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  1. 84241
    “…For patients receiving 2.5g IV q8h, CAZ and AVI median (IQR) AUCs were 525.6 hr*µg/ml (403.2, 762.0) and 83.7 (57.3, 129.5), respectively. …”
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    1298. Population Pharmacokinetics of Ceftazidime-avibactam among Critically-ill Patients with and without Receipt of Continuous Renal Replacement Therapy
  2. 84242
    “…No specific funding was received for the study. H.R. reports receiving personal fees from Plasma Surgical Inc., Ethicon Endosurgery, Olympus and Nordic Pharma for presentations related to his experience with endometriosis surgery. …”
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    Nonvisualized palpable bowel endometriotic satellites
  3. 84243
    Publicado 2021
    “…In participants with previous cardiovascular disease at baseline, the corresponding rates were 39·7 (95% CI 39·0–40·5) and 36·0 (95% CI 35·3–36·7), in the comparator and intervention groups, respectively. Hazard ratios (HR) associated with a reduction of systolic blood pressure by 5 mm Hg for a major cardiovascular event were 0·91, 95% CI 0·89–0·94 for partipants without previous cardiovascular disease and 0·89, 0·86–0·92, for those with previous cardiovascular disease. …”
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    Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis
  4. 84244
    “…Cox proportional hazard analysis demonstrated that C(RS) (+ 10 mL/cm H(2)O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02–1.28, p = 0.018). CONCLUSIONS: This multicentre report provides a comprehensive account of C(RS) in COVID-19 patients on MV. …”
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    An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
  5. 84245
    “…Similar effect sizes were seen for ChAdOx1 (adjusted HR 0·32, 95% CI 0·15–0·66) and BNT162b2 (0·35, 0·17–0·71) vaccines at 35–48 days. …”
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    Vaccine effectiveness of the first dose of ChAdOx1 nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of long-term care facilities in England (VIVALDI): a prospective cohort study
  6. 84246
    “…In the subset of patients who had undergone radical prostatectomy (n=81), the ClaD clinical nomogram resulted in a significant separation in Kaplan-Meier survival curves between patients with and without biochemical recurrence (HR 5·92 [2·34–15·00], p=0·044), whereas the DIN (1·22 [0·54–2·79], p=0·65) and PIN nomograms did not (1·30 [0·62–2·71], p=0·51). …”
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    An integrated nomogram combining deep learning, Prostate Imaging–Reporting and Data System (PI-RADS) scoring, and clinical variables for identification of clinically significant prostate cancer on biparametric MRI: a retrospective multicentre study
  7. 84247
    “…In all cohorts the 50(th) and lower percentile of admission RI was predictive of mortality in multivariable modeling (i.e. aspirin: 3(rd) and 4(th) admission RI quartiles with HR = 0.18 for both, p<0.001 for both). In PS matched patients, aspirin was associated with a significant decrease in mortality (OR 0.65 [0.42, 0.98], p=0.044) and a significant increase in mechanical ventilation (OR 1.49 [1.03, 2.18], p=0.037) and ICU status (OR = 1.45 [1.06, 1.98], p=0.021). …”
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    Admission Rothman Index, Aspirin, and Intermediate Dose Anticoagulation Effects on Outcomes in COVID-19: A Multi-Site Propensity Matched Analysis
  8. 84248
