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83561“…Her work up included blood work (done at 13: 42) which showed sodium level of 146 mEq/L, plasma aldosterone concentration of <1 ng/dL, plasma renin activity of 1.0 ng/mL/hr, total testosterone of 46 ng/dL, DHEA-S of 31 mcg/dL, plasma metanephrines <50 pg/mL, 24-hour urine metanephrines 70 ug, 24-hour urine normetanephrines 164 ug/24 hrs, ACTH 5 pg/mL, and cortisol 28.2 mcg/dl. …”
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83562por Ortiz, Yineli, Aviles, Astrid, Maldonado, Hiram, Irizarry, Maria, Magraner, Miguel“…On physical examination, there was a pronounced abdominal ascites with positive fluid wave accompanied by abdominal discomfort at palpation, tachycardia of 103bpm, oliguria (less than 0.5cc/kg/hr) but no palpable masses or visceromegaly. Evaluation showed leukocytosis of 23. 0K/uL, hematocrit level of 43.5 g/dl (N: 36-48% in females), hypotonic hyponatremia with sodium level: 134 (136-145mmol/L), serum osmolality of 268 mOsm/L (N: 269-295mOsm/L), estradiol level of 3,057 pg/ml and progesterone level of 253.3 ng/ml; hormones both well above normal range compatible with response to ovarian stimulation therapy received. …”
Publicado 2022
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83563por Patterson, Mary“…He was noted to have an increase in water intake and urine output post-operatively with intake of 6200 mL and output of 6768 mL over 24 hours (3.5 mL/kg/hr). His Na was 141 mmol/L with urine SG of 1. 002, and urine osmolality of 75 mosm/kg. …”
Publicado 2022
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83564“…ACTH stim test revealed cortisol level of 9. 0 ug/dl, 9.4 ug/dl, and 9.2 ug/dl at baseline, 30min and 1hr respectively with a baseline ACTH of 539. Lung biopsy showed necrotizing granuloma and fungal spores compatible with histoplasmosis. …”
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83565por Swerdloff, Ronald, Wang, Christina, Gittelman, Marc, Newmark, Jay, Woun Seo, B, Rohowsky, Nestor, Dudley, Robert“…During clinical trials, dose adjustments were based on 24-hr average T concentration (Cavg) because single T measurements were considered less accurate. …”
Publicado 2022
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83566“…For RNA-seq analysis of estrogen-responsive genes, total cellular RNAs from endometriotic cells treated with or without 10nM estradiol for 8hr were prepared. Following the quality control (concentration>50ng/ul, RIN>9), RNA samples were used for polyA+ selected library preparation and the strand-specific RNA-seq (NovaSeq, DNBSEQ-G400, 20M paired- end (PE) reads and 2×150bp PE/sample). …”
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83567por Alfares, Khalid“…Initial thyroid labs showed a T3 2.8 (2.5 - 4.4 pg/mL), T4 1.4 (0.61 - 1.44 ng/dL), TSH 1.4 (0.45 - 5.33 uIU/mL), TPO antibodies positive, thyroglobulin Ab undetectable, sedimentation rate of 42 (<30 mm/Hr). Ultrasound of the neck showed 1.7-centimeter TIRADS 4 nodules in the left lobe, and 0.9 cm on the right. …”
Publicado 2022
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83568“…She received hydrocortisone 100mg IV followed by 50mg IV q8hr. After the first dose of hydrocortisone, she was given levothyroxine 100mcg IV once followed by 75mcg IV daily. …”
