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83741“…First, a group of humanized mice was infused with 5 million GAD65 specific CAR-M/N Tregs co-expressing GFP, 24 hr before sacrifice. CAR Treg cells were then processed into single cell suspensions and tracked in peripheral blood, pancreas (PN), peri-pancreatic lymph nodes (PLN), and spleen using flow cytometry. …”
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83742por Singarayar, Carolina, Rajakumar, Radhamani, Kamaruddin, Nor, Sukor, Norlela, Rahmatullah, Ijaz, Rahim, Anilah, Wahab, Norasyikin“…A diagnosis of ACTH dependent CS was made based on elevated 24h urinary cortisol (1122 and 2448nmol/24hr, n<150-800), midnight cortisol (1322nmol/L, n<220nmol/L) and a detectable ACTH level (18.8pg/mL, n<10pg/mL). …”
Publicado 2019
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83743por Santoro, Nanette, Constantine, Ginger, Kagan, Risa, Graham, Shelli, Bernick, Brian, Mirkin, Sebastian“…In the REPLENISH trial, the oral 17β-estradiol/progesterone (E2/P4) softgel capsule (TX-001HR; 1 mg E2/100 mg P4 FDA approved as BIJUVA(TM); TherapeuticsMD, Boca Raton, FL), was shown to reduce moderate to severe hot flush frequency and severity and improve quality of life outcomes in menopausal women with a uterus, while protecting the endometrium. …”
Publicado 2019
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83744por Mallappa, Ashwini, Lao, Qizong, Lokhmatova, Kira, Veeraraghavan, Padmasree, Merke, Deborah“…Further workup (holding fludrocortisone for 48hrs) showed mildly elevated plasma renin activity 3.5 ng/mL/hr (0.8 - 2), low aldosterone 1.8 ng/dL (3.5 - 124), normal 18-hydroxycorticosterone 11 ng/dL (6 - 85). 18-hydroxycorticosterone/aldosterone ratio 6.1 (ratio <10) - suggesting the diagnosis of CMO type I deficiency (1). …”
Publicado 2019
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83745por Garcia Reyes, Yesenia, Carreau, Anne-Marie, Rahat, Haseeb, Nadeau, Kristen, Cree-Green, Melanie“…Fasting lipids and hormones were measured followed by a frequently-sampled 6-hr oral sugar tolerance test (OSTT, 75g glucose +25g fructose). …”
Publicado 2019
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83746“…Biochemical testing suggested ACTH-independent CS: elevated cortisol 33.79 ug/dL (4.30-22.40ug/dL), abnormal 1 mg dexamethasone suppression test (DST) cortisol 33.59 ug/dL (4.30-22.40ug/dL), ACTH undetectable <5 pg/mL (7.2-63 pg/mL), low-dose 48hr DST cortisol 37.21 ug/dL (4.30-22.40 ug/dL), normal metanephrine < 0.20 nmol/L (<0.50 nmol/L), normal normetanephrine 0.41 nmol/L (<0.90 nmol/L), aldosterone < 4.0 ng/dL (n < 21 ng/dL). …”
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83747“…Pathology was compatible with benign parathyroid adenoma. PTH within 1hr post op was 171 pg/ml, 24 hrs later was 22pg/ml. …”
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83748por Lightbourne, Marissa, Wolska, Anna, Remaley, Alan, Walter, Mary, Muniyappa, Ranganath, Rother, Kristina, Brown, Rebecca“…Samples were incubated with bovine LPL, and NEFA produced was measured enzymatically over 1hr at 37⁰C. Because the concentrations of added LPL and TG were equal in each patient sample, NEFA generation (nmole) reflected the net effect of LPL stimulators and inhibitors in plasma. …”
Publicado 2019
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83749por Grewal, Shivraj, Sharma, Susmeeta, McGlotten, Raven, Muniyappa, Ranganath, Nieman, Lynnette“…Design: We conducted a randomized, placebo-controlled, double-blind, crossover trial of mifepristone (50 mg orally, every six hr) in overweight/obese subjects (BMI 25-37 kg/m(2)), with abnormal glucose tolerance (n=16, women=7). …”
Publicado 2019
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83750por Phan, Qui Tu, Phung, Lam Khanh, Truong, Khanh Huu, Huynh, Trieu Trung, Phạm, Giang Thanh, Nguyen, Bich Ngọc, Tran, Quyen Thanh, Huynh, Vuong Ngoc Thien, Nguyen, Tien Thi My, Le, Thoa Phan Kim, Le, Nhan Nguyen Thanh, Sabanathan, Saraswathy, van Doorn, H. Rogier, Van Le, Tan, Nguyen, Toan Duc, Merson, Laura, Nguyen, Dung Thi Phuong, Geskus, Ronald, Nguyen, Hung Thanh, Nguyen, Chau Van Vinh, Wills, Bridget“…CONCLUSION: Although we could not demonstrate efficacy in these studies, there were no safety signals associated with use of 30-50 mg/kg/hr. MgSO(4) in severe HFMD. Intermittent outbreaks of HFMD are likely to continue across the region, and an adequately powered trial is still needed to evaluate use of MgSO(4) in controlling hypertension in severe HFMD, potentially involving a higher dose regimen. …”
