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921por Manzano Palomo, Maria Sagrario, Anaya Caravaca, Belen, Balsa Bretón, Maria Angeles, Castrillo, Sergio Muñiz, Vicente, Asuncion de la Morena, Castro Arce, Eduardo, Alves Prez, María Teresa“…CONCLUSION: Souvenaid had a significant effect on several cognitive domains, and on SCS in patients with MCI-HR-AD. Its intervention had an impact on preservation on (18)F-FDG PET scans.…”
Publicado 2019
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923por Lai, Szu-Chia, Chong, Pele Choi-Sing, Yeh, Chia-Tsui, Liu, Levent Shih-Jen, Jan, Jia-Tsrong, Chi, Hsiang-Yun, Liu, Hwan-Wun, Chen, Ann, Wang, Yeau-Ching“…Systematic epitope mapping showed that all these neutralizing mAbs recognized a 15-residues peptide (CB-119) corresponding to residues 1143–1157 (SPDVDLGDISGINAS) that was located to the second heptad repeat (HR2) region of the SARS-CoV spike protein. The peptide CB-119 could specifically inhibit the interaction of neutralizing mAbs and spike protein in a dose-dependent manner. …”
Publicado 2005
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924por Brunet, Scott C., Kuczynski, Michael T., Bhatla, Jennifer L., Lemay, Sophie, Pauchard, Yves, Salat, Peter, Barnabe, Cheryl, Manske, Sarah L.“…METHODS: Ten participants with RA completed HR-pQCT scans of the 2nd and 3rd MCP joints at enrolment to the study and at a 6-month follow-up interval. …”
Publicado 2020
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925por Svarre, Frederik Rose, Jensen, Mads Møller, Nielsen, Josephine, Villumsen, Morten“…RESULTS: The median of differences in steps between Garmin Vivosmart(®) HR and manual step count ranged from −49.5 (IQR = 101) at 1.6 km/h to −1 (IQR = 4) at 4.0 km/h. …”
Publicado 2020
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926por Rugo, Hope S., Dieras, Veronique, Cortes, Javier, Patt, Debra, Wildiers, Hans, O’Shaughnessy, Joyce, Zamora, Esther, Yardley, Denise A., Carter, Gebra Cuyun, Sheffield, Kristin M., Li, Li, Andre, Valerie A. M., Li, Xiaohong I., Frenzel, Martin, Huang, Yu-Jing, Dickler, Maura N., Tolaney, Sara M.“…Median OS was 22.3 months in the abemaciclib arm versus 13.6 months in the matched real-world chemotherapy cohort with an estimated hazard ratio (HR) of 0.54. The median DoT was 4.1 months in MONARCH 1 compared to 2.9 months in the real-world chemotherapy cohort with HR of 0.76. …”
Publicado 2020
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927por Thanopoulou, Eirini, Khader, Leila, Caira, Morena, Wardley, Andrew, Ettl, Johannes, Miglietta, Federica, Neven, Patrick, Guarneri, Valentina“…A growing body of evidence suggests that hormone receptor-positive (HR+)/HER2+ BC and HR-negative (HR−)/HER2+ BC are biologically different, with complex molecular bidirectional crosstalk between the estrogen receptor and HER2 pathway potentially affecting sensitivity to both HER2-targeted and endocrine therapy in patients with HR+/HER2+ BC. …”
Publicado 2020
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928por Gao, Hong-Fei, Lin, Ying-Yi, Zhu, Teng, Ji, Fei, Zhang, Liu-Lu, Yang, Ci-Qiu, Yang, Mei, Li, Jie-Qing, Cheng, Min-Yi, Wang, Kun“…Compared with ET, adjuvant CDK4/6 inhibitors with ET prolonged IDFS in patients with HR+/HER2- EBC (HR 0.87, 95% CI 0.76–0.98, p = 0.03, I(2) = 19%), with positive therapeutic responses observed in patients with N2/N3 nodal status (HR 0.83, 95% CI 0.71–0.97, p = 0.02, I(2) = 0%). …”
Publicado 2021
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929por Zhou, Jifang, Cueto, Jenilee, Ko, Naomi Y., Hoskins, Kent F., Nabulsi, Nadia A., Asfaw, Alemseged A., Hubbard, Colin C., Mitra, Debanjali, Calip, Gregory S., Law, Ernest H.“…BACKGROUND: Multiple independent risk factors are associated with the prognosis of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer (BC), the most common BC subtype. …”
Publicado 2021