    por Mammen, Joy John, Kumar, Snehil, Thomas, Lovely, Kumar, Gunjan, Zachariah, Anand, Jeyaseelan, Lakshmanan, Peter, John Victor, Agarwal, Anup, Mukherjee, Aparna, Chatterjee, Pranab, Bhatnagar, Tarun, Rasalam, Jess Elizabeth, Chacko, Binila, Mani, Thenmozhi, Joy, Melvin, Rupali, Priscilla, Murugesan, Malathi, Daniel, Dolly, Latha, B, Bundas, Sunita, Kumar, Vivek, Dosi, Ravi, Khambholja, Janakkumar R, de Souza, Rosemarie, Chander, B Thrilok, Bahadur, Shalini, Dube, Simmi, Suri, Amit, Jindal, Aikaj, Shrivastav, Om, Barge, Vijay, Bajpayee, Archana, Malhotra, Pankaj, Singh, Neha, Tambe, Muralidhar, Sharma, Nimisha, Bhat, Shreepad, Kaulgud, Ram S, Gurtoo, Anil, Reddy, D Himanshu, Upadhyay, Kamlesh, Jain, Ashish, Patel, Tinkal C, Nagori, Irfan, Jha, Pramod R, Babu, K V Sreedhar, Aparna, C, Panjwani, Sunil Jodharam, Natarajan, M, Baldi, Milind, Khadke, Vrushali Khirid, Dua, Seema, Singh, Ravindraa, Sharma, Ashish, Sharma, Jayashree, Gokhale, Yojana A, Yadav, Pragya D, Sapkal, Gajanan, Kaushal, Himanshu, Kumar, V Saravana
    Publicado 2021
    “…On multivariable Fine and Gray model, severity of illness (subdistribution HR 1.22, 95% CI 1.11 to 1.35, p<0.001), PaO(2)/FiO(2) ratio <100 (3.47, 1.64–7.37, p=0.001), neutrophil lymphocyte ratio >10 (9.97, 3.65–27.13, p<0.001), D-dimer >1.0 mg/L (2.50, 1.14–5.48, p=0.022), ferritin ≥500 ng/mL (2.67, 1.44–4.96, p=0.002) and lactate dehydrogenase ≥450 IU/L (2.96, 1.60–5.45, p=0.001) were significantly associated with death. …”
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    Factors associated with mortality among moderate and severe patients with COVID-19 in India: a secondary analysis of a randomised controlled trial
  9. 84249
    “…Based on prespecified adjusted analysis accounting for race, gender, age, and baseline eGFR, the risk of virologic failure was higher for 2DR compared to 3DR STRs (HR=2.2 CI 95% 1.1-4.5, p=0.032) [Table 2]. Adjusting for baseline CD4 was not feasible due to high proportion of missing CD4 at index. …”
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    77. Risk of Virologic Failure Among Treatment-experienced Suppressed People with HIV (PWH) Treated with Single-Tablet 2-Drug (2DR) vs 3-Drug (3DR) Regimens
  10. 84250
    “…OBJECTIVES: To deduce the impact of the surgical mask and filtering face piece type 2 (FFP2) or N95 respirator application on gas exchange (pulse-derived oxygen saturation (SpO(2)), carbon dioxide partial pressure (PCO(2)), carbon dioxide exhalation (VCO(2)) and oxygen uptake (VO(2))), pulmonary function (respiratory rate and ventilation) and physical performance (heart rate HR, peak power output W(peak)). METHODS: Systematic review with meta-analysis. …”
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    The Impact of Ubiquitous Face Masks and Filtering Face Piece Application During Rest, Work and Exercise on Gas Exchange, Pulmonary Function and Physical Performance: A Systematic Review with Meta-analysis
  11. 84251
    “…Une valeur de KL-6 initial élevée était significativement associée à la mortalité intra-hospitalière (HR: 8,66; IC 95%:1,1–69,2), à l’admission en réanimation (p = 0,049) et à l’extension radiologique des lésions au scanner (p = 0,0040). …”
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    Valeur pronostique du KL-6 initial (Krebs von den Lungen 6) au cours de la pneumopathie à SARS-CoV-2
  12. 84252
    “…White blood cells ranged from 4.3 to 20.1 (10^9/l), Neutrophils ranged from 1.1 to 11.4 (10^9/l), CRP 0.7 to 149.5 (mg/L), ESR 2 to 15 (mm/hr). Serum Amyloid A ranged from 8.0 to 370 (mg/L). …”
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    O19 A case of pyogenic arthritis, pyoderma gangrenosum and acne syndrome
  13. 84253
    “…This progressed to a month of not being able to walk, disturbed sleep and morning stiffness of > 1hr. Clinical examination showed no extra musculoskeletal manifestations, and no other joint pain. …”
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    O10 Multi-disciplinary working in SpA diagnosis: case study
  14. 84254
