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83461por Schonenberg-Meinema, Dieneke, Bergkamp, Sandy C, Nassar-Sheikh Rashid, Amara, Gruppen, Mariken P, Middelkamp-Hup, Maritza A, Armbrust, Wineke, Dolman, Koert, Hak, A Elisabeth, Hissink Muller, Petra C E, van Onna, Marieke, Swart, Joost F, Kuijpers, Taco W, Kamphuis, Sylvia S M, Smith, Vanessa, van den Berg, J Merlijn“…Already 5 years after disease onset, more than 50% of patients with a scleroderma pattern had SLE-related disease damage (HR 4.5, 95% CI 1.1 to 18.8, p=0.034), but they did not develop clinical features of systemic sclerosis at follow-up. …”
Publicado 2022
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83462por Xiaobin, Chen, Zhaojun, Xu, Tao, Liu, Tianzeng, Dai, Xuemei, Huang, Fan, Zheng, Chunyin, Huang, Jianqiang, Huang, Chen, Lin“…The Cox multivariate analysis validates that gastric cancer bone metastasis (HR = 0.584, 95% CI: 0.497~0.688, P < 0.001) is independent of the overall survival rate of gastric cancer patients. …”
Publicado 2022
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83463por Larsen, Britta, Greenstadt, Emily, Olesen, Brittany, Osuna, Lilliana, Godino, Job, Marcus, Bess, Dunsiger, Shira, Meyer, Dawn, Zive, Michelle“…The main outcome is change in weekly minutes of MVPA from baseline to 6 months, measured both objectively (ActiGraph accelerometers and Fitbit Inspire HR) and subjectively (7-Day Physical Activity Recall Interview). …”
Publicado 2022
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83464por Del Giudice, Francesco, Flammia, Rocco Simone, Chung, Benjamin I., Moschini, Marco, Pradere, Benjamin, Mari, Andrea, Soria, Francesco, Albisinni, Simone, Krajewski, Wojciech, Szydełko, Tomasz, Laukhtina, Ekaterina, D’Andrea, David, Gallioli, Andrea, Mertens, Laura S., Maggi, Martina, Sciarra, Alessandro, Salciccia, Stefano, Ferro, Matteo, Scornajenghi, Carlo Maria, Asero, Vincenzo, Cattarino, Susanna, De Angelis, Mario, Cacciamani, Giovanni E., Autorino, Riccardo, Pandolfo, Savio Domenico, Falagario, Ugo Giovanni, D’Altilia, Nicola, Mancini, Vito, Chirico, Marco, Cinelli, Francesco, Bettocchi, Carlo, Cormio, Luigi, Carrieri, Giuseppe, De Berardinis, Ettore, Busetto, Gian Maria“…In the sub-group setting of full adherence to European/American Urology Guidelines (EAU/NCCN), BCG TICE demonstrated longer 5-years RFS compared to RIVM (68% vs. 43%, p = 0.008; HR: 0.45 95% CI 0.25–0.81). Conclusion: When routinely performing re-TUR followed by a maintenance BCG schedule, TICE was superior to RIVM for RFS outcomes. …”
Publicado 2022
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83465por Wang, Yan, Huang, Xuewen, Peng, Fujun, Han, Huiling, Gu, Yanan, Liu, Xin, Feng, Zhichun“…We found that a series of routine blood indexes including systolic arterial blood pressure (SBP), heart rate (HR), white blood cell (WBC), and C-reactive protein (CRP) in the HAPE group presented higher and displayed significant differences compared with those in the non-HAPE group. …”
Publicado 2022
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83466por Huang, Mingliang, He, Jiehua, Lai, Wei, Liu, Lu, Xu, Heyang, Zeng, Yujie, Lan, Qiusheng, Lin, Xiangan, Chu, Zhonghua“…In multivariate regression analysis, mSEPT9 was also an independent predictor of prognosis (HR = 2.741, P = 0.009). The risk of local recurrence or distant metastasis in CRC patients after surgery was mSEPT9+ with stage III, mSEPT9- with stage III/mSEPT9+ with stage II, and mSEPT9- with stage II (P = 0.001), from highest to lowest. …”
Publicado 2022
