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  1. 4061
    “…The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. …”
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    The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
  2. 4062
    “…Progress can be seen, however, and international cooperation and harmonization is slowly but steadily expanding in the rare disease arena.…”
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    A Review of Rare Disease Policies and Orphan Drug Reimbursement Systems in 12 Eurasian Countries
  3. 4063
    “…Notwithstanding, the high variability of BMSi outcome between studies calls for age-dependent reference values, and for the harmonization of study protocols. Prospective multicenter trials using standard operating procedures are required to establish the value of IMI in the prediction of future fracture risk, before this technique is introduced in routine clinical practice.…”
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    Added Value of Impact Microindentation in the Evaluation of Bone Fragility: A Systematic Review of the Literature
  4. 4064
    “…METHODS: Questionnaires were developed to be used in 6 countries under standardized harmonization procedures and included questions regarding not only food intake and physical activity, but also questions of their determinants. …”
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    Development and reliability of questionnaires for the assessment of diet and physical activity behaviors in a multi-country sample in Europe the Feel4Diabetes Study
  5. 4065
    “…Although clinical studies for various typhoid conjugate vaccines (TCVs) have been performed, there are no comparative data on the immune responses of vaccines due to lack of harmonization of the serological assay. Recently, Typbar-TCV (Vi-TT) was prequalified by WHO and recommended for vaccination in endemic areas. …”
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    Comparison of anti-Vi IgG responses between two clinical studies of typhoid Vi conjugate vaccines (Vi-DT vs Vi-TT)
  6. 4066
    “…Speed up the process of integration of NTBLCP surveillance system with IDSR for data harmonization in the country.…”
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    Evaluation of the national tuberculosis surveillance and response systems, 2018 to 2019: National Tuberculosis, Leprosy and Buruli Ulcer Control Programme, Abuja, Nigeria
  7. 4067
    “…CONCLUSION: Despite the important achievements in the field, a better harmonization of eligibility, and outcome criteria across studies is an important objective to pursue in next future.…”
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    Randomized clinical trials in ANCA-associated vasculitis: a systematic analysis of the WHO - International Clinical Trials Registry Platform
  8. 4068
    “…Since the publication of these previous guidelines, new lines of evidence have been made available on semiquantification, harmonization, comparison with normal datasets, and longitudinal analyses of dopamine transporter imaging with SPECT. …”
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    EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0
  9. 4069
    “…Quantification of minimal disease by dPCR provides a promising tool to facilitate harmonization of minimal disease measurement between laboratories and for clinical studies.…”
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    Quantification of minimal disseminated disease by quantitative polymerase chain reaction and digital polymerase chain reaction for NPM-ALK as a prognostic factor in children with anaplastic large cell lymphoma
  10. 4070
    “…The EGMVI established regulatory and ethical oversight to ensure compliance with the International Conference on Harmonization and Good Clinical Practices for the first importation of investigational product, ethical approval, and conduct of a clinical trial in Equatoguinean history. …”
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    The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa
  11. 4071
    “…Mali’s approach includes the harmonization of research activities; leveraging of research laboratory capacity of the University Clinical Research Center, Mali International Center for Excellence and three other in-country laboratories for community COVID-19 testing; strengthening relationships amongst local and international stakeholders; and collaboration with the Ministry of Health to integrate scientific evidence into public policy and emergency management of COVID-19 through a platform of consultation and open communication. …”
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    Coordinating the research response to COVID-19: Mali’s approach
  12. 4072
