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83901por Lumlertgul, Nuttha, Wright, Rebeka, Hutson, Gareth, Milicevic, Jovana Kusic, Vlachopanos, Georgios, Lee, Ken Cheah Hooi, Pirondini, Leah, Gregson, John, Sanderson, Barnaby, Leach, Richard, Camporota, Luigi, Barrett, Nicholas A., Ostermann, Marlies“…Patients who received RRT had a higher risk of 1-year mortality than those who did not receive RRT (adjusted HR 1.80, 95% CI 1.06, 3.06; p = 0.029). ESKD occurred in 3 patients, all of whom were in the AKI-RRT group. …”
Publicado 2022
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83902por Guha, Indranil, Zhang, Xiaoliu, Rajapakse, Chamith S., Chang, Gregory, Saha, Punam K.“…Finite element (FE) modeling is used to estimate trabecular bone (Tb) modulus from high‐resolution three‐dimensional (3‐D) imaging modalities including micro‐computed tomography (CT), magnetic resonance imaging (MRI), and high‐resolution peripheral quantitative CT (HR‐pQCT). This paper validates an application of voxel‐based continuum finite element analysis (FEA) to predict Tb modulus from clinical CT imaging under a condition similar to in vivo imaging by comparing with measures derived by micro‐CT and experimental approaches. …”
Publicado 2022
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83903por Shamekhi, Jasmin, Nguyen, Thi Quynh Anh, Sigel, Helen, Maier, Oliver, Piayda, Kerstin, Zeus, Tobias, Al-Kassou, Baravan, Weber, Marcel, Zimmer, Sebastian, Sugiura, Atsushi, Wilde, Nihal, Kelm, Malte, Nickenig, Georg, Veulemans, Verena, Sedaghat, Alexander“…A lower LAFI has been identified as independent predictor of mortality in multivariate analysis (HR (95% CI) 2.0 (1.1–3.9); p = 0.03). CONCLUSION: A reduced LAFI is associated with adverse outcome and an independent predictor of mortality in TAVR patients. …”
Publicado 2022
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83904por Székely, Edina Gabriella, Orbán-Kálmándi, Rita, Szegedi, István, Katona, Éva, Baráth, Barbara, Czuriga-Kovács, Katalin Réka, Lóczi, Linda, Vasas, Nikolett, Fekete, István, Fekete, Klára, Berényi, Ervin, Oláh, László, Csiba, László, Bagoly, Zsuzsa“…In a Kaplan–Meier survival analysis, patients with an α2-PI antigen in the highest quartile on admission showed significantly better long-term survival as compared to those with α2-PI antigen in the lowest quartile (HR: 4.54; 95%CI:1.92–10.8, p < 0.001); however, in a multivariate analysis, a low admission α2-PI antigen did not prove to be an independent risk factor of poor long-term outcomes. …”
Publicado 2022
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83905por Contreras-Yáñez, Irazú, Guaracha-Basáñez, Guillermo Arturo, Cuevas-Montoya, Maximiliano, de Jesús Hernández-Bautista, José, Pascual-Ramos, Virginia“…Early PT was associated with DFR, while the % of the patient follow-up PT was not: HR = 3.84 [1.13–13.07] when the model was adjusted for cumulative N of DMARDs/patient and 3.16 [1.14–8.77] when also adjusted for baseline SF-36 physical component score. …”
Publicado 2022
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83906por Nakai, Michikazu, Iwanaga, Yoshitaka, Kanaoka, Koshiro, Sumita, Yoko, Nishioka, Yuichi, Myojin, Tomoya, Kubo, Shinichiro, Okada, Katsuki, Soeda, Tsunenari, Noda, Tatsuya, Sakata, Yasushi, Imamura, Tomoaki, Saito, Yoshihiko, Yasuda, Satoshi, Miyamoto, Yoshihiro“…In propensity-matched cohorts, SGLT2 inhibitor use was associated with a lower risk of mortality and HF readmission than DPP-4 inhibitor use (HR [95% CI]; 0.70 [0.56, 0.89] and 0.52 [0.45, 0.61], respectively). …”
Publicado 2022
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83907por Seitz, Robert S., Hurwitz, Michael E., Nielsen, Tyler J., Bailey, Daniel B., Varga, Matthew G., Ring, Brian Z., Metts, Carrie F., Schweitzer, Brock L., McGregor, Kimberly, Ross, Douglas T.“…IO Score positive patients (40%) had a significant Cox proportional hazard ratio (HR) of 0.59 (95% CI 0.45–0.78 p < 0.001) for OS and improved median OS (15.6 versus 7.5 months) compared to IO Score negative patients. …”
