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  1. 84081
    “…People with COPD who were prescribed ICSs were at increased risk of COVID-19-related death compared with those prescribed LABA–LAMA combinations (adjusted HR 1·39 [95% CI 1·10–1·76]). Compared with those prescribed SABAs only, people with asthma who were prescribed high-dose ICS were at an increased risk of death (1·55 [1·10–2·18]), whereas those given a low or medium dose were not (1·14 [0·85–1·54]). …”
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    Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
  2. 84082
    “…Self-sampling has been shown to be an effective strategy for screening women for high-risk human papillomavirus (HR-HPV) infection in specific contexts. However, its effectiveness among medically underserved women in safety net health systems has not been evaluated. …”
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    Mailed self-sample HPV testing kits to improve cervical cancer screening in a safety net health system: protocol for a hybrid effectiveness-implementation randomized controlled trial
  3. 84083
    “…After 4 years minimum follow-up, OS (HR; 95% CI) remained superior with NIVO+IPI vs SUN in ITT (0.69; 0.59 to 0.81) and I/P patients (0.65; 0.54 to 0.78). …”
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    Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 4-year follow-up of the phase III CheckMate 214 trial
  4. 84084
    “…Moreover, 3 of the upregulated genes (MGST1, GPX8, GCCT) were associated with reduced disease-free survival in patients [Hazard ratio (HR) 2.2-2.5; P = 0.03-0.0054], suggesting a critical role for this pathway in pancreatic cancer progression. …”
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    Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells
  5. 84085
    “…Compared to periods of non-glucocorticoid use, those with <5.0 mg daily prednisolone-equivalent dose had increased all-cause CVD risk (HR = 1.74; 95% confidence interval [CI] 1.64–1.84; range 1.52 for polymyalgia rheumatica and/or giant cell arteritis to 2.82 for systemic lupus erythematosus). …”
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    Dose-dependent oral glucocorticoid cardiovascular risks in people with immune-mediated inflammatory diseases: A population-based cohort study
  6. 84086
    “…Cox analyses revealed a hazard ratio (HR) of 19 (95% confidence interval [CI] 2.2–157.8) for future conversion of SCD subjects with high misfolding and of 11 (95% CI 1.0–110.1) for those with low misfolding. …”
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    Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline
  7. 84087
    “…A strong association between receipt of MenACWY and pneumococcal vaccines was seen for CD [hazard ratio (HR): 3.2; 95% CI: 1.8–5.7] and HIV [23.0; 13.9–38.1]. …”
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    26. Factors Associated with Meningococcal Vaccination among Patients with Newly Diagnosed High-Risk Conditions
  8. 84088
    “…In multivariate analyses, pts with resistance ≥ 1 ASPB had higher 30-day mortality (aOR=1.61 [CI: 1.01-2.56]) and were less likely to be discharged home (aHR [95%]: 0.5 [0.3-0.9]). Crude and Adjusted Associations Between Presence of Anti-Pseudomonal β-Lactam -Resistance (Reference= no ASPB resistance) and Outcomes among Adult, ICU patients with HAP/VAP due to PSA who received a Microbiologic Active Anti-Pseudomonal β-Lactam [Image: see text] CONCLUSION: Despite receiving a microbiologic active agent within ≤ 2 days of their PSA HAP/VAP, pts with PSA that were resistant to ≥ 1 ASPB had worse outcomes relative to those that had no ASPB resistance. …”
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    1623. Outcomes of Critically Ill Adults, Hospitalized Patients (Pts) with Pseudomonas aeruginosa (PSA) Hospital- and Ventilator-Associated Pneumonia (HAP/VAP) Who Received an Active Anti-Pseudomonal β-Lactam (ASPB): Does “S” Equal Success in the Presence of Resistance to other ASPB?
