 1·31 [95% CI 1·28–1·34]) and ischaemic stroke (1·30 [1·29–1·31]), but the association with intracerebral haemorrhage was about twice as steep (1·68 [1·65–1·71]). …”
Publicado 2018
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83198por Yeong, Joe, Lim, Jeffrey Chun Tatt, Lee, Bernett, Li, Huihua, Chia, Noel, Ong, Clara Chong Hui, Lye, Weng Kit, Putti, Thomas Choudary, Dent, Rebecca, Lim, Elaine, Thike, Aye Aye, Tan, Puay Hoon, Iqbal, Jabed“…Multivariate analysis revealed that patients bearing TNBCs with above-median densities of CD38(+) plasma cells had significantly better disease-free survival (DFS) (HR = 0.44; 95% CI 0.26–0.77; p = 0.004) but not overall survival (OS), after adjusting for the effects of known prognostic factors. …”
Publicado 2018
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83199por Inamoto, Teruo, Uehara, Hirofumi, Akao, Yukihiro, Ibuki, Naokazu, Komura, Kazumasa, Takahara, Kiyoshi, Takai, Tomoaki, Uchimoto, Taizo, Saito, Kenkichi, Tanda, Naoki, Yoshikawa, Yuki, Minami, Koichiro, Hirano, Hajime, Nomi, Hayahito, Kato, Ryuji, Hayashi, Tetsuya, Azuma, Haruhito“…Patients with the high-risk miRNA signature exhibited poorer OS than patients expressing the low-risk miRNA profile (HR = 7.05, p < 0.001). CONCLUSIONS: The miRNA array identified nine dysregulated miRNAs from clinical samples. …”
Publicado 2018
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83200por Ding, Xiaosheng, Li, Li, Tang, CHuanhao, Meng, Chao, Xu, Weiran, Wei, Xing, Guo, Ziwei, Zhang, Tingting, Fu, Yali, Zhang, Lingling, Wang, Xiangyi, Lin, Li, Liang, Jun“…Subsequent to adjusting for sex, smoking status and EGFR mutation status, the Cox repression analysis indicated that cytoplasmic expression of ERβ was a negative independent predictor for mPFS in the whole patient cohort (HR=1.870; 95% confidence interval 1.058–3.305; P=0.031). …”
Publicado 2018
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