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  1. 83961
    “…There was no significant difference in EFS between the nICT and nCT groups (HR=1.011, 95% CI: 0.421–2.425, P = 0.981). CONCLUSIONS: Neoadjuvant PD-1 blockade combined with chemotherapy was not superior to chemotherapy alone for patients with resectable locally advanced esophageal carcinoma. …”
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    Neoadjuvant PD-1 blockade combined with chemotherapy is not superior to neoadjuvant chemotherapy alone in resectable locally advanced esophageal carcinoma
  2. 83962
    “…Prospective data on demographics, presenting features, investigations, microbiology, management, and outcome of patients within the ‘Biomarker Validation in HR patients’ database in PERFORM, were analysed. …”
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    Febrile illness in high-risk children: a prospective, international observational study
  3. 83963
    “…Meta-analyses were further employed to evaluate the efficacy and safety of the domestic and imported anticancer drugs, including pooled hazard ratios (HR) for progression-free survival (PFS), overall survival (OS), objective response rates (ORR) for solid cancers, and relative risk for serious adverse events (SAE) and Grade ≥3 adverse events (AEs). …”
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    The price, efficacy, and safety of within-class targeted anticancer medicines between domestic and imported drugs in China: a comparative analysis
  4. 83964
    “…To account for immortal bias, a time-dependent Cox model and landmark analyses of irAE occurrence at 1, 3, 6, and 12 months from baseline were used to estimate the hazard ratio (HR) of overall survival (OS). RESULTS: Of 2503 randomized patients, 1577 were in the atezolizumab-containing arm and 926 were in the control arm. …”
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    Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer: Pooled Analyses of the Phase 3 IMpower130, IMpower132, and IMpower150 Randomized Clinical Trials
  5. 83965
    “…CD44 overexpression (3+) was correlated with poor prognosis (p = 0.0011; HR = 0.2), with a mOS of 14.5 months (95%CI 11.7 to 35.9) versus 30.7 months (95%CI 27.8 to 101) in lower CD44 expression. …”
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    New Horizons in Metastatic Colorectal Cancer: Prognostic Role of CD44 Expression
  6. 83966
    “…Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p = 0.017)]. The nomogram model showed that the addition of ALU 247 with other variables significantly improved (C-index 0.823) the predictive ability of the model. …”
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    Estimation of ALU Repetitive Elements in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
  7. 83967
    “…After incorporating several clinicopathologic features such as age, gender, and tumor mutation burden (TMB), the results of multivariate Cox regression analysis also demonstrated that the PI3K pathway mutation could indicate better immunotherapy outcomes in HNSC patients with a hazard ratio (HR) of 0.533 (95% CI: 0.313–0.910; p = 0.021) in the immunotherapy cohort MSKCC-2019, compared with 0.888 (95% CI: 0.636–1.241; p = 0.487) and 1.939 (95% CI: 0.483–7.781; p = 0.351) in the non-immunotherapy cohorts TCGA-HNSC and MD-Anderson. …”
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    PI3K pathway mutation predicts an activated immune microenvironment and better immunotherapeutic efficacy in head and neck squamous cell carcinoma
  8. 83968
    “…The primary endpoint of the study was to determine feasibility of continuous data capture, defined as 13 or more patients of each 20-patient cohort compliant with capturing data for ≥16 h of a 24-hr period in ≥60% of days of ≥4 induction cycles. …”
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    Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study
  9. 83969
    “…In multivariable analysis, multiplex status at recruitment was associated with increased risk of CD onset (adjusted HR 3.41, 95% CI 1.70-6.87, p=0.00055), after adjusting for demographics, FCP, LMR, and CD-PRS. …”
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    A39 HEALTHY FIRST-DEGREE RELATIVES FROM MULTIPLEX FAMILIES VERSUS SIMPLEX HARBOR A HIGHER RISK OF DEVELOPING CROHN'S DISEASE AND ARE ASSOCIATED WITH SUBCLINICAL INFLAMMATION AND ALTERED MICROBIOME COMPOSITION
  10. 83970
    “…Within 12 months, these rates were 1.59(95% CI, 1.58-1.59) and 1.42(95% CI, 1.42-1.42) per 100,000 person-days among people with and without IBD, respectively.After adjusting for vaccination status and history of VTE there was no difference in the risk of VTE for people with and without IBD (HR 1.08, 95%CI, 0.64 to 1.83). CONCLUSION(S): IBD patients with COVID-19 were not more likely to experience a VTE infection compared with the general popluation. …”
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    A177 RISK OF VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A POPULATION-BASED MATCHED COHORT STUDY
  11. 83971
    por Nellist, Clara
    Publicado 2016
    “…A possible solution would be the implementation of monolithic HV or HR CMOS sensors, also being actively studied. A specific R&D program has been started with the aim of producing and testing large size (1‐2 cm2) demonstrators of this technology by the end of 2016. …”
