“…First, a group of humanized mice was infused with 5 million GAD65 specific CAR-M/N Tregs co-expressing GFP, 24 hr before sacrifice. CAR Treg cells were then processed into single cell suspensions and tracked in peripheral blood, pancreas (PN), peri-pancreatic lymph nodes (PLN), and spleen using flow cytometry. …”
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“…A diagnosis of ACTH dependent CS was made based on elevated 24h urinary cortisol (1122 and 2448nmol/24hr, n<150-800), midnight cortisol (1322nmol/L, n<220nmol/L) and a detectable ACTH level (18.8pg/mL, n<10pg/mL). …”
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“…In the REPLENISH trial, the oral 17β-estradiol/progesterone (E2/P4) softgel capsule (TX-001HR; 1 mg E2/100 mg P4 FDA approved as BIJUVA(TM); TherapeuticsMD, Boca Raton, FL), was shown to reduce moderate to severe hot flush frequency and severity and improve quality of life outcomes in menopausal women with a uterus, while protecting the endometrium. …”
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“…Further workup (holding fludrocortisone for 48hrs) showed mildly elevated plasma renin activity 3.5 ng/mL/hr (0.8 - 2), low aldosterone 1.8 ng/dL (3.5 - 124), normal 18-hydroxycorticosterone 11 ng/dL (6 - 85). 18-hydroxycorticosterone/aldosterone ratio 6.1 (ratio <10) - suggesting the diagnosis of CMO type I deficiency (1). …”
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“…Fasting lipids and hormones were measured followed by a frequently-sampled 6-hr oral sugar tolerance test (OSTT, 75g glucose +25g fructose). …”
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“…Biochemical testing suggested ACTH-independent CS: elevated cortisol 33.79 ug/dL (4.30-22.40ug/dL), abnormal 1 mg dexamethasone suppression test (DST) cortisol 33.59 ug/dL (4.30-22.40ug/dL), ACTH undetectable <5 pg/mL (7.2-63 pg/mL), low-dose 48hr DST cortisol 37.21 ug/dL (4.30-22.40 ug/dL), normal metanephrine < 0.20 nmol/L (<0.50 nmol/L), normal normetanephrine 0.41 nmol/L (<0.90 nmol/L), aldosterone < 4.0 ng/dL (n < 21 ng/dL). …”
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“…Pathology was compatible with benign parathyroid adenoma. PTH within 1hr post op was 171 pg/ml, 24 hrs later was 22pg/ml. …”
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“…Samples were incubated with bovine LPL, and NEFA produced was measured enzymatically over 1hr at 37⁰C. Because the concentrations of added LPL and TG were equal in each patient sample, NEFA generation (nmole) reflected the net effect of LPL stimulators and inhibitors in plasma. …”
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“…Design: We conducted a randomized, placebo-controlled, double-blind, crossover trial of mifepristone (50 mg orally, every six hr) in overweight/obese subjects (BMI 25-37 kg/m(2)), with abnormal glucose tolerance (n=16, women=7). …”
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“…CONCLUSION: Although we could not demonstrate efficacy in these studies, there were no safety signals associated with use of 30-50 mg/kg/hr. MgSO(4) in severe HFMD. Intermittent outbreaks of HFMD are likely to continue across the region, and an adequately powered trial is still needed to evaluate use of MgSO(4) in controlling hypertension in severe HFMD, potentially involving a higher dose regimen. …”
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“…Multivariate analysis demonstrated that among IL-36α, IL-36β and IL-36γ, only IL-36α (HR, 0.37; 95% CI, 0.16–0.87; P = 0.02) was an independent factor in survival, using Cox proportional hazards regression analysis. …”
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“…Self-report questionnaires had large absolute error and wide limits of agreement for SED hr./day; SB2D measurement of SED% was the best self-report method. …”
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“…In phase 1, everyone wore a Fitbit tracker (Charge or Charge HR) and an ActiGraph for 7 days to compare daily step count estimated by the two devices under free-living conditions. …”
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“…The supplemental mHealth tools included a wearable activity tracker device (Fitbit Charge HR) and one-way text messages related to PA and asthma 3 times per week. …”
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“…Patients in the 2003 to 2007 cohort were less likely to undergo a lung biopsy (adjusted HR, .50; 95% CI, .29 to .83; P = .008) when compared with patients in the early cohort, but more patients in the early cohort underwent lung biopsy without antecedent bronchoscopy (25/54 [46%] versus 3/25 [12%], P = .005). …”
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“…RESULTS: Patients managed with an “appropriate” strategy had lower mortality rates (23/96 [24%] vs. 36/81 [44%]; p = 0.004), and an “appropriate” strategy was independently associated with reduced mortality (hazard ratio [HR] 0.51 [95% CI 0.30–0.89], p = 0.01). There was a trend to less acute kidney injury with the “appropriate” than with the “inappropriate” strategy (13% vs. 26%, p = 0.06), and the Sequential Organ Failure Assessment (SOFA) score decreased more rapidly (p = 0.01). …”
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“…DNAm prediction of smoking was most consistently associated with mortality risk (hazard ratio [HR], 1.38 per standard deviation (SD) increase in smoking DNAm score; 95% confidence interval [CI] 1.04 to 1.83; P 0.025, in a model adjusted for demographic, lifestyle, health and biological variables). …”
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“…Two weeks later the animals were fasted for 36hr, treated with saline (5 i.p. injections each 8hrs) and blood samples were collected from the facial vein at 10am. …”
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“…In the ED, the child was in a compensated shock and had a low normal BP: 76/35, HR: 169/min and fast breathing R/R: 80/minute and afebrile. …”
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“…The risk of mortality was higher for the control group, approximately 3 times, considering the adjustment for the covariates (HR 2.94, 95%CI=1.18 to 7.34, p=0.021). Overall survival was not affected by the covariates. …”
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