  9. 84089
    “…Patients were stratified into 3 groups according to bone marrow morphology, prednisone response, age, genotype, and karyotype information: standard risk (SR), intermediate risk (IR) and high risk (HR). For SR group, daunorubicin was decreased in induction IA while duration was reduced in Induction Ib (2 weeks in place of 4 weeks). …”
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    Reduced intensity of early intensification does not increase the risk of relapse in children with standard risk acute lymphoblastic leukemia - a multi-centric clinical study of GD-2008-ALL protocol
  10. 84090
    por Shi, Nannan, Liu, Bin, Liang, Ning, Ma, Yan, Ge, Youwen, Yi, Honggang, Wo, Hongmei, Gu, Heng, Kuang, Yuan, Tang, Shaowen, Zhao, Yang, Tong, Lin, Liu, Sihong, Zhao, Chen, Chen, Renbo, Bai, Weiguo, Fan, Yipin, Shi, Zhan, Li, Li, Liu, Jia, Gu, Hao, Zhi, Yingjie, Wang, Zhifei, Li, Yuanyuan, Li, Huizhen, Wang, Jingya, Jiao, Liwen, Tian, Yaxin, Xiong, Yibai, Huo, Ruili, Zhang, Xiaohui, Bai, Jiangfeng, Chen, Hong, Chen, Liying, Feng, Qiao, Guo, Tuanmao, Hou, Yong, Hu, Guifen, Hu, Xiaomei, Hu, Yunhong, Huang, Jin, Huang, Qiuhua, Huang, Shaozhen, Ji, Liang, Jin, Haihao, Lei, Xiao, Li, Chunyan, Wu, Guihui, Li, Jike, Li, Minqing, Li, Quntang, Li, Xianyong, Liu, Hongde, Liu, Jinping, Liu, Zhang, Ma, Yuting, Mao, Ya, Mo, Liufen, Na, Hui, Wang, Jingwei, Song, Fangli, Sun, Sheng, Wang, Dongting, Wang, Mingxuan, Wang, Xiaoyan, Wang, Yinzhen, Wang, Yudong, Wu, Wei, Wu, Lanping, Xiao, Yanhua, Xie, Haijun, Xu, Hongming, Xu, Shoufang, Xue, Ruixia, Yang, Chun, Yang, Kaijun, Yang, Puye, Yuan, Shengli, Zhang, Gongqi, Zhang, Jinbo, Zhang, Linsong, Zhao, Shusen, Zhao, Wanying, Zheng, Kai, Zhou, Yingchun, Zhu, Junteng, Zhu, Tianqing, Li, Guangxi, Wang, Wei, Zhang, Huamin, Wang, Yanping, Wang, Yongyan
    Publicado 2020
    “…Compared with treatment initiated after 3 weeks, early treatment with QFPDD after less than 1 week, 1-2 weeks, or 2-3 weeks had a higher likelihood of recovery, with adjusted hazard ratio (HR) (95 % confidence interval [CI]) of 3.81 (2.65–5.48), 2.63 (1.86-3.73), and 1.92 (1.34-2.75), respectively. …”
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    Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study
  11. 84091
    “…The median time of SARS-CoV-2 RNA clearance in CM and WM group were 12 days and 15.5 days respectively, the ratio of nucleic acid negative conversion of CM group at different follow-up time points was significantly higher than that of WM group (HR: 2.281, P = 0.018). Further, the chest CT imaging showed more widely lung lesion opacity absorbed in the CM group. …”
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    Efficacy and safety assessment of severe COVID-19 patients with Chinese medicine: A retrospective case series study at early stage of the COVID-19 epidemic in Wuhan, China
  12. 84092
    “…On multivariate Cox regression analysis, independent predictors of survival were use of tocilizumab (HR 0.621, 95% CI 0.427–0.903, P 0.013) and higher oxygen saturation. …”
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    Tocilizumab improves survival in severe COVID-19 pneumonia with persistent hypoxia: a retrospective cohort study with follow-up from Mumbai, India
  13. 84093
    “…Multivariate analyses showed that WT1 was an independent risk factor for relapse (HR 2.89; 95% confidence interval (CI), 1.25–6.71; P = 0.014). …”
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    Wilms’ tumor gene 1 is an independent prognostic factor for pediatric acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
  14. 84094
