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83641por Fox, Marlena A., Carothers, Chancey, Dircksen, Katie K., Birrer, Kara L., Choi, Min J., Mukkera, Satyanarayana R.“…Patients receiving opioid infusions greater than or equal to 72 hours, or a total daily fentanyl dose of greater than or equal to 1,200 μg (~ 50 μg/hr) are at a higher risk for developing IWS and should be monitored as part of clinical practice when opioid infusions are discontinued.…”
Publicado 2023
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83642por Ampatzidou, Mirella, Papadhimitriou, Stefanos I., Paisiou, Anna, Paterakis, Georgios, Tzanoudaki, Marianna, Papadakis, Vassilios, Florentin, Lina, Polychronopoulou, Sophia“…The presence of the CDKN2A/2B deletions clearly correlated with inferior outcomes within all protocol-defined risk groups (standard risk (SR): EFS 66.7% vs. 100%, p < 0.001, intermediate risk (IR): EFS 77.1% vs. 97.9%, p < 0.001, high risk (HR): EFS 42.1% vs. 70.5% p < 0.001 for deleted vs non-deleted cases in each patient risk group); additionally, in this study, the presence of the deletion differentiated prognosis within both MRD-positive and -negative subgroups on days 15 and 33 of induction. …”
Publicado 2023
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83643por Napolitano, Stefania, De Falco, Vincenzo, Martini, Giulia, Ciardiello, Davide, Martinelli, Erika, Della Corte, Carminia Maria, Esposito, Lucia, Famiglietti, Vincenzo, Di Liello, Alessandra, Avallone, Antonio, Cardone, Claudia, De Stefano, Alfonso, Montesarchio, Vincenzo, Zampino, Maria Giulia, Bordonaro, Roberto, Scartozzi, Mario, Santini, Daniele, Di Maio, Massimo, De Vita, Ferdinando, Altucci, Lucia, Marrone, Francesca, Ciardiello, Fortunato, Troiani, Teresa“…Median PFS was 4.0 months (95% CI, 2.8-5.3 months) in the panitumumab plus trifluridine-tipiracil arm vs 2.5 months (95% CI, 1.4-3.6 months) in the trifluridine-tipiracil only (hazard ratio [HR], 0.48; 95% CI, 0.28-0.82; P = .007). Pretreatment plasma RAS/BRAF WT ctDNA identified patients obtaining prolonged clinical benefit with panitumumab plus trifluridine-tipiracil compared with trifluridine-tipiracil, with PFS rates at 6 months of 38.5% vs 13.0% and at 12 months of 15.4% vs 0%. …”
Publicado 2023
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83644por Toennesen, J, Pallisgaard, J P, Rasmussen, P V R, Ruwald, M R, Zoerner, C Z, Riis-Vestergaard, L R V, Middelfart, C M, Gislason, G G, Hansen, M L H“…In the univariate analysis, the Hazard ratio (HR, [95% confidence interval]) increased incrementally from 1.03 [0.90 to 1.18], 1.28 [1.10 to 1.49], 1.43 [1.17 to 1.74] in overweight to morbidly obese respectively (Figure 2). …”
Publicado 2023
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83645por Davidson, J A, Farrer, A, Wan, S, Schmetz, A, Thompson Hilpert, S, Schrader, J, Bonhomme, C, Pettit, S“…In the adjusted analysis, ICD-10 or SNOMED coded diagnosis of AF was not significantly different between groups (HR: 0.88 [95% CI 0.70-1.10]; p-value=0.3). Stroke rates in the total cohort (with or without AF) were 5.7% in the VR ICD and 3.4% in the DR ICD cohort at 36 months. …”
Publicado 2023
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83646por Brito, J, Silverio Antonio, P, Nunes Ferreira, A, Lima Da Silva, G, Ricardo, I, Neves, I, Cortez-Dias, N, J Pinto, F, Sousa, J“…The presence of 2 and 3 positive LP represented an additionally 4.7-fold increased risk of MAE during follow-up (HR 4.693, 95% CI 1.506-14.624, p = 0.008) – figure 2. …”
Publicado 2023
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83647por Viveros, D, Penela, D, Marti-Almor, J, Soto-Iglesias, D, Falasconi, G, Alderete, J, Bellido, A, Franco, P, Francia, P, Ordonez, A, Ortiz-Perez, J T, Berruezo, A“…The average number of syncope events per year per patient prior to the procedure was 5 ±3. The mean HR on Holter Pre CNA was 65 ± 12 and 72 ± 9 post CNA. …”
Publicado 2023
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83648por Geist, Mary L., Radick, Andrea C., Tsui, Judith I., Blalock, Kendra L., Adwell, Addy, Tamru, Elsabeth, Connolly, Nancy C., James, Jocelyn R.“…HCV treatment was associated with a lower relative hazard for discharge/drop-out, although results did not meet statistical significance (aHR = 0.59;95% CI: 0.34–1.00; p = 0.052). Among the subset of 84 patients retained in OBOT at least 100 days, 18 received HCV treatment during that period. …”