Publicado 2022
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83908por Titmuss, Emma, Corbett, Richard D., Davidson, Scott, Abbasi, Sanna, Williamson, Laura M., Pleasance, Erin D., Shlien, Adam, Renouf, Daniel J., Jones, Steven J. M., Laskin, Janessa, Marra, Marco A.“…The clinical utility of TMBur-derived TMB estimates were validated, with a genomic TMB ≥ 10/Mb demonstrating improved time to progression, even after correcting for differences in tumor type (HR = 0.39, p = 0.012). CONCLUSIONS: TMBur, a shareable workflow, generates consistent whole genome derived TMB estimates predictive of response to ICIs across multiple analysis centres. …”
Publicado 2022
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83909por Tasca, Karen Ingrid, Hong, Michelle Venancio, Gonçalves Alves, Camila, Silva, Heloiza T.F.C., Pereira, João P.M., Castro, Victor H.A.P., Mezzomo, Diana Fernandes, Sousa, Jéssica C.T.N., Grotto, Rejane M.T., Fortaleza, Carlos M.C.B.“…Entretanto, apenas o modelo de Cox demonstrou que o maior número de doses de vacinas foi um fator protetor de mortalidade (HR: 0,855; 0,739-0,989). CONCLUSÃO: Os achados de modelos preditores dicotômicos e tempo-evento podem diferir, e seu significado depende dos pressupostos epidemiológicos e da questão de pesquisa.…”
Publicado 2022
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83910por Maamar, Adel, Liard, Clémence, Doucet, Willelm, Reizine, Florian, Painvin, Benoit, Delamaire, Flora, Coirier, Valentin, Quelven, Quentin, Guillot, Pauline, Lesouhaitier, Mathieu, Tadié, Jean Marc, Gacouin, Arnaud“…Agitation remained independently associated with mortality after adjustment for other factors (HR = 1.85, 95% CI 1.37–2.49, p < 0.001). CONCLUSION: Agitation in ARDS Covid-19 patients was more frequent than in ARDS influenza patients and was not associated with common risk factors, such as severity of illness or sedation. …”
Publicado 2022
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83911por Holloway-Kew, Kara L., Betson, Amelia G., Anderson, Kara B., Sepetavc, Filip, Gaston, James, Kotowicz, Mark A., Liao, Wan-Hui, Henneberg, Maciej, Pasco, Julie A.“…In unadjusted analyses, compared to non-users without hypertension, men in all three other groups had a higher risk of fracture (Hazard Ratio (HR, 95%CI) 1.54, 1.00–2.37; 1.90, 1.18–3.05; 2.15, 1.26–3.66), for non-users with hypertension, ACEI and ARB users, respectively). …”
Publicado 2022
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83912por Qiu, Zhenkang, Wang, Guobao, Yan, Huzheng, Qi, Han, Zuo, Mengxuan, Wang, Guisong, Jiang, Weiwei, Chen, Zixiong, Xue, Jingbing, Lu, Ligong, Zhang, Fujun, Gao, Fei“…Multivariable analysis showed that TIPS plus sequential systemic therapy (hazard ratio [HR] = 5.799; 95% CI: 3.177, 10.585; p < 0.001) was an independent prognostic factor related to OS. …”
Publicado 2022
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83913por Fatemikia, Hossein, Dehghanian, Amirreza, Ziaian, Bizhan, Farokhipour, Maryam, Ketabchi, Farzaneh“…RESULTS: Mean arterial blood pressure (MBP), heart rate (HR), PaO(2), PaO(2)/FiO(2) ratio, and pH decreased, whereas, maximal inspiratory (MIP) and expiratory (MEP) pressures, and PaCO(2) increased 1 h after the saline lavage. …”
Publicado 2022
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83914por Monteiro, Ana Carolina Costa, Vangala, Sitaram, Wick, Katherine D., Delucchi, Kevin L., Siegel, Emily R., Thompson, B. Taylor, Liu, Kathleen D., Sapru, Anil, Sinha, Pratik, Matthay, Michael A.“…Patients with VR > 2 (median) at day 1 had a significantly lower 90-day survival compared to patients with VR ≤ 2 (HR 1.36, 95% CI 1.10–1.69). VR at day 1 was significantly associated with 28-day mortality (OR = 1.40, 95% CI 1.15–1.72). …”
Publicado 2022
