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83601“…TRIAL REGISTRATION: Open Science Framework osf.io/d28hr [20 December 2021] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-022-06981-8.…”
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83602por Quintanilha, Julia C. F., Graf, Ryon P., Fisher, Virginia A., Oxnard, Geoffrey R., Ellis, Haley, Panarelli, Nicole, Lin, Douglas I., Li, Gerald, Huang, Richard S. P., Ross, Jeffrey S., Myer, Parvathi A., Klempner, Samuel J.“…Patients receiving first-line ICIs vs chemotherapy had longer TTNT (median, not reached [NR] vs 7.23 months [IQR, 6.21-9.72 months]; adjusted hazard ratio [AHR], 0.17; 95% CI, 0.08-0.35; P < .001), PFS (median, 24.87 months [IQR, 19.10 months to NR] vs 5.65 months [IQR, 4.70-8.34 months]; AHR, 0.31; 95% CI, 0.18-0.52; P < .001), and OS (median, NR vs 24.1 months [IQR, 13.90 months to NR]; HR, 0.45; 95% CI, 0.23-0.88; P = .02). MSI added to DMMR better anticipated TTNT and PFS in patients receiving ICIs than DMMR alone. …”
Publicado 2023
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83603por Kaalby, Lasse, Deding, Ulrik, Al-Najami, Issam, Berg-Beckhoff, Gabriele, Bjørsum-Meyer, Thomas, Laurberg, Tinne, Shaukat, Aasma, Steele, Robert J. C., Koulaouzidis, Anastasios, Rasmussen, Morten, Kobaek-Larsen, Morten, Baatrup, Gunnar“…This risk increased steadily from aHR 1.38 (95% CI: 1.32, 1.44) in those with a f-Hb of 7.1–11.9 μg Hb/g faeces to 2.20 (95% CI: 2.10, 2.30) in those with a f-Hb ≥60.0 μg Hb/g faeces, when compared to those with a f-Hb ≤7.0 μg Hb/g faeces. …”
Publicado 2023
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83604por Yu, Bowei, Sun, Ying, Du, Xinyue, Zhang, Haojie, Chen, Chi, Tan, Xiao, Yang, Zhongyi, Lu, Yingli, Wang, Ningjian“…After adjusting for various covariates, the individuals in the highest quintiles of VAT and FMR had the highest hazard ratios (HRs) of all‐cause mortality [1.24 (95% confidence interval: 1.17–1.33) for VAT and 1.24 (1.17–1.31) for FMR in men; and 1.11 (1.03–1.21) for VAT in women], except that the 1st quintile of FMR in women had the greatest HR [1.18 (1.09–1.27)]. Significant interactions were observed in both sexes according to age category (P for interaction < 0.05). …”
Publicado 2022
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83605“…Resting and peak heart rate (HR) as well as systolic blood pressure (SBP) measurements were recorded. …”
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83606por Singh, Pushpendra, Sharma, Kuldeep, Shaw, Dipika, Bhargava, Anudita, Negi, Sanjay Singh“…The spike gene showed the signature mutations of T19I and V213G in the N-terminal domain (NTD), S373P, S375F, T376A, and D405N in receptor-binding domain (RBD), D614G, H655Y, N679K, and P681H at the furin cleavage site, N764K and D796K in fusion peptide, and Q954H and N969K in heptapeptide repeat sequence (HR)1. Notably, BA.2.43 exhibited a novel mutation of E1202Q in the C terminal. …”
Publicado 2023
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83607por Benjamim, Cicero Jonas R., Sousa, Yaritza Brito Alves, Porto, Andrey Alves, de Moraes Pontes, Yasmim Mota, Tavares, Simone Sakagute, da Silva Rodrigues, Guilherme, da Silva, Leonardo Santos Lopes, da Silva Goncalves, Leonardo, Guimaraes, Carolina Scoqui, Rebelo, Macário Arosti, da Silva Sobrinho, Andressa Crystine, Tanus-Santos, Jose E., Valenti, Vitor Engracia, Gualano, Bruno, Bueno Júnior, Carlos Roberto“…METHODS: We will investigate the effects of beetroot juice rich in NO3 acutely (800 mg) and during a week with daily doses (400 mg) on blood pressure, heart rate (HR), cardiac autonomic control, endothelial function, inflammatory, hormonal, and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation, under resting conditions, as well as mediated by submaximal aerobic exercise sessions. …”
