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83361“…This was followed with 1 and 8 mg dexamethasone suppression tests that she failed with cortisol levels of 37.8 and 41.6 mcg/dL respectively, late-night salivary cortisol of 0.974 ug/dL (n <0.181), and extremely elevated 24-hr urinary cortisol of 3,700.2 ug/d (n<45). Of the steroid hormone precursors, 11 deoxycortisol was elevated at 725 ng/dL (n<32) and DHEA-S was 29mcg/dL (n 35-430). …”
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83362por Warde, Kate, Lim, Yi-Jan, Beuschlein, Felix, Hantel, Constanze, Dennedy, Michael Conall“…Methodology: ATCC-H295R (mitotane sensitive) and MUC-1 (mitotane resistant) ACC cells were evaluated for neutral lipid content using BODIPY493/503 under baseline and cholesterol loaded conditions using Amnis ImageStream, additionally cells were treated with mitotane (H295R - 20, 40, 50µM; MUC1 - 50, 100, 200µM) for 6hr. Analysis of LDs using CE-BODIPY and FA-BODIPY identified cholesterol ester (CE) and triacylglycerol (TAG)-containing LDs, respectively. …”
Publicado 2021
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83363“…Aldosterone <0.1(0.0–30 ng/dL), renin 0.195 (0.167–5.38 ng/mL/hr). Urine metabolic screen, urine amino acid screen, plasma amino acid screen and white cell lysosomal enzymes were normal for the nephew and not performed in our patient. …”
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83364“…Background: Phosphoinositide 3-kinase inhibitors (PI3Ki) are a new class of medications used to treat HR positive, HER2 negative, PIK3CA mutated advanced or metastatic breast cancer. …”
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83365“…Adrenal incidentaloma workup revealed a normal 24-hour urine cortisol level of 29 mcg, abnormal mid-night salivary cortisol of 0.13 mcg/dL and 0.31 mcg/dL, elevated cortisol after 1 mg dexamethasone suppression test (DST) of 343 mcg/dL, elevated cortisol after 8 mg DST of 90 mcg/dL, normal metanephrines of 10 pg/mL and normal normetanephrine of 49 pg/mL, normal aldosterone of 6.1 ng/dL, normal renin activity of 0.36 ng/ml/hr (Aldo/ PRA ratio 16). ACTH was 4.5 pg/ml. The endocrine surgeon was consulted for left adrenalectomy. …”
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83366por Prasad, Apurwa, Ali, Faisal S, Thapa, Pratikshya, Tuason, John P W, Kim, Keun Young“…Introduction: Alpelisib (PIQRAY) is a Phosphatidylinositol 3-Kinase Inhibitor (PIP-3K) recently approved by the united states food and drug administration (FDA) for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-mutated, advanced, or metastatic breast cancer in post-menopausal women or men with an adjuvant to Fulvestrant. …”
Publicado 2021
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83367“…PAC was 36.3 ng/dL and PRA was 0.19 ng/ml/hr (ARR 191), suggestive of hyperaldosteronism. …”
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83368por Moyers, Julie S, Hansen, Ryan J, Day, Jonathan W, Dickinson, Craig D, Zhang, Chen, Kahl, Steven D, Ruan, Xiaoping, Ding, Liyun, Brown, Robin M, Baker, Hana E, Beals, John M“…In STZ-treated rats, BIF reached a T(max) at 48 hours, possessed an apparent clearance rate of ~0.85 mL/hr/kg, and t(1/2) of ~120 hrs. Collectively, these results demonstrate that BIF possesses selective IR agonism with a pharmacological profile similar to native insulin, however with a significantly reduced potency, and a significantly extended time action profile in preclinical animal models supporting once weekly testing in the clinic.…”
Publicado 2021
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83369“…On August 24, the patient was tachycardic (HR 120–140 bpm) associated with headache and fever (38 °C). …”
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83370“…Repeat 1 mg overnight dexamethasone suppression test: AM cortisol was 36.5 ug/dl (4-22 ug/dl), Dexamethasone 249.2 ng/dl (140-295 expected post 1 mg DXA the night before). 24 hr urine free cortisol was 391.4 (<=45.0 ug/d). …”
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83371por Höhn, Andreas, Jeyam, Anita, Caparrotta, Thomas M., McGurnaghan, Stuart J., O’Reilly, Joseph E., Blackbourn, Luke A. K., McCrimmon, Rory J., Leese, Graham P., McKnight, John A., Kennon, Brian, Lindsay, Robert S., Sattar, Naveed, Wild, Sarah H., McKeigue, Paul M., Colhoun, Helen M.“…Controlling for age, sex, area-based socioeconomic deprivation and health status, each additional drug at baseline was associated with an increase in the hazard for hospitalisation for falls, hypoglycaemia and death but not for DKA admissions (HR [95% CI]: falls 1.03 [1.01, 1.06]; DKA 1.01 [1.00, 1.03]; hypoglycaemia 1.05 [1.02, 1.07]; death 1.04 [1.02, 1.06]). …”
Publicado 2021
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83372por Nestsiarovich, Anastasiya, Kumar, Praveen, Lauve, Nicolas Raymond, Hurwitz, Nathaniel G, Mazurie, Aurélien J, Cannon, Daniel C, Zhu, Yiliang, Nelson, Stuart James, Crisanti, Annette S, Kerner, Berit, Tohen, Mauricio, Perkins, Douglas J, Lambert, Christophe Gerard“…Psychotherapy alone (without medication) had a lower self-harm risk than no treatment (HR 0.56, 95% CI 0.52-0.60; P=8.76×10(-58)). The sensitivity analysis showed that the direction of drug-outcome associations did not change as a function of the self-harm probability threshold. …”