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83569por Gasperetti, Alessio, Carrick, Richard T., Costa, Sarah, Compagnucci, Paolo, Bosman, Laurens P., Chivulescu, Monica, Tichnell, Crystal, Murray, Brittney, Tandri, Harikrishna, Tadros, Rafik, Rivard, Lena, van den Berg, Maarten P., Zeppenfeld, Katja, Wilde, Arthur A.M., Pompilio, Giulio, Carbucicchio, Corrado, Dello Russo, Antonio, Casella, Michela, Svensson, Anneli, Brunckhorst, Corinna B., van Tintelen, J. Peter, Platonov, Pyotr G., Haugaa, Kristina H., Duru, Firat, te Riele, Anneline S.J.M., Khairy, Paul, Tondo, Claudio, Calkins, Hugh, James, Cynthia A., Saguner, Ardan M., Cadrin-Tourigny, Julia“…Inducible ventricular tachycardia predicted clinical sustained VA during the 5-year follow-up and remained an independent predictor after accounting for the calculator-predicted risk (HR, 2.52 [1.58–4.02]; P<0.001). Compared with ARVC risk calculator predictions in isolation (C-statistic 0.72), addition of PVS inducibility showed improved prediction of VA events (C-statistic 0.75; log-likelihood ratio for nested models, P<0.001). …”
Publicado 2022
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83570por Serin, Istemi, Baltali, Sevim, Cinli, Tahir Alper, Goze, Hasan, Demir, Burçak, Yokus, Osman“…The risk of death was 1.66 (HR: 1.66, 95% CI: 1.02–2.86, p < 0.05) times higher in patients with an LFA result of ≥ 0.5 ODI than those with < 0.5 (p < 0.05). …”
Publicado 2022
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83571por Tump, Danielle, Narayan, Nitin, Verbiest, Vera, Hermsen, Sander, Goris, Annelies, Chiu, Chui-De, Van Stiphout, Ruud“…The smartwatch measurements positively related to stress were the number of active intensity periods (P<.001), the number of highly active intensity periods (P=.04), steps (P<.001), and the SD in the heart rate (HR; P<.001). In a multivariate setting, only a history of burnout (P<.001) and family and daily life getting in the way of work (P<.001) were positively associated with stress, while self-reports of social activities (P<.001) and going outdoors (P=.03) were negatively associated with stress. …”
Publicado 2022
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83572por Nägele, Felix, Graber, Michael, Hirsch, Jakob, Pölzl, Leo, Sahanic, Sabina, Fiegl, Manuel, Hau, Dominik, Engler, Clemens, Lechner, Sophia, Stalder, Anna Katharina, Mertz, Kirsten D., Haslbauer, Jasmin D., Tzankov, Alexandar, Grimm, Michael, Tancevski, Ivan, Holfeld, Johannes, Gollmann-Tepeköylü, Can“…The clinical course of patients with cardiac SARS-CoV-2 manifestation is unfavorable, resulting in impaired survival (median, 12 days and 4.5 days, respectively, HR 0.30, 95% CI, 0.13 to 0.73, p = 0.0005) CONCLUSIONS: We provide evidence for a correlation between SHD, altered ACE2 receptor expression, and cardiac SARS-CoV-2 manifestation. …”
Publicado 2022
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83573por Pedersen, Dorthe C., Jensen, Britt W., Tjønneland, Anne, Andersen, Zorana J., Mellemkjaer, Lene, Bjerregaard, Lise G., Aarestrup, Julie, Baker, Jennifer L.“…Hormone replacement therapy use came from the Danish National Prescription Registry. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox regression. …”
Publicado 2022
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83574por Ben Khaled, Najib, Hammer, Katharina, Ye, Liangtao, Alnatsha, Ahmed, Widholz, Sebastian A., Piseddu, Ignazio, Sirtl, Simon, Schneider, Julia, Munker, Stefan, Mahajan, Ujjwal Mukund, Montero, Juan José, Griger, Joscha, Mayerle, Julia, Reiter, Florian P., De Toni, Enrico N.“…Investigations of the genetic features of PDAC have demonstrated a frequent occurrence of mutations in genes involved in homologous recombination (HR), especially in the breast cancer susceptibility gene 2 (BRCA2). …”