Publicado 2023
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83608por Hjorth, Cathrine F., Damkier, Per, Stage, Tore B., Feddersen, Søren, Hamilton-Dutoit, Stephen, Ejlertsen, Bent, Lash, Timothy L., Bøggild, Henrik, Sørensen, Henrik T., Cronin-Fenton, Deirdre“…From 6 months to 10 years after surgery, return-to-work increased from 25 to 94% in wildtypes (n = 1600), from 17 to 94% in heterozygotes (n = 249), and from 7 to 82% in homozygotes (n = 15). The HR showed delayed return-to-work in CYP3A5 rs776746 homozygotes throughout follow-up (0.48, 95% CI 0.26, 0.86), compared with wildtypes. …”
Publicado 2023
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83609por Lee, Hyun-Jung, Park, Chan Soon, Lee, Sahmin, Park, Jun-Bean, Kim, Hyung-Kwan, Park, Sung-Ji, Kim, Yong-Jin, Lee, Seung-Pyo“…Diabetes was a significant predictor of heart failure and death, independent of clinical covariates and aortic valve replacement (HR 1.88, 95% CI 1.06−3.31, p = 0.030). CONCLUSIONS: Plasma proteomic analyses indicate that diabetes potentiates the systemic proinflammatory−profibrotic milieu in AS patients. …”
Publicado 2023
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83610por Patel, Avignat S., Miller, Ezra, Regis, Shawn M., Hunninghake, Gary M., Price, Lori Lyn, Gawlik, Melissa, McKee, Andrea B., Rieger-Christ, Kimberly M., Pinto-Plata, Victor, Liesching, Timothy N., Wald, Christoph, Hashim, Jeffrey, McKee, Brady J., Gazourian, Lee“…On multivariable modeling, the presence of ILA remained a significant predictor of death, HR 3.87 (2.07, 7.21; p < 0.001) when adjusted for age, sex, BMI, pack years and active smoking, but not of lung cancer and all-cause hospital admission. …”
Publicado 2023
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83611por Shao, Bin, Li, Huiping, Liu, Xiaoran, Song, Guohong, Jiang, Hanfang, Yan, Ying, Zhang, Ruyan, Ran, Ran, Zhang, Jiayang, Liu, Yaxin, Wang, Huan, Wang, Jing, Di, Lijun“…RESULTS: A total of 128 patients between January 2011 and December 2020 were enrolled. 70 (54.7%) cases were hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 79 (61.7%) patients had visceral metastasis and 67 (52.3%) patients had more than 2 metastatic sites. …”
Publicado 2023
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83612por Curtis, Jeffrey R, Yamaoka, Kunihiro, Chen, Yi-Hsing, Bhatt, Deepak L, Gunay, Levent M, Sugiyama, Naonobu, Connell, Carol A, Wang, Cunshan, Wu, Joseph, Menon, Sujatha, Vranic, Ivana, Gómez-Reino, Juan J“…In the overall study population, the risk of malignancies excluding NMSC was similar between both tofacitinib doses and TNFi until month 18 and diverged from month 18 onwards (HR (95% CIs) for combined tofacitinib doses: 0.93 (0.53 to 1.62) from baseline to month 18 vs 1.93 (1.22 to 3.06) from month 18 onwards, interaction p=0.0469). …”
Publicado 2023
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83613por Chen, Ruichao, Zhang, Renchao, Zhang, Minfen, Liu, Shaoyan, Xie, Mingyu, Yang, Zhongfeng, Shi, Quan, Chen, Hui, Xiong, Hanzhen, Wang, Na, Jiang, Qingping“…METHODS: After routine H&E review, 85 lesions graded CIN 1, 2, or 3 were investigated primarily by HPV RNAscope to detect HR-HPV and LR-HPV, in combination with an HPV-DNA test and P16/Ki67 immunohistochemistry (IHC). …”
Publicado 2023