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83467“…The multivariate Cox analysis showed that the prognostic risk model was an independent risk factor (HR = 2.44, 95% CI = 1.21~3.56, p = 0.029). Patients with a high-risk group had worse overall survival both in TCGA (p = 0.018) and GSE43131 (p = 0.00017). …”
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83468por Krens, Stefanie D., van Erp, Nielka P., Groenland, Stefanie L., Moes, Dirk Jan A. R., Mulder, Sasja F., Desar, Ingrid M. E., van der Hulle, Tom, Steeghs, Neeltje, van Herpen, Carla M. L.“…. ≥ 2)) in the multivariable analysis, the need for dose reduction remained significantly associated with improved PFS (HR 0.32, 95% CI:0.14–0.70, p = .004). CONCLUSION: In these explorative analyses, no clear relationship between increased cabozantinib exposure and improved PFS was observed. …”
Publicado 2022
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83469por Schroeder, Brett A., Zhang, Yuzheng, Smythe, Kimberly S., Desai, Parth, Thomas, Anish, Viveiros, Pedro, Alexiev, Borislav A., Obeidin, Farres, Chen, Eleanor Y., Cranmer, Lee D., Wagner, Michael J., Jones, Robin L., Campbell, Jean S., Pierce, Robert H., He, Qianchuan, Pollack, Seth M.“…At 5 years, increased PD-L1 expression corresponded to worse outcomes (HR = 1.87, p = 0.04, q = 0.199). Additionally, six immunologic gene signatures were associated with up to 7-year survival by MiRKAT-S, notably myeloid-derived suppressor cells (p = 0.023, q = 0.058) and M2 macrophages (p = 0.03, q = 0.058). …”
Publicado 2022
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83470por Francisco-Pascual, Jaume, Rivas-Gándara, Nuria, Bach-Oller, Montserrat, Badia-Molins, Clara, Maymi-Ballesteros, Manel, Benito, Begoña, Pérez-Rodon, Jordi, Santos-Ortega, Alba, Sambola-Ayala, Antonia, Roca-Luque, Ivo, Cantalapiedra-Romero, Javier, Rodríguez-Silva, Jesús, Pascual-González, Gabriel, Moya-Mitjans, Àngel, Ferreira-González, Ignacio“…Women had a lower risk of developing atrioventricular block (AVB) (adjusted odds ratio [OR] 0.44–95% CI 0.26–0.74, p = 0.002) and of requiring permanent pacemaker implantation (adjusted hazard ratio [HR] 0.72–95% CI: 0.52–0.99, p = 0.046). The mortality rate was lower in women (4.5 per 100 person-years [95% CI 3.1–6.4 per 100 person-years] vs. 7.3 per 100 person-years [95% CI 5.9–9.1 per 100 person-years]). …”
Publicado 2022
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83471por Xi, Yuzhi, Richardson, David B., Kshirsagar, Abhijit V., Wade, Timothy J., Flythe, Jennifer E., Whitsel, Eric A., Peterson, Geoffrey C., Wyatt, Lauren H., Rappold, Ana G.“…RESULTS: Among 314,079 hemodialysis patients, a 10 µg/m(3) increase in the average lag 0–1 daily PM(2.5) exposure was associated with CVD incidence (HR: 1.03 (95% CI: 1.02, 1.04)), CVD mortality (1.05 (95% CI: 1.03, 1.08)), and all-cause mortality (1.04 (95% CI: 1.03, 1.06)). …”
Publicado 2022
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83472por McNeel, Douglas G, Eickhoff, Jens C, Wargowski, Ellen, Johnson, Laura E, Kyriakopoulos, Christos E, Emamekhoo, Hamid, Lang, Joshua M, Brennan, Mary Jane, Liu, Glenn“…The development of irAE was significantly associated with a prolonged time on treatment (HR=0.42, p=0.003). Baseline DNA homologous recombination repair mutations were not associated with longer time to progression. …”
Publicado 2022
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83473por Swain, Christopher T. V., Bassett, Julie K., Hodge, Allison M., Dunstan, David W., Owen, Neville, Yang, Yi, Jayasekara, Harindra, Hébert, James R., Shivappa, Nitin, MacInnis, Robert J., Milne, Roger L., English, Dallas R., Lynch, Brigid M.“…More TV time was associated with earlier mortality; however, this relationship diminished with increasing age. The hazard ratio (HR) and 95% confidence interval (95% CI) for > 3 h/day compared with < 2 h/day of TV time was 1.34 (1.16, 1.55) at 70 years, 1.14 (1.04, 1.23) at 80 years, and 0.95 (0.84, 1.06) at 90 years. …”
