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83661por Yuan, Huiyang, Qin, Xin, Yang, Qingya, Liu, Li, Fang, Zhiqing, Fan, Yidong, Xu, Dawei“…However, DKC1 rather than TERC acted as an independent predictor (P < 0.001, HR = 2.0, 95% CI 1.480–2.704). In male patients, DKC1 expression was associated with neither Sunitinib response (P = 0.131) nor PFS (P = 0.184), while higher TERC levels did not predict response rates. …”
Publicado 2023
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83662por Lan, Yulong, Wu, Dan, Cai, Zhiwei, Xu, Yuancheng, Ding, Xiong, Wu, Weiqiang, Lan, Shaocong, Chen, Lan, Guo, Zheng, Balmer, Lois, Li, Xingang, Song, Manshu, Wu, Shouling, Gao, Jingli, Wang, Wei, Chen, Youren“…Compared to CumAIP < -0.0699 and CumCRP < 1 mg/L, co-exposure to CumAIP ≥ − 0.0699 and CumCRP ≥ 3 mg/L had a significant hazard ratio (HR) [2.55 (2.23–2.92)] after adjusting for socio-demographic, life-style factors, family history of diabetes, blood pressure, renal function and medication use. …”
Publicado 2023
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83663“…Furthermore, Cox regression showed that high baseline CSF GFAP levels were associated with a high risk of developing dementia over an 8-year period in the PD–NC group (adjusted HR = 3.070, 95% CI 1.119–8.418, p = 0.029). In addition, the baseline CSF GFAP was positively correlated with the longitudinal changes of not only CSF α-synuclein (β = 0.313, p < 0.001), but also CSF biomarkers associated with AD, namely, amyloid-β 42 (β = 0.147, p = 0.034), total tau (β = 0.337, p < 0.001) and phosphorylated tau (β = 0.408, p < 0.001). …”
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83664“…In the fully adjusted model, per 1.0-SD increment in CVAI has a significant increased risk of incident stroke: hazard ratio (HR) [95% confidence interval (CI)] was 1.17 (1.07–1.28); compared with participants in Q1 of CVAI, the HRs (95% CI) of incident stroke among those in Q2–4 were 1.47 (1.10–1.95), 1.62 (1.22–2.15), and 1.70 (1.28–2.27), respectively. …”
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83665por Koh, Sky Wei Chee, Ng, Tracy Si Min, Loh, Victor Weng Keong, Goh, Jun Cong, Low, Si Hui, Tan, Wei Zhi, Wong, Hung Chew, Durai, Pradeep, Sun, Louisa Jin, Young, Doris, Tambyah, Paul Anantharajah“…Among 1894 patients treated with AC + N matched to 947 patients treated with C + C, patients treated with C + C were 50% more likely to fail treatment (RR 1.49, 95% CI 1.10–2.01), with significantly higher risk of experiencing shorter time to failure (HR 1.61, 95% CI 1.12–2.33), compared to patients treated with AC + N. …”
Publicado 2023
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83666por Lin, Kun-Pei, Li, Hsin-Yi, Chen, Jen-Hau, Lu, Feng-Ping, Wen, Chiung-Jung, Chou, Yi-Chun, Wu, Meng-Chen, (Derrick) Chan, Ding-Cheng, Chen, Yung-Ming“…In multivariable models adjusted for age and sex, the increased risk of all three events combined in the high- vs. low-risk group remained significant (adjusted hazard ratio (aHR) = 3.08, 95% confidence interval (CI): 1.87–5.07). …”
Publicado 2023
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83667por Rajendrakumar, Aravind Lathika, Hapca, Simona M., Nair, Anand Thakarakkattil Narayanan, Huang, Yu, Chourasia, Mehul Kumar, Kwan, Ryan Shun-Yuen, Nangia, Charvi, Siddiqui, Moneeza K., Vijayaraghavan, Prathiba, Matthew, Shona Z., Leese, Graham P., Mohan, Viswanathan, Pearson, Ewan R., Doney, Alexander S. F., Palmer, Colin N. A.“…NLR was associated with incident DR in both Cause-specific hazard (CSH = 1.63; 95% CI: 1.28–2.07) and FGR models the subdistribution hazard (sHR = 2.24; 95% CI: 1.70–2.94). Both age and HbA(1c) were found to modulate the association between NLR and the risk of DR. …”
Publicado 2023
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83668por Wang, Jianing, Wu, Yajing, Zhang, Wei, Chen, Yujia, Liu, Qing, Jing, Shaowu, Zhang, Jiandong, Wu, Fengpeng, Wang, Jun, Qiao, Xueying“…The median OS, 1-, 3-, 5-, and 8-year OS rates for ENI and IFI group were 32.0 months, 83.7%, 48.5%, 38.5% and 31.1% versus 45.2 months, 89.8%, 52.5%, 37.5%, 26.1%, respectively (P = 0.966; HR 0.99, 95% CI 0.61–1.61). Similar locoregional control was obtained in both groups. …”
Publicado 2023
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83669por Park, Song Ee, Kim, Du Hwan, Kim, Don-Kyu, Ha, Joo Young, Jang, Joung-Soon, Choi, Jin Hwa, Hwang, In Gyu“…The good compliance group had a significantly longer median OS compared with the poor compliance group (25.3 months vs. 7.9 months, HR = 0.306, 95% CI = 0.120–0.784, p = 0.014). The QoL showed a better score for insomnia (p = 0.042). …”
Publicado 2023
