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3121por Khoury, David S., Wheatley, Adam K., Ramuta, Mitchell D., Reynaldi, Arnold, Cromer, Deborah, Subbarao, Kanta, O’Connor, David H., Kent, Stephen J., Davenport, Miles P.“…However, the apparent potency of different interventions can vary considerably between assays and animal models, leading to very different predictions of clinical efficacy. Complete harmonization of experimental methods may be intractable at the current pace of research. …”
Publicado 2020
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3122por Yamashita, Ayumu, Sakai, Yuki, Yamada, Takashi, Yahata, Noriaki, Kunimatsu, Akira, Okada, Naohiro, Itahashi, Takashi, Hashimoto, Ryuichiro, Mizuta, Hiroto, Ichikawa, Naho, Takamura, Masahiro, Okada, Go, Yamagata, Hirotaka, Harada, Kenichiro, Matsuo, Koji, Tanaka, Saori C., Kawato, Mitsuo, Kasai, Kiyoto, Kato, Nobumasa, Takahashi, Hidehiko, Okamoto, Yasumasa, Yamashita, Okito, Imamizu, Hiroshi“…For the discovery dataset with 713 participants from 4 imaging sites, we removed site differences using our recently developed harmonization method and developed a machine learning MDD classifier. …”
Publicado 2020
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3123por Facchetti, Samantha V., La Spina, Rita, Fumagalli, Francesco, Riccardi, Nicoletta, Gilliland, Douglas, Ponti, Jessica“…Despite the extensive literature on the subject, there is still an insufficient harmonization of methodologies for the collection and analysis of microplastics (MPs) in complex matrices; especially for high density polymers; such as polyvinyl chloride (PVC), which tend to sink and accumulate in sediments, becoming available to benthonic organisms. …”
Publicado 2020
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3124por Afzali, Maryam, Pieciak, Tomasz, Newman, Sharlene, Garyfallidis, Eleftherios, Özarslan, Evren, Cheng, Hu, Jones, Derek K“…Finally, yet importantly, typical approaches to deal with experimental factors are depicted, including unbiased measures and harmonization. We conclude the review with some future directions and recommendations on this topic.…”
Publicado 2021
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3125“…Asian countries and regions have their own regulations on the quality of starting cells, and these regulations are not harmonized. As cell therapy products are being developed across countries and regions, we propose a risk-based approach based on donor location, window period of virus test, and additional virus tests on the master cell bank to fill the gaps in regulation while controlling the risk of viral contamination. …”
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3126por Monteiro Bastos da Silva, Juliana, Chaker, Jade, Martail, Audrey, Costa Moreira, Josino, David, Arthur, Le Bot, Barbara“…This works aims to fuel and expand the discussion in order to subsidize new opportunities of harmonization for non-targeted and suspect screening.…”
Publicado 2021
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3127por Perego, Elisa, Balzarini, Federica, Botteri, Marco, Favetti, Stefania, Zoli, Alberto, Sechi, Giuseppe Maria, Odone, Anna, Signorelli, Carlo, Villa, Guido Francesco“…BACKGROUND AND AIM OF THE WORK: The main objectives of our work were the regional harmonization and standardization of pharmaceutical supplies on MSA in Lombardy. …”
Publicado 2020
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3128“…The WEBIRA method allows the best harmonization of ranking results according to different criteria groups—this is its advantage over other multiple-criteria methods. …”
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3129por Vo, Thanh-Hoa, Liaw, Chia-Ching, Lin, Yu-Chi, Nguyen, Duc Hanh, Nguyen, Thi Tuyet Nhung, Lee, Ching-Kuo, Kuo, Yao-Haur“…A simple, accurate high-performance liquid chromatography–photodiode array (HPLC–PDA) detection method has been developed and validated with significantly statistical impacts according to International Conference on Harmonization (ICH) guidelines. The Response Surface Methodology (RSM), Artificial Neural Network (ANN) models were employed to predictive performance and optimization of the extraction process. …”
Publicado 2021
