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84121por Morgenstern, Jakob, Groener, Jan B., Jende, Johann M. E., Kurz, Felix T., Strom, Alexander, Göpfert, Jens, Kender, Zoltan, Le Marois, Maxime, Brune, Maik, Kuner, Rohini, Herzig, Stephan, Roden, Michael, Ziegler, Dan, Bendszus, Martin, Szendroedi, Julia, Nawroth, Peter, Kopf, Stefan, Fleming, Thomas“…A follow-up study revealed that increased neurofilament light chain was associated with the development of a hyperalgesic phenotype (p < 0.05), whereas decreased myelin protein zero predicted hypoalgesia (p < 0.001) and progressive loss of nerve function 24 months in advance (HR of 6.519). CONCLUSIONS/INTERPRETATION: This study introduces a dynamic and non-invasive assessment strategy for the underlying pathogenesis of diabetic peripheral neuropathy. …”
Publicado 2021
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84122por Ejaz, Muslima, Mubarak, Muhammad, Ali, Tazeen Saeed, Andersson, Sören, Ekström, Anna Mia“…The overall, HPV16 positivity was 35.5% (33/93) among all abnormal anal lesions and all 3 HSIL were HPV16 positive, however, HPV16 positivity could show its association with ASIL detection in univariate model only (PR(crude): 2.11(1.39–3.18)). Moreover, any HR-HPV type (PR 3.04; 95% CI 1.75–5.26), concurrent sexually transmitted infection (STI) (2.13; (1.28–3.55)) and HIV + /HPV + coinfection (1.75; (1.07–2.88)) remained independently associated with ASIL in the multivariate model. …”
Publicado 2021
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84123por Veziris, Nicolas, Andréjak, Claire, Bouée, Stéphane, Emery, Corinne, Obradovic, Marko, Chiron, Raphaël“…Mortality was lower for patients treated with antibiotics compared to untreated patients (HR = 0.772 (95% CI [0.628; 0.949]). Annual total expenses the year following the infection in a societal perspective were € 24,083 (SD: 29,358) in NTM-PD subjects vs. € 3402 (SD: 8575) in controls (p < 0.0001). …”
Publicado 2021
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84124por Xin, Yuanfang, Shen, Guoshuang, Zheng, Yonghui, Guan, Yumei, Huo, Xingfa, Li, Jinming, Ren, Dengfeng, Zhao, Fuxing, Liu, Zhen, Li, Zitao, Zhao, Jiuda“…Three RCTs (N = 1615) reported EFS and the results showed that adding PD-1/PD-L1 inhibitors increased EFS (HR 0.65, 95% CI 0.50–0.83, P = 0.0007) in ITT populations with a short follow-up time. …”
Publicado 2021
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84125Publicado 2021“…Light restrictions were associated with a 0·6% reference non-operation rate, moderate lockdowns with a 5·5% rate (HR 0·81, 95% CI 0·77–0·84, p<0·0001), and full lockdowns with a 15·0% rate (0·51, 0·50– 0·53, p<0·0001). …”
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84126por Davidson, Jennifer A, Banerjee, Amitava, Smeeth, Liam, McDonald, Helen I, Grint, Daniel, Herrett, Emily, Forbes, Harriet, Pebody, Richard, Warren-Gash, Charlotte“…After adjustment (for age, sex, ethnicity, socioeconomic status, body-mass index, alcohol consumption, and smoking status in the hypertension analysis; and for alcohol consumption in the QRISK2 analysis), hypertension (HR 1·98 [95% CI 1·83–2·15]) and a QRISK2 score of 10% or higher (3·65 [3·42–3·89]) were associated with a substantially increased risk of acute cardiovascular events after acute respiratory infection. …”
Publicado 2021