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    Module and electronics developments for the ATLAS ITK pixel system
  12. 83972
    por CERN. Geneva
    Publicado 2022
    “…</em></td> </tr> </tbody> </table> <hr /> <h3><em><strong>Une conférence publique de Dr. …”
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    Our Milky Way seen by the Gaia Mission
  13. 83973
    por CERN. Geneva
    Publicado 2023
    “…&nbsp;<br>La conférence est basée sur son dernier livre : « Physique en Crises, des Multivers aux fake news » (L’Harmattan)<br>&nbsp;</p><p><i>Conférence en français | Gratuit, inscription recommandée</i><br><i>Un enregistrement sera disponible en ligne après l'événement</i></p><hr><h3><i>Physics in questions (from multiverses to fake news)</i><br><i>A lecture by Bruno Mansoulié, Physicist at CERN and in the Particle Physics Department of CEA-Saclay</i></h3><p><i>Modern Physics demonstrates its effectiveness every day in our daily lives, yet its status is by no means a quiet reign. …”
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    Physique en questions - Des multivers aux fake-news
  14. 83974
    “…Multivariable Cox’s proportional hazards model and Hazard ratios (HR) for all-cause or cause specific mortality will be used to determine independent predictors of overall survival, recurrence etc. …”
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    The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers
  15. 83975
    “…Among patients who survived to day 90, lower DAAH(90) was associated with higher mortality at 1 year after ICU admission (tertile 1 vs tertile 3: adjusted hazard ratio [HR], 0.18 [95% CI, 0.07-0.43]; P < .001). At 3 months of follow-up, lower DAAH(90) was independently associated with lower median scores on the FIM (tertile 1 vs tertile 3, 76 [IQR, 46.2-101] vs 121 [IQR, 112-124.2]; P = .04), 6MWT (tertile 1 vs tertile 3, 98 [IQR, 0-239] vs 402 [IQR, 300-494]; P < .001), MRC (tertile 1 vs tertile 3, 48 [IQR, 32-54] vs 58 [IQR, 51-60]; P < .001), and SF-36 PCS (tertile 1 vs tertile 3, 30 [IQR, 22-38] vs 37 [IQR, 31-47]; P = .001) measures. …”
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    Association of Days Alive and at Home at Day 90 After Intensive Care Unit Admission With Long-term Survival and Functional Status Among Mechanically Ventilated Patients
  16. 83976
    “…RESULTS: Compared with HER2(neg) TNBC, HER2(low) TNBC patients exhibited malignant clinical features with larger tumor size (P = 0.04), more lymph nodes involvement (P = 0.02), higher histological grade of lesions (P < 0.001), higher Ki67 status (P < 0.01), and a worse prognosis (P < 0.001; HR [CI 95%] = 3.44 [2.10–5.62]). Cox proportional hazards analysis showed that neoadjuvant systemic therapy, lymph nodes involvement and Ki67 levels were prognostic factors in HER2(low) TNBC but not in HER2(neg) TNBC patients. …”
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    Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low
  17. 83977
    “…At a median follow-up of 8.39 months, the median OS was 13.2 (95% CI, 8.17–18.3) and 6.36 months (95% CI, 3.27–9.45) in the low and high exoPD-L1 groups, respectively (HR = 0.61; 95% CI, 0.35–1.04; p = 0.059). ExoPD-L1 levels did not affect the proportion of CD8(+)CD69(+) effector cytotoxic T cells in either of the groups (p = 0.166). …”
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    Clinical significance of serum-derived exosomal PD-L1 expression in patients with advanced pancreatic cancer
  18. 83978
    “…Patients with higher TyG index and HUA were at higher risk of MACE (Kaplan–Meier analysis: log-rank P < 0.001; Cox regression: HR = 4.10; 95% CI 2.80–6.00, P < 0.001). A significant synergistic interaction was found between the TyG index and SUA [RERI (95% CI): 1.83 (0.32–3.34), P = 0.017; AP (95% CI): 0.41 (0.17–0.66), P = 0.001; SI (95% CI): 2.13 (1.13–4.00), P = 0.019]. …”
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    The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study
  19. 83979
    “…Après ajustement sur les facteurs de confusion, les patients avec IMC < 20 avaient un risque plus élevé de mortalité à un an (Hazard ratio [intervalle de confiance à 95 %] : 1,75 [1,00–3,05], p = 0,048), contrairement aux patients avec un IMC > 30 (HR 1,06 [0,65–1,74], p = 0,8). Le taux d’albumine n’a pas permis de prédire le pronostic à court (C statistics = 0,56 [0,48–0,65], p = 0,2) et à long terme (C statistics = 0,55 [0,47–0,62], p = 0,2). …”
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    IMC et risque de mortalité à un an chez des patients très âgés hospitalisés pour COVID-19 : étude observationnelle
  20. 83980
    “…Upon Cox regression analysis adjustment patients enrolled at an AUEC setting remained at significant risk of the primary composite outcome, HR 3.40 (95% CI 1.46, 7.94). CONCLUSIONS: Patients with clinically stable COVID-19 presenting to an AUEC enrollment setting represent a population at increased risk of arterial and venous thrombosis complications, hospitalization for cardiopulmonary events, or death, when adjusted for other risk factors, compared with patients enrolled at a MC setting. …”
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    Clinically stable covid-19 patients presenting to acute unscheduled episodic care venues have increased risk of hospitalization: secondary analysis of a randomized control trial
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