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930por Cuyún Carter, Gebra, Mohanty, Maitreyee, Stenger, Keri, Morato Guimaraes, Claudia, Singuru, Shivaprasad, Basa, Pradeep, Singh, Sheena, Tongbram, Vanita, Kuemmel, Sherko, Guarneri, Valentina, Tolaney, Sara M“…PURPOSE: Advanced breast cancer is a heterogeneous disease with several well-defined subtypes, among which, hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) is most prevalent. Determination of HR and HER2 status influences prognosis and, thus, disease management. …”
Publicado 2021
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931por Liu, Qin, Zhou, Xin, Zhang, Xiaofei, Strickland, Amanda Louise, zheng, wenxin, Chen, Hao, Zhou, Feng“…PURPOSE: To investigate the prevalence of precancers [high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS)] and cancers [squamous cell carcinoma (SCC) and adenocarcinoma (ADC)] in various high-risk human papillomavirus (hrHPV) genotypes or age groups among women with negative for intraepithelial lesion or malignancy (NILM) and hrHPV-positive pap results. …”
Publicado 2021
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932“…Explorations of synthesized PPMA are carried out by FT-IR spectral analysis, nuclear magnetic resonance (NMR) and high resolution scanning electron microscopy (HR-SEM). The inhibition activity is investigated by potentio-dynamic method. …”
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933por Wen, Nan, Qiu, Juanjuan, Xu, Li, Wang, Yu, Zhang, Jia, Xie, Yanyan, Lv, Qing, Du, Zhenggui“…METHODS: A total of 144,735 patients with HR(+), HER2(−), pT1–3N0–1 breast cancer from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015 were included. …”
Publicado 2021
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934por Guerrero-Ramos, Félix, González-Padilla, Daniel A., González-Díaz, Alejandro, de la Rosa-Kehrmann, Federico, Rodríguez-Antolín, Alfredo, Inman, Brant A., Villacampa-Aubá, Felipe“…METHODS: A pilot phase II randomized clinical trial was conducted including HR-NMIBC patients, excluding carcinoma in situ. …”
Publicado 2022
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935por Calaminus, Gabriele, Frappaz, Didier, Ajithkumar, Thankamma, Müller, Jans-Enno, Zimmermann, Martin, Conter, Cecile Faure, Timmermann, Beate, Alapetite, Claire, Murray, Matthew, Garre, Maria Luisa, Dieckmann, Karin, Peyrl, Andreas, Gerber, Nicolas U, Kortmann, Rolf-Dieter, Nicholson, James“…Between 2/2012 and 7/2018, 112 patients with CNS NGGCT were registered, of whom 23 were identified as HR patients; 18/23 had an AFP higher or 1000 ng/ml and were older than 6 years. …”
Publicado 2022
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936“…Here, we engineered a novel HR1 trimer (HR1MFd) by conjugating the trimerization motif foldon to the C terminus of the HR1-derived peptide. …”
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937“…FT-IR spectroscopic analysis revealed various characteristic band values with various functional groups in the formulation extract such as amines, alcohol, fluoro compounds, phenol, alkane, alkene, and conjugated acid groups. HR-LC/MS analyses identified nearly 51 compounds including 9 small peptides and 42 potential phytochemical compounds. …”
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938por Venetis, Konstantinos, Pepe, Francesco, Munzone, Elisabetta, Sajjadi, Elham, Russo, Gianluca, Pisapia, Pasquale, Ivanova, Mariia, Bonizzi, Giuseppina, Vacirca, Davide, Rappa, Alessandra, Ranghiero, Alberto, Taormina, Sergio Vincenzo, Viale, Giuseppe, Troncone, Giancarlo, Barberis, Massimo, Guerini-Rocco, Elena, Malapelle, Umberto, Fusco, Nicola“…Somatic mutations in PIK3CA are present in ~40% breast cancers (BC); their detection in hormone receptor (HR)+/HER2− tumors allows for selecting patients with advanced disease eligible for PIK3CA targeting with alpelisib. …”
Publicado 2022
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939por Mutlu, Muzaffer, Bingol, Zeynebe, Uc, Eda Mehtap, Köksal, Ekrem, Goren, Ahmet C., Alwasel, Saleh H., Gulcin, İlhamiEnlace del recurso
Publicado 2023
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