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84127por Temesgem, Zelalem, Burger, Charles, Baker, Jason, Polk, Christopher, Libertin, Claudia R, Kelley, Colleen F, Marconi, Vincent, Orenstein, Robert, Catterson, Victoria, Aronstein, William, Durrant, Cameron, Chappell, Dale, Ahmed, Omar, Chappell, Gabrielle, Badley, Andrew“…Lenzilumab improved the primary endpoint, likelihood of SWOV in the mITT population, by 1.54-fold (HR: 1.54; 95%CI: 1.02-2.32, p=0.0403). Lenzilumab improved SWOV by 1.91-fold (nominal p=0.0073) and 1.92-fold (nominal p=0.0067) in patients receiving remdesivir or remdesivir and corticosteroids, respectively. …”
Publicado 2021
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84128por Colussi, GianLuca, Perrotta, Giacomo, Pillinini, Pierpaolo, Dibenedetto, Alessia G., Da Porto, Andrea, Catena, Cristiana, Sechi, Leonardo A.“…In survival analysis, SAPS II cut-off showed the highest difference in 30-day mortality (Hazards Ratio, HR, 5.24, 95% CI 2.99–9.21, P < 0.001). Best independent negative predictors of 30-day mortality were body temperature, mean arterial pressure, arterial oxygen saturation, and hematocrit levels. …”
Publicado 2021
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84129por Drake, Isabel, Fryk, Emanuel, Strindberg, Lena, Lundqvist, Annika, Rosengren, Anders H., Groop, Leif, Ahlqvist, Emma, Borén, Jan, Orho-Melander, Marju, Jansson, Per-Anders“…However, galectin-1 was associated with increased risk of type 2 diabetes (per SD increase, HR 1.12; 95% CI 1.02, 1.24). Two-sample MR analyses could not ascertain a causal effect of galectin-1 on CKD (OR 0.92; 95% CI 0.82, 1.02) or type 2 diabetes (OR 1.05; 95% CI 0.98, 1.14) in a general population. …”
Publicado 2021
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84130“…The secondary endpoints were intraoperative fluid infusion volume, urine volume, mean arterial pressure (MAP), heart rate (HR), cardiac index (CI), regional cerebral oxygen saturation (rSO(2)) value, lactic acid value, and visual analog scale (VAS) pain score at 1–3 days after surgery. …”
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84131por Oki, Eiji, Shinto, Eiji, Shimokawa, Mototsugu, Yamaguchi, Shigeki, Ishiguro, Megumi, Hasegawa, Seiji, Takii, Yasumasa, Ishida, Hideyuki, Kusumoto, Tetsuya, Morita, Masaru, Tomita, Naohiro, Shiozawa, Manabu, Tanaka, Masafumi, Ozawa, Heita, Hashiguchi, Yojiro, Ohnuma, Shinobu, Tada, Sachiyo, Matsushima, Tomoko, Hase, Kazuo“…The 5-year RFS rates were 84.3 and 72.0% in patients treated with and without oxaliplatin, respectively, for the MSI-like subtype (HR, 0.495; 95% CI, 0.145–1.692; P = 0.25). No differences in RFS rates were noted in the CIN-like or stromal subtypes. …”
Publicado 2021
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84132por Susanti, Susanti, Wibowo, Satrio, Akbariani, Gilang, Yoshuantari, Naomi, Heriyanto, Didik Setyo, Ridwanuloh, Asep Muhamad, Hariyatun, Hariyatun, Handaya, Adeodatus Yuda, Kurnianda, Johan, Hutajulu, Susanna Hilda, Ilyas, Mohammad“…Stage, node status, histological grading and ECOG score were significantly associated with patient overall survival (p < 0.005), yet only ECOG was an independent factor for OS (HR: 4.38; 95% CI: 1.72–11.2; p = 0.002). In summary, this study is the first to reveal a potentially higher frequency of LS among CRC patients in Indonesia, which may partially contribute to the reported much higher number of EOCRC as compared to the incidence in the West.…”
Publicado 2021
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84133por Teyateeti, Ajalaya, Mahvash, Armeen, Long, James, Abdelsalam, Mohamed, Avritscher, Rony, Kaseb, Ahmed, Odisio, Bruno, Ravizzini, Gregory, Surasi, Devaki, Teyateeti, Achiraya, Macapinlac, Homer, Kappadath, Srinivas Cheenu“…TTP was longest in TARE_alone (8.6 mo; 95%CI: 3.4-13.8), followed by TARE_sorafenib (5.1 mo; 95%CI: 4.0-6.2) and TARE_no_sorafenib (2.7 mo; 95%CI: 2.2-3.1). Pre-existing EHD (HR: 0.37, 95%CI: 0.24-0.56, P < 0.001) was a sole prognostic factor for TTP in TARE_sorafenib with no prognostic factor for TTP in TARE_alone. …”