Publicado 2023
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83649por Dumusc, Alexandre, Alromaih, Fahad, Perreau, Matthieu, Hügle, Thomas, Zufferey, Pascal, Dan, Diana“…Moderate to severe hypogammaglobulinaemia was observed more frequently in patients with vasculitis (35%) than with RA (13%) or CTD (9%) and was associated with an increased risk of presenting a first infectious SAE (HR 2.01, 95% CI 1.04 to 3.91). The incidence rate of SAE was 23.3 SAE/100 patient-years (36% were infectious). …”
Publicado 2023
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83650por Li, Yukun, Peng, Xiaodong, Wang, Xuesi, Lin, Rong, Liu, Xinmeng, Meng, Fanchao, Liu, Xiaoying, Li, Linling, Bai, Rong, Wen, Songnan, Ruan, Yanfei, Tang, Ribo, Liu, Nian“…Cox regression analysis showed that shift work was associated with higher risk of all-cause mortality (hazard ratio [HR], 1.48; 95% CI, 1.07–2.06) compared with non-shift workers. …”
Publicado 2023
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83651por Warisawa, Takayuki, Cook, Christopher M., Kawase, Yoshiaki, Howard, James P., Ahmad, Yousif, Seligman, Henry, Rajkumar, Christopher, Toya, Takumi, Doi, Shunichi, Nakajima, Akihiro, Tanigaki, Toru, Omori, Hiroyuki, Nakayama, Masafumi, Vera-Urquiza, Rafael, Yuasa, Sonoka, Sato, Takao, Kikuta, Yuetsu, Nishina, Hidetaka, Al-Lamee, Rasha, Sen, Sayan, Lerman, Amir, Akashi, Yoshihiro J., Escaned, Javier, Matsuo, Hitoshi, Davies, Justin E.“…At a median follow-up period of 2.8 years, the primary endpoint occurred in 8.3% in PCI group and 20.8% in CABG group, respectively (HR 3.80; 95% CI 1.04–13.9; p = 0.043). There was no difference in each component of the primary event (p > 0.05 for all). …”
Publicado 2023
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83652por Stadler, Julia-Christina, Keller, Laura, Mess, Christian, Bauer, Alexander T, Koett, Julian, Geidel, Glenn, Heidrich, Isabel, Vidal-y-Sy, Sabine, Andreas, Antje, Stramaglia, Carlotta, Sementsov, Mark, Haberstroh, Wiebcke, Deitert, Benjamin, Hoehne, Inka Lilott, Reschke, Robin, Haalck, Thomas, Pantel, Klaus, Gebhardt, Christoffer, Schneider, Stefan W“…With a median clinical follow-up of 26 months, vWF:Ag interrogated as a continuous variable was significantly associated with PFS in univariate and multivariate analysis (HR=1.04; p=0.007). Lower values of vWF:Ag at baseline were observed in the primary responders group (median: 29.4 µg/mL vs 32.9 µg/mL; p=0.048) when compared with primary resistant patients. …”
Publicado 2023
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83653por Lee, Wan-Ju Annabelle, Chung, Wei-Pang, Shao, Shih-Chieh, Lai, Edward Chia-Cheng, Chen, Yi-Chen, Ho, Chung-Han“…There was no statistically significant difference in RVO risk between the anti-VEGF and control groups (HR: 2.21, 95% CI: 0.87–5.61). CONCLUSION: Our results indicated no association between use of anti-VEGF and occurrence of RVO among CRC patients, although the crude incidence rate of RVO was higher in patients receiving anti-VEGF, compared to control patients. …”
Publicado 2023
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83654“…After adjusting for confounding factors in the Cox survival analysis, the risk of death within 30 days after discharge was significantly higher in the real ARDS group than in the non-ARDS group (hazard ratio(HR): 4.633, 95% CI: 1.012–21.202, P < 0.05). CONCLUSION: Preoperative hypoxemia is an independent risk factor for post-operative simple hypoxemia and ARDS. …”
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83655por Mekinian, Arsène, Biard, Lucie, Lorenzo, Dagna, Novikov, Pavel I, Salvarani, Carlo, Espitia, Olivier, Sciascia, Savino, Michaud, Martin, Lambert, Marc, Hernández-Rodríguez, José, Schleinitz, Nicolas, Awisat, Abid, Puechal, Xavier, Aouba, Achille, Munoz Pons, Helene, Smitienko, Ilya, Gaultier, Jean Baptiste, Edwige, Le Mouel, Benhamou, Ygal, Perlat, Antoinette, Jego, Patrick, Goulenok, Tiphaine, Sacre, Karim, Lioger, Bertrand, Hassold, Nolan, Broner, Jonathan, Dufrost, Virginie, Sené, Thomas, Seguier, Julie, Maurier, Francois, Berthier, Sabine, Belot, Alexandre, Frikha, Faten, Denis, Guillaume, Audemard-Verger, Alexandra, Koné-Paut, Isabelle, Humbert, Sebastien, Woaye-Hune, Pascal, Tomelleri, Alessandro, Baldissera, Elena