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  1. 3821
    “…Differences in laboratory environment is a known factor contributing to poor reproducibility of findings between research sites, and well-controlled multisite efforts are an important next step to identify the relevant factors needed to reduce variation in study outcome between laboratories. Through harmonization of apparatus, test protocol, and aligned and non-aligned environmental variables, the present study shows that behavioral pharmacological responses in Shank2 knockout (KO) rats, a model of synaptic dysfunction relevant to autism spectrum disorders, were highly replicable across three research centers. …”
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    Reproducibility via coordinated standardization: a multi-center study in a Shank2 genetic rat model for Autism Spectrum Disorders
  2. 3822
    “…Our results point out that international harmonization effort is needed not only to harmonize differences in regulations between countries but also to overcome diversity in perspectives existing at the site of medical device use.…”
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    Differences in Perspectives of Medical Device Adverse Events: Observational Results in Training Program Using Virtual Cases
  3. 3823
    “…METHODS/STUDY POPULATION: We analyzed data collected by the Joint Task Force on the Harmonization of Core Competencies from a survey of research professionals working in the United States and Canada. …”
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    2069: Competency indices for clinical research professionals
  4. 3824
    “…The influence of ComBatHarmonization was assessed for correction of batch effects. …”
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    Tumor grading of soft tissue sarcomas using MRI-based radiomics
  5. 3825
    “…Reproducibility testing and harmonization are fundamental requirements for wide generalizability of radiomics‐based clinical prediction models. …”
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    Multicenter CT phantoms public dataset for radiomics reproducibility tests
  6. 3826
    “…For the creation of an ecoTTC tool, a large, diverse environmental data set was developed from multiple sources, with harmonization, characterization, and information quality assessment steps to ensure that the information could be effectively organized and mined. …”
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    Creation of a Curated Aquatic Toxicology Database: EnviroTox
  7. 3827
    “…The results of this study will contribute to the harmonization of diagnostic criteria and treatment for ME/CFS in Europe.…”
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    Myalgic encephalomyelitis/chronic fatigue Syndrome (ME/CFS): Investigating care practices pointed out to disparities in diagnosis and treatment across European Union
  8. 3828
    “…Our results show that a urine suite such as that used in this ILS could be employed for testing and harmonization among different platforms. A limited quantity of test materials will be made available for researchers who are willing to repeat the protocols presented here and contribute their data.…”
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    Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite
  9. 3829
    “…Our data show that the number of laboratories providing BRCA1/2 germline assays is significantly increased with further implementation of the somatic test coming soon. The harmonization of the complete laboratory diagnostic path should be encouraged, particularly in order to reduce the gap between laboratories with high and low throughput.…”
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    BRCA1/2 Molecular Assay for Ovarian Cancer Patients: A Survey through Italian Departments of Oncology and Molecular and Genomic Diagnostic Laboratories
  10. 3830
    “…This paper presents a summary of the discussions and consensus opinions of the workshop participants on the initial challenges of harmonization of the detection and clinical use of predictive markers of NSCLC. …”
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    Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity
  11. 3831
    “…This paper should be regarded as a first step in a long-term evidence-based iterative process towards ever increasing harmonization of scan protocols across sites, to ultimately facilitate clinical implementation. …”
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    Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI
  12. 3832
    “…OBJECTIVE: To evaluate the content of ICFs obtained from different genetic studies accomplished in Jordan and their adherence to ethical guidelines proposed by the International Conference on Harmonization—Good Clinical Practice (ICHGCP). METHODS AND MEASURES: A total of 44 ICFs obtained from master theses and grant proposals at two major universities in Jordan were analyzed according to the good clinical practice criteria proposed by ICHGCP. …”
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    Informed Consent Form Challenges for Genetic Research in Jordan
  13. 3833
    “…By contrast, application of our renormalization algorithm regRCPqn: (i) reduces variability and (ii) increases agreement between meta-analysed datasets, both critical components of data harmonization.…”
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    Evaluation of pre-processing on the meta-analysis of DNA methylation data from the Illumina HumanMethylation450 BeadChip platform
  14. 3834
    “…They may also serve as an aid for surveillance, and the full validation permits easy method-transfer allowing worldwide harmonization.…”
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    A new multiplex RT-qPCR method for the simultaneous detection and discrimination of Zika and chikungunya viruses
  15. 3835
    por Mackey, Tim K., Cuomo, Raphael E.
    Publicado 2020
    “…Future efforts should focus on tying cost-saving measurements with anti-corruption indicators, prioritizing centralization of e-procurement systems, establishing regulatory harmonization with standards setting, and incorporating additional anti-corruption technologies into procurement processes for improving access to medicines and to reach the overall goal of Universal Health Coverage.…”
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    An interdisciplinary review of digital technologies to facilitate anti-corruption, transparency and accountability in medicines procurement
  16. 3836
    por Lezotre, Pierre-Louis
    Publicado 2014
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    State of Play and Review of Major Cooperation Initiatives
  17. 3837
    “…CONCLUSIONS: Large, pooled datasets provide great opportunities, justifying the efforts for data harmonization. Still, caution is warranted when using recoded variables which variance is explained limitedly by their original variables as this may jeopardize the validity of study results.…”
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    Pooling individual participant data from randomized controlled trials: Exploring potential loss of information
  18. 3838
    “…Five of the 9 features showed excellent agreement with CV < 1%; 1 feature had moderate agreement (CV < 10%), and 3 features had larger variations (CV ≥ 10%) even after attempts at harmonization of feature calculations. This work highlights the value of feature definition standardization as well as the need to further clarify definitions for some features.…”
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    Standardization in Quantitative Imaging: A Multicenter Comparison of Radiomic Features from Different Software Packages on Digital Reference Objects and Patient Data Sets
  19. 3839
    “…DISCUSSION: The evidence-based methods defined in the NNR2022 project are compatible with most contemporary methods used by leading national food and health authorities. Global harmonization of methodological approaches to nutrition recommendations is strongly encouraged. …”
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    The Nordic Nutrition Recommendations 2022 – principles and methodologies
  20. 3840
    “…The use of different bioinformatic pipelines affects the estimation of the relative abundance of gut microbial community, indicating that studies using different pipelines cannot be directly compared. A harmonization procedure is needed to move the field forward.…”
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    Comparison of Bioinformatics Pipelines and Operating Systems for the Analyses of 16S rRNA Gene Amplicon Sequences in Human Fecal Samples
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