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  1. 83641
    “…Patients receiving opioid infusions greater than or equal to 72 hours, or a total daily fentanyl dose of greater than or equal to 1,200 μg (~ 50 μg/hr) are at a higher risk for developing IWS and should be monitored as part of clinical practice when opioid infusions are discontinued.…”
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    Prevalence and Risk Factors for Iatrogenic Opioid Withdrawal in Medical Critical Care Patients
  2. 83642
    “…The presence of the CDKN2A/2B deletions clearly correlated with inferior outcomes within all protocol-defined risk groups (standard risk (SR): EFS 66.7% vs. 100%, p < 0.001, intermediate risk (IR): EFS 77.1% vs. 97.9%, p < 0.001, high risk (HR): EFS 42.1% vs. 70.5% p < 0.001 for deleted vs non-deleted cases in each patient risk group); additionally, in this study, the presence of the deletion differentiated prognosis within both MRD-positive and -negative subgroups on days 15 and 33 of induction. …”
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    The Prognostic Effect of CDKN2A/2B Gene Deletions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM-Based Protocols
  3. 83643
    “…Median PFS was 4.0 months (95% CI, 2.8-5.3 months) in the panitumumab plus trifluridine-tipiracil arm vs 2.5 months (95% CI, 1.4-3.6 months) in the trifluridine-tipiracil only (hazard ratio [HR], 0.48; 95% CI, 0.28-0.82; P = .007). Pretreatment plasma RAS/BRAF WT ctDNA identified patients obtaining prolonged clinical benefit with panitumumab plus trifluridine-tipiracil compared with trifluridine-tipiracil, with PFS rates at 6 months of 38.5% vs 13.0% and at 12 months of 15.4% vs 0%. …”
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    Panitumumab Plus Trifluridine-Tipiracil as Anti–Epidermal Growth Factor Receptor Rechallenge Therapy for Refractory RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial
  4. 83644
    “…In the univariate analysis, the Hazard ratio (HR, [95% confidence interval]) increased incrementally from 1.03 [0.90 to 1.18], 1.28 [1.10 to 1.49], 1.43 [1.17 to 1.74] in overweight to morbidly obese respectively (Figure 2). …”
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    5 years incident stroke, heart failure, acute myocardial infarction, and death in patients having undergone atrial fibrillation ablation according to BMI
  5. 83645
    “…In the adjusted analysis, ICD-10 or SNOMED coded diagnosis of AF was not significantly different between groups (HR: 0.88 [95% CI 0.70-1.10]; p-value=0.3). Stroke rates in the total cohort (with or without AF) were 5.7% in the VR ICD and 3.4% in the DR ICD cohort at 36 months. …”
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    Atrial fibrillation diagnosis in patients with single- and dual chamber ICD devices in England: a real-world cohort study
  6. 83646
    “…The presence of 2 and 3 positive LP represented an additionally 4.7-fold increased risk of MAE during follow-up (HR 4.693, 95% CI 1.506-14.624, p = 0.008) – figure 2. …”
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    Late potentials assessment - an useful tool for Brugada Syndrome risk stratification
  7. 83647
    “…The average number of syncope events per year per patient prior to the procedure was 5 ±3. The mean HR on Holter Pre CNA was 65 ± 12 and 72 ± 9 post CNA. …”
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    Head up tilt test response patterns in patients undergoing cardioneuroablation
  8. 83648
    “…HCV treatment was associated with a lower relative hazard for discharge/drop-out, although results did not meet statistical significance (aHR = 0.59;95% CI: 0.34–1.00; p = 0.052). Among the subset of 84 patients retained in OBOT at least 100 days, 18 received HCV treatment during that period. …”
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    Timing of hepatitis C treatment initiation and retention in office-based opioid treatment with buprenorphine: a retrospective cohort study
  9. 83649
    “…Moderate to severe hypogammaglobulinaemia was observed more frequently in patients with vasculitis (35%) than with RA (13%) or CTD (9%) and was associated with an increased risk of presenting a first infectious SAE (HR 2.01, 95% CI 1.04 to 3.91). The incidence rate of SAE was 23.3 SAE/100 patient-years (36% were infectious). …”
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    Real-life drug retention rate and safety of rituximab when treating rheumatic diseases: a single-centre Swiss retrospective cohort study
  10. 83650
    “…Cox regression analysis showed that shift work was associated with higher risk of all-cause mortality (hazard ratio [HR], 1.48; 95% CI, 1.07–2.06) compared with non-shift workers. …”
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    Association of shift work and dietary inflammatory potential with all-cause death among us hypertensive population: national health and nutrition examination study, 2005–2010
  11. 83651
    “…At a median follow-up period of 2.8 years, the primary endpoint occurred in 8.3% in PCI group and 20.8% in CABG group, respectively (HR 3.80; 95% CI 1.04–13.9; p = 0.043). There was no difference in each component of the primary event (p > 0.05 for all). …”
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    Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry
  12. 83652
    “…With a median clinical follow-up of 26 months, vWF:Ag interrogated as a continuous variable was significantly associated with PFS in univariate and multivariate analysis (HR=1.04; p=0.007). Lower values of vWF:Ag at baseline were observed in the primary responders group (median: 29.4 µg/mL vs 32.9 µg/mL; p=0.048) when compared with primary resistant patients. …”
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    Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors
  13. 83653
    “…There was no statistically significant difference in RVO risk between the anti-VEGF and control groups (HR: 2.21, 95% CI: 0.87–5.61). CONCLUSION: Our results indicated no association between use of anti-VEGF and occurrence of RVO among CRC patients, although the crude incidence rate of RVO was higher in patients receiving anti-VEGF, compared to control patients. …”
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    Risk of retinal vein occlusion in colorectal cancer patients receiving anti-vascular endothelial growth factors – a population-based cohort study
  14. 83654
    “…After adjusting for confounding factors in the Cox survival analysis, the risk of death within 30 days after discharge was significantly higher in the real ARDS group than in the non-ARDS group (hazard ratio(HR): 4.633, 95% CI: 1.012–21.202, P < 0.05). CONCLUSION: Preoperative hypoxemia is an independent risk factor for post-operative simple hypoxemia and ARDS. …”
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    Effect of pre-operative hypoxemia on the occurrence and outcomes of post-operative ARDS in Stanford type a aortic dissection patients
  15. 83655
    por Mekinian, Arsène, Biard, Lucie, Lorenzo, Dagna, Novikov, Pavel I, Salvarani, Carlo, Espitia, Olivier, Sciascia, Savino, Michaud, Martin, Lambert, Marc, Hernández-Rodríguez, José, Schleinitz, Nicolas, Awisat, Abid, Puechal, Xavier, Aouba, Achille, Munoz Pons, Helene, Smitienko, Ilya, Gaultier, Jean Baptiste, Edwige, Le Mouel, Benhamou, Ygal, Perlat, Antoinette, Jego, Patrick, Goulenok, Tiphaine, Sacre, Karim, Lioger, Bertrand, Hassold, Nolan, Broner, Jonathan, Dufrost, Virginie, Sené, Thomas, Seguier, Julie, Maurier, Francois, Berthier, Sabine, Belot, Alexandre, Frikha, Faten, Denis, Guillaume, Audemard-Verger, Alexandra, Koné-Paut, Isabelle, Humbert, Sebastien, Woaye-Hune, Pascal, Tomelleri, Alessandro, Baldissera, Elena Marina, Kuwana, Masataka, Lo Gullo, Alberto, Mukuchyan, Vahan, Dellal, Azeddine, Gaches, Francis, Zeminsky, Pierre, Galli, Elena, Alvarado, Moya, Boiardi, Luigi, Francesco, Muratore, Vautier, Mathieu, Campochiaro, Corrado, Moiseev, Sergey, Vieira, Matheus, Cacoub, Patrice, Fain, Olivier, Saadoun, David
    Publicado 2023
    “…During the median follow-up of 30.1 months (0.4; 105.8) and 10.8 (0.1; 46.4) (p<0.0001) in patients who received tocilizumab in intravenous and SC forms, respectively, the risk of relapse was significantly higher in TAK patients on SC tocilizumab (HR=2.55, 95% CI 1.08 to 6.02; p=0.033). The overall cumulative incidence of relapse at 12 months in TAK patients was at 13.7% (95% CI 7.6% to 21.5%), with 10.3% (95% CI 4.8% to 18.4%) for those on intravenous tocilizumab vs 30.9% (95% CI 10.5% to 54.2%) for patients receiving SC tocilizumab. …”
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    Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study
  16. 83656
    “…P16 expression was associated with shorter PFS (HR = 5.88, 95 CI [1.56–25], p = 0.009). Transcriptomic analyzes revealed a specific transcriptomic profile notably with a high expression of immune response-associated genes in uterine CCC displaying a very good overall prognosis. …”
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    Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma: a retrospective national study from TMRG and GINECO network
  17. 83657
    “…The survival time was shorter in SPICT positive patients than in SPICT negative ones (p < 0.001), the former having a higher 1-year mortality rate (HR = 4.21; p < 0.001). CONCLUSIONS: SPICT successfully identifies older patients at high risk of health degradation and death. …”
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    SPICT as a predictive tool for risk of 1-year health degradation and death in older patients admitted to the emergency department: a bicentric cohort study in Belgium
  18. 83658
    “…Patients with 1–5 total metastatic lesions had a significantly longer median OS of 24.3 months compared to those with greater than 5 total metastatic lesions with a median OS of 12.2 months (P < 0.001; multivariate HR 0.55, 95% CI, 0.43–0.72). Among the patients with 1–5 metastatic lesions, median OS for GPA 0–1.0 was 9.8 months, compared to 22.8, 28.8 and 71.0 for GPA 1.5–2.0, 2.5–3.0 and 3.5–4.0 respectively, which is much longer than the corresponding patients with greater than 5 total metastatic lesions, with medium OS of 6.8, 11.6, 18.6 and 42.6 months respectively for GPA 0–1.0, 1.5–2.0, 2.5–3.0 and 3.5–4.0. …”
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    Favorable prognosis of breast cancer brain metastases patients with limited intracranial and extracranial metastatic lesions
  19. 83659
    “…However, the association between obesity and restrictive spirometry pattern was attenuated when additionally adjusting for cardiorespiratory fitness (HR: 1.08, 95% CI: 0.84–1.39). Compared to the ‘unfit and overweight/obese’ group, HRs (95% CIs) for restrictive spirometry pattern were 1.35 (0.98–1.85), 0.77 (0.63–0.96), and 0.70 (0.56–0.87) in the ‘unfit and normal weight,’ ‘fit and overweight/obese,’ and ‘fit and normal weight’ groups, respectively. …”
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    Associations of Cardiorespiratory Fitness and Body Mass Index with Incident Restrictive Spirometry Pattern
  20. 83660
    “…Compared with their siblings, patients with psychiatric disorders experienced higher rates of CVD during the first year after diagnosis (hazard ratio [HR], 1.88; 95% confidence interval [CI], 1.79–1.98) and thereafter (1.37; 95% CI, 1.34–1.39). …”
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    Psychiatric disorders and subsequent risk of cardiovascular disease: a longitudinal matched cohort study across three countries
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