    por Llera, Andrea Sabina, Abdelhay, Eliana Saul Furquim Werneck, Artagaveytia, Nora, Daneri-Navarro, Adrián, Müller, Bettina, Velazquez, Carlos, Alcoba, Elsa B., Alonso, Isabel, Alves da Quinta, Daniela B., Binato, Renata, Bravo, Alicia Inés, Camejo, Natalia, Carraro, Dirce Maria, Castro, Mónica, Castro-Cervantes, Juan M., Cataldi, Sandra, Cayota, Alfonso, Cerda, Mauricio, Colombo, Alicia, Crocamo, Susanne, Del Toro-Arreola, Alicia, Delgadillo-Cisterna, Raúl, Delgado, Lucía, Dreyer-Breitenbach, Marisa, Fejerman, Laura, Fernández, Elmer A., Fernández, Jorge, Fernández, Wanda, Franco-Topete, Ramón A., Gabay, Carolina, Gaete, Fancy, Garibay-Escobar, Adriana, Gómez, Jorge, Greif, Gonzalo, Gross, Thomas G., Guerrero, Marisol, Henderson, Marianne K., Lopez-Muñoz, Miguel E., Lopez-Vazquez, Alejandra, Maldonado, Silvina, Morán-Mendoza, Andrés J., Nagai, Maria Aparecida, Oceguera-Villanueva, Antonio, Ortiz-Martínez, Miguel A., Quintero, Jael, Quintero-Ramos, Antonio, Reis, Rui M., Retamales, Javier, Rivera-Claisse, Ernesto, Rocha, Darío, Rodríguez, Robinson, Rosales, Cristina, Salas-González, Efrain, Sanchotena, Verónica, Segovia, Laura, Sendoya, Juan Martín, Silva-García, Aida A., Trinchero, Alejandra, Valenzuela, Olivia, Vedham, Vidya, Zagame, Livia, Podhajcer, Osvaldo L.
    Publicado 2022
    “…While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. …”
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    The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients
  15. 84255
    “…Am J Sports Med, 2019. 44(5): p. 1039-1042. 6. Morris BJ, Mir HR. The opioid epidemic: Impact on orthopaedic surgery. …”
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    Poster 223: Evidence-Based Opioid Prescribing Guidelines Following Anterior Cruciate Ligament Reconstruction (ACLR)
  16. 84256
    “…Relative to the unassisted conception group, the adjusted HR for ADHD was 1.19 (95% CI 1.16–1.22) in the infertility without fertility treatment group, 1.09 (95% CI 1.01–1.17) in the OI/IUI group and 1.12 (95% CI 1.04–1.20) in the IVF/ICSI group. …”
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    Attention-deficit hyperactivity disorder in children born to mothers with infertility: a population-based cohort study
  17. 84257
    “…Moderate certainty evidence showed that gonadotrophins reduced the time to conception leading to a live birth when compared to CC (6 RCTs, 2058 women, HR 1.37, 95% CI 1.15–1.63, I(2) = 22%). No strong evidence on the treatment–covariate (female age, BMI or primary versus secondary infertility) interactions was found. …”
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    Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis
  18. 84258
    “…In the predefined analysis without site-stratification, vilobelimab significantly reduced all-cause mortality at 28 days (HR 0·67, 95% CI 0·48–0·96; p=0·027). The most common TEAEs were acute kidney injury (35 [20%] of 175 in the vilobelimab group vs 40 [21%] of 189 in the placebo), pneumonia (38 [22%] vs 26 [14%]), and septic shock (24 [14%] vs 31 [16%]). …”
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    Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
  19. 84259
    “…Initial investigations included ESR 30 (mm/hr), CRP 17 (mg/L) with a normal FBC, iron profile, U&E, LFT, rheumatoid factor, CK, immunoglobulins and LDH. …”
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    OA26 A case of Weber-Christian disease: a diagnostic conundrum
  20. 84260
    “…Investigations showed severe anemia (Hb 46g/L), leukocytosis (WBC 24/L), thrombocytosis (662/L), high inflammatory markers (CRP >300mg/L, ESR 160mm/hr), high ferritin (600ug/L). CT thorax with cardiac angiogram revealed a large intra-atrial septal mass, extensive pulmonary nodules, bilateral hilar and mediastinal lymphadenopathy and pericardial effusion. …”
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    OA28 A rare case of cardiac tumour in infancy mimicking sarcoidosis
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