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83961por Cheng, Daoan, Zhao, Weiqing, Chen, Rui, Li, Dong, Tang, Shuxian, Fang, Cheng, Ji, Mei“…There was no significant difference in EFS between the nICT and nCT groups (HR=1.011, 95% CI: 0.421–2.425, P = 0.981). CONCLUSIONS: Neoadjuvant PD-1 blockade combined with chemotherapy was not superior to chemotherapy alone for patients with resectable locally advanced esophageal carcinoma. …”
Publicado 2023
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83962por van der Velden, Fabian J. S., de Vries, Gabriella, Martin, Alexander, Lim, Emma, von Both, Ulrich, Kolberg, Laura, Carrol, Enitan D., Khanijau, Aakash, Herberg, Jethro A., De, Tisham, Galassini, Rachel, Kuijpers, Taco W., Martinón-Torres, Federico, Rivero-Calle, Irene, Vermont, Clementien L., Hagedoorn, Nienke N., Pokorn, Marko, Pollard, Andrew J., Schlapbach, Luregn J., Tsolia, Maria, Elefhteriou, Irini, Yeung, Shunmay, Zavadska, Dace, Fink, Colin, Voice, Marie, Zenz, Werner, Kohlmaier, Benno, Agyeman, Philipp K. A., Usuf, Effua, Secka, Fatou, de Groot, Ronald, Levin, Michael, van der Flier, Michiel, Emonts, Marieke“…Prospective data on demographics, presenting features, investigations, microbiology, management, and outcome of patients within the ‘Biomarker Validation in HR patients’ database in PERFORM, were analysed. …”
Publicado 2022
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83963por Luo, Xingxian, Du, Xin, Huang, Lin, Guo, Qixiang, Tan, Ruijie, Zhou, Yue, Li, Zhuangqi, Xue, Xuecai, Li, Taifeng, Le, Kaidi, Qian, Feng, Chow, Shein-Chung, Yang, Yue“…Meta-analyses were further employed to evaluate the efficacy and safety of the domestic and imported anticancer drugs, including pooled hazard ratios (HR) for progression-free survival (PFS), overall survival (OS), objective response rates (ORR) for solid cancers, and relative risk for serious adverse events (SAE) and Grade ≥3 adverse events (AEs). …”
Publicado 2022
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83964por Socinski, Mark A., Jotte, Robert M., Cappuzzo, Federico, Nishio, Makoto, Mok, Tony S. K., Reck, Martin, Finley, Gene G., Kaul, Monika D., Yu, Wei, Paranthaman, Nindhana, Bāra, Ilze, West, Howard J.“…To account for immortal bias, a time-dependent Cox model and landmark analyses of irAE occurrence at 1, 3, 6, and 12 months from baseline were used to estimate the hazard ratio (HR) of overall survival (OS). RESULTS: Of 2503 randomized patients, 1577 were in the atezolizumab-containing arm and 926 were in the control arm. …”
Publicado 2023
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83965por Ziranu, Pina, Aimola, Valentina, Pretta, Andrea, Dubois, Marco, Murru, Raffaele, Liscia, Nicole, Cau, Flaviana, Persano, Mara, Deias, Giulia, Palmas, Enrico, Loi, Francesco, Migliari, Marco, Pusceddu, Valeria, Puzzoni, Marco, Lai, Eleonora, Cascinu, Stefano, Faa, Gavino, Scartozzi, Mario“…CD44 overexpression (3+) was correlated with poor prognosis (p = 0.0011; HR = 0.2), with a mOS of 14.5 months (95%CI 11.7 to 35.9) versus 30.7 months (95%CI 27.8 to 101) in lower CD44 expression. …”
Publicado 2023
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83966por Nair, Madhumathy G., Ramesh, Rakesh S., Naidu, Chandrakala M., Mavatkar, Apoorva D., V. P., Snijesh, Ramamurthy, Vishakha, Somashekaraiah, Vidya M., C. E., Anupama, Raghunathan, Kiruthiga, Panigrahi, Anuradha, Das, Manjula, Dhar, Sujan K., Prabhu, Jyothi S.“…Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p = 0.017)]. The nomogram model showed that the addition of ALU 247 with other variables significantly improved (C-index 0.823) the predictive ability of the model. …”
Publicado 2023
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83967por Wang, Libo, Chen, Kejun, Weng, Siyuan, Xu, Hui, Ren, Yuqing, Cheng, Quan, Luo, Peng, Zhang, Jian, Liu, Zaoqu, Han, Xinwei“…After incorporating several clinicopathologic features such as age, gender, and tumor mutation burden (TMB), the results of multivariate Cox regression analysis also demonstrated that the PI3K pathway mutation could indicate better immunotherapy outcomes in HNSC patients with a hazard ratio (HR) of 0.533 (95% CI: 0.313–0.910; p = 0.021) in the immunotherapy cohort MSKCC-2019, compared with 0.888 (95% CI: 0.636–1.241; p = 0.487) and 1.939 (95% CI: 0.483–7.781; p = 0.351) in the non-immunotherapy cohorts TCGA-HNSC and MD-Anderson. …”