Publicado 2021
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83373por Wang, Bo, Chen, Shiqun, Liu, Jin, Liang, Yan, Meng, Liangguang, Yan, Xiaoming, Huang, Haozhang, Chen, Guanzhong, Huang, Zhidong, Xu, Danyuan, Li, Min, Liang, Jingjing, Liu, Shuangxin, Chen, Jiyan, Liu, Yong, Tan, Ning“…After adjusting for full 24 confounders (e.g., age, diabetes, heart failure, and dialysis, etc.), multivariate Cox regression analysis revealed that lower LDL-C level (< 1.8 mmol/L) was significantly associated with higher risk of all-cause death (adjusted HR, 1.38; 95% CI, 1.01–1.89). CONCLUSIONS: Our data demonstrated that among patients with CAD and AKD, a lower baseline LDL-C level (< 1.8 mmol/L) did not present a higher survival rate but was related to a worse prognosis, suggesting a cautiousness of too low LDL-C levels among patients with CAD and AKD. …”
Publicado 2021
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83374“…However, the completeness of cytoreduction score (HR, 2.99; 95% CI, 1.14–7.84; P = 0.026), rather than NAC, was independently associated with overall survival (OS) in the multivariate analysis after controlling for confounding factors. …”
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83375por Clemmensen, Silas Zacharias, Kragholm, Kristian H., Melgaard, Dorte, Hansen, Lene T., Riis, Johannes, Cavallius, Christian, Mørch, Marianne M., Krogager, Maria Lukács“…There was a significantly lower mortality among the patients who received IV Monofer compared to those who received no treatment (HR 0.17, 95% CI [0.03–0.93], P = 0.041). Among the 86 patients with available hemoglobin measurements within 14 to 30 days post-surgery, there was no significant difference in hemoglobin level between the various treatment groups (mean 6.6 mmol/L, P = 0.1165). …”
Publicado 2021
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83376por Bottiroli, Maurizio, Calini, Angelo, Pinciroli, Riccardo, Mueller, Ariel, Siragusa, Antonio, Anelli, Carlo, Urman, Richard D., Nozari, Ala, Berra, Lorenzo, Mondino, Michele, Fumagalli, Roberto“…Allocation to AM group was associated with a significantly increased risk of death after adjusting for covariates (HR 4.05, 95% CI: 1.75–9.33, p = 0.001). Several incidents and complications were reported with Anesthesia Machine care, raising safety concerns. …”
Publicado 2021
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83377“…Further workup confirmed acute respiratory distress syndrome with pneumonia; severe acute kidney injury (AKI, creatinine of 4.56 mg/dL); presumed myocarditis (ST elevation on EKG, troponin 4.47 ng/mL, BNP 129.8 pg/mL); punctuate intraparenchymal hemorrhage in the splenium of the corpus callosum; transaminitis (AST 188 u/L, ALT 100 u/L); pancreatitis (amylase 651 u/L, lipase >9500 u/L); thrombocytopenia with consumptive coagulopathy (platelet 81 X 10(3)/µL, d-dimer 5.91 mcg FEU/mL), increased inflammatory markers (ESR 53 mm/hr, ferritin 127 ng/mL), and positive SARS-CoV-2 serology. …”
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83378por Wurcel, Victoria, Scherrer, Emilie, Aguiar-Ibanez, Raquel, Altuna, Juan Ignacio, Carabajal, Fernando, Jain, Shrishti, Baluni, Gargi“…INTRODUCTION: The KEYNOTE-054 trial demonstrated that adjuvant pembrolizumab improves recurrence-free survival in completely resected stage III melanoma versus watchful waiting (hazard ratio [HR] = 0.57; 98.4% confidence interval [CI], 0.43–0.74). …”
Publicado 2021
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83379por Mureed, Shumaila, Naz, Sadia, Haider, Ali, Raza, Ali, Ul-Hamid, Anwar, Haider, Junaid, Ikram, Muhammad, Ghaffar, Rabia, Irshad, Muneeb, Ghaffar, Abdul, Saeed, Aamer“…UV–visible spectroscopy revealed reduction in band gap with increasing Ag content. SEM and HR-TEM micrographs revealed spherical morphology of Ag-doped Cu bimetallic with small and large scale agglomerations. …”
Publicado 2021
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83380por Ferro, Matteo, de Cobelli, Ottavio, Musi, Gennaro, Lucarelli, Giuseppe, Terracciano, Daniela, Pacella, Daniela, Muto, Tommaso, Porreca, Angelo, Busetto, Gian Maria, Del Giudice, Francesco, Soria, Francesco, Gontero, Paolo, Cantiello, Francesco, Damiano, Rocco, Crocerossa, Fabio, Farhan, Abdal Rahman Abu, Autorino, Riccardo, Vartolomei, Mihai Dorin, Muto, Matteo, Marchioni, Michele, Mari, Andrea, Scafuri, Luca, Minervini, Andrea, Longo, Nicola, Chiancone, Francesco, Perdona, Sisto, De Placido, Pietro, Verde, Antonio, Catellani, Michele, Luzzago, Stefano, Mistretta, Francesco Alessandro, Ditonno, Pasquale, Caputo, Vincenzo Francesco, Battaglia, Michele, Zamboni, Stefania, Antonelli, Alessandro, Greco, Francesco, Russo, Giorgio Ivan, Hurle, Rodolfo, Crisan, Nicolae, Manfredi, Matteo, Porpiglia, Francesco, Di Lorenzo, Giuseppe, Crocetto, Felice, Buonerba, Carlo“…A showed a worse non-cancer specific overall survival at univariate analysis (HR= 2.53; 95 CI= 1.05 - 6.10; p=0.046), although this finding was not confirmed at multivariate analysis. …”
Publicado 2021
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