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3130“…A continued monitoring approach is needed, at national and international levels, with enhanced surveillance and reporting of trends, as well as harmonization of surveillance systems toward a one-health approach to monitoring antimicrobial resistance in animal production particularly if increased resistance rates are being demonstrated.…”
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3131por Stašková, Andrea, Sondorová, Miriam, Nemcová, Radomíra, Kačírová, Jana, Maďar, Marián“…Oral probiotics are increasingly used in the harmonization of the oral microbiota in the prevention or therapy of various oral diseases. …”
Publicado 2021
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3132“…The cited method was fully validated according to the international conference on harmonization (ICH-Q2B) guidelines, then it was applied successfully for quantification of the studied PPIs in real wastewater samples after their solid phase extraction (SPE).…”
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3133por Hahn, Stefan, Meyer, Jessica, Roitzsch, Michael, Delmaar, Christiaan, Koch, Wolfgang, Schwarz, Janine, Heiland, Astrid, Schendel, Thomas, Jung, Christian, Schlüter, Urs“…Model predictions could be improved by more accurate consideration of variation in spray equipment. Inter-model harmonization with regard to spray input parameters and appropriate grouping of spray exposure situations is recommended. …”
Publicado 2021
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3134por Flear, Mark L“…The central role of scientific-technical knowledge and expertise to harmonization abets the latter by minimizing the value to governance of public knowledges on systemic issues. …”
Publicado 2021
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3135por Bravo-Pérez, Carlos, Sola, María, Teruel-Montoya, Raúl, García-Malo, María Dolores, Ortuño, Francisco José, Vicente, Vicente, de Arriba, Felipe, Jerez, Andrés“…In this work, we address lessons learned from the use of MRD in other neoplasms, the steps followed for the harmonization of current methods for comprehensively measuring MRD, and the challenges that new therapies and concepts pose in the MM clinical field.…”
Publicado 2021
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3136por Joshi, Deeksha, Sharma, Ishita, Gupta, Saurabh, Singh, Thakur Gurjeet, Dhiman, Sonia, Prashar, Abhimanyu, Gulati, Monica, Kumar, Bimlesh, Vishwas, Sukriti, Chellappan, Dinesh Kumar, Gupta, Gaurav, Jha, Niraj Kumar, Gupta, Piyush Kumar, Negi, Poonam, Dua, Kamal, Singh, Sachin Kumar“…It not only manages adverse events (AE) but also creates harmonization among countries. Keeping these objectives in focus, the principles, perspectives, and practices with regard to materiovigilance that are followed in the USA, Europe, China, Japan, Australia, Canada, and India are being compared. …”
Publicado 2021
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3137por Ouranidis, Andreas, Davidopoulou, Christina, Tashi, Reald-Konstantinos, Kachrimanis, Kyriakos“…Continuous mRNA drugs manufacturing is perceived to nurture flow processes featuring quality by design, controlled automation, real time validation, robustness, and reproducibility, pertaining to regulatory harmonization. However, the actual adaptation of the latter remains elusive, hence batch-to-continuous transition would a priori necessitate holistic process understanding. …”
Publicado 2021
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3138“…The proposed methods have been validated according to the International Conference on Harmonization guidelines. The approaches provide linear assay of duloxetine hydrochloride over 0.1–2.4 µg ml(−1) and 0.2–2.0 µg ml(−1) for spectrofluorimetric and RRS methods, respectively. …”
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3139por Yoon, Jin H., Sun, Shawn H., Xiao, Manjun, Yang, Hao, Lu, Lin, Li, Yajun, Schwartz, Lawrence H., Zhao, Binsheng“…In conclusion, the CNN based method showed great potential in improving feature reproducibility and generalizability by harmonizing medical images with heterogeneous reconstruction kernels.…”
Publicado 2021
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3140por Picone, Andrea, Finazzi, Marco, Duò, Lamberto, Giannotti, Dario, Ciccacci, Franco, Brambilla, Alberto“…This achievement can be important for hybrid magnetic interfaces, where the harmonization between the molecular and the magnetic orders can enhance the development of hybrid magnetic states.…”
Publicado 2021
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