Publicado 2021
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84134por He, Jiaoyu, Li, Qiufu, Ma, Shiyu, Li, Tianjun, Chen, Yuning, Liu, Yiran, Cui, Yanru, Peng, Jianying, Shi, Yunfan, Wei, Xia, Ding, Xianping“…Mutations influence the validity of HPV clinical diagnostic probes, the polymorphism analysis of α-9 HPV E6 enrich the data of HR-risk HPV in Sichuan China, and the detection probes designed with the polymorphism data in mind can improve the efficiency of clinical detection; Mutations influence epitopes affinity, the association of E6 polymorphism and epitope affinity can improve the design of therapeutic vaccine with good immunity and high generality antigen epitope; The above study all provide a good theoretical basis for the prevention and treatment of HPV-related diseases. …”
Publicado 2022
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84135“…HNRNPA2B1 was upregulated in advanced stages (GS > 7, pT3, HR > 1, and TP53 mutation), as verified using clinical PCa tissue. …”
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84136por Romeo, Clémence, Le Saux, Olivia, Jacobs, Margaux, Joly, Florence, Ferron, Gwenael, Favier, Laure, Fumet, Jean-David, Isambert, Nicolas, Colombo, Pierre-Emmanuel, Sabatier, Renaud, Bastide, Ludovic, Charreton, Amandine, Devouassoux-Shisheboran, Mojgan, Gertych, Witold, Dubot, Coraline, Bello Roufai, Diana, Bataillon, Guillaume, Berton, Dominique, Kalbacher, Elsa, Pautier, Patricia, Pomel, Christophe, Cornou, Caroline, Treilleux, Isabelle, Lardy-Cleaud, Audrey, Ray-Coquard, Isabelle“…In the early stage UCS subgroup (i.e., stage IA, n = 86, 30%), mPFS for patients treated with adjuvant chemotherapy (n = 24) was not reached (95% CI 22.2–NR), while mPFS for untreated patients (n = 62) was 19.9 months (95% IC 13.9–72.9) (HR 0.44 (0.20–0.95) p = 0.03). At the first relapse, median PFS for all patients was 4.2 months (95% CI 3.5–5.3). …”
Publicado 2022
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84137por Mu, Wei, Xie, Yaoli, Li, Jinhu, Yan, Runzhi, Zhang, Jingxian, Liu, Yu’e, Fan, Yimin“…Multivariate Cox hazards regression showed that high expression of PBK may be an independent risk factor for overall survival in HCC patients (HR = 1.566, 95% CI=1.062–2.311, P= 0.024). The Protein–protein interaction network showed that PBK significantly interacted with LRRC47, ARAF, LGALS9B, TTK, DLG1, and other essential genes. …”
Publicado 2022
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84138por Huhn, Sophie, Axt, Miriam, Gunga, Hanns-Christian, Maggioni, Martina Anna, Munga, Stephen, Obor, David, Sié, Ali, Boudo, Valentin, Bunker, Aditi, Sauerborn, Rainer, Bärnighausen, Till, Barteit, Sandra“…Typical measurements included steps (95/179, 53.1%), heart rate (HR; 55/179, 30.7%), and sleep duration (51/179, 28.5%). …”
Publicado 2022
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84139“…Her bloods showed microcytic anaemia, raised ESR (peak 97mm/hr), CRP (peak 30mg/l), CK (peak 628 IU/l), and LDH (peak 512 IU/l), but normal ferritin and ACE. …”
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84140“…Compared with the lowest total sedentary time category (median duration, 2.98 h/d), participants in the highest category (median duration, 10.2 h/d) had an increased risk of CVD mortality (pooled HR, 1.29; 95% CI, 1.13–1.47). The association between screen time and CVD risks was similar to total sedentary time with the cut-off point of 5–6 h/d. …”
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