Publicado 2022
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83474por Michalet, Morgan, Bordeau, Karl, Cantaloube, Marie, Valdenaire, Simon, Debuire, Pierre, Simeon, Sebastien, Portales, Fabienne, Draghici, Roxana, Ychou, Marc, Assenat, Eric, Dupuy, Marie, Gourgou, Sophie, Colombo, Pierre-Emmanuel, Carrere, Sebastien, Souche, François-Regis, Aillères, Norbert, Fenoglietto, Pascal, Azria, David, Riou, Olivier“…Resected patients had a significantly better OS as compared to unresected patients (p = 0.0219, hazard ratio (HR) = 5.78 (95% CI: 1.29–25.9)). CONCLUSION: SMART for pancreatic tumors is feasible without limiting toxicities. …”
Publicado 2022
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83475por Faust, Hilary E., Oniyide, Oluwatosin, Wang, Yiyue, Forker, Caitlin M., Dunn, Thomas, Yang, Wei, Lanken, Paul N., Sims, Carrie A., Yehya, Nadir, Christie, Jason D., Meyer, Nuala J., Reilly, John P., Mangalmurti, Nilam S., Shashaty, Michael G. S.“…MEASUREMENTS AND MAIN RESULTS: AKI developed in 17 patients (31%), a median of 12.0 hours (interquartile range, 6.2–24.1 hr) after presentation. mtDNA demonstrated a time-varying association with AKI (p = 0.022, interaction with time point), with differences by AKI status not emerging until 24 hours (β = 0.97 [95% CI, 0.03–1.90] log copies/uL; p = 0.043). …”
Publicado 2022
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83476por Harrow, Brooke, Fagnani, Francis, Nevoret, Camille, Truong-Thanh, Xuan-Mai, de Zélicourt, Marie, de Mestier, Louis“…OCT (n = 2090) had greater median treatment duration (31.8 months vs. 22.1 months, respectively; p < 0.0001; log-rank test) and were less likely to discontinue treatment; adjusted hazard ratio (HR) 0.74 (95% confidence interval [CI] 0.69–0.80). …”
Publicado 2022
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83477por van Loevezijn, Ariane A., van der Noordaa, Marieke E. M., Stokkel, Marcel P. M., van Werkhoven, Erik D., Groen, Emma J., Loo, Claudette E., Elkhuizen, Paula H. M., Sonke, Gabe S., Russell, Nicola S., van Duijnhoven, Frederieke H., Vrancken Peeters, Marie-Jeanne T. F. D.“…The overall recurrence risk remained highest for patients with ALND (HR 4.36; 95% CI 0.95–20.04, p = 0.059). CONCLUSIONS: De-escalation of axillary treatment according to the MARI-protocol prevented ALND in 80% of cN+ patients with an excellent three-year aRFI of 98%.…”
Publicado 2022
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83478por Xu, Shaohua, Miao, Hui, Gong, Liming, Feng, Lijie, Hou, Xuliang, Zhou, Manhong, Shen, Hong, Chen, Wei“…However, both the heart rate (HR) (p < 0.01) and LVEDV (28°C vs. 35°C, p < 0.01, 28°C vs. 37°C and 33°C, p < 0.05) were lowest in the 28°C group when compared with the other groups. …”
Publicado 2022
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83479por Hamdy, Rehab M, Abdel-Tawab, Hayam, Abd Elaziz, Ola H, Sobhy El attar, Rasha, Kotb, Fatma M“…Both controlled and refractory epileptic patients had significantly higher average heart rate (AV.HR), sympatho-vagal ratio (low-frequency/high-frequency (LF/HF) ratio in 24 hours, daytime, and nighttime), and LF and HF values compared to controls. …”
Publicado 2022
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83480“…Compared to the unhealthy lifestyle group, the healthy lifestyle group had a HR and 95% CI of 0.78 and 0.72-0.83. The population attributable risk of total death among those without a healthy lifestyle was 25.2%. …”
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