Publicado 2023
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83968por Korde, Neha, Tavitian, Elizabet, Mastey, Donna, Lengfellner, Joseph, Hevroni, Gil, Zarski, Andrew, Salcedo, Meghan, Mailankody, Sham, Hassoun, Hani, Smith, Eric L., Hultcrantz, Malin, Shah, Urvi, Tan, Carlyn, Diamond, Benjamin, Shah, Gunjan, Scordo, Michael, Lahoud, Oscar, Chung, David J., Landau, Heather, Giralt, Sergio, Derkach, Andriy, Atkinson, Thomas M., Sabbatini, Paul, König, Francesca, Usmani, Saad Z., Landgren, Ola, Lesokhin, Alexander M.“…The primary endpoint of the study was to determine feasibility of continuous data capture, defined as 13 or more patients of each 20-patient cohort compliant with capturing data for ≥16 h of a 24-hr period in ≥60% of days of ≥4 induction cycles. …”
Publicado 2023
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83969por Olivera, P, Martinez-Lozano, H, Leibovitzh, H, Xue, M, Xu, W, Espin-Garcia, O, Madsen, K, Meddings, J, Guttman, D, Griffiths, A, Huynh, H, Turner, D, Panancionne, R, Steinhart, H, Aumais, G, Jacobson, K, Mack, D, Marshall, J, Moayyedi, P, Lee, S -H, Turpin, W, Croitoru, K“…In multivariable analysis, multiplex status at recruitment was associated with increased risk of CD onset (adjusted HR 3.41, 95% CI 1.70-6.87, p=0.00055), after adjusting for demographics, FCP, LMR, and CD-PRS. …”
Publicado 2023
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83970por Khan, R, Kuenzig, E, Tang, A, Im, J, Widdifield, J, McCurdy, J, Kaplan, G, Benchimol, E“…Within 12 months, these rates were 1.59(95% CI, 1.58-1.59) and 1.42(95% CI, 1.42-1.42) per 100,000 person-days among people with and without IBD, respectively.After adjusting for vaccination status and history of VTE there was no difference in the risk of VTE for people with and without IBD (HR 1.08, 95%CI, 0.64 to 1.83). CONCLUSION(S): IBD patients with COVID-19 were not more likely to experience a VTE infection compared with the general popluation. …”
Publicado 2023
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83971por Nellist, Clara“…A possible solution would be the implementation of monolithic HV or HR CMOS sensors, also being actively studied. A specific R&D program has been started with the aim of producing and testing large size (1‐2 cm2) demonstrators of this technology by the end of 2016. …”
Publicado 2016
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83972por CERN. Geneva“…</em></td> </tr> </tbody> </table> <hr /> <h3><em><strong>Une conférence publique de Dr. …”
Publicado 2022
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83973por CERN. Geneva“… <br>La conférence est basée sur son dernier livre : « Physique en Crises, des Multivers aux fake news » (L’Harmattan)<br> </p><p><i>Conférence en français | Gratuit, inscription recommandée</i><br><i>Un enregistrement sera disponible en ligne après l'événement</i></p><hr><h3><i>Physics in questions (from multiverses to fake news)</i><br><i>A lecture by Bruno Mansoulié, Physicist at CERN and in the Particle Physics Department of CEA-Saclay</i></h3><p><i>Modern Physics demonstrates its effectiveness every day in our daily lives, yet its status is by no means a quiet reign. …”
Publicado 2023
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83974por Trama, Annalisa, Licitra, Lisa, Cavalieri, Stefano, Bonfarnuzzo, Simone, Baili, Paolo, Ciarfella, Antonio, Parente, Pablo, Almadori, Giovanni, Ansarin, Mohssen, Bacigalupo, Almalina, Baumeister, Philipp, Baujat, Bertrand, Bossi, Paolo, Cavalera, Elisa, Cercato, Maria Cecilia, Dieleman, Francois, Fakhry, Nicolas, Ferraresi, Virginia, Gaino, Francesca, Galizia, Danilo, Halamkova, Jana, Halme, Elina, Hardillo, Jose, Hofauer, Benedikt, Kinloch, Emma, Livi, Lorenzo, Locati, Laura Deborah, Mattheis, Stefan, Mercante, Giuseppe, Mirabile, Aurora, Molteni, Gabriele, Orlandi, Ester, Persio, Roberto, Sciallero, Stefania, Smeele, Ludi, Tagliabue, Marta, Valentini, Valentino, Van Harpen, Carla, Westphalen, Christoph Benedikt, Botta, Laura“…Multivariable Cox’s proportional hazards model and Hazard ratios (HR) for all-cause or cause specific mortality will be used to determine independent predictors of overall survival, recurrence etc. …”