    “…Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. …”
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    Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
  13. 4073
    “…Proficiency tests are important instruments of validation, harmonization, and standardization. Within the European Union funded project COMPARE [COllaborative Management Platform for detection and Analyses of (Re-) emerging and foodborne outbreaks in Europe], we conducted a proficiency test to scrutinize the ability to assess diagnostic metagenomics data. …”
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    Proficiency Testing of Metagenomics-Based Detection of Food-Borne Pathogens Using a Complex Artificial Sequencing Dataset
  14. 4074
    por Scherer, Jonas, Nolden, Marco, Kleesiek, Jens, Metzger, Jasmin, Kades, Klaus, Schneider, Verena, Bach, Michael, Sedlaczek, Oliver, Bucher, Andreas M., Vogl, Thomas J., Grünwald, Frank, Kühn, Jens-Peter, Hoffmann, Ralf-Thorsten, Kotzerke, Jörg, Bethge, Oliver, Schimmöller, Lars, Antoch, Gerald, Müller, Hans-Wilhelm, Daul, Andreas, Nikolaou, Konstantin, la Fougère, Christian, Kunz, Wolfgang G., Ingrisch, Michael, Schachtner, Balthasar, Ricke, Jens, Bartenstein, Peter, Nensa, Felix, Radbruch, Alexander, Umutlu, Lale, Forsting, Michael, Seifert, Robert, Herrmann, Ken, Mayer, Philipp, Kauczor, Hans-Ulrich, Penzkofer, Tobias, Hamm, Bernd, Brenner, Winfried, Kloeckner, Roman, Düber, Christoph, Schreckenberger, Mathias, Braren, Rickmer, Kaissis, Georgios, Makowski, Marcus, Eiber, Matthias, Gafita, Andrei, Trager, Rupert, Weber, Wolfgang A., Neubauer, Jakob, Reisert, Marco, Bock, Michael, Bamberg, Fabian, Hennig, Jürgen, Meyer, Philipp Tobias, Ruf, Juri, Haberkorn, Uwe, Schoenberg, Stefan O., Kuder, Tristan, Neher, Peter, Floca, Ralf, Schlemmer, Heinz-Peter, Maier-Hein, Klaus
    Publicado 2020
    “…In multiple complementary use cases, we show that the platform fulfills all relevant requirements to serve as a foundation for multicenter medical imaging trials and research on large cohorts, including the harmonization and integration of data, interactive analysis, automatic analysis, federated machine learning, and extensibility and maintenance processes, which are elementary for the sustainability of such a platform. …”
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    Joint Imaging Platform for Federated Clinical Data Analytics
  15. 4075
    “…Data cleaning and harmonization were done at the GEI-funded GENEVA Coordinating Center at the University of Washington. …”
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    Effects of the BDNF Val66Met polymorphism on functional status and disability in young stroke patients
  16. 4076
    “…Logical steps towards improving prediction accuracies include: further collection of input (training) point samples, further harmonization of measurement methods, addition of more detailed covariates specific to Africa, and implementation of a full spatiotemporal statistical modeling framework.…”
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    Soil nutrient maps of Sub-Saharan Africa: assessment of soil nutrient content at 250 m spatial resolution using machine learning
  17. 4077
    “…Continuous efforts are required to achieve test standardization and harmonization, especially for sirolimus and everolimus.…”
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    Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories
  18. 4078
    “…Significant opportunities for harmonization of exposure toward the lower range has been identified.…”
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    Fluoroscopy usage in contemporary interventional electrophysiology: Insights from a European registry
  19. 4079
    “…However, borrowing from previous experiences in lung cancer, the heterogeneity of antibodies and platforms used in the routine clinical practice requires a strict multi-institutional harmonization effort. In this setting, the present study is aimed to assess the performances of different PD-L1 staining protocols and the inter-observer reliability for its interpretation. …”
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    PD-L1 Testing and Squamous Cell Carcinoma of the Head and Neck: A Multicenter Study on the Diagnostic Reproducibility of Different Protocols
  20. 4080
    “…This was the first prospective clinical investigation conducted according to the Good Clinical Practice Guideline of the International Conference on Harmonization for the treatment of this potentially life-threatening disease. …”
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    Impact of adding tacrolimus to initial treatment of interstitial pneumonitis in polymyositis/dermatomyositis: a single-arm clinical trial
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