    “…It is worth noting that IOC independent of other factors was associated with a favor prognosis in CRC patients with stage II/III (HR 0.50, 95%CI 0.30–0.82, P=.006). Moreover, for patients with stage II colorectal carcinoma, DFS did not differ between two groups (P=.553, Kaplan-Meier log-rank), and OS was no exception. …”
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    Effect and safety of intraoperative intraperitoneal chemotherapy on patients suffering from colorectal cancer
  15. 84095
    “…Multivariate COX regression showed that after demographics, baseline laboratory values and remission status at 6th month were adjusted, aMN group had similar renal outcome compared with iMN group, the HR of primary outcome was 0.735 (95 % CI 0.360 ~ 1.503, p = 0.399). …”
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    Renal outcomes of idiopathic and atypical membranous nephropathy in adult Chinese patients: a single center retrospective cohort study
  16. 84096
    “…Multivariate Cox regression analysis identified the combined expression of the 6 genes as an independent predictor of better clinical outcome in TNBC (HR: 0.56, 95% CI 0.38-0.82, P = 0.003). In conclusion, our findings evidence that DHT-activated AR induces Src-mediated ErbB-2 rapid activation and its migration to the nucleus where it binds to HAS sites in the DNA. …”
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    Androgen Receptor Highjacks ErbB-2 Nuclear Function to Induce Triple Negative Breast Cancer Growth
  17. 84097
    “…Initial Vital signs: BP 117/67, HR 62, RR 14, T 98, SpO2 99% on room air. BMI 19. …”
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    Factitious Total Triiodothyronine(T3) Elevation in a Euthyroid Patient With Paraproteinemia
  18. 84098
    “…Laboratory tests showed lipase 69 U/L (13-60U/L), albumin-corrected calcium 14.3 mg/dL (8.8-10.3mg/dL), phosphorus 3.30 mg/dL (2.4-4.2mg/dL), magnesium 1.58 mg/dL (1.8-2.2mg/dL), creatinine 1.38 mg/dL (0.90-1.30 mg/dL), alkaline phosphatase 77 IU/L (43-115IU/L), iPTH 4 pg/mL (11-67pg/mL), PTHrp <0.4 pmol/L (≤4.2pmol/L), 25-OH vitamin D 32.1 ng/mL (30-100ng/mL), 1,25-dihydroxyvitamin D <5.0 pg/mL(19.9-79.3pg/mL), hemoglobin 11.6 g/dL (14-18g/dL), negative serum and urine protein electrophoresis, TSH 0.003 uIU/mL (0.45-5.33 uIU/mL), free T4 2.80 ng/dL (0.71-1.85ng/dL), total T3 2.57 ng/mL (0.80-2.00ng/mL), TSI: 486% (<140%), urine calcium 24hr 525mg/day (100-300mg/day). Thoracic and abdominopelvic CT scan without contrast was unremarkable for masses, adenopathies, osseous lesions, or acute abdominal processes. …”
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    Graves’ Disease Induced Severe Hypercalcemia
  19. 84099
    “…Kaplan–Meier analysis in the derivation cohort demonstrated higher all-cause mortality in patients with high (≥ 0.60 K/μL) vs. low monocyte count (< 0.60 K/μL) [HR 2.05, (95% CI 1.19–3.53), (P = 0.01)]. CONCLUSIONS: Increased monocyte count and RDW may represent negative prognostic biomarkers in patients with IPF. …”
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    Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis
  20. 84100
    “…We have used inclusion criteria as1Not known diabetes 2Either RT PCR + ve OR COVID-19 Ag +ve OR HR CT SCAN show atypical pneumonia or COVID-19 Ab positive 3Presented as hyperglycemia RBG > 200 mg% 4HbA1c > 7 with Urine Ketones + Exclusion Criteria Received steroids in recent past <2 wk. …”
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    COVID19 Induced Diabetes; New Type of Diabetes Mellitus? Viral Genetic Material a Step Towards Cure of Diabetes?
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