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83670“…The weighted polygenic risk score was calculated based on risk variants associated with NAFLD. Hazard ratios (HR) and 95% confidential intervals (CI) were estimated by Cox proportional hazards model. …”
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83671por Badar, Talha, Vanegas, Yenny A. Moreno, Nanaa, Ahmad, Foran, James M., Al-Kali, Aref, Mangaonkar, Abhishek, Murthy, Hemant, Alkhateeb, Hassan B., Viswanatha, David, He, Rong, Shah, Mithun, Yi, Cecilia Arana, Litzow, Mark R., Gangat, Naseema, Tefferi, Ayalew, Patnaik, Mrinal M.“…OS was favorably affected by allogeneic hematopoietic stem cell transplantation (HR: 0.16, 95% CI; 0.04-0.61, P = 0.007). The current study defines the prevalence and co-mutational profiles of U2AF1 pathogenic variants in AML, MDS/AML, MDS, and CCUS, and suggests prognostic heterogeneity in patients with ≥10% blasts.…”
Publicado 2023
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83672por Alifu, Jiasuer, Xiang, Lanqing, Zhang, Wen, Qi, Penglong, Chen, Huiying, Liu, Lu, Yin, Guoqing, Mohammed, Abdul-Quddus, Lv, Xian, Shi, Tingting, Abdu, Fuad A., Che, Wenliang“…Furthermore, the multivariate Cox regression analysis demonstrated that individuals in the Q4 group had a 7.892-fold increased risk of MACE compared to those in the Q1 group (adjusted HR, 7.892; 95% CI 1.818–34.269; P = 0.006). Additionally, the ROC curve analysis revealed an optimal AIP cut-off value of 0.24 for predicting clinical MACE in patients with CCS. …”
Publicado 2023
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83673“…The Kaplan–Meier survival analysis revealed that patients with a high-risk score, which was predicted by the six-gene signature model, had poor prognoses (log-rank test p < 0.001; HR = 1.83). The patients with HCC were grouped into three distinct cuproptosis subtypes (Cu-clusters A, B, and C) based on the expression pattern of cuproptosis regulator genes. …”
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83674por Yoon, Dongwon, Jeong, Han Eol, Park, Sohee, You, Seng Chan, Bang, Soo-Mee, Shin, Ju-Young“…The emulated estimates for effectiveness outcomes showed superior effectiveness of NOAC (AMPLIFY: relative risk 0.81, 95% confidence interval 0.70–0.94; RE-COVER II: hazard ratio [HR] 0.60, 0.37–0.96; Hokusai-VTE: 0.49, 0.31–0.78; EINSTEIN-DVT: 0.54, 0.33–0.89; EINSTEIN-PE: 0.50, 0.34–0.74), when contrasted with trials that showed non-inferiority. …”
Publicado 2023
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83675por Gopinath, Chaitra, Pagadala, Prathyusha, Choudhary, Chitra, Tilden, Daniel Robert“…Dexamethasone suppression testing revealed elevated cortisol of 26.7 mcg/dl, AM cortisol -44.7mcg/dl (6.7-22.6mcg/dl),ACTH-280 pg/mL(7-63 pg/mL),24 hour urine free cortisol was elevated 2065 mcg/24 hour(3.5-45 mcg/24 hr). Given initial negative ACTH staining on the macroadenoma, there was concern for ectopic ACTH given acute presentation and absence of growth on the MRI compared to post radiation scans. …”
Publicado 2023
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83676“…BMI 23.7. Vitals: BP 184/104, HR 110. Labs: blood glucose was 439 mg/dL (n=70-99), CO2 23 mEq/L (n=21-31), AG 12 mmol/L (n=4-11), Beta-Hydroxybutyrate/Acetate 2.0 mmol/L (n=0.1-0.3), venous pH 7.36 (n=7.35-7.45). …”
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83677por Fariduddin, Maria, Perez, Julienne Sanchez, Syed, Uzma Naeem, Eisenberg, Yuval, Sargis, Robert Michael“…ACTH level was 312 pg/mL (7.2 - 63.3) and 24-hr urine cortisol was 3586 ug/dL (<= 60.0). Abdominopelvic CT showed new bilateral adrenal thickening without discrete nodularity or mass. …”
Publicado 2023
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83678por Hernandez, Natalia, Askar, Esraa, Fredrick, Jason Regis, Schulman-Rosenbaum, Rifka C“…Initial 8AM cortisol was 41 ug/dL (6.8-18.4 ug/dL) and 24 hr urine cortisol was 2327 mcg/24 h (3.5-45 mcg/24 h) which proved the diagnosis of ACTH-dependent hypercortisolemia. …”
Publicado 2023
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83679“…Additional screening tests included: 24 hour urine cortisol collection of 32 ug/24hr but volume not reported and late-night salivary cortisol (LNSC) of >0.1 ug/dL. …”
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83680“…Initial tests were consistent with ACTH-dependent CS: elevated cortisol PM: 18.2 (n <10ug/dL) and LNSC 0.58 and 0.64 mcg/dl (n <0.09), 24-hr UFC 264 (n <50 mcg/dl), abnormal ACTH 150 (n <50 pg/ml).Brain MRI revealing extra-axial mass of 1.6 x1.1 cm overlying posterior aspect of right cerebellar hemisphere and focal lesion in left prepontine cistern of 0.8 cm. …”
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