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83915por Rebuzzi, Sara Elena, Signori, Alessio, Banna, Giuseppe Luigi, Gandini, Annalice, Fornarini, Giuseppe, Damassi, Alessandra, Maruzzo, Marco, De Giorgi, Ugo, Basso, Umberto, Chiellino, Silvia, Galli, Luca, Zucali, Paolo Andrea, Fantinel, Emanuela, Naglieri, Emanuele, Procopio, Giuseppe, Milella, Michele, Boccardo, Francesco, Fratino, Lucia, Pipitone, Stefania, Ricotta, Riccardo, Panni, Stefano, Mollica, Veronica, Sorarù, Mariella, Santoni, Matteo, Cortellini, Alessio, Prati, Veronica, Soto Parra, Hector Josè, Santini, Daniele, Atzori, Francesco, Di Napoli, Marilena, Caffo, Orazio, Messina, Marco, Morelli, Franco, Prati, Giuseppe, Nolè, Franco, Vignani, Francesca, Cavo, Alessia, Roviello, Giandomenico, Rescigno, Pasquale, Buti, Sebastiano“…RESULTS: Patients who underwent nephrectomy showed a significantly reduced risk of death (HR 0.44, 95% CI 0.32–0.60, p < 0.001) with a longer median overall survival (OS) (35.9 months vs 12.1 months), 1-year OS of 71.6% vs 50.5% and 2-years OS of 56.5% vs 22.0% compared to those who did not. …”
Publicado 2022
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83916“…RESULTS: In the five trials reported by QLQ-C30, TTD was longer in PD-1/PD-L1 inhibitors compared with control groups (HR = 0.86; 95% CI = 0.76, 0.97; P = 0.013), with similar results in terms of physical function, role function, and pain. …”
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83917por Sun, Song, Zheng, Shan, Shen, Chun, Dong, Rui, Dong, Kuiran, Jiang, Jingying, Yang, Yifan, Chen, Gong“…In addition, the 2-year native liver survival rate in the low-GGT group was significantly lower than that of the high-GGT group (52.5 vs. 66.3%, P < 0.001 HR 1.80, 95% CI 1.38–2.33). CONCLUSION: Compared to patients with high GGT, patients with normal or minimally elevated pre-operative GGT in BA were found to have poorer pre-operative liver function parameters, and post-operatively had lower jaundice clearance rates and worse 2-year native liver survival. …”
Publicado 2022
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83918por Ruggiero, Carmelinda, Baroni, Marta, Talesa, Giuseppe Rocco, Cirimbilli, Alessandro, Prenni, Valentina, Bubba, Valentina, Parretti, Luca, Bogini, Riccardo, Duranti, Giuliana, Caraffa, Auro, Boccardi, Virginia, Mecocci, Patrizia, Rinonapoli, Giuseppe“…The FLS-CP group experienced a lower 1-year (87.2% vs 74.3%; p = 0.001) and 3-year mortality (67.9% vs 55.6%; p = 0.0245) and a lower adjusted 5-year mortality hazard ratio (50.2% vs 58%; HR = 0.76; 95% CI 0.60; 0.96). CONCLUSION: The FLS-CP may improve initiation and adherence to secondary prevention of fragility fractures, reduces healthcare facility admission, and improves long-term survival. …”
Publicado 2022
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83919por Huang, Jiaqi, Zhao, Bin, Weinstein, Stephanie J., Albanes, Demetrius, Mondul, Alison M.“…Participants with a higher metabolic score based on the discovery set had an elevated risk of prostate cancer-specific mortality in the replication set (fourth versus first quartile, HR=3.9, P-value for trend<0.0001). CONCLUSIONS: The metabolic traits identified in this study, including for choline, glutamate, arachidonate, gamma-glutamyl amino acids, fibrinopeptides, and endocannabinoid and redox pathways and their composite risk score, corroborate our previous analysis of fatal prostate cancer and provide novel insights and potential leads regarding the molecular basis of prostate cancer progression and mortality. …”
Publicado 2022
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83920por Yu, Yi-Tong, Ren, Xin-Shuang, An, Yun-Qiang, Yin, Wei-Hua, Zhang, Jie, Wang, Xiang, Lu, Bin“…False lumen thrombosis in the abdominal aorta and/or the renal artery was the predictor of renal atrophy [hazard ratio (HR) =17.757; P=0.008]. CONCLUSIONS: Patients with type 2 or 3 renal artery and false lumen thrombosis in the abdominal aorta and/or renal artery should be monitored closely and actively intervened to prevent renal atrophy.…”
Publicado 2022
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