Marina, Kuwana, Masataka, Lo Gullo, Alberto, Mukuchyan, Vahan, Dellal, Azeddine, Gaches, Francis, Zeminsky, Pierre, Galli, Elena, Alvarado, Moya, Boiardi, Luigi, Francesco, Muratore, Vautier, Mathieu, Campochiaro, Corrado, Moiseev, Sergey, Vieira, Matheus, Cacoub, Patrice, Fain, Olivier, Saadoun, David“…During the median follow-up of 30.1 months (0.4; 105.8) and 10.8 (0.1; 46.4) (p<0.0001) in patients who received tocilizumab in intravenous and SC forms, respectively, the risk of relapse was significantly higher in TAK patients on SC tocilizumab (HR=2.55, 95% CI 1.08 to 6.02; p=0.033). The overall cumulative incidence of relapse at 12 months in TAK patients was at 13.7% (95% CI 7.6% to 21.5%), with 10.3% (95% CI 4.8% to 18.4%) for those on intravenous tocilizumab vs 30.9% (95% CI 10.5% to 54.2%) for patients receiving SC tocilizumab. …”
Publicado 2023
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83656por Nigon, Elsa, Lefeuvre-Plesse, Claudia, Martinez, Alejandra, Chauleur, Céline, Lortholary, Alain, Favier, Laure, Bats, Anne-Sophie, Guille, Arnaud, AdélaÏde, José, Finetti, Pascal, de Casteljac, Victoire, Provansal, Magali, Mamessier, Emilie, Bertucci, François, Ray-Coquard, Isabelle, Sabatier, Renaud“…P16 expression was associated with shorter PFS (HR = 5.88, 95 CI [1.56–25], p = 0.009). Transcriptomic analyzes revealed a specific transcriptomic profile notably with a high expression of immune response-associated genes in uterine CCC displaying a very good overall prognosis. …”
Publicado 2023
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83657por Bourmorck, Delphine, de Saint-Hubert, Marie, Desmedt, Marianne, Piers, Ruth, Flament, Julien, De Brauwer, Isabelle“…The survival time was shorter in SPICT positive patients than in SPICT negative ones (p < 0.001), the former having a higher 1-year mortality rate (HR = 4.21; p < 0.001). CONCLUSIONS: SPICT successfully identifies older patients at high risk of health degradation and death. …”
Publicado 2023
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83658por Shi, Wei, Li, Yang, Sun, Hua, Zhang, Li, Meng, Jin, Wang, Xiaofang, Chen, Xingxing, Zhang, Xiaomeng, Mei, Xin, Ma, Jinli, Mo, Miao, Zhou, Changming, Liang, Fei, Shao, Zhimin, Zhang, Zhen, Guo, Xiaomao, Yu, Xiaoli, Yang, Zhaozhi“…Patients with 1–5 total metastatic lesions had a significantly longer median OS of 24.3 months compared to those with greater than 5 total metastatic lesions with a median OS of 12.2 months (P < 0.001; multivariate HR 0.55, 95% CI, 0.43–0.72). Among the patients with 1–5 metastatic lesions, median OS for GPA 0–1.0 was 9.8 months, compared to 22.8, 28.8 and 71.0 for GPA 1.5–2.0, 2.5–3.0 and 3.5–4.0 respectively, which is much longer than the corresponding patients with greater than 5 total metastatic lesions, with medium OS of 6.8, 11.6, 18.6 and 42.6 months respectively for GPA 0–1.0, 1.5–2.0, 2.5–3.0 and 3.5–4.0. …”
Publicado 2023
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83659por Saavedra, Joey M., Brellenthin, Angelique G., Song, Bong Kil, Lee, Duck-chul, Sui, Xuemei, Blair, Steven N.“…However, the association between obesity and restrictive spirometry pattern was attenuated when additionally adjusting for cardiorespiratory fitness (HR: 1.08, 95% CI: 0.84–1.39). Compared to the ‘unfit and overweight/obese’ group, HRs (95% CIs) for restrictive spirometry pattern were 1.35 (0.98–1.85), 0.77 (0.63–0.96), and 0.70 (0.56–0.87) in the ‘unfit and normal weight,’ ‘fit and overweight/obese,’ and ‘fit and normal weight’ groups, respectively. …”
Publicado 2023
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83660por Shen, Qing, Mikkelsen, Dorte Helenius, Luitva, Laura Birgit, Song, Huan, Kasela, Silva, Aspelund, Thor, Bergstedt, Jacob, Lu, Yi, Sullivan, Patrick F., Ye, Weimin, Fall, Katja, Tornvall, Per, Pawitan, Yudi, Andreassen, Ole A., Buil, Alfonso, Milani, Lili, Fang, Fang, Valdimarsdóttir, Unnur“…Compared with their siblings, patients with psychiatric disorders experienced higher rates of CVD during the first year after diagnosis (hazard ratio [HR], 1.88; 95% confidence interval [CI], 1.79–1.98) and thereafter (1.37; 95% CI, 1.34–1.39). …”
Publicado 2023
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