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83614por Sedlmeier, Anja M., Viallon, Vivian, Ferrari, Pietro, Peruchet-Noray, Laia, Fontvieille, Emma, Amadou, Amina, Seyed Khoei, Nazlisadat, Weber, Andrea, Baurecht, Hansjörg, Heath, Alicia K., Tsilidis, Kostas, Kaaks, Rudolf, Katzke, Verena, Inan-Eroglu, Elif, Schulze, Matthias B., Overvad, Kim, Bonet, Catalina, Ubago-Guisado, Esther, Chirlaque, María-Dolores, Ardanaz, Eva, Perez-Cornago, Aurora, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, Pasanisi, Fabrizio, Borch, Kristin B., Rylander, Charlotta, Weiderpass, Elisabete, Gunter, Marc J., Fervers, Béatrice, Leitzmann, Michael F., Freisling, Heinz“…PC1 (overall adiposity) was positively associated with the risk of overall cancer, with a HR per 1 standard deviation (SD) increment equal to 1.07 (95% confidence interval 1.05 to 1.08). …”
Publicado 2022
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83615por Stone, Jack, Bothma, Rutendo, Gomez, Gabriela B., Eakle, Robyn, Mukandavire, Christinah, Subedar, Hasina, Fraser, Hannah, Boily, Marie‐Claude, Schwartz, Sheree, Coetzee, Jenny, Otwombe, Kennedy, Milovanovic, Minja, Baral, Stefan, Johnson, Leigh F., Venter, Willem Daniel Francois, Rees, Helen, Vickerman, Peter“…FSWs can transition between adherence levels, with lower loss‐to‐follow‐up among highly adherent FSWs (aHR: 0.58; 95% CI: 0.40–0.85; TAPS data). The model was calibrated to monthly data on the national scale‐up of PrEP among FSWs over 2016–2020, including reductions in PrEP initiations during 2020. …”
Publicado 2023
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83616“…We used a BRS cutoff of < 3 (lower resilience, LR), 3-3.9 (intermediate resilience, IR), and >=4 (high resilience, HR) to create three cohorts. Patients also completed a PROMIS Physical Function (PF) Computer Adaptive Test (CAT), PROMISE Pain Interference (PI) CAT, PROMISE Depression (D) CAT, and Global Health (GH) Short Form pre-operatively as well as 3-, 6-, 12-, and 24- months post-operatively, as applicable. …”
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83617por Okoth, Kelvin, Thomas, G. Neil, Nirantharakumar, Krishnarajah, Adderley, Nicola J.“…Adjusted hazard ratios (aHR) and 95% CI for cardiometabolic outcomes were estimated using Cox proportional hazards models. …”
Publicado 2023
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83618por Freire, Ana Paula, Lira, Fabio, Morano, Ana Elisa Ah, Santos, Vanessa, Coelho-E-Silva, Manuel-Joao, Amin, Shaan, Caseiro, Armando, Pereira, Telmo, Silva, Bruna“…For intergroup analysis, we observed that PCOV group presents significant higher reductions in sympathetic activity over time when compared to CT demonstrated by HR (p=0.0088) and SNS index (p=0.0068). Observations of parasympathetic nervous system activity reveals a statistical increase between baseline and follow up in Mean RR (p=0.0312) and pNN50 (p=0.0312) for PCOV group. …”
Publicado 2023
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83619“…The TyG index was further demonstrated to be independent of MACCE by multivariable Cox regression analysis (hazard ratio [HR], 1.493; 95% confidence interval [CI], 1.230–1.812; p<0.001). …”
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83620por Baalbaki, Nadia, Duijvelaar, Erik, Said, Medhat M., Schippers, Job, Bet, Pierre M., Twisk, Jos, Fritchley, Sarah, Longo, Cristina, Mahmoud, Kazien, Maitland-van der Zee, Anke H., Bogaard, Harm Jan, Swart, Eleonora L., Aman, Jurjan, Bartelink, Imke H.“…Ct(trough), not AUCt(ave), associated significantly with P/F (β=-19,64; p-value=0.014) and O(2)lib (HR 0.78; p-value= 0.032), after adjusting for sex, age, neutrophil-lymphocyte ratio, dexamethasone concomitant treatment, AAG and baseline P/F-and WHO-score. …”
Publicado 2023
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