Publicado 2023
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83975por Taran, Shaurya, Coiffard, Benjamin, Huszti, Ella, Li, Qixuan, Chu, Leslie, Thomas, Claire, Burns, Stacey, Robles, Priscila, Herridge, Margaret S., Goligher, Ewan C.“…Among patients who survived to day 90, lower DAAH(90) was associated with higher mortality at 1 year after ICU admission (tertile 1 vs tertile 3: adjusted hazard ratio [HR], 0.18 [95% CI, 0.07-0.43]; P < .001). At 3 months of follow-up, lower DAAH(90) was independently associated with lower median scores on the FIM (tertile 1 vs tertile 3, 76 [IQR, 46.2-101] vs 121 [IQR, 112-124.2]; P = .04), 6MWT (tertile 1 vs tertile 3, 98 [IQR, 0-239] vs 402 [IQR, 300-494]; P < .001), MRC (tertile 1 vs tertile 3, 48 [IQR, 32-54] vs 58 [IQR, 51-60]; P < .001), and SF-36 PCS (tertile 1 vs tertile 3, 30 [IQR, 22-38] vs 37 [IQR, 31-47]; P = .001) measures. …”
Publicado 2023
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83976por Hu, Xi′e, Yang, Ping, Chen, Songhao, Wei, Gang, Yuan, Lijuan, Yang, Zhenyu, Gong, Li, He, Li, Yang, Lin, Peng, Shujia, Dong, Yanming, He, Xianli, Bao, Guoqiang“…RESULTS: Compared with HER2(neg) TNBC, HER2(low) TNBC patients exhibited malignant clinical features with larger tumor size (P = 0.04), more lymph nodes involvement (P = 0.02), higher histological grade of lesions (P < 0.001), higher Ki67 status (P < 0.01), and a worse prognosis (P < 0.001; HR [CI 95%] = 3.44 [2.10–5.62]). Cox proportional hazards analysis showed that neoadjuvant systemic therapy, lymph nodes involvement and Ki67 levels were prognostic factors in HER2(low) TNBC but not in HER2(neg) TNBC patients. …”
Publicado 2023
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83977por Park, Se Jun, Park, Ju Yeon, Shin, Kabsoo, Hong, Tae Ho, Lee, MyungAh, Kim, Younghoon, Kim, In-Ho“…At a median follow-up of 8.39 months, the median OS was 13.2 (95% CI, 8.17–18.3) and 6.36 months (95% CI, 3.27–9.45) in the low and high exoPD-L1 groups, respectively (HR = 0.61; 95% CI, 0.35–1.04; p = 0.059). ExoPD-L1 levels did not affect the proportion of CD8(+)CD69(+) effector cytotoxic T cells in either of the groups (p = 0.166). …”
Publicado 2023
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83978por Wu, Zhenguo, Cheng, Cheng, Sun, Xiangfei, Wang, Juan, Guo, Dachuan, Chen, Sha, Zhang, Yerui, Liu, Xiaoyu, Liu, Li, Zhang, Cheng, Yang, Jianmin“…Patients with higher TyG index and HUA were at higher risk of MACE (Kaplan–Meier analysis: log-rank P < 0.001; Cox regression: HR = 4.10; 95% CI 2.80–6.00, P < 0.001). A significant synergistic interaction was found between the TyG index and SUA [RERI (95% CI): 1.83 (0.32–3.34), P = 0.017; AP (95% CI): 0.41 (0.17–0.66), P = 0.001; SI (95% CI): 2.13 (1.13–4.00), P = 0.019]. …”
Publicado 2023
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83979“…Après ajustement sur les facteurs de confusion, les patients avec IMC < 20 avaient un risque plus élevé de mortalité à un an (Hazard ratio [intervalle de confiance à 95 %] : 1,75 [1,00–3,05], p = 0,048), contrairement aux patients avec un IMC > 30 (HR 1,06 [0,65–1,74], p = 0,8). Le taux d’albumine n’a pas permis de prédire le pronostic à court (C statistics = 0,56 [0,48–0,65], p = 0,2) et à long terme (C statistics = 0,55 [0,47–0,62], p = 0,2). …”
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83980por Bledsoe, Joseph, Woller, Scott C., Brooks, Maria, Sciurba, Frank C., Krishnan, Jerry A., Martin, Deborah, Hou, Peter, Lin, Janet Y., Kindzelski, Andrei, Handberg, Eileen, Kirwan, Bridget-Anne, Zaharris, Elaine, Castro, Lauren, Shapiro, Nancy L., Pepine, Carl J., Majercik, Sarah, Fu, Zhuxuan, Zhong, Yongqi, Venugopal, Vidya, Lai, Yu-Hsuan, Ridker, Paul M., Connors, Jean M.“…Upon Cox regression analysis adjustment patients enrolled at an AUEC setting remained at significant risk of the primary composite outcome, HR 3.40 (95% CI 1.46, 7.94). CONCLUSIONS: Patients with clinically stable COVID-19 presenting to an AUEC enrollment setting represent a population at increased risk of arterial and venous thrombosis complications, hospitalization for cardiopulmonary events, or death, when adjusted for other risk factors, compared with patients enrolled at a MC setting. …”
Publicado 2023
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