Publicado 2019
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83751por Chen, Feier, Qu, Meng, Zhang, Feng, Tan, Zhenyu, Xia, Qinghua, Hambly, Brett D., Bao, Shisan, Tao, Kun“…Multivariate analysis demonstrated that among IL-36α, IL-36β and IL-36γ, only IL-36α (HR, 0.37; 95% CI, 0.16–0.87; P = 0.02) was an independent factor in survival, using Cox proportional hazards regression analysis. …”
Publicado 2020
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83752por Barone Gibbs, Bethany, Paley, Joshua L., Jones, Melissa A., Whitaker, Kara M., Connolly, Christopher P., Catov, Janet M.“…Self-report questionnaires had large absolute error and wide limits of agreement for SED hr./day; SB2D measurement of SED% was the best self-report method. …”
Publicado 2020
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83753por Liew, Seaw Jia, Gorny, Alex Wilhelm, Tan, Chuen Seng, Müller-Riemenschneider, Falk“…In phase 1, everyone wore a Fitbit tracker (Charge or Charge HR) and an ActiGraph for 7 days to compare daily step count estimated by the two devices under free-living conditions. …”
Publicado 2020
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83754por Nyenhuis, Sharmilee M, Balbim, Guilherme Moraes, Ma, Jun, Marquez, David X, Wilbur, JoEllen, Sharp, Lisa K, Kitsiou, Spyros“…The supplemental mHealth tools included a wearable activity tracker device (Fitbit Charge HR) and one-way text messages related to PA and asthma 3 times per week. …”
Publicado 2020
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83755por Cheng, Guang-Shing, Stednick, Zach J., Madtes, David K., Boeckh, Michael, McDonald, George B., Pergam, Steven A.“…Patients in the 2003 to 2007 cohort were less likely to undergo a lung biopsy (adjusted HR, .50; 95% CI, .29 to .83; P = .008) when compared with patients in the early cohort, but more patients in the early cohort underwent lung biopsy without antecedent bronchoscopy (25/54 [46%] versus 3/25 [12%], P = .005). …”
Publicado 2016
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83756por Fogagnolo, Alberto, Taccone, Fabio Silvio, Vincent, Jean Louis, Benetto, Giulia, Cavalcante, Elaine, Marangoni, Elisabetta, Ragazzi, Riccardo, Creteur, Jacques, Volta, Carlo Alberto, Spadaro, Savino“…RESULTS: Patients managed with an “appropriate” strategy had lower mortality rates (23/96 [24%] vs. 36/81 [44%]; p = 0.004), and an “appropriate” strategy was independently associated with reduced mortality (hazard ratio [HR] 0.51 [95% CI 0.30–0.89], p = 0.01). There was a trend to less acute kidney injury with the “appropriate” than with the “inappropriate” strategy (13% vs. 26%, p = 0.06), and the Sequential Organ Failure Assessment (SOFA) score decreased more rapidly (p = 0.01). …”
Publicado 2020
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83757por Langdon, Ryan J., Beynon, Rhona A., Ingarfield, Kate, Marioni, Riccardo E., McCartney, Daniel L., Martin, Richard M., Ness, Andy R., Pawlita, Michael, Waterboer, Tim, Relton, Caroline, Thomas, Steven J., Richmond, Rebecca C.“…DNAm prediction of smoking was most consistently associated with mortality risk (hazard ratio [HR], 1.38 per standard deviation (SD) increase in smoking DNAm score; 95% confidence interval [CI] 1.04 to 1.83; P 0.025, in a model adjusted for demographic, lifestyle, health and biological variables). …”
Publicado 2020
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83758por Vieira, Luane da Guia, Fernandes, Alan Carlos, Nascimento, Tais, França, Suzelei de Castro, Antunes-Rodrigues, Jose, Vella, Kristen R, Elias, Lucila, Rorato, Rodrigo“…Two weeks later the animals were fasted for 36hr, treated with saline (5 i.p. injections each 8hrs) and blood samples were collected from the facial vein at 10am. …”
Publicado 2020
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83759por Babar, Ghufran S“…In the ED, the child was in a compensated shock and had a low normal BP: 76/35, HR: 169/min and fast breathing R/R: 80/minute and afebrile. …”
Publicado 2020
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83760por Ferreira, Joana Lima, Costa, Cláudia Fernandes, Castro, Sofia, Oliveira, Joana, Santos, Ana Paula, Sampaio, Inês Lucena, Duarte, Hugo, Torres, Isabel“…The risk of mortality was higher for the control group, approximately 3 times, considering the adjustment for the covariates (HR 2.94, 95%CI=1.18 to 7.34, p=0.021). Overall survival was not affected by the covariates. …”
Publicado 2020
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