Publicado 2022
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83575“…No statistical differences were found in oxygen saturation (SaO(2)), PvO(2) (partial pressure of oxygen in venous blood), partial pressure of end-tidal carbon dioxide (ETCO(2)), partial pressure of carbon dioxide in artery (PaCO(2)), heart rate (HR), mean arterial pressure (MAP), and complications among the four groups (P>0.05). …”
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83576por Duan, Ming-Xuan, Zhao, Xi, Li, Shao-Lin, Tao, Jun-Zhong, Li, Bo-Yan, Meng, Xin-Guo, Dai, Dong-Pu, Lu, Yan-Yu, Yue, Zhen-Zhen, Du, Yang, Rui, Zi-Ao, Pang, Shuo, Zhou, Yuan-Hang, Miao, Guang-Rui, Bai, Lin-Peng, Zhang, Qing-Yang, Zhao, Xiao-Yan“…The cut-off point of EuroSCORE II was determined to be 14, and there were statistically significant differences between the EuroSCORE II < 14 group and EuroSCORE II≥14 group (HR = 0.2596, 95%CI: 0.1800–0.3744, Logrank P < 0.001). …”
Publicado 2022
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83577por Wang, Dong, Lin, Huajun, Guan, Chengjian, Zhang, Xiaodong, Li, Peixin, Xin, Chenglin, Yang, Xiaobao, Feng, Zhewen, Min, Yiyang, Gu, Xiaozhe, Guo, Wei“…The overall survival time was 47.9 ± 2.45 months, with survival being slightly lower in the PBD group (43.61 ± 3.26 months) than in the control group (52.24 ± 3.54 months), although this difference was not significant (hazard ratio (HR)=0.65, p=0.104). CONCLUSION: In patients with malignant biliary obstruction, PBD does not affect the incidence of postoperative complications after pancreaticoduodenectomy nor does it affect patient survival. …”
Publicado 2022
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83578por Antonio-Arques, Violeta, Caylà, Joan A., Real, Jordi, Moreno-Martinez, Antonio, Orcau, Àngels, Mauricio, Didac, Mata-Cases, Manel, Julve, Josep, Navas Mendez, Elena, Puig Treserra, Rai, Millet, Joan Pau, Del Val García, Jose Luis, Vlacho, Bogdan, Franch-Nadal, Josep“…An increase in the risk of TB was also observed according to a poorer optimization of glycemic control: adjusted HR 1.80 (95% CI 0.60–5.42), 2.06 (95% CI 0.67–6.32), and 2.82 (95% CI 0.88–9.06), respectively. …”
Publicado 2022
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83579“…Multivariate analysis indicated that the N stage was associated with OS (HR = 1.86 P = 0.042). CONCLUSION: Surgery and adjuvant therapy were found to have encouraging outcomes in postoperative unsuspected SCLC. …”
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83580por Han, Xiao, Tang, Xiaoyong, Zhu, Hui, Zhu, Dongyuan, Zhang, Xiqin, Meng, Xiangjiao, Hua, Ying, Wang, Zhongtang, Zhang, Yan, Huang, Wei, Wang, Linlin, Yuan, Shuanghu, Zhang, Pinliang, Gong, Heyi, Sun, Yulan, Zhang, Yingjie, Liu, Zengjun, Dong, Xiaomeng, Gai, Fei, Huang, Zhan, Zhu, Changbin, Guo, Jun, Wang, Zhehai“…Clearance of clonal mutations and none new clonal formation at 6th week were associated with longer PFS (mPFS 89 vs 266 days, p =0.003). ctDNA clearance at 6th week was an independent risk factor for progression or death (HR=100 (95% CI 4.10 to 2503.00), p=0.005). CONCLUSION: ctDNA status and ctDNA mutation clearance putatively serve as predictive biomarkers for sintilimab combined with docetaxel chemotherapy in pretreated advanced NSCLC patients.…”
Publicado 2022
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